Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
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Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Northern blot analysis of poly ( A ) + mRNA from cells treated with compound CD 367 , alpha bromopalmitate , or a combination of both agonists , did not show a dramatic effect , if any , on the expression of RAR alpha , RAR gamma , RXR alpha and RXR beta genes . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Among the two classes of retinoid acid receptors ( RARs ) and retinoid 10 receptors ( RXRs ) , RAR alpha , RAR gamma , RXR alpha and RXR beta mRNAs could be detected in growing adipoblasts and were found to be increased in committed preadipocytes and differentiated cells upon retinoid treatment . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
RAR beta , RAR gamma and RXR beta displayed both epithelial and mesenchymal expression . ^^^ Odontoblasts expressed RAR beta and RAR gamma , RXR alpha and RXR beta . ^^^ The pattern of CRABPI transcripts overlapped at least partially with expressions of all the studied nuclear receptors whereas CRABPII epithelial expression was superimposed with the transcription of RAR alpha , RXR alpha and RXR beta . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
In P 19 cells trans activation of the rCRBPII promoter by RXR alpha 5 in the absence of exogenous ligand was inhibited by RAR alpha and the constitutive forms of RAR alpha , RAR beta , RAR gamma , RXR beta , and to a lesser extent RXR gamma . . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
These are the RAR alpha , RAR beta and RAR gamma genes and the RXR alpha , RXR beta and RXR gamma genes . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Further , these cells were defective in RA induced mRNA expression of Hox 1 . 3 and RAR beta , as well as in RA induced down regulation of Oct 3 mRNA . ^^^ By genomic footprinting , we show that RA treatment induces in vivo occupancy of the RARE in the endogenous RAR beta gene in control P 19 cells but that this occupancy is not observed with the DBD cells . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
RAR alpha , RAR gamma , RXR alpha and RXR beta mRNAs were abundant in adipose tissue and 3T3 L 1 cells . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Region 2 binding activity was present in undifferentiated cells at low levels but was greatly augmented by RA treatment because of activation of a nuclear hormone receptor heterodimer composed of the retinoid 10 receptor ( RXR beta ) and the RA receptor ( RAR beta ) . ^^^ The RXR beta RAR beta heterodimer also bound RA responsive elements present in other genes which are likely to be involved in RA triggering of EC cell differentiation . ^^^ A similar increase in MHC class 1 reporter activity was demonstrated by cotransfection of RXR beta and RAR beta . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Northern blot analysis revealed high levels of mRNA for retinoid 10 receptor alpha ( RXR alpha ) , moderate levels of mRNA for retinoic acid receptor gamma ( RAR gamma ) , and low levels of mRNA for RAR alpha and RXR beta . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
These are the retinoic acid receptors ( RAR alpha , RAR beta , RAR gamma ) and the retinoid 10 receptors ( RXR alpha , RXR beta , RXR gamma ) . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
We present preliminary evidence from RT PCR that all six retinoid receptors , the three retinoic acid receptors ( RARs ) , and the three retinoid 10 receptors ( RXRs ) , are present in the normal tail blastema and that after retinoid treatment RAR alpha , RXR alpha , and RXR beta may be up regulated . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
RAR alpha , RAR beta , RAR gamma , RXR alpha , and RXR beta mRNAs were detected by in situ hybridization in specimens from normal oral mucosa , and all but RAR beta were also expressed in most of the adjacent normal , hyperplastic , dysplastic , and malignant HN tissues . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Northern blot analysis revealed high levels of mRNA for the retinoid 10 receptor beta ( RXR beta ) and moderate levels of mRNAs for retinoic acid receptors alpha ( RAR alpha ) and gamma ( RAR gamma ) . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
These regions correspond to the domains of expression of the retinoid receptors RAR gamma and RXR beta . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
No synergy was observed between the effects of mutations of either RXR beta or RXR gamma mutations and those of any of the RAR mutations . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
P 19 embryonal carcinoma cells stably expressing the truncated RXR beta ( termed delta C 2 ) were deficient in activating the endogenous RAR beta gene and an RA responsive reporter . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Co injecting synthetic mRNA encoding retinoic acid receptor alpha ( NR1B1 ) and retinoid 10 receptor beta ( NR2B2 ) results in an increase in the number of primary neurons and this is further enhanced by the addition of retinoic acid indicating that elevated retinoid signalling promotes an increase in the number of cells undergoing primary neurogenesis . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Since nuclear retinoid receptors are implicated in the biological effects of RA , we examined the expression of retinoic acid receptors ( RARs ) RAR alpha , RAR beta , RAR gamma , and the retinoid 10 receptors ( RXRs ) RXR alpha , RXR beta , and RXR gamma in the RA resistant cell lines by northern blotting and by RNase protection analysis for RAR beta . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
OA alone induced chloramphenicol acetyltransferase ( CAT ) activity in cells transfected with RAR alpha , RAR beta , RXR alpha , RXR beta , or RXR gamma ( 3 to 18 fold induction ) . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Interestingly , three different RA receptor : retinoid 10 receptor ( RAR : RXR ) heterodimers , RAR alpha : RXR alpha , RAR beta : RXR alpha , and RAR beta : RXR beta , specifically bind and activate Oct 3 / 4 promoter through the RAREoct site in a ligand dependent manner . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Cotransfection with RAR alpha and retinoid 10 receptor beta induced TSH beta expression by 3 . 5 fold , and treatment with RA suppressed this induction by 46 % . ^^^ These results show that vitamin A levels play a significant role in regulating the expression of the TSH beta gene , but not the GH gene , in vivo and suggest that RA may suppress TSH beta gene transcription directly by an RAR retinoid 10 receptor heterodimer mediated mechanism . . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
