| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| Cbl suppresses B cell receptor mediated phospholipase C ( PLC ) gamma 2 activation by regulating B cell linker protein PLC gamma 2 binding . ^^^ A possible explanation for the involvement of Cbl in PLC gamma 2 activation was provided by findings that Cbl interacts via its Src homology 2 ( SH 2 ) domain with B cell linker protein ( BLNK ) after BCR ligation . ^^^ |
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| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| Until recently , the molecular mechanism underlying the double requirement for Syk and Btk in PLC gamma 2 activation remained unclear , but new data suggest that an adapter molecule , B cell linker protein ( alternatively named SLP 65 or BASH ) , phosphorylated by Syk , provides docking sites for Btk SH 2 domain as well as PLC gamma 2 SH2 domains , thus bringing Btk into close proximity with PLC gamma 2 . ^^^ |
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| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| Cbl b interacted with PLC gamma 2 and helped the association of PLC gamma 2 with Bruton ' s tyrosine kinase ( Btk ) , as well as B cell linker protein ( BLNK ) . ^^^ |
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| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylated SLP 65 assembles intracellular signaling complexes such as the Ca ( 2 + ) initiation complex encompassing phospholipase C gamma 2 and Bruton ' s tyrosine kinase . ^^^ |
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| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| Specific phosphoacceptor sites in SLP 65 serve as docking sites for Ca ( 2+ ) mobilizing enzymes Btk and PLC gamma 2 . ^^^ We now show that receptor induced tyrosine phosphorylation of NTAL and concomitant Grb 2 complex formation critically modulate the Ca ( 2+ ) response without affecting SLP 65 and PLC gamma 2 phosphorylation . ^^^ Thus , elevation of Ca ( 2+ ) is regulated by at least two signaling modules , the B cell specific Ca ( 2+ ) initiation complex comprising SLP 65 , Btk , and PLC gamma 2 and the more ubiquitously expressed NTAL / Grb2 complex , which acts as an amplifier by switching off inhibitory elements . . ^^^ |
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| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| BLNK required for coupling Syk to PLC gamma 2 and Rac 1 JNK in B cells . ^^^ The BCR induced PLC gamma 2 activation , but not the JNK activation , was restored by introduction of PLC gamma 2 membrane associated form into BLNK deficient B cells . ^^^ As JNK activation requires both Rac 1 and PLC gamma 2 , our results suggest that BLNK regulates the Rac 1 JNK pathway , in addition to modulating PLC gamma 2 localization . . ^^^ |
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| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| Cutting edge : association of phospholipase C gamma 2 Src homology 2 domains with BLNK is critical for B cell antigen receptor signaling . ^^^ A possible explanation for the SH 2 ( N ) requirement was provided by findings that this mutation abrogates the association of PLC gamma 2 with an adaptor protein BLNK . ^^^ Together , our results suggest a central role for the SH 2 ( N ) domain in directing PLC gamma 2 into the close proximity of BCR signaling complex by its association with BLNK , whereby PLC gamma 2 becomes tyrosine phosphorylated and thereby activated . . ^^^ |
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| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| SLP 76 and BLNK link immunoreceptor tyrosine based activation motif containing receptors to signaling molecules that include phospholipase C gamma , mitogen activated protein kinases , and the GTPases Ras and Rho . ^^^ |
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| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| These were derived from decreased inositol 1 , 4 , 5 trisphosphate generation through PLC gamma 2 in BLNK deficient cells . ^^^ Moreover , viability of BLNK deficient as well as PLC gamma 2 deficient cells after exposure to low doses of H2O2 was dramatically enhanced compared with that of the wild type cells . ^^^ These findings have led to the suggestion that BLNK is required for coupling Syk to PLC gamma 2 , thereby accelerating cell apoptosis in B cells exposed to low doses of H2O2 . . ^^^ |
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| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| In contrast , the tumor cells in all cases of lymphocyte predominance Hodgkin disease were positive for Fyn , Syk , BLNK , and PLC gamma 2 , and Lyn immunostaining was seen in a minority of biopsies . ^^^ |
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| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| Significantly , 2 APB induced InsP ( 3 ) R and TRPC 3 activation was prevented in DT 40 knockout cells devoid of the BCR and PLC gamma 2 coupled adaptor / kinases , Syk , Lyn , Btk or BLNK . ^^^ |
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| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| Deficiency of BLNK hampers PLC gamma 2 phosphorylation and Ca2+ influx induced by the pre B cell receptor in human pre B cells . ^^^ By contrast , phospholipase C gamma 2 ( PLC gamma 2 ) phosphorylation and an increase in intracellular Ca ( 2+ ) level mediated by pre BCR cross linking were observed only in the BLNK expressing cells , indicating that BLNK is essential for PLC gamma 2 induced Ca ( 2+ ) influx . ^^^ |
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| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| We report that these signaling molecules are frequently present , and in particular that Syk , BLNK and PLC gamma 2 ( absent from Reed Sternberg cells ) are present in the majority of mediastinal B cell lymphomas . ^^^ |
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| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P16885 |
Pubmed |
SVM Score :0.0 |
| NA |
|