| Interacting proteins: Q86US8 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| In smg 5 , smg 6 , and smg 7 mutants , a phosphorylated isoform of SMG 2 accumulated to abnormally high levels . ^^^ In smg 2 ( r 866 ) and smg 2 ( r 895 ) mutants , which harbor single amino acid substitutions of the SMG 2 nucleotide binding site , phosphorylated SMG 2 accumulated to abnormally high levels , similar to those observed in smg 5 , smg 6 , and smg 7 mutants . ^^^ |
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| Interacting proteins: Q86US8 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| Here we show that the Drosophila orthologs of UPF 1 3 , SMG 1 , SMG 5 and SMG 6 are required for the degradation of PTC containing mRNAs , but that there is no SMG 7 ortholog in this organism . ^^^ |
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| Interacting proteins: Q86US8 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| The proteins UPF 1 , SMG 5 , SMG 6 , and SMG 7 are essential NMD factors in metazoa . ^^^ Here we show that SMG 5 and SMG 7 colocalize in cytoplasmic mRNA decay bodies , while SMG 6 forms separate cytoplasmic foci . ^^^ When SMG 7 is tethered to a reporter transcript , it elicits its degradation , bypassing the requirement for a PTC , UPF 1 , SMG 5 , or SMG 6 . ^^^ |
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| Interacting proteins: Q86US8 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| UPF 1 is targeted for dephosphorylation by three related proteins , SMG 5 , SMG 6 , and SMG 7 . ^^^ The 14 3 3 site of SMG 7 is conserved in SMG 5 and SMG 6 . ^^^ |
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| Interacting proteins: Q86US8 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| We show that UPF 1 , UPF 2 , UPF 3 , SMG 1 , SMG 5 , and SMG 6 regulate in concert the expression of a cohort of genes with functions in a wide range of cellular activities , including cell cycle progression . ^^^ |
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| Interacting proteins: Q86US8 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86US8 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| NA |
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