| Here , we demonstrate that TCR induced nuclear export of HDAC 7 and Nur 77 expression is mediated by activation of protein kinase D ( PKD ) . ^^^ Indeed , active PKD stimulates HDAC 7 nuclear export and Nur 77 expression . ^^^ In contrast , inhibition of PKD prevents TCR mediated nuclear exclusion of HDAC 7 and associated Nur 77 activation . ^^^ Furthermore , we show that HDAC 7 is an interaction partner and a substrate for PKD . ^^^ We identify four serine residues in the NH ( 2 ) terminus of HDAC 7 as targets for PKD . ^^^ |