| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Vanilloid receptor like protein 1 expressing neurons did not express the vanilloid receptor 1 . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| The presence of mRNA was demonstrated using reverse transcriptase PCR in neutrophils ( controlled to be CD 5 negative ) as well as in human leukaemic cell line 60 ( HL 60 ) cells , for the following TRP species : the long TRPC 2 ( LTRPC 2 ) , the vanilloid receptor 1 , the vanilloid receptor like protein 1 and epithelial Ca ( 2+ ) channels 1 and 2 . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry for two nociceptive transducers , the vanilloid receptor 1 ( VR 1 ) and vanilloid receptor 1 like receptor ( VRL 1 ) , was performed on the vagal sensory ganglia . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| The vanilloid receptor 1 ( VR 1 ) is a nonselective cation channel that is activated by pungent vanilloid compound , extracellular protons , or noxious heat . mRNA of VR 1 and vanilloid receptor 1 like receptor ( VRL 1 ) were expressed in PC 12 cells , and only VRI mRNA was detected in glioma and A 10 cell lines . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Noxious heat may act as an endogenous activator of the ionotropic capsaicin receptor ( VR 1 ) and of its recently found homologue VRL 1 , expressed in rat dorsal root ganglion cells and present along their nerve fibres . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| The capsaicin receptor ( VR 1 ) homologue , VRL 1 , is thought to be responsible for transducing high threshold heat responses in Adelta fiber neurons . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| The co expression of vanilloid receptor 1 like receptor ( VRL 1 ) , a newly cloned capsaicin receptor homologue , with calbindin D 28k was examined in the rat sensory ganglia . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| The co expression of osteocalcin ( OC ) with the capsaicin receptor ( VR 1 ) and vanilloid receptor 1 like receptor ( VRL 1 ) was examined in the dorsal root ( DRG ) and trigeminal ganglia ( TG ) . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Immunoreactive TRPV 2 ( VRL 1 ) , a capsaicin receptor homolog , in the spinal cord of the rat . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Cell size of primary sensory neurons and distribution patterns of neurons that are immunopositive ( ip ) for VRL 1 , a newly cloned capsaicin receptor homologue , were examined in trigeminal ganglia ( TGs ) of knockout mice for trkA , trkB or trkC to determine the developmental dependency of myelinated nociceptors on expression of the genes . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| TRPV 2 , a capsaicin receptor homologue , is expressed predominantly in the neurotrophin 3 dependent subpopulation of primary sensory neurons . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Extensive co localization and heteromultimer formation of the vanilloid receptor like protein TRPV 2 and the capsaicin receptor TRPV 1 in the adult rat cerebral cortex . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Mammalian TRP channels that are gated by heat and capsaicin ( > 43 degrees C ; TRPV 1 ( ref . 1 ) ) , noxious heat ( > 52 degrees C ; TRPV 2 ( ref . 2 ) ) , and cooling ( < 22 degrees C ; TRPM 8 ( refs 3 , 4 ) ) have been cloned ; however , little is known about the molecular determinants of temperature sensing in the range between approximately 22 degrees C and 40 degrees C . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Several members of the transient receptor potential ( TRP ) family of ion channels have been implicated as transducers of thermal stimuli , including TRPV 1 and TRPV 2 , which are activated by heat , and TRPM 8 , which is activated by cold . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| We assessed specimens with immunohistochemistry and image analysis using specific antibodies to TRPV 1 ; nerve growth factor ( NGF ) receptor tyrosine kinase A ; glial cell line derived neurotrophic factor ( GDNF ) ; neuropeptides calcitonin gene related peptide ( CGRP ) and substance P ; the related vanilloid receptor like protein ( VRL ) 2 ; glial markers S 100 and glial fibrillary acid protein ( GFAP ) ; and the nerve structural marker peripherin . