| Interacting proteins: Q8N474 and P04628 |
Pubmed |
SVM Score :0.0 |
| The observed abnormalities included overexpression of Wnt 1 , Frizzled 1 and 2 receptors , Dishevelled 1 , downregulation of Secreted frizzled related protein 1 , GSK 3beta inactivation , microsatellite instability at the Axin locus as well as induction of beta catenin target genes , such as glutamine synthetase , glutamate transporter 1 , and Wisp 1 . ^^^ |
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| Interacting proteins: Q8N474 and P04628 |
Pubmed |
SVM Score :0.0 |
| Wnt signaling was up regulated in normal FLS by transfection with a Wnt 1 expression plasmid and was down regulated in RA FLS by transfection with dominant negative lymphoid enhancer factor 1 ( LEF 1 ) / T cell factor 4 ( TCF 4 ) and secreted Frizzled receptor protein 1 ( sFRP 1 ) expression plasmids . ^^^ Recombinant sFRP 1 and anti Wnt 1 antibody were also administered to RA FLS to block Wnt signaling . ^^^ In a complementary manner , interference with Wnt signaling using anti Wnt 1 antibody , the Wnt antagonist sFRP 1 , or dominant negative vectors that inhibited the transcription factors TCF 4 / LEF 1 blocked the expression of fibronectin by RA FLS and reduced cell survival . ^^^ Anti Wnt 1 antibody and sFRP 1 also blocked the expression of proMMP 3 . ^^^ |
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| Interacting proteins: Q8N474 and P04628 |
Pubmed |
SVM Score :0.0 |
| We also identified expression patterns for the Wnt 1 , Wnt3a , Wnt 6 , Wnt7b , Wnt9a , Wnt10b , and Sfrp 1 genes at the blastocyst stage . ^^^ In particular , the expression of Wnt 1 and Sfrp 1 predominantly in the inner cell mass and of Wnt9a in the mural trophoblast and inner cell mass cells surrounding the blastocoele suggests new roles for the Wnt pathway in preimplantation development . ^^^ |
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| Interacting proteins: Q8N474 and P04628 |
Pubmed |
SVM Score :0.0 |
| In the developing chick neural tube , sfrp 1 , 2 , and 3 transcripts are expressed in and adjacent to the dorsal neural tube , where Wnt 1 and Wnt 3a are expressed . ^^^ |
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| Interacting proteins: Q8N474 and P04628 |
Pubmed |
SVM Score :0.0 |
| Investigation of the mechanisms responsible for FRP inhibition revealed that FRP forms complexes with WNT 1 or WNT 2 through its CRD domain . ^^^ |
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| Interacting proteins: Q8N474 and P04628 |
Pubmed |
SVM Score :0.0 |
| To explore the role of Frp and its relationship to the Wnt signalling pathway in breast cancer , in situ hybridization and immunohistochemical analyses of Frp , Wnt 1 , APC , beta catenin , and its target genes c myc and cyclin D 1 were conducted in 70 specimens of invasive ductal carcinomas of the human breast . ^^^ The level of Wnt 1 was linearly correlated with its downstream target beta catenin ( p < 0 . 05 ) , but was inversely correlated with Frp ( p < 0 . 05 ) , suggesting a possible negative regulatory role of Frp with regard to Wnt 1 . ^^^ |
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| Interacting proteins: Q8N474 and P04628 |
Pubmed |
SVM Score :0.0 |
| A secreted frizzled related protein , FrzA , selectively associates with Wnt 1 protein and regulates wnt 1 signaling . ^^^ Here we demonstrate that FrzA , a sFRP that is highly expressed in vascular endothelium and a variety of epithelium , specifically binds to Wnt 1 protein , but not Wnt 5a protein , and modulates Wnt 1 signaling . ^^^ FrzA associated with Wnt 1 either when expressed in the same cell or when soluble FrzA was incubated with Wnt 1 expressing cells . ^^^ FrzA efficiently inhibited the Wnt 1 mediated increase in cytoplasmic ( beta ) catenin levels as well as the Wnt 1 induction of transcription from a Lef / tcf reporter gene . ^^^ The effects of FrzA on ( beta ) catenin levels could be demonstrated when co expressed with Wnt 1 or when individual cells expressing FrzA and Wnt 1 were co cultured . ^^^ |
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| Interacting proteins: Q8N474 and P04628 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q8N474 and P04628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8N474 and P04628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8N474 and P04628 |
Pubmed |
SVM Score :0.0 |
| NA |
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