| Interacting proteins: Q7L590 and O75419 |
Pubmed |
SVM Score :0.0 |
| Xenopus Mcm 10 binds to origins of DNA replication after Mcm 2 7 and stimulates origin binding of Cdc 45 . ^^^ |
|
| Interacting proteins: Q7L590 and O75419 |
Pubmed |
SVM Score :0.0 |
| At the G ( 1 ) / S transition , MCM 10 and the protein kinases Cdc 7 Dbf4 and Cdk 2 cyclin E cooperate to recruit Cdc 45 to the pre RC , followed by origin unwinding , RPA binding , and recruitment of DNA polymerases . ^^^ |
|
| Interacting proteins: Q7L590 and O75419 |
Pubmed |
SVM Score :0.0 |
| Mini chromosome maintenance ( MCM ) 2 7 recruitment to origins in G 1 requires origin recognition complex ( ORC ) , Cdt 1 , and Cdc 6 , and activation at G1 / S requires MCM 10 and the protein kinases Cdc 7 and S Cdk , which together recruit Cdc 45 , a putative MCM 2 7 cofactor required for origin unwinding . ^^^ |
|
| Interacting proteins: Q7L590 and O75419 |
Pubmed |
SVM Score :0.0 |
| Interactions were also detected between Mcm 10 and itself , Cdc 45 , and Hp 1 . ^^^ Furthermore , depletion of Mcm 10 , Cdc 45 , Mcm 2 , Mcm 5 , and Orc 2 , respectively , results in aberrant chromosome condensation . ^^^ |
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| Interacting proteins: Q7L590 and O75419 |
Pubmed |
SVM Score :0.0 |
| Inactivating Cdc 23 during an S phase block after Cdc 45 has bound causes a small reduction in Cdc 45 chromatin binding , and replication does not terminate in the absence of Mcm 10 function . ^^^ These observations show that Cdc23 / Mcm10 function is conserved between fission yeast and Xenopus , where in vitro analysis has indicated a similar requirement for Cdc 45 binding , but apparently not compared with Saccharomyces cerevisiae , where Mcm 10 is needed for Mcm 2 chromatin binding . ^^^ |
|
| Interacting proteins: Q7L590 and O75419 |
Pubmed |
SVM Score :0.0 |
| MCM 10 and TopBP 1 function in the initiation of DNA replication , by regulating the chromatin binding of the DNA polymerase alpha loading factor , CDC 45 . ^^^ |
|
| Interacting proteins: Q7L590 and O75419 |
Pubmed |
SVM Score :0.0 |
| Mcm 10 and Cdc 45 cooperate in origin activation in Saccharomyces cerevisiae . ^^^ Association of Cdc 45 with ARS 1 is reduced in the mcm 10 1 mutant , suggesting that Mcm 10 is involved in recruiting Cdc 45 to the pre RC . ^^^ We find that overexpression of either Mcm 10 1 or Cdc 45 suppresses the growth defect of mcm 10 1 , and that a physical interaction between Cdc 45 and Mcm 10 is disrupted in the mcm 10 1 mutant . ^^^ Our results show that interaction between the Mcm 10 and Cdc 45 proteins facilitates the recruitment of Cdc 45 onto the ARS 1 origin . . ^^^ |
|
| Interacting proteins: Q7L590 and O75419 |
Pubmed |
SVM Score :0.0 |
| In temperature sensitive mcm 10 td mutants , depletion of Mcm 10 during S phase results in degradation of the catalytic subunit of polalpha , without affecting other fork components such as Cdc 45 . ^^^ |
|
| Interacting proteins: Q7L590 and O75419 |
Pubmed |
SVM Score :0.0 |
| This approach identifies DNA pol alpha , DNA pol delta , DNA pol varepsilon , MCM 2 7 , Cdc 45 , GINS , and Mcm 10 as components of the vertebrate replisome . ^^^ |
|
| Interacting proteins: Q7L590 and O75419 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7L590 and O75419 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7L590 and O75419 |
Pubmed |
SVM Score :0.0 |
| NA |
|