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| A delta fibres exhibit properties that may be explained by TRPV 2 containing channels which is present in large diameter sensory neurons that do not express TRPV 1 . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Members of the transient receptor potential ( TRP ) family for which mRNA can be demonstrated in neutrophil granulocytes with RT PCR include TRPC 6 ( as only `` short ' ' TRP ) , TRPM 2 , TRPV 1 , TRPV 2 , TRPV 5 and TRPV 6 . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Recently , several members of the transient receptor potential vanilloid ( TRPV ) subfamily of ion channels have been identified that can be gated by increases in temperature into the warm ( TRPV 3 and TRPV 4 ) or painfully hot ( TRPV 1 and TRPV 2 ) range . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Expression of the heat sensitive cation channels TRPV 1 and TRPV 2 was investigated by immunofluorescence in rat dorsal root ganglion ( DRG ) neurons . ^^^ TRPV 1 positive neurons were more frequent and had smaller diameters than TRPV 2 positive neurons ( 35 . 7 % vs 7 . 3 % ; 22 . 3 microm vs 27 . 6 microm ) , but size distributions overlapped and significant co expression was seen in 20 . 7 % of TRPV 2 positive neurons ( 1 . 7 % of all ) . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| In addition , RT PCR of single nodose cell bodies , which had been retrogradely labeled from the upper gut , detected transcripts for TRPV 1 , TRPV 2 , TRPV 4 , TRPN 1 , and TRPM 8 in a proportion of cells . ^^^ Immunohistochemical labeling detected TRPV 1 and TRPV 2 proteins in nodose ganglia . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| These cells express the mRNA of TRPV 1 , TRPV 2 , TRPV 3 and TRPV 4 channels , but not those of TRPV 5 and TRPV 6 . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Five of them can alternatively be activated by nonthermal stimuli such as capsaicin [ transient receptor potential vanilloid 1 ( TRPV 1 ) ] or hypo osmolarity ( TRPV 2 and TRPV 4 ) . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| TRPV 1 , TRPV 2 , and TRPV 3 . ^^^ Among the six TRPV members , TRPV 1 , TRPV 2 , TRPV 3 , and TRPV 4 form heat activated cation channels , which serve diverse functions ranging from nociception to osmolality regulation . ^^^ Although chemical activators for TRPV 1 and TRPV 4 are well documented , those for TRPV 2 and TRPV 3 are lacking . ^^^ Here we show that in the absence of other stimuli , 2 aminoethoxydiphenyl borate ( 2APB ) activates TRPV 1 , TRPV 2 , and TRPV 3 , but not TRPV 4 , TRPV 5 , and TRPV 6 expressed in HEK 293 cells . ^^^ Our data suggest the existence of a common activation mechanism for TRPV 1 , TRPV 2 , and TRPV 3 that may serve as a therapeutic target for pain management and treatment for diseases caused by hypersensitivity and temperature misregulation . . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| TRP channels of the vanilloid family ( TRPV 1 , TRPV 2 , TRPV 3 , TRPV 4 ) are excited by heat stimuli whereas TRPM 8 and ANKTM 1 are cold responsive . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| These include TRPV 1 ( VR 1 ) , TRPV 2 ( VRL 1 ) , TRPV 3 , TRPV 4 , TRPM 8 ( CMR 1 ) , and TRPA 1 ( ANKTM 1 ) . ^^^ These channels exhibit distinct thermal activation thresholds ( > 43 degrees C for TRPV 1 , > 52 degrees C for TRPV 2 , > approximately 34 38 degrees C for TRPV 3 , > approximately 27 35 degrees C for TRPV 4 , < approximately 25 28 degrees C for TRPM 8 and < 17 degrees C for TRPA 1 ) , and are expressed in primary sensory neurons as well as other tissues . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| These include TRPV 1 ( VR 1 ) , TRPV 2 ( VRL 1 ) , TRPV 3 , TRPV 4 , TRPM 8 ( CMR 1 ) , and TRPA 1 ( ANKTM 1 ) . ^^^ These channels exhibit distinct thermal activation thresholds ( > 43 degrees C for TRPV 1 , > 52 degrees C for TRPV 2 , > 32 39 degrees C for TRPV 3 , > 27 35 degrees C for TRPV 4 , < 25 28 degrees C for TRPM 8 , and < 17 degrees C for TRPA 1 ) and are expressed in primary sensory neurons as well as other tissues . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Using RT PCR , transcripts homologous to TRPV 2 and TRPV 4 , but not to TRPV 1 or TRPV 3 , were found . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| TRPV 1 , TRPV 2 , TRPV 3 and TRPV 4 mRNAs were expressed in spiral and vestibular ganglia , and TRPV 2 and TRPV 1 mRNAs were most predominant in control mice . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Biphasic currents evoked by chemical or thermal activation of the heat gated ion channel , TRPV 3 . 2 Aminoethyl diphenylborinate was recently identified as a chemical activator of TRPV 1 , TRPV 2 , and TRPV 3 , three heat gated members of the transient receptor potential vanilloid ( TRPV ) ion channel subfamily . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Recently , 2 aminoethoxydiphenyl borate was introduced as a TRPV 3 agonist , but its selectivity was questioned by showing that it activated recombinant TRPV 1 and TRPV 2 as well . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Heteromerization and colocalization of TrpV 1 and TrpV 2 in mammalian cell lines and rat dorsal root ganglia . ^^^ Coassociation of the vanilloid transient receptor potential ( Trp ) ion channels , TrpV 1 and TrpV 2 , was investigated by immunoprecipitation and immunofluorescence in transfected mammalian cell lines , rat dorsal root ganglia and spinal cord . ^^^ Immunofluorescent labelling of transfected F 11 cells revealed colocalization of TrpV 1 and TrpV 2 at the cell surface . ^^^ Immunoprecipitation from rat dorsal root ganglion lysates identified a minor population of receptor complexes composed of TrpV1 / TrpV2 heteromers , consistent with a small proportion of cells double labelled with TrpV 1 and TrpV 2 antibodies in rat dorsal root ganglion sections . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| TRPV 2 expression is concentrated in a subset of medium sized dorsal root ganglion neurons , independent of transient receptor potential vanilloid subfamily member 1 ( TRPV 1 ) expression . ^^^ Intraplantar injection of nerve growth factor increased TRPV 1 expression but not TRPV 2 , suggesting that induction of TRPV 2 expression is driven by a mechanism distinct from that for TRPV 1 . ^^^ Heat hyperalgesia assessment after chemical desensitization of TRPV 1 by resiniferatoxin demonstrates a possible role for TRPV 2 in inflammation at high temperatures ( > 56 degrees C ) . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| With RT PCR , mRNA of TRPM 2 , TRPM 3 , TRPM 4 , TRPM 7 , and TRPM 8 of TRPM family and TRPV 1 , TRPV 2 , TRPV 3 , and TRPV 4 of TRPV family were detected in both PAs and aorta . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| Participation of TRPV 1 and TRPV 2 in the rat laryngeal sensory innervation . ^^^ We investigated the participation of TRPV 1 and its homologue TRPV 2 in the rat laryngeal sensory innervation using immunohistochemistry and the neuronal tracer , fluoro gold ( FG ) . ^^^ Neurons immunoreactive for TRPV 1 or TRPV 2 were distributed throughout the NG . ^^^ TRPV 1 immunoreactivity was seen in 49 . 0+ / 4 . 5 % of the FG labeled neurons , while TRPV 2 immunoreactivity was seen in 12 . 5+ / 4 . 1 % of the FG labeled neurons . ^^^ These findings suggest that both TRPV 1 and TRPV 2 participate in laryngeal nociception , but that TRPV 1 may have a particularly important role . . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| No member of the PACSIN protein family was able to biochemically interact with TRPV 1 and TRPV 2 . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| These include more than ten transient receptor potential ( TRP ) superfamily members such as TRPC 1 , TRPC 3 6 , TRPV 1 , TRPV 2 , TRPV 4 , TRPM 4 , TRPM 7 , and polycystin ( TRPP 2 ) . ^^^ |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8NER1 and Q9Y5S1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Vanilloid receptor like protein 1 expressing neurons did not express the vanilloid receptor 1 . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| The presence of mRNA was demonstrated using reverse transcriptase PCR in neutrophils ( controlled to be CD 5 negative ) as well as in human leukaemic cell line 60 ( HL 60 ) cells , for the following TRP species : the long TRPC 2 ( LTRPC 2 ) , the vanilloid receptor 1 , the vanilloid receptor like protein 1 and epithelial Ca ( 2+ ) channels 1 and 2 . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Noxious heat may act as an endogenous activator of the ionotropic capsaicin receptor ( VR 1 ) and of its recently found homologue VRL 1 , expressed in rat dorsal root ganglion cells and present along their nerve fibres . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| The capsaicin receptor ( VR 1 ) homologue , VRL 1 , is thought to be responsible for transducing high threshold heat responses in Adelta fiber neurons . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| The co expression of osteocalcin ( OC ) with the capsaicin receptor ( VR 1 ) and vanilloid receptor 1 like receptor ( VRL 1 ) was examined in the dorsal root ( DRG ) and trigeminal ganglia ( TG ) . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry for two nociceptive transducers , the vanilloid receptor 1 ( VR 1 ) and vanilloid receptor 1 like receptor ( VRL 1 ) , was performed on the vagal sensory ganglia . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Immunoreactive TRPV 2 ( VRL 1 ) , a capsaicin receptor homolog , in the spinal cord of the rat . ^^^ The vanilloid receptor like 1 protein ( VRL 1 , also called TRPV 2 ) is a member of the TRPV family of proteins and is a homolog of the capsaicin / vanilloid receptor ( VR 1 , or TRPV 1 ) . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| The vanilloid receptor 1 ( VR 1 ) is a nonselective cation channel that is activated by pungent vanilloid compound , extracellular protons , or noxious heat . mRNA of VR 1 and vanilloid receptor 1 like receptor ( VRL 1 ) were expressed in PC 12 cells , and only VRI mRNA was detected in glioma and A 10 cell lines . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| These include TRPV 1 ( VR 1 ) , TRPV 2 ( VRL 1 ) , TRPV 3 , TRPV 4 , TRPM 8 ( CMR 1 ) , and TRPA 1 ( ANKTM 1 ) . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| These include TRPV 1 ( VR 1 ) , TRPV 2 ( VRL 1 ) , TRPV 3 , TRPV 4 , TRPM 8 ( CMR 1 ) , and TRPA 1 ( ANKTM 1 ) . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Cell size of primary sensory neurons and distribution patterns of neurons that are immunopositive ( ip ) for VRL 1 , a newly cloned capsaicin receptor homologue , were examined in trigeminal ganglia ( TGs ) of knockout mice for trkA , trkB or trkC to determine the developmental dependency of myelinated nociceptors on expression of the genes . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Mammalian TRP channels that are gated by heat and capsaicin ( > 43 degrees C ; TRPV 1 ( ref . 1 ) ) , noxious heat ( > 52 degrees C ; TRPV 2 ( ref . 2 ) ) , and cooling ( < 22 degrees C ; TRPM 8 ( refs 3 , 4 ) ) have been cloned ; however , little is known about the molecular determinants of temperature sensing in the range between approximately 22 degrees C and 40 degrees C . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Several members of the transient receptor potential ( TRP ) family of ion channels have been implicated as transducers of thermal stimuli , including TRPV 1 and TRPV 2 , which are activated by heat , and TRPM 8 , which is activated by cold . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| The co expression of vanilloid receptor 1 like receptor ( VRL 1 ) , a newly cloned capsaicin receptor homologue , with calbindin D 28k was examined in the rat sensory ganglia . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| A delta fibres exhibit properties that may be explained by TRPV 2 containing channels which is present in large diameter sensory neurons that do not express TRPV 1 . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Members of the transient receptor potential ( TRP ) family for which mRNA can be demonstrated in neutrophil granulocytes with RT PCR include TRPC 6 ( as only `` short ' ' TRP ) , TRPM 2 , TRPV 1 , TRPV 2 , TRPV 5 and TRPV 6 . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Recently , several members of the transient receptor potential vanilloid ( TRPV ) subfamily of ion channels have been identified that can be gated by increases in temperature into the warm ( TRPV 3 and TRPV 4 ) or painfully hot ( TRPV 1 and TRPV 2 ) range . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Expression of the heat sensitive cation channels TRPV 1 and TRPV 2 was investigated by immunofluorescence in rat dorsal root ganglion ( DRG ) neurons . ^^^ TRPV 1 positive neurons were more frequent and had smaller diameters than TRPV 2 positive neurons ( 35 . 7 % vs 7 . 3 % ; 22 . 3 microm vs 27 . 6 microm ) , but size distributions overlapped and significant co expression was seen in 20 . 7 % of TRPV 2 positive neurons ( 1 . 7 % of all ) . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| In addition , RT PCR of single nodose cell bodies , which had been retrogradely labeled from the upper gut , detected transcripts for TRPV 1 , TRPV 2 , TRPV 4 , TRPN 1 , and TRPM 8 in a proportion of cells . ^^^ Immunohistochemical labeling detected TRPV 1 and TRPV 2 proteins in nodose ganglia . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| These cells express the mRNA of TRPV 1 , TRPV 2 , TRPV 3 and TRPV 4 channels , but not those of TRPV 5 and TRPV 6 . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Five of them can alternatively be activated by nonthermal stimuli such as capsaicin [ transient receptor potential vanilloid 1 ( TRPV 1 ) ] or hypo osmolarity ( TRPV 2 and TRPV 4 ) . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| TRPV 1 , TRPV 2 , and TRPV 3 . ^^^ Among the six TRPV members , TRPV 1 , TRPV 2 , TRPV 3 , and TRPV 4 form heat activated cation channels , which serve diverse functions ranging from nociception to osmolality regulation . ^^^ Although chemical activators for TRPV 1 and TRPV 4 are well documented , those for TRPV 2 and TRPV 3 are lacking . ^^^ Here we show that in the absence of other stimuli , 2 aminoethoxydiphenyl borate ( 2APB ) activates TRPV 1 , TRPV 2 , and TRPV 3 , but not TRPV 4 , TRPV 5 , and TRPV 6 expressed in HEK 293 cells . ^^^ Our data suggest the existence of a common activation mechanism for TRPV 1 , TRPV 2 , and TRPV 3 that may serve as a therapeutic target for pain management and treatment for diseases caused by hypersensitivity and temperature misregulation . . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Biphasic currents evoked by chemical or thermal activation of the heat gated ion channel , TRPV 3 . 2 Aminoethyl diphenylborinate was recently identified as a chemical activator of TRPV 1 , TRPV 2 , and TRPV 3 , three heat gated members of the transient receptor potential vanilloid ( TRPV ) ion channel subfamily . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Extensive co localization and heteromultimer formation of the vanilloid receptor like protein TRPV 2 and the capsaicin receptor TRPV 1 in the adult rat cerebral cortex . ^^^ We examined the possibility of multimer formation between TRPV 1 and TRPV 2 , using biochemical techniques . ^^^ We present evidence that TRPV 1 and TRPV 2 can heteromultimerize efficiently in vitro . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Recently , 2 aminoethoxydiphenyl borate was introduced as a TRPV 3 agonist , but its selectivity was questioned by showing that it activated recombinant TRPV 1 and TRPV 2 as well . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Heteromerization and colocalization of TrpV 1 and TrpV 2 in mammalian cell lines and rat dorsal root ganglia . ^^^ Coassociation of the vanilloid transient receptor potential ( Trp ) ion channels , TrpV 1 and TrpV 2 , was investigated by immunoprecipitation and immunofluorescence in transfected mammalian cell lines , rat dorsal root ganglia and spinal cord . ^^^ Immunofluorescent labelling of transfected F 11 cells revealed colocalization of TrpV 1 and TrpV 2 at the cell surface . ^^^ Immunoprecipitation from rat dorsal root ganglion lysates identified a minor population of receptor complexes composed of TrpV1 / TrpV2 heteromers , consistent with a small proportion of cells double labelled with TrpV 1 and TrpV 2 antibodies in rat dorsal root ganglion sections . