| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.60709003 |
| In vitro displacement of apoAI by apoAII in HDLs or in Lp AI purified from HDL by immunoaffinity enhances their ability to compete with POPC AI to bind to SR BI and also enhances their direct binding capacity . 0.60709003^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.59520383 |
| The interaction of apoA 1 with SR BI not only prevents fusion of the lipid donor with the plasma membrane but also allows the optimal selective lipid uptake . 0.59520383^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.65840937 |
| In the case of apoA 1 , peptides corresponding to segments 1 85 , 44 65 , 44 87 , 149 243 , and 209 241 all had the same IC 50 as each other ( P = 0 . 86 ) , showing that a specific amino acid sequence in apoA 1 is not responsible for the interaction with SR BI . 0.65840937^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| SR BI / CLA 1 ligands such as HDL , apoA 1 , and L 37pA efficiently competed against iodinated L 37pA . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Scavenger receptor BI ( SR BI ) is up regulated in adrenal gland in apolipoprotein A 1 and hepatic lipase knock out mice as a response to depletion of cholesterol stores . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Recent studies comparing mice with similarly low levels of HDL , due to the absence of either of the two major HDL associated apolipoproteins apoA 1 and apoA 2 , suggest that apoA 1 is crucial in modulating this process , possibly through interaction with scavenger receptor class B type 1 ( SR BI ) . ^^^ These studies demonstrate that LCAT deficiency , similar to apoA 1 deficiency , is associated with a marked decrease in adrenal cholesterol delivery and supports the hypothesis that adrenal SR BI expression is regulated by the adrenal cholesterol . . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| We have examined the ability of individual human HDL apolipoproteins ( apoA 1 , apoA 2 , and apoC 3 ) reconstituted into phospholipid / unesterified cholesterol complexes to bind to murine SR BI ( mSR BI ) expressed in stably transfected cultured cells . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| HDL cholesteryl ester transporter activity and scavenger receptor type B 1 ( SR BI ) protein and mRNA levels were not up regulated in any organ of apoA 1 / mice even though these animals lack normal HDL . . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| On a chow diet SR BI transgenic ( SR BI Tg ) mice have decreased HDL CE , apoA 1 , and apoA 2 levels ; plasma triglycerides , low density lipoprotein ( LDL ) cholesterol , and very low density lipoprotein ( VLDL ) and LDL apoB were also decreased , compared with control mice . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| There was an inverse correlation between SR BI expression and apoA 1 and HDL cholesterol levels in transgenic mice fed either mouse chow or a diet high in fat and cholesterol . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| To investigate whether HL enhances the uptake of HDL cholesteryl ester ( CE ) via the newly described scavenger receptor BI ( SR BI ) , we measured the effects of expressing HL and SR BI on HDL cell association as well as uptake of 125I labeled apoA 1 and [ 3H ] CE HDL , by embryonal kidney 293 cells . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Ligand blottings on liver membranes showed that purified HDL 1 , containing about 70 % apolipoprotein E and 10 % apolipoprotein AI , bind to the LDL receptor ( 130 kDa ) and not to HB 2 ( 100 kDa ) or SR BI ( 82 kDa ) , candidate HDL receptors . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Adrenal SR BI is increased both in adrenocorticotropic hormone ( ACTH ) treated mice and also in apolipoprotein A 1 knock out ( apoA I 0 ) mice which have depleted adrenal cholesterol stores . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| The initial clearance of HDL FC was increased in SR BI Tg mice by 72 % and decreased in SR BI att mice by 53 % , but was unchanged in apoA 1 knockout mice compared with wild type mice . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Similar levels of expression of class B , type 1 scavenger receptor ( SR BI ) and caveolin in human and rat SMC suggested these proteins do not account for the differences in apoAI binding or lipid efflux seen in these cells . