| Interacting proteins: Q8NFZ5 and P19838 |
Pubmed |
SVM Score :0.0 |
| NF kappaB activation induced by TNF and interleukin 1 is inhibited by overexpression of ABIN 2 . ^^^ In contrast , NF kappaB activation by overexpression of IKKbeta or direct activators of the IKK complex , such as Tax , can not be inhibited by ABIN 2 . ^^^ These results indicate that ABIN 2 interferes with NF kappaB activation upstream of the IKK complex and that it might contribute to the NF kappaB inhibitory function of A20 . . ^^^ |
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| Interacting proteins: Q8NFZ5 and P19838 |
Pubmed |
SVM Score :0.0 |
| This protein was found to be human A 20 binding inhibitor of NF kappaB activation 2 , ABIN 2 , an inhibitor of NF kappaB mediated inflammatory gene expression . ^^^ Expression of ABIN 2 deletion mutants in endothelial cells suppressed the ability of angiopoietin 1 to inhibit phorbol ester stimulated NF kappaB dependent reporter gene activity . ^^^ |
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| Interacting proteins: Q8NFZ5 and P19838 |
Pubmed |
SVM Score :0.0 |
| The human ABIN 2 was originally identified as an A 20 associating cytosolic protein to block NF kappaB activation induced by various stimuli . ^^^ |
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| Interacting proteins: Q8NFZ5 and P19838 |
Pubmed |
SVM Score :0.0 |
| A 20 binding inhibitor of NF kappaB activation 2 , ABIN 2 , is a newly identified intracellular protein that interacts with the zinc finger protein A 20 . ^^^ ABIN 2 inhibits nuclear factor kappaB ( NF kappaB ) activity and is a possible effector of A 20 regulation of NF kappaB . ^^^ |
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| Interacting proteins: Q8NFZ5 and P19838 |
Pubmed |
SVM Score :0.0 |
| Identification of a novel mechanism of NF kappaB inactivation by progesterone through progesterone receptors in Hec50co poorly differentiated endometrial cancer cells : induction of A 20 and ABIN 2 . ^^^ |
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| Interacting proteins: Q8NFZ5 and P19838 |
Pubmed |
SVM Score :0.0 |
| Overexpression of ABIN 2 , a negative regulator of NF kappaB , delays liver regeneration in the ABIN 2 transgenic mice . ^^^ The A 20 binding inhibitor of NF kappaB activation 2 , ABIN 2 , is an inhibitor of NF kappaB . ^^^ To test that the inducible expression of ABIN 2 serves to regulate NF kappaB during liver regeneration , transgenic mice overexpressing human ABIN 2 protein in the liver were generated . ^^^ Our transgenic data demonstrated that overexpression of ABIN 2 inhibited NF kappaB nuclear translocation , which peaked at around 2 4h post hepatectomy , and this led to an impairment of the G1 / S transition as well as a delay in hepatocyte cell cycle progression of the regenerating liver . ^^^ In conclusion , ABIN 2 may function as a negative regulator that downregulates NF kappaB activation during liver regeneration . . ^^^ |
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| Interacting proteins: Q8NFZ5 and P19838 |
Pubmed |
SVM Score :0.0 |
| TPL 2 is found in complex with ABIN 2 ( A 20 binding inhibitor of NF kappaB 2 ) . ^^^ In contrast , ABIN 2 deficiency did not affect agonist induced regulation of transcription factor NF kappaB . ^^^ |
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| Interacting proteins: Q8NFZ5 and P19838 |
Pubmed |
SVM Score :0.0 |
| In addition , we found that ectopic expression of FLIP 1 selectively blocks cytokine induced NF kappaB activation . ^^^ The involvement of FLIP 1 in the regulation of NF kappaB activity may shed new light on the role of LKB 1 in tumor suppression . . ^^^ |
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