| Interacting proteins: Q9UBR4 and Q86U70 |
Pubmed |
SVM Score :0.56210612 |
| Using in vivo function and protein interaction assays , we found that Lhx 3 binds directly to the LIM cofactor NLI to trigger V 2 interneuron differentiation . 0.56210612^^^ |
|
| Interacting proteins: Q9UBR4 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| Although the interaction between most LIM homeodomain proteins is dependent on NLI , a direct interaction between the LIM domains of Lhx 3 and the homeodomains of Isl 1 and Isl 2 was also observed . ^^^ This interaction was disrupted by NLI , demonstrating that the conformational state of Lhx 3 Isl1 / Isl2 complexes is modified by NLI . ^^^ |
|
| Interacting proteins: Q9UBR4 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| The tyrosine missense mutation inhibits the ability of LHX 3 to induce transcription from selected target genes but does not prevent DNA binding and interaction with partner proteins such as NLI and Pit 1 . ^^^ |
|
| Interacting proteins: Q9UBR4 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| A more complex molecular language consisting of a hexamer complex involving NLI and 2 LIM homeodomain proteins , Lhx 3 and Isl 1 determines ventral motor neuron formation . ^^^ |
|
| Interacting proteins: Q9UBR4 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| However , the amino acid replacements did not significantly affect the capability of LHX 3 to interact with the NLI , PIT 1 , and MRG 1 partner proteins , or its ability to bind to a high affinity DNA site . ^^^ |
|
| Interacting proteins: Q9UBR4 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| NA |
|