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| By contrast , the same competition experiments using ( 125 ) 1 labeled free apoA 1 clearly excluded SR BI as the high affinity binding receptor . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| The binding of apoA 1 containing ligands to the HDL receptor scavenger receptor class B type 1 ( SR BI ) was characterized using two different assays . ^^^ These findings suggest an important role for apoA 1 and its conformation / organization within particles in mediating HDL binding to SR BI and indicate that the NH ( 2 ) and COOH termini of apoA 1 directly or indirectly contribute independently to binding to SR BI . . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| In contrast , the mRNA levels of the potential regulatory proteins of the HDL level such as apoA 1 , apoE , LCAT , PLTP , SRB 1 and ABC 1 did not change with probucol . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| We have used direct binding analysis and chemical cross linking to examine the interaction of murine ( m ) SR BI with apoA 1 , the major protein of HDL . ^^^ When complexed with dimyristoylphosphatidylcholine , the N terminal and C terminal CNBr fragments of apoA 1 each bound to SR BI in a saturable , high affinity manner , and each cross linked efficiently to mSR BI . ^^^ These studies identify the amphipathic alpha helix as a recognition motif for SR BI and lead to the hypothesis that mSR BI interacts with HDL via the amphipathic alpha helical repeat units of apoA 1 . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| However , in SR BI transfected RAW cells , cAMP treatment produced a much smaller increment in cholesterol efflux to HDL ( 1 . 1 fold ) or apoA 1 ( 3 . 3 fold ) compared with control cells . ^^^ In macrophages loaded with cholesterol by acetyl LDL treatment , SR BI overexpression did not increase cholesterol efflux to HDL but did inhibit cAMP mediated cholesterol efflux to apoA 1 or HDL . ^^^ Transfection of a murine ABC 1 cDNA into 293 cells led to a 2 . 3 fold increase of cholesterol efflux to apoA 1 , whereas co transfection of SR BI with ABC 1 blocked this increase in cholesterol efflux . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| In contrast to scavenger receptor BI ( SR BI ) , another cell surface molecule capable of facilitating cholesterol efflux , ABC 1 preferentially bound lipid free apoA 1 but not HDL . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Binding of apolipoprotein A 1 to SR BI of rabbit brush border membrane is cooperative , characterized by a dissociation constant K ( d ) = 0 . 45 microM and a Hill coefficient of n = 2 . 8 . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Labeled cDNA from livers of apolipoprotein AI ( apoAI ) knockout mice , scavenger receptor BI ( SR BI ) transgenic mice , and control mice were cohybridized to microarrays . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| SR BI mediated HDL CE selective uptake is a two step process in which SR BI first interacts with multiple sites in apoA 1 with the amphipathic inverted alpha helical repeat units of apoA 1 serving as recognition motifs . ^^^ ApoA 1 knockout HDL particles bind normally to SR BI but do not permit efficient CE transfer to the cell . ^^^ These findings suggest that apoA 1 has an important role in the transfer of HDL CE that goes beyond its function as a ligand for interaction with SR BI . . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| This review gives an overview of the genes regulating these mechanisms , such as those encoding apolipoprotein AI , lecithin : cholesterol acyltransferase ( LCAT ) , scavenger receptor B 1 ( SR BI ) , and the ATP binding cassette transporter 1 ( ABC 1 ) , and the potential to exploit them to develop gene based therapeutic approaches to increase the level or function of HDL . . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Ovarian SR BI expression varies seasonally in the turtle as do plasma levels of apoA 1 and cholesterol ester . ^^^ It is possible that changing levels of SR BI , the receptor for apoA 1 , is physiologically relevant to the demands of the turtle ovarian cycle and cholesterol distribution . . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| The high density lipoprotein receptor , scavenger receptor class B type 1 ( SR BI ) , recognizes lipid bound apolipoprotein A 1 ( apoA 1 ) and other apolipoproteins . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| The effects of mutations in helices 4 and 6 of ApoA 1 on scavenger receptor class B type 1 ( SR BI ) mediated cholesterol efflux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR BI is required for efficient lipid transport . ^^^ We have studied the effects of mutations in apoA 1 on reconstituted high density lipoprotein ( HDL ) particle ( rHDL ( apoA 1 ) ) binding to and cholesterol efflux from wild type ( WT ) and mutant forms of the HDL receptor SR BI expressed by ldlA 7 cells . ^^^ SR BI with an M158R mutation bound poorly to rHDL with WT and helix 4 mutant apoA 1 ; the helix 6 mutant restored tight binding to SR BI ( M158R ) ( K ( d ) values of 48 , 60 , and 7 microg of protein / ml , respectively ) . ^^^ We propose that formation of a productive complex between apoA 1 in rHDL and SR BI , in which the lipoprotein and the receptor must either be precisely aligned or have the capacity to undergo appropriate conformational changes , is required for efficient SR BI mediated cholesterol efflux . ^^^ Some mutations in apoA 1 and / or SR BI can result in high affinity , but non productive , binding that does not permit efficient cholesterol efflux . . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| The severe depletion of cholesteryl ester ( CE ) in steroidogenic cells of apoA 1 ( / ) mice suggests that apolipoprotein ( apo ) A 1 plays a specific role in the high density lipoprotein ( HDL ) CE selective uptake process mediated by scavenger receptor BI ( SR BI ) in vivo . ^^^ In this study the role of apoA 1 in SR BI mediated HDL CE selective uptake was tested via analyses of the biochemical properties of apoA 1 ( / ) HDL and its interaction with SR BI on adrenocortical cells , hepatoma cells , and cells expressing a transfected SR BI . apoA 1 ( / ) HDL are large heterogeneous particles with a core consisting predominantly of CE and a surface enriched in phospholipid , free cholesterol , apoA 2 , and apoE . ^^^ Functional analysis showed apoA 1 ( / ) HDL to bind to SR BI with the same or higher affinity as compared with apoA 1 ( + / + ) HDL , but apoA 1 ( / ) HDL showed a 2 3 fold decrease in the 5 ( max ) for CE transfer from the HDL particle to adrenal cells . ^^^ These results indicate that the absence of apoA 1 results in HDL particles with a reduced capacity for SR BI mediated CE selective uptake . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| We identified that , in addition to scavenger receptor class B , type 1 ( SR BI ) , pBCEC express ABCA 1 and apolipoprotein A 1 ( apoA 1 ) mRNA and protein . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| We therefore investigated the effect of testosterone on the gene expression of apolipoprotein A 1 ( apoA 1 ) , hepatic lipase ( HL ) , scavenger receptor B 1 ( SR BI ) , and the ATP binding cassette transporter A 1 ( ABCA 1 ) , all of which are important regulators of HDL metabolism . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Overexpression of SR BI by adenoviral vector promotes clearance of apoA 1 , but not apoB , in human apoB transgenic mice . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| To characterize SR BI mediated HDL processing in vivo , we expressed high levels of this receptor in livers of apoA 1 ( / ) mice by adenoviral vector gene transfer , and then injected the mice with a bolus of human HDL ( 2 ) traced with ( 125 ) 1 dilactitol tyramine . ^^^ HDL recovered from apoA 1 ( / ) mice over expressing SR BI was significantly smaller than HDL recovered from control mice as measured by non denaturing gel electrophoresis . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| The severe depletion of cholesteryl ester ( CE ) in adrenocortical cells of apoA 1 ( / ) mice suggests that apolipoprotein ( apo ) A 1 plays an important role in the high density lipoprotein ( HDL ) CE selective uptake process mediated by scavenger receptor BI ( SR BI ) in vivo . ^^^ A recent study showed that apoA 1 ( / ) HDL binds to SR BI with the same affinity as apoA 1 ( + / + ) HDL , but apoA 1 ( / ) HDL has a decreased 5 ( max ) for CE transfer from the HDL particle to adrenal cells . ^^^ These results show a unique role for apoA 1 in HDL CE selective uptake that is distinct from its role as a ligand for HDL binding to SR BI . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Furthermore , as a consequence of the downregulation of CETP , the expression of scavenger receptor class B type 1 ( SR BI ) , an HDL receptor , was also reduced by approximately 50 % in mRNA and protein levels , whereas the apolipoprotein A 1 ( apoA 1 ) expression and secretion were increased by 30 and 92 % , respectively . ^^^ Taken together , these findings suggest that although acute suppression of CETP expression leads to an elevation in cellular cholesterol stores , apoA 1 secretion , and cellular cholesterol efflux to apoA 1 , the return of HDL CE to hepatocytes via an SR BI pathway was inhibited in vitro . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| SR BI mediates selective HDL cholesterol uptake by formation of a productive lipoprotein / receptor complex , which requires specific structural domains and conformation states of apolipoprotein A 1 present in HDL particles . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| High density lipoprotein ( HDL ) , apolipoprotein A 1 ( apoA 1 ) , and the principal high affinity HDL receptor , scavenger receptor class B type 1 ( SR BI ) , are antiatherogenic and beneficial to the response to vascular injury . ^^^ Recent work in both cell culture and in mice indicates that HDL causes robust activation of endothelial nitric oxide synthase ( eNOS ) , and that this effect is mediated in endothelial cell caveolae by SR BI through a process that requires apoA 1 binding . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| In addition , cytoplasmic lipid droplets that greatly increased in size and number were strongly labelled by the SR BI antibody whereas apolipoprotein A 1 positive chylomicrons were largely devoid of the receptor . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| No difference in cholesterol efflux from SR BI+ / + apoE / or SR BI / apoE / macrophages to HDL or apoA 1 discs was detected . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| The effects of in vivo modulation of HDL phospholipid ( PL ) on scavenger receptor class BI ( SR BI ) and ATP binding cassette transporter 1 ( ABCA 1 ) mediated efflux were examined by overexpressing either endothelial lipase ( EL ) or phosphatidylserine phospholipase ( PS PLA 1 ) in human apolipoprotein A 1 ( apoA 1 ) transgenic mice . ^^^ There were significant positive correlations between SR BI mediated efflux and a number of serum parameters , including PL / apoA 1 ratio , PL , TC , free cholesterol ( FC ) , and HDL cholesterol . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| However , changes in the plasma cholesterol concentration or loss of function of ATP binding cassette AI transporter ( ABCA 1 ) , scavenger receptor class B , type 1 ( SR BI ) , low density lipoprotein receptor ( LDLR ) , APOE or APOAI had no effect on sterol turnover in the brain . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| In vitro functional analyses showed that reconstituted HDL ( rHDL ) particles containing the mutant apoA 1 had 53 % of scavenger receptor class B type 1 ( SR BI ) mediated cholesterol efflux capacity and 37 % capacity to activate lecithin : cholesterol acyltransferase ( LCAT ) as compared to the WT control . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Uptake of N Rh PE from liposomes containing phosphatidylserine was higher than [ ( 3 ) H ] COE , and was further enhanced by apolipoprotein A 1 , confirming involvement of SR BI in the selective uptake of liposomal N Rh PE by cells . . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Lipid free SAA , unlike lipid free apoA 1 , was an effective inhibitor of both SR BI dependent binding and selective cholesteryl ester uptake of HDL . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| The finding of decreased hepatic scavenger receptor class B type 1 ( SR BI ) protein levels may explain the persistence of LDL / HDL1 in obese apoA 1 ( / ) mice . ^^^ Our studies suggest that the maturation and removal of large HDLs depends on the integrity of a functional axis of apoA 1 , HL , and SR BI . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Our objective was to evaluate the associations of individual apolipoprotein A 1 ( apoA 1 ) containing HDL subpopulation levels with ABCA 1 and scavenger receptor class B type 1 ( SR BI ) mediated cellular cholesterol efflux . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| SR BI mediated selective lipid uptake segregates apoA 1 and apoA 2 catabolism . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| In Chinese hamster ovary cells , SAA promoted cellular cholesterol efflux in an SR BI dependent manner , whereas apoA 1 did not . ^^^ Similarly , SAA , but not apoA 1 , promoted cholesterol efflux from HepG 2 cells in an SR BI dependent manner as shown by using the SR BI inhibitor BLT 1 . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Nevertheless , SR BI transgenic mice showed a decrease of total cholesterol but an increase of triglyceride content in plasma without any change in the high density lipoprotein apoA 1 level . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Role of apoA 1 , ABCA 1 , LCAT , and SR BI in the biogenesis of HDL . ^^^ The interactions of lipid bound apoA 1 with SR BI are affected in vitro by specific mutations in apoA 1 or SR BI . ^^^ Here we review the current status of the pathway of HDL biogenesis and mutations in apoA 1 , ABCA 1 , and SR BI that disrupt different steps of the pathway and may lead to dyslipidemia and atherosclerosis in mouse models . ^^^ The phenotypes generated in experimental mouse models for apoA 1 , ABCA 1 , LCAT , SR BI , and other proteins of the HDL pathway may facilitate early diagnosis of similar phenotypes in the human population and provide guidance for proper treatment . . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Because apoA 1 gene transcription alone was not sufficient to account for the lowering of plasma HDL levels , scavenger receptor B 1 ( SR B 1 ) and hepatic lipase ( HL ) mRNAs levels were quantitated . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Among other factors , apoA 1 , cholesterol ester transfer protein ( CETP ) , scavenger receptor B 1 ( SR B 1 ) , and hepatic lipase are potential candidates that modulate plasma levels of HDL . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Recently , it was demonstrated that pioglitazone is also an agonist of PPAR alpha , which plays a central role in lipid metabolism through enhancing the synthesis of apo AI , apo AII and reverse cholesterol transporters , such as fatty acid transporter molecules , and SR B 1 and ABCA 1 reverse cholesterol transport receptors . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| The data indicate that TO increases the secretion of HDL and its components ( apoA 1 and LCAT ) , and stimulates the production of hepatic SR B 1 receptor protein . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| A critical part of RCT is cholesterol efflux , in which accumulated cholesterol is removed from macrophages in the subintima of the vessel wall by ATP binding membrane cassette transporter A 1 ( ABCA 1 ) or by other mechanisms , including passive diffusion , scavenger receptor B 1 ( SR B 1 ) , caveolins and sterol 27 hydroxylase , and collected by HDL and apoA 1 . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| Brain capillary endothelial cells , representing a physiological barrier to the central nervous system , express apolipoprotein A 1 ( apoA 1 , the major high density lipoprotein ( HDL ) associated apolipoprotein ) , ATP binding cassette transporter A 1 ( ABCA 1 ) , and scavenger receptor , class B , type 1 ( SR BI ) , proteins that promote cellular cholesterol mobilization . ^^^ To clarify the functional impact of LXR / PPAR activation , sterol transport along the : ( 1 ) ABCA1 / apoA 1 and ( 2 ) SR BI / HDL pathway was investigated in primary , polarized brain capillary endothelial cells , an in vitro model of the blood brain barrier . ^^^ Activation of LXR ( 24 ( S ) OH cholesterol , TO 901317 ) , PPARalpha ( bezafibrate , fenofibrate ) , and PPARgamma ( troglitazone , pioglitazone ) modulated expression of apoA 1 , ABCA 1 , and SR BI on mRNA and / or protein levels without compromising transendothelial electrical resistance or tight junction protein expression . ^^^ Summarizing , in cerebrovascular endothelial cells apoA 1 , ABCA 1 , and SR BI represent drug targets for LXR and PPAR agonists to interfere with cholesterol homeostasis at the periphery of the central nervous system . . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| APOA 1 , LCAT , and SRB 1 exerted no measurable influence . ^^^ |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WTV0 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|