| Interacting proteins: Q6N084 and Q13485 |
Pubmed |
SVM Score :0.0 |
| Ten genes [ macrophage inhibitory cytokine 1 , CGD , fibronectin ( FN ) , hypoxia inducible factor 1 , Fc epsilon receptor gamma chain , lactate dehydrogenase A , HLA DBP 1 , AH receptor , tissue inhibitor of metalloproteinase ( TIMP 1 ) , and glycyl tRNA synthetase ] were found to be up regulated > 2 fold in 40 100 % of cancers , whereas 9 genes ( GADD 153 , polykystic kidney disease 1 , CYR 61 , DPC 4 , HBA 1 , gravin , DLG 3 , protein tyrosine phosphatase sigma , and heterochromatin protein 1 homologue alpha ) were down regulated to < 50 % of their normal levels in 40 94 % of cases . ^^^ |
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| Interacting proteins: Q6N084 and Q13485 |
Pubmed |
SVM Score :0.0 |
| The ECM genes , alpha 1 type 1 collagen ( COL1A1 ) , plasminogen activator inhibitor 1 ( PAI 1 ) and fibronectin ( FN ) were assessed in wild type mesangial cells and stably transfected Smad 4 DN cell lines in the absence and presence of TGF beta . ^^^ For FN , TGF beta induced expression was maintained in Smad 4 dominant negative cells . ^^^ However , TGF beta induced FN expression is independent of Smad 4 . ^^^ |
|
| Interacting proteins: Q6N084 and Q13485 |
Pubmed |
SVM Score :0.0 |
| Dominant negative Smad 4 did not affect the FN mRNA increase induced by TGF beta 1 and high glucose . ^^^ |
|
| Interacting proteins: Q6N084 and Q13485 |
Pubmed |
SVM Score :0.0 |
| Although T 3 induces the expression of TGF beta , neither wild type nor dominant negative Smad 3 or Smad 4 over expression affected the activation of FN by T 3 . ^^^ |
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