| Interacting proteins: Q6N083 and Q8IXK0 |
Pubmed |
SVM Score :0.0 |
| Upon completion of surgery , neuromuscular block was reversed by injecting normal saline ( Group PLAC ) , edrophonium 0 . 125 mg . kg 1 ( Group EDR 1 ) , 0 . 25 mg . kg 1 ( Group EDR 2 ) , or 0 . 50 mg . kg 1 ( Group EDR 3 ) , in addition to a corresponding dose of atropine . ^^^ |
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| Interacting proteins: Q6N083 and Q8IXK0 |
Pubmed |
SVM Score :0.0 |
| Here , we identify two human proteins , HPH 1 and HPH 2 , that are associated with the vertebrate PcG protein BMI 1 . ^^^ HPH 1 and HPH 2 coimmunoprecipitate and cofractionate with each other and with BMI 1 . ^^^ HPH 1 and HPH 2 have little sequence homology with each other , except in two highly conserved domains , designated homology domains 1 and 2 . ^^^ They share these homology domains 1 and 2 with the Drosophila PcG protein Polyhomeotic ( Ph ) , and we , therefore , have named the novel proteins HPH 1 and HPH 2 . ^^^ HPH 1 , HPH 2 , and BMI 1 show distinct , although overlapping expression patterns in different tissues and cell lines . ^^^ |
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| Interacting proteins: Q6N083 and Q8IXK0 |
Pubmed |
SVM Score :0.0 |
| HPH 1 ( YOR324C ) and its homolog HPH 2 ( YAL028W ) encode tail anchored integral membrane proteins that interact with each other in the yeast two hybrid assay and colocalize to the endoplasmic reticulum . ^^^ |
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| Interacting proteins: Q6N083 and Q8IXK0 |
Pubmed |
SVM Score :0.0 |
| Mammalian polyhomeotic homologues Phc 2 and Phc 1 act in synergy to mediate polycomb repression of Hox genes . ^^^ The Drosophila polyhomeotic genes and their mammalian orthologues , Phc 1 , Phc 2 , and Phc 3 , encode nuclear proteins that are constituents of evolutionarily conserved protein complexes designated class 2 PcG complexes . ^^^ Synergistic actions of a Phc 2 mutation with Phc 1 and Rnf 110 mutations during A P specification , coimmunoprecipitation of their products from embryonic extracts , and chromatin immunoprecipitation by anti Phc 2 monoclonal antibodies suggest that Hox repression by Phc 2 is mediated through the class 2 PcG complexes , probably via direct binding to the Hox locus . ^^^ The genetic interactions further reveal the functional overlap between Phc 2 and Phc 1 and a strict dose dependent requirement during A P specification and embryonic survival . ^^^ Functional redundancy between Phc 2 and Phc 1 leads us to hypothesize that the overall level of polyhomeotic orthologues in nuclei is a parameter that is critical in enabling the class 2 PcG complexes to exert their molecular functions . . ^^^ |
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| Interacting proteins: Q6N083 and Q8IXK0 |
Pubmed |
SVM Score :0.0 |
| NA |
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