| Interacting proteins: Q92890 and Q8TAT6 |
Pubmed |
SVM Score :0.0 |
| In contrast to RNAi of VCP , RNAi of Ufd 1 or Npl 4 depleting approximately 90 % of the VCP Ufd 1 Npl4 complexes does not induce unfolded protein response , indicating that the Ufd 1 Npl4 dimer is not involved in the regulation of ER function by VCP . ^^^ RNAi of Ufd 1 or Npl 4 is associated with a 2 fold increase in the levels of polyubiquitinated proteins , which form dispersed aggregates often associated with calnexin positive structures . ^^^ However , contrary to the effects of proteasome inhibition , RNAi of Ufd 1 or Npl 4 does not induce an accumulation of alpha TCR and delta CD 3 , two ERAD substrates overexpressed in HeLa cells . ^^^ |
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| Interacting proteins: Q92890 and Q8TAT6 |
Pubmed |
SVM Score :0.0 |
| A complex of mammalian ufd 1 and npl 4 links the AAA ATPase , p 97 , to ubiquitin and nuclear transport pathways . ^^^ We now describe another binding complex comprising mammalian Ufd 1 and Npl 4 . ^^^ In rat liver cytosol , Ufd 1 and Npl 4 form a binary complex , which exists either alone or bound to p 97 . ^^^ |
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| Interacting proteins: Q92890 and Q8TAT6 |
Pubmed |
SVM Score :0.0 |
| Mutations in NPL 4 , UFD 1 , and CDC 48 cause a block in Mga2p and Spt23p processing , with concomitant loss of OLE 1 expression . ^^^ |
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| Interacting proteins: Q92890 and Q8TAT6 |
Pubmed |
SVM Score :0.0 |
| Whereas Cdc48 / p97 was previously known to function in a complex with the cofactor p 47 ( ref . 5 ) in membrane fusion , we demonstrate that its role in ER protein export requires the interacting partners Ufd 1 and Npl 4 . ^^^ |
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| Interacting proteins: Q92890 and Q8TAT6 |
Pubmed |
SVM Score :0.0 |
| The elucidation of Cdc 48 , Ufd 1 and Npl 4 action not only provides long sought functions for these specific proteins , but illuminates a poorly understood part of the ubiquitin proteasome pathway . . ^^^ |
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| Interacting proteins: Q92890 and Q8TAT6 |
Pubmed |
SVM Score :0.0 |
| Recently it has been suggested that Cdc 48 in a complex with Ufd 1 and Npl 4 acts as an ubiquitin dependent chaperone . ^^^ |
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| Interacting proteins: Q92890 and Q8TAT6 |
Pubmed |
SVM Score :0.0 |
| Several studies have demonstrated that Ufd 1 is a component of the Cdc 48 Ufd1 Npl 4 multiprotein complex which is active in the recognition of several polyubiquitin tagged proteins and facilitates their presentation to the 26S proteasome for protein degradation or even more specific processing . ^^^ |
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| Interacting proteins: Q92890 and Q8TAT6 |
Pubmed |
SVM Score :0.0 |
| The second binding site is located at the N terminus of Npl 4 and is activated upon binding of Ufd 1 to Npl 4 . ^^^ |
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| Interacting proteins: Q92890 and Q8TAT6 |
Pubmed |
SVM Score :0.0 |
| Ufd 1 mediates ubiquitin fusion degradation by association with Npl 4 and Cdc48 / p97 . ^^^ |
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| Interacting proteins: Q92890 and Q8TAT6 |
Pubmed |
SVM Score :0.0 |
| In addition , Ufd 1 and Npl 4 , which complex with p 97 , also associated with IP ( 3 ) receptors upon hormonal stimulation . ^^^ |
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| Interacting proteins: Q92890 and Q8TAT6 |
Pubmed |
SVM Score :0.0 |
| In response to oxidative stress , VCP strengthened the interaction with Npl 4 and Ufd 1 , both of which are essential in endoplasmic reticulum associated protein degradation . ^^^ |
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| Interacting proteins: Q92890 and Q8TAT6 |
Pubmed |
SVM Score :0.0 |
| Cloning and characterization of the gene encoding human NPL 4 , a protein interacting with the ubiquitin fusion degradation protein ( UFD1L ) . ^^^ In order to test a potential relationship between nuclear transport defects and some aspect of the DGS / VCFS phenotype , we also exclude the presence of mutations in the NPL 4 coding sequence in a subset of patients with DGS / VCFS and no detectable 22q11 deletion or mutations at the UFD1L locus . . ^^^ |
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