| Cathepsin B and its interacting proteins , bikunin and TSRC 1 , correlate with TNF induced apoptosis of ovarian cancer cells OV 90 . ^^^ Two cathepsin B binding proteins , bikunin and TSRC 1 , were identified by yeast two hybrid method and the interactions were confirmed in vitro and in vivo . ^^^ The presented results suggest that cathepsin B and its interacting proteins , bikunin and TSRC 1 , are involved in the apoptotic pathway of ovarian cancer cells . . ^^^ |