| Interacting proteins: Q8IVT5 and Q02750 |
Pubmed |
SVM Score :1.1050811 |
| However , because KSR 1 constitutively associates with MEK 1 and this interaction appears critical for KSR 1 scaffolding function , it has been argued that the kinase activity detected is an artifact of KSR 1 bound MEK 1 . 1.1050811^^^ |
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| Interacting proteins: Q8IVT5 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Ceramide activated protein kinases , such as the kinase suppressor of Ras ( KSR ) and protein kinase Czeta ( PKCzeta ) , are involved in the regulation of c Raf , which promotes sequential activation of MEK 1 and p42 / p44 MAPK in mammalian cells . ^^^ |
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| Interacting proteins: Q8IVT5 and Q02750 |
Pubmed |
SVM Score :0.0 |
| We report here that the activity of kinase suppressor of ras ( KSR 1 ) , a kinase upstream of raf 1 , is inhibited by both these compounds at concentrations similar to those that inhibit MEK 1 . ^^^ |
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| Interacting proteins: Q8IVT5 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Ectopically expressed mKsr 1 co precipitated with endogenous MEK 1 in COS 1 cells , and endogenous Ksr and MEK co precipitated from PC 12 cells . ^^^ |
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| Interacting proteins: Q8IVT5 and Q02750 |
Pubmed |
SVM Score :0.0 |
| RESULTS : To gain insight into the biological function of Ksr , we used a yeast two hybrid screen and found an interaction between the carboxy terminal region of mKsr 1 and mitogen activated protein ( MAP ) kinase kinase 1 ( MAPKK 1 or MEK 1 ) . ^^^ |
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| Interacting proteins: Q8IVT5 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we observe that murine KSR forms a multimolecular signaling complex in human embryonic kidney 293T cells composed of HSP 90 , HSP 70 , HSP 68 , p 50 ( CDC 37 ) , MEK 1 , MEK 2 , 14 3 3 , and several other , unidentified proteins . ^^^ |
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| Interacting proteins: Q8IVT5 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Moreover , KSR reconstituted mitogen activated protein kinase activation was detected in KSR immunoprecipitates depleted of all contaminating kinases ( c Raf 1 , MEK 1 , ERK 2 ) by multiple high salt washes . ^^^ |
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| Interacting proteins: Q8IVT5 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Furthermore , TNF alpha induced Raf 1 threonine phosphorylation , kinase activity toward MEK 1 , and association with KSR are also inhibited by kiKSR expression . ^^^ |
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| Interacting proteins: Q8IVT5 and Q02750 |
Pubmed |
SVM Score :0.0 |
| We show that , similar to the known human KSR , hKSR 2 co immunoprecipitates with many signaling components of the Ras / MAPK pathway , including Ras , Raf , MEK 1 , and ERK 1 / 2 . ^^^ |
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| Interacting proteins: Q8IVT5 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Leukocyte specific protein 1 targets the ERK / MAP kinase scaffold protein KSR and MEK 1 and ERK 2 to the actin cytoskeleton . ^^^ We show that LSP 1 associates with the ERK scaffold protein KSR and with MEK 1 and ERK 2 . ^^^ Confocal microscopy showed that LSP 1 targets KSR , MEK 1 and ERK 2 to peripheral actin filaments . ^^^ Thus our data show that LSP 1 is a cytoskeletal targeting protein for the ERK / MAP kinase pathway and support a model in which MEK 1 and ERK 2 are organized in a cytoskeletal signaling complex together with KSR , PKCbetaI and LSP 1 and are activated by anti IgM in a PKCbetaI dependent manner . . ^^^ |
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| Interacting proteins: Q8IVT5 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Ceramide signaled apoptosis in BAD expressing cells by a pathway involving sequentially kinase suppressor of Ras ( KSR ) / ceramide activated protein kinase , Ras , c Raf 1 , and MEK 1 . ^^^ |
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| Interacting proteins: Q8IVT5 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q8IVT5 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
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