| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| The p 16 ( INK4A ) , p 15 ( INK4B ) , and p 18 ( INK4C ) CDKIs , which have an ankyrin repeat motifs , belong to the other group . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| To study the structural integrity of the cyclin dependent kinase inhibitors known as INK4A ( p 16 ) , INK4B ( p 15 ) and INK4C ( p 18 ) in multiple myeloma , we examined 20 primary myeloma samples ( including one case of plasma cell leukaemia ) using polymerase chain reaction single strand conformation polymorphism , and 17 samples were examined by Southern blot analysis . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| A group of cyclin dependent kinase inhibitors , p 15 ( INK4B ) , p 16 ( INK4A ) , p 18 ( INK4C ) and p 19 ( INK4D ) , are candidate tumor suppressor genes . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| In a human megakaryoblastic leukemia cell line , CMK , that showed some degree of megakaryocytic differentiation after culture with TPO , the cyclin dependent kinase ( Cdk ) inhibitor p 21 ( WAF1 / Cip1 ) , but not p 27 ( Kip 1 ) , p 16 ( INK4A ) , p 15 ( INK4B ) , or p 18 ( INK4C ) , was found to be upregulated in an immediately early response to TPO . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : A newly recognized class of INK 4 family of cyclin dependent kinase inhibitors CDKIs ) include its prototype , p 16 ( INK4A / MTS1 / CDKN2 ) , and three others , p 15 ( INK4B / MTS2 ) , p 18 ( INK4C ) , and p 19 ( INK4D ) . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Restriction fragment length polymorphisms between BALB / c and DBA / 2 for Cdkn2a ( p 16 ) and Cdkn2b ( p 15 ) , and between BALB / c and Mus spretus for Cdkn2c ( p 18 ( INK4c ) ) were used to position these loci with respect to the Pctr 1 locus . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| While the INK family ( p 15 ( INK4B ) / p16 ( INK4A ) / p18 ( INK4C ) / p19 ( INK4D ) ) of CKIs is not detectable in hearts , the KIP / CIP family ( p 21 ( CIP 1 ) , p 27 ( KIP 1 ) and p 57 ( KIP 2 ) ) of CKIs is detectable in most organs including the heart . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| We also found that cdk inhibitors , including p 21 ( CIP 1 ) , p 27 ( KIP 1 ) , p 57 ( KIP 2 ) , p 16 ( INK4a ) , and p 18 ( INK4c ) , could block phosphorylation by p 40 ( MO 15 ) but not phosphorylation by Cak1p . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| The four members of the INK 4 gene family , p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) and p 19 ( INK4d ) , are known to bind to and inhibit the closely related cyclin dependent kinases CDK 4 and CDK 6 as part of the regulation of the G1 / S transition in the cell division cycle . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The four members of the INK 4 gene family ( p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) and p 19 ( INK4d ) ) inhibit the closely related cyclin dependent kinases CDK 4 and CDK 6 as part of the regulation of the G 1 > S transition in the cell division cycle . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Similarly , G 1 associated cell cycle kinases ( CDK ) inhibitory ( CKI ) synthetic peptides derived from p 16 ( INK4a ) , p 18 ( INK4c ) and p 21 ( Cip1 / Waf1 ) , which can be delivered directly into cells from the tissue culture medium , do not affect non alphavbeta 3 dependent spreading on collagen 4 , laminin and fibronectin at concentrations that inhibit cell cycle progression in late G 1 . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Tumor suppressor INK 4 : comparisons of conformational properties between p 16 ( INK4A ) and p 18 ( INK4C ) . ^^^ The INK 4 ( inhibitor of cyclin dependent kinase 4 ) family consists of four tumor suppressor proteins : p 15 ( INK4B ) , p 16 ( INK4A ) , p 18 ( INK4C ) , and p 19 ( INK4D ) . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| The INK 4 family of cyclin dependent kinase ( CDK ) inhibitors includes four 15 to 19 kDa polypeptides ( p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) , and p 19 ( INK4d ) ) that bind to CDK 4 and CDK 6 . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Distinct versus redundant properties among members of the INK 4 family of cyclin dependent kinase inhibitors . p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) and p 19 ( INK4d ) comprise a family of cyclin dependent kinase inhibitors and tumor suppressors . