| Interacting proteins: Q8TEY7 and P40337 |
Pubmed |
SVM Score :0.72780246 |
| A novel protein named VHL interacting deubiquitinating enzyme 1 ( VDU 1 ) was identified as being able to directly interact with pVHL in vitro and in vivo . 0.72780246^^^ |
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| Interacting proteins: Q8TEY7 and P40337 |
Pubmed |
SVM Score :0.0 |
| In our previous studies , we have shown that VDU 1 ( pVHL interacting deubiquitinating enzyme 1 ) can be ubiquitinated for rapid degradation in a pVHL dependent manner . ^^^ Like VDU 1 , VDU 2 interacts with pVHL beta domain and these two proteins can compete with each other to bind to pVHL . ^^^ Based on their amino acid sequence homology and functional interaction with pVHL , VDU 1 and VDU 2 define a subfamily of ubiquitin specific processing proteases . ^^^ Since deubiquitination , by reversing ubiquitination , has been recognized as an important regulatory step in ubiquitination related processes , VDU 1 and VDU 2 could be important substrates of pVHL E 3 ligase complex . . ^^^ |
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| Interacting proteins: Q8TEY7 and P40337 |
Pubmed |
SVM Score :0.0 |
| Here , we show that pVHL interacting deubiquitinating enzyme 2 , VDU 2 , but not VDU 1 , interacts with HIF 1alpha . ^^^ |
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