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| TRP channels of the vanilloid family ( TRPV 1 , TRPV 2 , TRPV 3 , TRPV 4 ) are excited by heat stimuli whereas TRPM 8 and ANKTM 1 are cold responsive . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| TRPV 2 , a capsaicin receptor homologue , is expressed predominantly in the neurotrophin 3 dependent subpopulation of primary sensory neurons . ^^^ In the present study , using immunohistochemistry , we found that TRPV 2 was first expressed in DRG neurons at embryonic day ( E ) 11 . 5 , when neither TRPV 1 nor TRPM 8 was detected yet . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Using RT PCR , transcripts homologous to TRPV 2 and TRPV 4 , but not to TRPV 1 or TRPV 3 , were found . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| TRPV 1 , TRPV 2 , TRPV 3 and TRPV 4 mRNAs were expressed in spiral and vestibular ganglia , and TRPV 2 and TRPV 1 mRNAs were most predominant in control mice . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| TRPV 2 expression is concentrated in a subset of medium sized dorsal root ganglion neurons , independent of transient receptor potential vanilloid subfamily member 1 ( TRPV 1 ) expression . ^^^ Intraplantar injection of nerve growth factor increased TRPV 1 expression but not TRPV 2 , suggesting that induction of TRPV 2 expression is driven by a mechanism distinct from that for TRPV 1 . ^^^ Heat hyperalgesia assessment after chemical desensitization of TRPV 1 by resiniferatoxin demonstrates a possible role for TRPV 2 in inflammation at high temperatures ( > 56 degrees C ) . ^^^ |
|
| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| With RT PCR , mRNA of TRPM 2 , TRPM 3 , TRPM 4 , TRPM 7 , and TRPM 8 of TRPM family and TRPV 1 , TRPV 2 , TRPV 3 , and TRPV 4 of TRPV family were detected in both PAs and aorta . ^^^ |
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| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| Participation of TRPV 1 and TRPV 2 in the rat laryngeal sensory innervation . ^^^ We investigated the participation of TRPV 1 and its homologue TRPV 2 in the rat laryngeal sensory innervation using immunohistochemistry and the neuronal tracer , fluoro gold ( FG ) . ^^^ Neurons immunoreactive for TRPV 1 or TRPV 2 were distributed throughout the NG . ^^^ TRPV 1 immunoreactivity was seen in 49 . 0+ / 4 . 5 % of the FG labeled neurons , while TRPV 2 immunoreactivity was seen in 12 . 5+ / 4 . 1 % of the FG labeled neurons . ^^^ These findings suggest that both TRPV 1 and TRPV 2 participate in laryngeal nociception , but that TRPV 1 may have a particularly important role . . ^^^ |
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| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| No member of the PACSIN protein family was able to biochemically interact with TRPV 1 and TRPV 2 . ^^^ |
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| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| These include more than ten transient receptor potential ( TRP ) superfamily members such as TRPC 1 , TRPC 3 6 , TRPV 1 , TRPV 2 , TRPV 4 , TRPM 4 , TRPM 7 , and polycystin ( TRPP 2 ) . ^^^ |
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| Interacting proteins: Q9Y5S1 and Q8NER1 |
Pubmed |
SVM Score :0.0 |
| We assessed specimens with immunohistochemistry and image analysis using specific antibodies to TRPV 1 ; nerve growth factor ( NGF ) receptor tyrosine kinase A ; glial cell line derived neurotrophic factor ( GDNF ) ; neuropeptides calcitonin gene related peptide ( CGRP ) and substance P ; the related vanilloid receptor like protein ( VRL ) 2 ; glial markers S 100 and glial fibrillary acid protein ( GFAP ) ; and the nerve structural marker peripherin . ^^^ |
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