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Cyclin dependent kinase ( CDK ) inhibitors represented by the INK 4 family ( including p 16 ( INK4a , CDKN2A ) , p 15 ( INK4b , CDKN2B ) , p 18 ( INK4c , CDKN2C ) , and p 19 ( INK4d , CDKN2D ) ) are regulators of the cell cycle shown to be aberrant in many types of human cancer . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Growth arrest was not associated with upregulation of the CDK inhibitors p 21 ( Waf1 / Cip1 ) , p 18 ( ink4c ) or p 16 ( ink4a ) , but was associated with a decrease in reactive oxygen species ( ROS ) . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| In order to elucidate the mechanism for these changes , we examined the ontogeny of expression for the known cyclin dependent kinase inhibitors ( CKIs ) , p 15 ( Ink4b ) , p 16 ( Ink4a ) , p 18 ( Ink4c ) , p 19 ( Ink4d ) , p 21 ( Cip 1 ) , p 27 ( Kip 1 ) and p 57 ( Kip 2 ) . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Here we present the 2 . 9 A crystal structure of the inactive ternary complex between Cdk 6 , the INK 4 inhibitor p 18 ( INK4c ) , and a D type viral cyclin . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| A chimera consisting of the kinase binding region of p 16 ( INK4a ) fused to the COOH terminus of p 18 ( INK4c ) is active in all known biochemical assays for INK 4 function , but it does not arrest CEM cells . ^^^ Although the gene encoding p 16 ( INK4a ) is commonly inactivated in human tumors , p 18 ( INK4c ) is rarely altered . ^^^ We show here that overexpression of p 18 ( INK4c ) does not block cell cycle progression in a T cell acute lymphocytic leukemia cell line ( CEM ) sensitive to p 16 ( INK4a ) mediated G ( 1 ) arrest . ^^^ These data imply a novel level of p 18 ( INK4c ) regulation mediated through the COOH terminus and suggest that functional differences might underlie the distinct mutational profiles observed for p 16 ( INK4a ) and p 18 ( INK4c ) in tumors . . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| SH F , which expresses basal amounts of p 16 ( INK4A ) , responds to RA with elevation of p 18 ( INK4C ) , marked down regulation of cyclin D 1 , and swift inhibition of cyclin D dependent kinases ( cdks ) . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Alterations of the tumor suppressor genes CDKN2A ( p 16 ( INK4a ) ) , p 14 ( ARF ) , CDKN2B ( p 15 ( INK4b ) ) , and CDKN2C ( p 18 ( INK4c ) ) in atypical and anaplastic meningiomas . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Moreover , by using targeted mice deficient for other INK 4 inhibitors , we show that deletion of p 18 ( INK4c ) but not of p 15 ( INK4b ) confers proliferative advantage to melanocytic tumor growth . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| We investigated p 14 ( ARF ) , p 15 ( INK4B ) , p 16 ( INK4A ) , p 18 ( INK4C ) , and RB 1 genes in a series of HCCs and associated cirrhosis with the goal of ascertaining their pattern of inactivation by gene methylation . ^^^ With the exception of p 18 ( INK4C ) the genes under study showed promoter methylation with frequency ranging from 82 % ( p 16 ( INK4A ) in HCC ) to 33 % and 39 % ( p 15 ( INK4B ) and p 16 ( INK4A ) in cirrhoses ) . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| The status of RB 1 , INK4A , INK4B , INK4C , INK4D , and ARF in 13 adult and 2 juvenile ovarian GCTs was determined by reverse transcription polymerase chain reaction of total RNA and exon specific sequencing of genomic DNA . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Structure based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity . p 18 ( INK4c ) is a member of the INK 4 family of proteins that regulate the G ( 1 ) to S cell cycle transition by binding to and inhibiting the pRb kinase activity of cyclin dependent kinases 4 and 6 . ^^^ Based on this observation , we used p 18 ( INK4c ) as a model to test the proposal that INK 4 proteins with increased stability might have enhanced cell cycle inhibitory activity . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Whereas loss of function of other INK 4 genes in mice leads to little or no tumor development , targeted deletion of p 18 ( INK4c ) causes spontaneous pituitary tumors and lymphoma late in life . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Previously , it was shown that even inhibitors of the Cdks as p 16 ( INK4a ) , p 18 ( INK4c ) or p 27 ( KIP 1 ) are expressed in neurons of AD patients , indicating a rather complete involvement of cell cycle machinery in affected neurons . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Antitumour effect of cyclin dependent kinase inhibitors ( p 16 ( INK4A ) , p 18 ( INK4C ) , p 19 ( INK4D ) , p 21 ( WAF1 / CIP1 ) and p 27 ( KIP 1 ) ) on malignant glioma cells . ^^^ Using recombinant adenoviral vectors that express CDKIs ( p 16 ( INK4A ) , p 18 ( INK4C ) , p 19 ( INK4D ) , p 21 ( WAF1 / CIP1 ) and p 27 ( KIP 1 ) ) , we compared the antitumour effect of CDKIs on malignant glioma cell lines ( A 172 , GB 1 , T98G , U 87 MG , U 251 MG and U 373 MG ) . p 27 ( KIP 1 ) showed higher ability to suppress the growth of all tumour cells tested than other CDKIs . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Of interest , the induction of HSC senescence was associated with a prolonged elevation of p 21 ( Cip1 / Waf1 ) , p 19 ( Arf ) , and p 16 ( Ink4a ) mRNA expression , while the expression of p 27 ( Kip 1 ) and p 18 ( Ink4c ) mRNA was not increased following TBI . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| METHODS : Genes for the CDKIs p 16 ( INK4a ) and p 18 ( INK4c ) , a constitutively active form of retinoblastoma ( RB ) gene product , cyclin D 1 , and CDK 4 , were transferred into RA synovial fibroblasts ( RASFs ) . ^^^ RESULTS : Transfer of the p 16 ( INK4a ) and p 18 ( INK4c ) genes and CDK4I suppressed the production of MMP 3 and MCP 1 . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Analysis of cyclin dependent kinase inhibitor genes ( CDKN2A , CDKN2B , and CDKN2C ) in childhood rhabdomyosarcoma . p16INK4A , p15INK4B , and p 18 proteins are highly specific inhibitors of cyclin dependent serine / threonine kinase ( CDK ) activities required for GI S transition in the eukaryotic cell division cycle . ^^^ We looked for homozygous deletions of CDKN2A , CDKN2B ( p15INK4B ) , and CDKN2C ( p 18 ) in 12 primary rhabdomyosarcoma ( RMS ) specimens and in five cell lines established from this cancer type . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Structural and functional analysis of cyclin dependent kinase inhibitor genes ( CDKN2A , CDKN2B , and CDKN2C ) in neuroblastoma . ^^^ The status of the CDKN2A gene family , including CDKN2A , CDKN2B , and CDKN2C , was investigated in 24 cases of neuroblastoma . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Analysis of CDKN2A , CDKN2B , CDKN2C , and cyclin Ds gene status in hepatoblastoma . ^^^ The status and the expression of cyclin dependent kinase inhibitor A ( CDKN2A ) family genes , named CDKN2A , CDKN2B , and CDKN2C and of cyclin Ds ( D 1 , D 2 , and D 3 ) genes were investigated in 14 cases of human hepatoblastomas . ^^^ Structural analysis of the CDKN2A , CDKN2B , and CDKN2C genes in hepatoblastoma cases showed the absence of deletions and / or point mutations . ^^^ Messenger RNA ( mRNA ) analysis showed that CDKN2C is expressed in all hepatoblastoma samples studied , while both CDKN2A and CDKN2B genes are not transcribed in the cancer specimens as well as in the matched normal liver tissues . ^^^ Indeed , p16INK4A and p15INK4B ( products of expression of CDKN2A and CDKN2B respectively ) were not observable while pl8INK4C ( which is codified by CDKN2C ) was clearly detectable in the samples analyzed . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| All markers within the bands RNO5q31 . 3 q 35 were shown to be lost , including known cancer related genes such as Ifna ( 5q32 ) , Cdkn2a , b ( 5q32 ) , Jun ( 5q34 ) , and Cdkn2c ( 5q35 ) . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| The genomic status of the CDKN2A ( INK 4 ARF , p16 / p14 ( ARF ) ) , CDKN2B ( p 15 ) and CDKN2C ( p 18 ) genes was determined by PCR SSCP ( single strand conformation polymorphism ) in 46 of these cases . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| In this report we present the results of mutational analysis of the CDKN2B , CDKN2C , CDK 4 , p 53 genes and 5 ' UTR of the CDKN2A gene in a set of 44 sporadic primary melanomas , which had been earlier analysed for mutations in the CDKN2A ( p16 / p14 ( ARF ) ) gene . ^^^ A single nucleotide polymorphism in the 3 ' untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B , CDKN2C , CDK 4 and p 53 genes are rare . