| Interacting proteins: Q8WV28 and Q92918 |
Pubmed |
SVM Score :0.0 |
| Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP 76 in lymphocytes . ^^^ |
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| Interacting proteins: Q8WV28 and Q92918 |
Pubmed |
SVM Score :0.0 |
| B cell adaptor containing src homology 2 domain ( BASH ) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1 . ^^^ We have now identified hematopoietic progenitor kinase ( HPK ) 1 , a STE 20 related serine / threonine kinase , as a protein that inducibly interacts with the BASH SH 2 domain . ^^^ BCR ligation induced rapid tyrosine phosphorylation of HPK 1 mainly by Syk and Lyn , resulting in its association with BASH and catalytic activation . ^^^ BCR mediated activation of HPK 1 was impaired in Syk or BASH deficient B cells . ^^^ The functional SH 2 domain of BASH and Tyr 379 within HPK 1 which we identified as a Syk phosphorylation site were both necessary for interaction of both proteins and efficient HPK 1 activation after BCR stimulation . ^^^ |
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| Interacting proteins: Q8WV28 and Q92918 |
Pubmed |
SVM Score :0.0 |
| Subsequent analysis revealed that Src and Syk / ZAP 70 tyrosine kinases and the adaptor proteins LAT , SLP 76 , BLNK , Grb 2 , and Grap are involved in HPK 1 activation . ^^^ |
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| Interacting proteins: Q8WV28 and Q92918 |
Pubmed |
SVM Score :0.0 |
| NA |
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