| Interacting proteins: Q8N726 and P17980 |
Pubmed |
SVM Score :0.0 |
| In particular , we demonstrate that p14ARF interacts with the SUMO E 2 conjugating enzyme , Ubc 9 and enhances the sumoylation of its binding partners , hdm 2 , E2F 1 , HIF 1alpha , TBP 1 and p120E4F . ^^^ |
|
| Interacting proteins: Q8N726 and P17980 |
Pubmed |
SVM Score :0.0 |
| Functional and physical interaction of the human ARF tumor suppressor with Tat binding protein 1 . ^^^ We report here that the so called human immunodeficiency virus Tat binding protein 1 ( TBP 1 ) , a component of the 19 S regulatory subunit of the proteasome 26 S , also involved in transcriptional regulation and with a supposed role in the control of cell proliferation , specifically interacts with ARF , both in yeast and mammalian cells . ^^^ We present evidence that the overexpression of TBP 1 in various cell lines results in a sharp increase of both transfected and endogenous ARF protein levels . ^^^ We also show that the ARF increase following TBP 1 overexpression results in an increase in p 53 protein levels and activity . ^^^ |
|