Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q8N726 and P06748	Pubmed	SVM Score :0.63225843
An NPM mutant lacking its carboxyl terminal nucleic acid binding domain oligomerizes with endogenous NPM , inhibits p 19 ( Arf ) from entering into 2 to 5 MDa particles , and overrides the ability of p 19 ( Arf ) to retard rRNA processing . . 0.63225843^^^
Interacting proteins: Q8N726 and P06748	Pubmed	SVM Score :0.0
DNA damage disrupts the p14ARF B 23 ( nucleophosmin ) interaction and triggers a transient subnuclear redistribution of p14ARF . ^^^
Interacting proteins: Q8N726 and P06748	Pubmed	SVM Score :0.0
Nucleophosmin is required for DNA integrity and p19Arf protein stability . ^^^
Interacting proteins: Q8N726 and P06748	Pubmed	SVM Score :0.0
Through as yet uncharacterized mechanisms , p19Arf induces p 53 independent sumoylation of a variety of cellular target proteins with which it interacts , including both Mdm 2 and NPM . ^^^ A naturally occurring NPM mutant ( NPMc ) expressed in myeloid leukemia cells redirects both wild type NPM and p19Arf to the cytoplasm , inhibits Arf induced sumoylation , and attenuates p 53 activity . ^^^
Interacting proteins: Q8N726 and P06748	Pubmed	SVM Score :0.0
In search of p 53 independent ARF targets , we isolated nucleophosmin ( NPM / B23 ) , a protein we show is required for proliferation , as a novel ARF binding protein . ^^^ ARF impedes NPM / B23 shuttling in an Mdm 2 sensitive tumor suppressor pathway . ^^^ In response to hyperproliferative signals , ARF is upregulated , resulting in the nucleolar retention of NPM and concomitant cell cycle arrest . ^^^ The Mdm 2 oncogene outcompetes NPM / B23 for ARF binding , and introduction of Mdm 2 reverses ARF ' s p 53 independent properties : in vitro , NPM is released from ARF containing protein complexes , and in vivo S phase progression ensues . ^^^ ARF induction by oncogenes or replicative senescence does not alter NPM / B23 protein levels but rather prevents its nucleocytoplasmic shuttling without inhibiting rRNA processing . ^^^
Interacting proteins: Q8N726 and P06748	Pubmed	SVM Score :0.0
Nucleophosmin ( B 23 ) targets ARF to nucleoli and inhibits its function . ^^^ We suggest ARF primarily functions outside the nucleolus and provide evidence that it is sequestered and held inactive in that compartment by a nucleolar phosphoprotein , nucleophosmin ( NPM ) . ^^^ Most cellular ARF is bound to NPM regardless of whether cells are proliferating or growth arrested , indicating that ARF NPM association does not correlate with growth suppression . ^^^ Notably , ARF binds NPM through the same domains that mediate nucleolar localization and Mdm 2 binding , suggesting that NPM could control ARF localization and compete with Mdm 2 for ARF association . ^^^ Indeed , NPM knockdown markedly enhanced ARF Mdm 2 association and diminished ARF nucleolar localization . ^^^
Interacting proteins: Q8N726 and P06748	Pubmed	SVM Score :0.0
Nucleophosmin ( NPM ) is a nucleocytoplasmic shuttling protein involved in leukemia associated chromosomal translocations , and it regulates the alternate reading frame ( ARF ) p 53 tumor suppressor pathway . ^^^ Nucleophosmin ( NPM ) is a nucleocytoplasmic shuttling protein involved in leukemia associated chromosomal translocations , and it regulates the alternate reading frame ( ARF ) p 53 tumor suppressor pathway . ^^^
Interacting proteins: Q8N726 and P06748	Pubmed	SVM Score :0.0
Arf triggers sumoylation of many cellular proteins , including Mdm 2 and nucleophosmin ( NPM / B23 ) , with which p 19 ( Arf ) physically interacts in vivo , and this occurs equally well in cells expressing or lacking functional p 53 . ^^^ In an Arf null NIH 3T3 cell derivative ( MT Arf cells ) engineered to reexpress an Arf transgene driven by a zinc inducible metallothionein promoter , sumoylation of endogenous Mdm 2 and NPM proteins was initiated as p 19 ( Arf ) was induced and was observed before p 53 dependent cell cycle arrest . ^^^ Two Arf mutants , one of which binds to Mdm 2 and NPM but is excluded from nucleoli and the other of which enters nucleoli but is handicapped in binding to Mdm 2 and NPM , were defective in inducing sumoylation of these two target proteins and did not localize bulk sumoylated molecules to nucleoli . ^^^
Interacting proteins: Q8N726 and P06748	Pubmed	SVM Score :0.0
Delocalization and destabilization of the Arf tumor suppressor by the leukemia associated NPM mutant . ^^^ It has been recently shown that NPM is required for the stabilization and proper nucleolar localization of the tumor suppressor p 19 ( Arf ) . ^^^ We report here that the AML associated NPM mutant localizes mainly in the cytoplasm due to an alteration of its nucleus cytoplasmic shuttling equilibrium , forms a direct complex with p 19 ( Arf ) , but is unable to protect it from degradation . ^^^ Consequently , cells or leukemic blasts expressing the NPM mutant have low levels of cytoplasmic Arf . ^^^ Furthermore , we show that expression of the NPM mutant reduces the ability of Arf to initiate a p 53 response and to induce cell cycle arrest . ^^^
Interacting proteins: Q8N726 and P06748	Pubmed	SVM Score :0.0
We have found that UV irradiation of cells disrupts the interaction of ARF with two of its nucleolar binding partners , B 23 ( NPM , nucleophosmin , NO 38 , numatrin ) and topoisomerase 1 , and promotes an immediate and transient subnuclear redistribution of ARF to the nucleoplasm , where it can engage the p 53 pathway ( Lee et al , Cancer Res 65 : 9834 42 ; 2005 ) . ^^^
Interacting proteins: Q8N726 and P06748	Pubmed	SVM Score :0.0
C terminal somatic mutations in nucleophosmin ( NPM ) , a nucleolar shuttling protein that binds p 53 and p 19 ( Arf ) , were recently described in karyotypically normal acute myeloid leukaemia ( AML ) . ^^^
Interacting proteins: Q8N726 and P06748	Pubmed	SVM Score :0.0
Furthermore , we show that ARF protects against viral infection in a gene dosage dependent manner , and that this antiviral action is mediated in part by PKR through a mechanism that involves ARF induced release of PKR from nucleophosmin complexes . ^^^