We sought to determine if ZER 6 proteins are expressed in ERalpha positive breast cancer cells and if ZER 6 is expressed in association with ERalpha in breast cancers . 0.74393166^^^
To identify other factors that are regulated by ERalpha , a yeast two hybrid screen was performed that identified a novel Cys ( 2 ) His ( 2 ) zinc finger protein named ZER 6 . ^^^ In COS 1 cells , both the p 52 and p 71 isoforms can activate transcription through the ZER 6 binding element ; however , in the presence of ERalpha , transactivation by the p 52 isoform is specifically repressed . ^^^