| TPL 2 is found in complex with ABIN 2 ( A 20 binding inhibitor of NF kappaB 2 ) . ^^^ Here , using antigen presenting cells from ABIN 2 deficient mice , we show that ABIN 2 was required for optimal activation of Erk induced by receptors that signal via TPL 2 , including Toll like receptor 4 and tumor necrosis factor receptor 1 in macrophages , and CD 40 in B cells . ^^^ ABIN 2 was necessary for the maintenance of TPL 2 protein stability . ^^^ Thus , ABIN 2 acts to positively regulate the Erk signaling potential by stabilizing TPL 2 . . ^^^ |