| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :1.0143917 |
| We show that cyclin G 1 interacts with ARF , Mdm 2 , and p 53 in vitro and in vivo . 1.0143917^^^ |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Tumor suppressor p 53 is expressed in proliferating and newly formed neurons of the embryonic and postnatal rat brain : comparison with expression of the cell cycle regulators p21Waf1 / Cip1 , p27Kip1 , p57Kip2 , p16Ink4a , cyclin G 1 , and the proto oncogene Bax . ^^^ To elucidate possible functions of p 53 in the regulation of cell division and cell death during development of the rat central nervous system , we compared the spatial and temporal expressions of p 53 mRNA and protein with those of its transcriptional targets Bax , p21Waf1 , and cyclin G 1 and with the cyclin dependent kinase inhibitors p27Kip1 , p57Kip2 , and p16Ink4a . ^^^ In addition to its expression in proliferating cell populations , p 53 was expressed in postmitotic cells of the cerebral cortex and hippocampus at embryonic and early postnatal stages . p 53 , p27Kip1 , p16Ink4a , and bax alpha mRNA colocalized in the ventricular and subventricular zones at embryonic and early postnatal stages , but the distribution of p 53 differed from that of its transcriptional targets cyclin G 1 and p21Waf1 and from that of the cyclin dependent kinase inhibitor p57Kip2 , which were predominantly expressed in fully differentiated neurons . ^^^ |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Cyclin G 1 interacted directly with MDM 2 and promoted the formation of the ARF / MDM2 complex within the initial 24 h period following DNA damage . ^^^ In contrast , in 48 h postirradiated wild type cells , the cyclin G 1 MDM2 complex was found not to be associated with ARF but with the B ' alpha subunit of protein phosphatase A . ^^^ CONCLUSION : These results suggest that cyclin G 1 stabilizes and promotes the degradation of p 53 protein by associating , respectively , with MDM 2 complexes containing ARF and PP2A . . ^^^ |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51959 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|