| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Unlike its relatives SLP 76 and B cell linker protein ( Blnk ) , Clnk is not expressed uniformly within a given hemopoietic cell lineage . ^^^ |
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| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| The SLP 76 ( Src homology 2 domain containing leukocyte protein of 76 kDa ) adapter protein is expressed in T cells and myeloid cells , whereas its homologue BLNK ( B cell linker protein ) is expressed in B cells . ^^^ |
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| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| B cell linker protein ( BLNK ) and Src homology 2 domain containing leukocyte protein of 76 kD ( SLP 76 ) are adaptor proteins required for B cell receptor ( BCR ) and T cell receptor function , respectively . ^^^ |
|
| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP 76 in lymphocytes . ^^^ B cell linker protein ( BLNK ) is a SLP 76 related adaptor protein essential for signal transduction from the BCR . ^^^ |
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| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Closely related molecules with overlapping functions , such as the Syk kinases , SYK , and ZAP 70 , and adaptor molecules , SH 2 domain containing leukocyte protein of 76 kDa and B cell linker protein , are expressed in activated NK cells and are all recruited to the center of the cytolytic synapse . ^^^ |
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| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| The N terminal SH 3 domain of GrpL binds c Cbl while the C terminal SH 3 domain binds B cell linker protein and SH 2 domain containing leukocyte protein of 76 kDa . ^^^ |
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| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| However , at the hierarchial signalling level of SLP 76 [ Src homology 2 ( SH 2 ) domain containing leukocyte protein of 76 kDa ] and LAT ( linker for activation of T cells ) in T cells , the only corresponding protein in B cells was known to be BLNK ( B cell linker protein ) . ^^^ |
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| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| The SLP 76 family of adapters includes SH 2 domain containing leukocyte phosphoprotein of 76kDa ( SLP 76 ) , B cell linker protein ( BLNK ) , and cytokine dependent hematopoietic cell linker ( Clnk ) . ^^^ |
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| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| This protein , named SLP 65 , is part of a signaling complex involving Grb 2 and Vav and shows homology to SLP 76 , a signaling element of the T cell receptor . ^^^ |
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| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| They bind selectively to tyrosine phosphorylated SLP 65 and SLP 76 in activated B and T cells , respectively . ^^^ |
|
| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Together , our results suggest that the adaptor proteins LAT and SLP 76 are involved in pre BCR signaling , thereby rescuing arrested murine SLP 65 ( / ) pre B cells . . ^^^ |
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| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| SLP 76 and SLP 65 : complex regulation of signalling in lymphocytes and beyond . ^^^ SLP 76 and SLP 65 are adaptor proteins that lack intrinsic enzymatic activity but contain multiple protein binding domains . ^^^ In this Review , we discuss the role of SLP 76 and SLP 65 in several signalling pathways in haematopoietic cells , with an emphasis on recent studies that provide insight into their mechanisms of action . . ^^^ |
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| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| BASH shows a substantial sequence similarity to SLP 76 , an adaptor protein functioning in TCR signal transduction . ^^^ |
|
| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| BASH structurally resembles SLP 76 , which is essential for T cell development and T cell receptor signaling . ^^^ |
|
| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Subsequent analysis revealed that Src and Syk / ZAP 70 tyrosine kinases and the adaptor proteins LAT , SLP 76 , BLNK , Grb 2 , and Grap are involved in HPK 1 activation . ^^^ |
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| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Recent studies have demonstrated a requirement for the SLP 76 ( SH 2 domain containing leukocyte protein of 76 kDa ) and LAT ( linker for activation of T cells ) adaptor / linker proteins in T cell antigen receptor activation and T cell development as well as the BLNK ( B cell linker ) linker protein in B cell antigen receptor ( BCR ) signal transduction and B cell development . ^^^ Functional complementation of BLNK by SLP 76 and LAT linker proteins . ^^^ Whereas the SLP 76 and LAT adaptor proteins are expressed in T , natural killer , and myeloid cells and platelets , BLNK is preferentially expressed in B cells and monocytes . ^^^ Although BLNK is structurally homologous to SLP 76 , BLNK interacts with a variety of downstream signaling proteins that interact directly with both SLP 76 and LAT . ^^^ Here , we demonstrate that neither SLP 76 nor LAT alone is sufficient to restore the signaling deficits observed in BLNK deficient B cells . ^^^ |
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| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| This differs from mice lacking the tyrosine kinase Syk that is upstream of BLNK in BCR signaling and contrasts with mice lacking SLP 76 that is the equivalent adaptor molecule in TCR signal transduction . ^^^ |
|
| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Their essential role in lymphocyte signaling was revealed by recent analyses of mice and cell lines deficient in LAT , SLP 76 and BLNK . ^^^ |
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| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Like SLP 76 and Blnk , Clnk was shown to act as a positive regulator of immunoreceptor signaling . ^^^ |
|
| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Mechanisms of signaling by the hematopoietic specific adaptor proteins , SLP 76 and LAT and their B cell counterpart , BLNK / SLP 65 . ^^^ This review summarizes recent research on SLP 76 , LAT , and BLNK . ^^^ In the case of LAT , SLP 76 , and BLNK , the availability of tractable genetic systems , deficient in expression of each of these adaptor proteins , has facilitated in depth investigation of their signaling functions and mechanisms of action . ^^^ |
|
| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|