| Interacting proteins: Q8WV28 and P11912 |
Pubmed |
SVM Score :0.0 |
| BCR induced tyrosine phosphorylation of CD79a , Lyn , B cell linker protein , and phospholipase Cgamma 2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag . ^^^ |
|
| Interacting proteins: Q8WV28 and P11912 |
Pubmed |
SVM Score :0.0 |
| Association of SLP 65 / BLNK with the B cell antigen receptor through a non ITAM tyrosine of Ig alpha . ^^^ Here we show that following B cell stimulation , SLP 65 associates directly with the BCR signaling subunit , the Ig alpha / Ig beta heterodimer . ^^^ The interaction is mediated by the Src homology 2 domain of SLP 65 and the phosphorylated Ig alpha tyrosine 204 , which is located outside of the immunoreceptor tyrosine based activation motif . ^^^ |
|
| Interacting proteins: Q8WV28 and P11912 |
Pubmed |
SVM Score :0.0 |
| Using chimeric receptors with wild type and mutant Ig alpha cytoplasmic tails we show that the non immunoreceptor tyrosine based activation motif ( ITAM ) tyrosines , Y 176 and Y 204 , are required to activate BLNK dependent pathways . ^^^ Subsequent analysis demonstrated that BLNK bound directly to phospho Y 204 and that fusing BLNK to mutated Ig alpha reconstituted downstream signaling events . ^^^ These data demonstrate that the non ITAM tyrosines of Ig alpha couple Syk activation to BLNK dependent pathways . . ^^^ |
|
| Interacting proteins: Q8WV28 and P11912 |
Pubmed |
SVM Score :0.0 |
| In these patients , various autosomal recessive disorders have been identified such as mutations affecting IGHM , CD79A , IGLL 1 genes involved in the composition of the pre B cell receptor ( pre BCR ) or the BLNK gene implicated in pre BCR signal transduction . ^^^ |
|
| Interacting proteins: Q8WV28 and P11912 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P11912 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P11912 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P11912 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P11912 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P11912 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P11912 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P11912 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WV28 and P11912 |
Pubmed |
SVM Score :0.0 |
| NA |
|