| Interacting proteins: Q7Z6Z7 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| To understand the mechanism of ARF mediated tumor suppression , we identified a ubiquitin ligase , ARF BP 1 , as a key factor associated with ARF in vivo . ^^^ ARF BP 1 harbors a signature HECT motif , and its ubiquitin ligase activity is inhibited by ARF . ^^^ Notably , inactivation of ARF BP 1 , but not Mdm 2 , suppresses the growth of p 53 null cells in a manner reminiscent of ARF induction . ^^^ Surprisingly , in p 53 wild type cells , ARF BP 1 directly binds and ubiquitinates p 53 , and inactivation of endogenous ARF BP 1 is crucial for ARF mediated p 53 stabilization . ^^^ Thus , our study modifies the current view of ARF mediated p 53 activation and reveals that ARF BP 1 is a critical mediator of both the p 53 independent and p 53 dependent tumor suppressor functions of ARF . ^^^ |
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| Interacting proteins: Q7Z6Z7 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| The discoveries of MdmX , HAUSP , ARF , COP 1 , Pirh 2 , and ARF BP 1 continue to uncover the multiple facets of this pathway . ^^^ |
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| Interacting proteins: Q7Z6Z7 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| ARF BP 1 as a potential therapeutic target . ^^^ In this review , we discuss the recent identification of ARF BP 1 ( also known as Mule , UREB 1 , E 3 ( histone ) , LASU 1 , and HectH 9 ) . ^^^ ARF BP 1 , a HECT domain containing E 3 ubiquitin ligase , interacts with ARF and p 53 . ^^^ Inactivation of ARF BP 1 stabilised p 53 and induced apoptosis . ^^^ Notably , inactivation of ARF BP 1 also caused cell growth repression in p 53 null cells and breast cancer cells with mutant p 53 . ^^^ |
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| Interacting proteins: Q7Z6Z7 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
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