| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.71800498 |
| Cell fractionation studies revealed that KSR formed a complex with 14 3 3 in both the membrane and cytoplasmic fractions of cell lysates ; however , KSR only formed a complex with Raf 1 in the membrane fraction . 0.71800498^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| Ceramide signaled apoptosis in BAD expressing cells by a pathway involving sequentially kinase suppressor of Ras ( KSR ) / ceramide activated protein kinase , Ras , c Raf 1 , and MEK 1 . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| Accordingly , palmitate activated ERK by a process that was dependent on ceramide synthesis de novo and Raf 1 , but independent of kinase suppressor of Ras . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| Ceramide activated protein kinases , such as the kinase suppressor of Ras ( KSR ) and protein kinase Czeta ( PKCzeta ) , are involved in the regulation of c Raf , which promotes sequential activation of MEK 1 and p42 / p44 MAPK in mammalian cells . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of raf 1 by kinase suppressor of ras is inhibited by `` MEK specific ' ' inhibitors PD 098059 and U 0126 in differentiating HL 60 cells . ^^^ We report here that the activity of kinase suppressor of ras ( KSR 1 ) , a kinase upstream of raf 1 , is inhibited by both these compounds at concentrations similar to those that inhibit MEK 1 . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| Our laboratory reported that kinase suppressor of Ras ( KSR ) regulates TNF activation of the Raf / mitogen activated protein ( MAP ) kinase / extracellular signal regulated kinase ( ERK ) kinase / ERK signaling cassette by threonine phosphorylation of Raf 1 , regulating proliferation and differentiation pathways . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| Kinase suppressor of Ras ( KSR ) is a conserved component of the Ras pathway that acts as a molecular scaffold to promote signal transmission from Raf 1 to MEK and MAPK . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| In marked contrast to the isolated amino and carboxy terminal domains of Raf 1 , the KSR amino terminus also cooperates with Ras , whereas the carboxy terminal kinase domain blocks Ras signaling as well as MEK and MAPK activation . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| KSR overexpression constitutively activates Raf 1 . ^^^ TNF alpha or ceramide analogs markedly enhance KSR autophosphorylation and its ability to complex with , phosphorylate , and activate Raf 1 . ^^^ In vitro , low nanomolar concentrations of natural ceramide stimulate KSR to autophosphorylate , and transactivate Raf 1 . ^^^ Moreover , Thr 269 the Raf 1 site phosphorylated by CAP kinase , is also recognized by KSR . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| KSR stimulates Raf 1 activity in a kinase independent manner . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| Hypothesis : ceramide conditionally activates atypical protein kinases C , Raf 1 and KSR through binding to their cysteine rich domains . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| In response to signal activation , the phosphorylation state of S 392 is reduced , allowing the KSR 1 complex to colocalize with activated Ras and Raf 1 at the plasma membrane , thereby facilitating the phosphorylation reactions required for the activation of MEK and MAPK . . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| Using MEK 2 as bait in yeast two hybrid screening , besides c Raf and KSR , A Raf was identified as a novel partner that interacts with MEK 2 . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR 1 and Raf 1 on critical 14 3 3 binding sites . ^^^ Moreover , we find that PP2A activity is required for activation of the Raf 1 kinase and that both Raf and KSR 1 must be dephosphorylated by PP2A on critical regulatory 14 3 3 binding sites for KSR 1 to promote MAPK pathway activation . ^^^ Further , these results elucidate a common regulatory mechanism for KSR 1 and Raf 1 whereby their localization and activity are modulated by the PP2A mediated dephosphorylation of critical 14 3 3 binding sites . . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that the connector enhancer of Ksr 1 , CNK 1 , mediates Src dependent tyrosine phosphorylation and activation of Raf 1 . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| A mammalian homolog of CTR 1 was previously reported to be c Raf ; we now report that CTR 1 also exhibits homology to the kinase suppressor of Ras ( KSR ) , a scaffold protein for the mitogen activated protein kinase ( MAPK ) cascade . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| The activity of kinase suppressor of ras ( KSR ) , a kinase or a molecular scaffold upstream from Raf 1 , is involved in the MEK / ERK MAP kinase cascade which can signal cell growth , survival , or differentiation , depending on the cellular context . ^^^ |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8IVT5 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|