| Interacting proteins: Q8IUQ4 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8IUQ4 and P35222 |
Pubmed |
SVM Score :0.0 |
| Moreover , ES uses a pathway independent of the Siah 1 protein in targeting beta catenin for proteasome mediated degradation . ^^^ |
|
| Interacting proteins: Q8IUQ4 and P35222 |
Pubmed |
SVM Score :0.0 |
| Up regulation of beta catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cells . ^^^ We provide evidence that two distinct ubiquitin dependent degradation pathways for beta catenin are active in the same Burkitt ' s lymphoma cells : Along with the classical glycogen synthase kinase 3beta dependent destruction machinery , degradation of beta catenin through seven in absentia homolog 1 ( Siah 1 ) ubiquitin ligase is functional in these cells . ^^^ |
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| Interacting proteins: Q8IUQ4 and P35222 |
Pubmed |
SVM Score :0.0 |
| Free beta catenin is eliminated by two adenomatous polyposis coli ( APC ) dependent proteasomal degradation pathways regulated by glycogen synthase kinase 3beta ( GSK 3 beta ) or p 53 inducible Siah 1 . ^^^ |
|
| Interacting proteins: Q8IUQ4 and P35222 |
Pubmed |
SVM Score :0.0 |
| The level of beta catenin is regulated by two mechanisms : the adenomatous polyposis coli / Axin / glycogen synthase kinase 3beta dependent degradation pathway and the Siah 1 / Siah interacting protein / Ebi mediated degradation pathway . ^^^ |
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| Interacting proteins: Q8IUQ4 and P35222 |
Pubmed |
SVM Score :0.0 |
| Siah 1 can induce cell cycle arrests , tumor suppression , and apoptosis through a novel beta catenin degradation pathway . ^^^ The effect of Siah 1 on beta catenin degradation was further examined in wild and mutant type Siah 1 transfected HEK 293T cells . ^^^ The cases with Siah 1 mutation showed nuclear translocation and cytoplasmic staining of beta catenin . ^^^ Interestingly , two mutants of Siah 1 stabilized cytoplasmic levels of beta catenin , even after treatment of adriamycin . ^^^ These data suggest that inactivating mutations of the Siah 1 may contribute to the development of gastric cancer through beta catenin stabilization and apoptosis block . . ^^^ |
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| Interacting proteins: Q8IUQ4 and P35222 |
Pubmed |
SVM Score :0.0 |
| Siah interacting protein ( SIP ) was identified as a novel adaptor that physically links the E 3 ubiquitin ligase activity of Siah 1 with Skp 1 and Ebi F Box protein in the degradation of beta catenin , a transcriptional activator of TCF / LEF genes . ^^^ |
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| Interacting proteins: Q8IUQ4 and P35222 |
Pubmed |
SVM Score :0.0 |
| Siah 1 is the central component of a multiprotein E 3 ubiquitin ligase complex that targets beta catenin for destruction in response to p 53 activation . ^^^ Here we show that SIP engages Siah 1 by means of two elements , both of which are required for mediating beta catenin destruction in cells . ^^^ |
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| Interacting proteins: Q8IUQ4 and P35222 |
Pubmed |
SVM Score :0.0 |
| Later , it was found that CacyBP / SIP interacted with Siah 1 and Skp 1 and that it was involved in the ubiquitination and degradation of an oncogen , namely beta catenin . ^^^ |
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| Interacting proteins: Q8IUQ4 and P35222 |
Pubmed |
SVM Score :0.0 |
| Previously , we discovered a novel pathway for p 53 induced beta catenin degradation through a ubiquitin E 3 ligase complex involving Siah 1 , SIP ( CacyBP ) , Skp 1 , and Ebi . ^^^ |
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| Interacting proteins: Q8IUQ4 and P35222 |
Pubmed |
SVM Score :0.0 |
| Our findings suggest that hexachlorophene attenuates Wnt / beta catenin signaling through the Siah 1 mediated beta catenin degradation . . ^^^ |
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