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| We have characterized cyclin dependent kinase inhibitor p 15 ( CDKN2B ) , p 16 ( CDKN2A ) and p 18 ( CDKN2C ) deletions in cyclin D 1 expressing and non expressing MM cell lines . p 18 was found to be frequently deleted ( 38 % ) ; in some cases p 18 deletions coexisted with hemizygous p 16 deletion . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Progression through the G 1 phase of the cell cycle is dependent on the activity of holoenzymes formed between D type cyclins and their catalytic partners , the cyclin dependent kinases cdk 4 and cdk 6 . p16INK4a , p15INK4b , and p18INK4c , a group of structurally related proteins , function as specific inhibitors of the cyclin D dependent kinases and are likely to play physiologic roles as specific regulators of these kinases in vivo . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| The first group , including p16Ink4a , p15Ink4b , p18Ink4c and p19Ink4d , is specific for the G 1 CDKs , CDK 4 and CDK 6 , inhibiting the kinase activity of cyclin D / CDK4 CDK 6 complexes on pRb . p16Ink4a , down regulated by pRb , inhibits G 1 CDKs by competition with cyclin D ; p15Ink4b , the synthesis of which is induced by TGF beta , seems to be a mediator of TGF beta mediated cell cycle arrest . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Moreover , the INK 4 family including p15INK4b , p18INK4c , and p19INK4d was isolated . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| These results together with our previous data that showed a 22 % deletion frequency in p15INK4b and rare alterations in the pl8INK4c gene , indicating that the p16INK4a and pl5INK4b , but not the p18INK4c and pl9INK4d genes , are frequently mutated in human tumors . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Expression and regulation of G 1 cell cycle inhibitors ( p16INK4A , p15INK4B , p18INK4C , p19INK4D ) in human acute myeloid leukemia and normal myeloid cells . ^^^ We examined constitutive and differentiation induced expression and regulation of the four members of the G 1 CKI family p16INK4A , p15INK4B , p18INK4C and p19INK4D in acute myeloid leukemia as well as their expression in normal granulocytes and monocytes . p18INK4C and p19INK4D mRNA were expressed constitutively at high levels in seven myeloid cell lines and 16 AML patient samples , whereas expression of p15INK4B mRNA was very low and only detectable by nested RT PCR analysis . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Therefore , considerable efforts have been made to determine the role of CDK4 / 6 inhibitors in hematologic malignancies : This article will review alterations of components of the cell cycle machinery in brief and summarize the role of the CDK4 / 6 inhibitors p16INK4A , p15INK4B , p18INK4C and p19INK4D in leukemias and lymphomas . . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| We found that status of p 107 , p 130 , p15INK4b , p18INK4c , p21Cip1 , p27Kip1 , cyclin D 1 , and Cdk 4 were not correlated with the growth inhibitory activity of exogenous p16INK4a . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Both p18INK4c and p19INK4d were widely expressed during mouse embryogenesis , but p16INK4a and p15INK4b were not readily detected prenatally . ^^^ Although p15INK4b , p18INK4c and p19INK4d were demonstrated in many tissues by 4 weeks after birth , p16INK4a protein expression was restricted to the lung and spleen of older mice , with increased , more widespread mRNA expression during aging . ^^^ The levels of p16INK4a and p18INK4c , but not p15INK4b or p19INK4d , further increased as MEFs approached senescence . ^^^ Whereas p18INK4c and p19INK4d may regulate pre and postnatal development , p16INK4a more likely plays a checkpoint function during cell senescence that underscores its selective role as a tumor suppressor . . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Using a multiprobe RNase protection assay encompassing riboprobe panels for cell cycle and apoptosis related genes , we found that these cells exhibited high expression of certain members of the Ink 4 ( p18Ink4C ) and Cip / Kip ( p21Cip1 ) families of cyclin kinase inhibitors as well as of the apoptosis inhibiting Bcl xL gene . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Analysis of p18INK4C in adult T cell leukaemia and non Hodgkin ' s lymphoma . p18INK4C , a cyclin dependent kinase inhibitor , is a homologue of p15INK4B and p16INK4A which are frequently altered in a variety of malignancies . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Comparative detection and quantitation of human CDK inhibitor mRNA expression of p15INK4B , p16INK4A , p16beta , p18INK4C , p19INK4D , p21WAF1 , p27KIP1 and p57KIP2 by RT PCR using a polycompetitive internal standard . ^^^ For comparative and quantitative analysis of human cyclin dependent kinase inhibitor gene expression ( CKI ; p15INK4B , p16INK4A , p16beta , p18INK4C , p19INK4D , p21WAF1 , p27KIP1 and p57KIP2 ) we set up an RT PCR assay with a construct termed pCKIquant producing polycompetitive RNA as an internal standard . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Crystal structure of the CDK4 / 6 inhibitory protein p18INK4c provides insights into ankyrin like repeat structure / function and tumor derived p16INK4 mutations . p18INK4c is a member of a family of INK 4 proteins that function to arrest the G 1 to S cell cycle transition by inhibiting the activity of the cyclin dependent kinases 4 and 6 . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| The CDKIs include the Ink 4 family ( p15Ink4b , p16Ink4a , p18Ink4c , p19Ink4d ) and the KIP family ( p21Cip1 and p27Kip1 ) . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| The investigated genes were RB 1 , p 53 and six cyclin dependent kinase inhibitor genes ( p15INK4B , p16INK4A , p18INK4C , p21WAF1 / CIP1 , p27Kip1 , p57Kip2 ) . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| In the present study , we demonstrate that other members of the INK 4 family of cyclin dependent kinase inhibitors such as p15INK4b , p18INK4c and p19INK4d that bind directly to cdk4 / 6 or to complexes of cdk4 / 6 with D type cyclins are all elevated . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Tumor suppressor INK 4 : determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A . ^^^ The results suggest that loop 2 is likely to be part of the recognition surface of p18INK4C or p16INK4A for CDK 4 , and they provide quantitative functional contributions of specific residues . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A , p18INK4C , p19INK4D , p 21 ( WAF1 / CIP1 ) and p27KIP1 in inducing cell cycle arrest , apoptosis and inhibition of tumorigenicity . ^^^ Adenovirus vectors were constructed to overexpress cyclin kinase inhibitors p16INK4A , p18INK4C , p19INK4D , p 21 ( WAF1 / CIP1 ) and p27KIP1 under the control of the murine cytomegalovirus immediate early gene promoter . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined the effects of Tax on other members of the INK 4 family and found that Tax can bind to p15ink4b similarly to p16ink4a , but not to p18ink4c and p19ink4d . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Tumor suppressor INK 4 : quantitative structure function analyses of p18INK4C as an inhibitor of cyclin dependent kinase 4 . ^^^ We report the first detailed structure function analyses of p18INK4C ( p 18 ) , which is a homologue of the important tumor suppressor p16INK4A ( p 16 ) . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| A new member of the INK 4 family of CDK inhibitors , the p18INK4c gene , has recently been mapped to this chromosomal arm . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| In this study , we report the isolation and characterization of a panel of 10 mouse monoclonal antibodies ( MAbs ) that specifically recognize p21WAF1 / CIP1 ( p 21 ) or the individual members of the INK 4 family of CKIs : p15INK4b ( p 15 ) , p16INK4a ( p 16 ) , p18INK4c ( p 18 ) , or p19INK4d ( p 19 ) . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Assembly and activity of the proto oncogenic cyclin D / CDK4 ( 6 ) complexes , the major driving force of G 1 phase progression , is negatively regulated by a family of INK 4 CDK inhibitors p16INK4a , p15INK4b , p18INK4c , and p19INK4d . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| While members of the INK 4 family ( p16INK4A , p15INK4B , p18INK4C , p19INK4D ) interact specifically with CDK 4 and CDK 6 , the CIP / KIP inhibitors p21CIP1 / WAF1 , p27KIP1 and p57KIP2 inhibit a broader spectrum of CDK . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| METHODS : Samples of normal colonic mucosa ( n = 41 ) and flat ( n = 45 ) and exophytic ( n = 26 ) adenomas were examined immunohistochemically using antibodies to cyclins D 1 , D 2 , D 3 , cyclin dependent kinase ( CDK ) 4 , retinoblastoma protein ( pRB ) , and the CDK inhibitors p16INK4a , p18INK4c , and p19INK4d . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| At birth , olfactory neural progenitors , the basal cells , exhibited a high mitogenic and neurogenic activity , decreasing in the following weeks together with the drop in expression of several cell cycle regulators . p27Kip1 and p18Ink4c , at birth , were expressed in the whole basal cell layer , whereas p16Ink4a , p19Ink4d , and p21Cip1 were rather located in differentiating or mature neurons . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas : correlation with tumor grade and clinical outcome . ^^^ OBJECTIVE : To investigate immunoexpression of 2 cyclin dependent kinase inhibitors , p18INK4C ( p 18 ) and p14ARF ( p 14 ) , in oligodendrogliomas and to evaluate the possible association with tumor grade and clinical outcome . ^^^ Tumor specimens were immunohistochemically examined with antibodies to p18INK4C ( 118 . 2 ) and p14ARF ( FL 132 ) proteins . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| There are two groups of inhibitors : INK 4 ( p16INK4a , p15INK4b , p18INK4c , p19INK4d ) and proteins p21WAF1 / Clip1 , p27Kip1 , p57Kip2 . ^^^ |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analysis of p16INK4a , p14ARF , p18INK4c , p21CIP1 , p27KIP1 and p 73 expression in 271 meningiomas correlation with tumor grade and clinical outcome . ^^^ We investigated the prognostic significance of p16INK4a , p14ARF , p18INK4c , p21CIP1 , p27KIP1 and p 73 expression by immunohistochemical analysis of 271 meningiomas . ^^^ Thus , the immunohistochemical assessment of p16INK4a , p14ARF , p18INK4c , p21CIP1 , p27KIP1 and p 73 expression in meningiomas does not appear to provide prognostically useful information . ^^^ Significant differences between the number of p16INK4a , p18INK4c and p21CIP1 positive cases were noted among the 3 grades of meningiomas . p16INK4a and p21CIP positive tumors were found to prevail among benign meningiomas , whereas p18INK4c immunostaining was closely associated to anaplastic meningiomas . ^^^ |
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| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Among the CDK inhibitors ( CKIs ) , p16ink4a and p21Cip1 were moderately increased and decreased , respectively , whereas the abundance of most of the CKIs , including p27Kip1 , p57Kip2 , p15ink4b and p18ink4c , was relatively maintained in the migrating epithelial tongue . ^^^ |
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| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| We report here that HDAC inhibitor , Trichostatin A , activates another member of the INK 4 family , the p18INK4c gene , through its promoter in Jurkat cells . ^^^ |
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| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Cyclins , cyclin dependent kinases ( Cdks ) , and Cdk inhibitors ( CdkIs ) are frequently altered in human cancer . p18INK4C , a member of the INK 4 family of CdkIs , is a potential tumor suppressor gene product . ^^^ |
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| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| These inhibitors included the CDKIs of the CIP / KIP family ( p21CIP1 p27KIP1 , and p57KIP2 ) and the INK 4 family ( p15INK4b , p16INK4a , p18INK4c , and p19INK4d ) as well as the retinoblastoma protein family ( pRb , p 107 , and p 130 ) and the tumor suppressor p 53 . ^^^ |
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| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| Interestingly , we also found that , in the absence of p16INK4a , reexpression of hSNF 5 also increased protein levels of a second cyclin dependent kinase ( CDK ) inhibitor , p18INK4c . ^^^ |
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| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and Q8N726 |
Pubmed |
SVM Score :0.0 |
| NA |
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