| Interacting proteins: Q9Y6H5 and Q8IUQ4 |
Pubmed |
SVM Score :0.0 |
| We previously identified synphilin 1 as an alpha synuclein interacting protein and more recently found that synphilin 1 also interacts with the E 3 ubiquitin ligases SIAH 1 and SIAH 2 . ^^^ |
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| Interacting proteins: Q9Y6H5 and Q8IUQ4 |
Pubmed |
SVM Score :0.0 |
| Siah 1 facilitates ubiquitination and degradation of synphilin 1 . ^^^ To investigate the proteins that interact with synphilin 1 , the present study performed a yeast two hybrid screening and identified a novel interacting protein , Siah 1 ubiquitin ligase . ^^^ Synphilin 1 and Siah 1 proteins were endogenously expressed in the central nervous system and were found to coimmunoprecipitate each other in rat brain homogenate . ^^^ Siah 1 was found to interact with the N terminus of synphilin 1 through its substrate binding domain and to specifically ubiquitinate synphilin 1 via its RING finger domain . ^^^ Siah 1 facilitated synphilin 1 degradation via the ubiquitin proteasome pathway more efficiently than Parkin . ^^^ |
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