| Interacting proteins: P15976 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| The composite motif binds a multi protein hematopoietic specific transcription factor complex which includes GATA 1 , SCL / tal 1 , E2A , Lmo 2 and Ldb 1 . ^^^ |
|
| Interacting proteins: P15976 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| We show here that a nuclear complex containing TAL 1 , its DNA binding partner E 47 , zinc finger transcription factor GATA 1 , LIM domain protein LMO 2 , and LIM domain binding protein Ldb 1 transactivates the protein 4 . 2 ( P4 . 2 ) gene through two E box GATA elements in its proximal promoter . ^^^ These studies define a physiologic target for a TAL 1 and GATA 1 containing ternary complex and reveal a positive role for Ldb 1 in erythroid gene expression and differentiation . . ^^^ |
|
| Interacting proteins: P15976 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| GPA promoter activation is dependent on the assembly of a multifactorial complex containing SCL as well as ubiquitous ( E 47 , Sp 1 , and Ldb 1 ) and tissue specific ( LMO 2 and GATA 1 ) transcription factors . ^^^ |
|
| Interacting proteins: P15976 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| In vivo , they both bind the transcription factors GATA 1 , SCL , LMO 2 , and Ldb 1 . ^^^ |
|
| Interacting proteins: P15976 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| Levels of Scl , Rbtn 2 , GATA 1 , and Ldb 1 expression were comparable in AML and APL blasts , while the levels of expression of Rbtn 1 , GATA 2 , and GATA 3 were absent or markedly lower in APL cells . ^^^ |
|
| Interacting proteins: P15976 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : The LIM finger protein LMO 2 forms a transcription factor complex with other hematopoietic regulator proteins , such as TAL 1 ( SCL ) , LDB 1 , GATA 1 , 2 , and 3 , in the promoters of several erythroid genes . ^^^ |
|
| Interacting proteins: P15976 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| We next applied the biotinylation tag to Ldb 1 , a known partner of GATA 1 , and characterized a number of novel interaction partners that are essential in erythroid development , in particular , Eto 2 , Lmo 4 , and CdK 9 . ^^^ |
|
| Interacting proteins: P15976 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| In addition to known TAL 1 partners , GATA 1 , E2A , HEB , LMO 2 and Ldb 1 , we identify the ETO 2 repressor as a novel component recruited to TAL 1 complexes through interaction with E2A / HEB . ^^^ |
|
| Interacting proteins: P15976 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| We recently established that a DNA binding complex containing TAL1 / SCL , E 47 , GATA 1 , LMO 2 and Ldb 1 stimulates P4 . 2 ( protein 4 . 2 ) transcription in erythroid progenitors via two E box GATA elements in the gene ' s proximal promoter . ^^^ |
|
| Interacting proteins: P15976 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15976 and Q86U70 |
Pubmed |
SVM Score :0.0 |
| NA |
|