We demonstrate that these cells express the retinoid receptors RAR alpha , RAR gamma , and RXR beta . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Using chemical cross linking , co immunoprecipitation , gel mobility shift and streptavidin biotin DNA precipitation assays , we show that H 2RIIBP formed heterodimers with thyroid hormone ( T 3 ) and RA receptors ( T3R alpha and RAR alpha ) . ^^^ H 2RIIBP heterodimer formation required a conserved sub domain of its C terminal region , occurred independently of target DNA and was much more efficient than either T3R alpha / RAR alpha heterodimer or H 2RIIBP homodimer formation . ^^^ A functional role for heterodimers in vivo was demonstrated by synergistic enhancement of MHC class 1 transcription following co transfection of H 2RIIBP with T3R alpha or RAR alpha . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
The retinoic acid receptor ( RAR ) also heterodimerized with COUP TF as well as with RXR alpha , RXR beta , and the TR heterodimerization partner in liver . ^^^ In contrast to its ability to heterodimerize with the TR and RAR , we did not detect heterodimers between COUP TF and either RXR alpha , RXR beta , or the liver nuclear protein in the context of binding to the TREp . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
This protein , termed RXR beta , forms heterodimers with RAR , preferentially increasing its DNA binding and transcriptional activity on promoters containing retinoic acid , but not thyroid hormone or vitamin D , response elements . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
The RAR beta mRNA level was lowest in the SqCC / Y1 cells , and RXR beta and RXR gamma were not detected in any of the cell lines . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
RXR alpha and RXR beta were cloned from HSG cells , and these RXRs , together with RAR , seemed to play a physiological role in RA signaling in vivo . . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
However , the expression of RAR gamma and RXR beta was somewhat decreased in lung cancers . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Sensitive and resistant cell lines were then compared for their baseline and / or retinoic acid regulated expression of total cellular retinoic acid binding protein , retinoic acid receptor ( RAR ) alpha , RAR beta , RAR gamma mRNA , retinoid 10 receptor ( RXR ) alpha , RXR beta , RXR gamma mRNA , transforming growth factor ( TGF ) beta 1 and TGF beta 1 receptors , and Fas ( Apo 1 ) mRNA . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
These data demonstrate that RXR beta plays an important role in retinoid regulated signal transduction pathways in human dermal fibroblasts and the regulation of expression of the RXR gene family is different from that of the RAR gene family . . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Their action is mediated by nuclear receptors , retinoic acid receptors ( RAR alpha , RAR beta , RAR gamma ) and retinoid 10 receptors ( RXR alpha , RXR beta , RXR gamma ) and modulated by cellular retinol binding proteins ( CRBP ) . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
METHODS : Transcripts of nuclear retinoid receptors were detected in formalin fixed , paraffin embedded specimens by use of digoxigenin labeled riboprobes specific for RAR alpha , RAR beta , RAR gamma , RXR alpha , RXR beta , and RXR gamma for in situ hybridization to histologic specimens from 79 patients with NSCLC and as control from 17 patients with non lung cancer . ^^^ In contrast , RAR beta , RAR gamma , and RXR beta expression was detected in only 42 % , 72 % , and 76 % of NSCLC , respectively . ^^^ CONCLUSIONS : These data suggest that the expression of RAR alpha , RXR alpha , and RXR gamma is not altered in NSCLC ; however , expression of RAR beta and possibly also of RAR gamma and RXR beta is suppressed in a large percentage of patients with lung cancer . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
In contrast , such manifestations of synergism are not observed between the RXR beta or RXR gamma and the RAR ( alpha , beta or gamma ) null mutations . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
However , the expression of RAR gamma and RXR beta was somewhat decreased in lung cancers . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
RNA was analyzed by Northern blotting using the cDNA probes for RAR alpha , RAR beta , RAR gamma , RXR alpha , RXR beta and RXR gamma mRNA . ^^^ RESULTS : RAR alpha mRNA transcripts ( 3 . 7 kb ) , RAR beta mRNA transcripts ( 3 . 3 kb ) and RAR gamma mRNA transcripts ( 3 . 3 kb ) are expressed by all the cell types studied , as are the RXR alpha mRNA transcripts ( 5 . 0 kb ) and RXR beta mRNA transcripts ( 3 . 3 kb ) . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
RAR alpha and gamma and RXR alpha but not RAR beta or RXR beta and gamma were detected by immunohistochemical analysis of H 441 cells . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Expression of RAR alpha , RAR beta , RAR gamma , RXR alpha and RXR beta was found in most cell types in gastric mucosa tissues from normal individuals as well as in distal normal tissues from cancer patients . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
In an analysis of the expression patterns for retinoid receptors ( RARs and RXRs ) , all primary culture samples yielded positive results for RAR gamma and RXR alpha and negative results for RAR alpha , RAR beta , and RXR gamma , whereas the results of RXR beta expression were heterogeneous among different patients . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
The biological action of retinoic acid and synthetic analogs , referred to as retinoids , is mediated by RAR alpha , RAR beta , or RAR gamma and / or by RXR alpha , RXR beta , or RXR gamma , all being nuclear receptors . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Immunoreactivities for RAR alpha , RXR alpha , RXR beta , and RXR gamma were all detected in the nuclei of normal ductal epithelia . ^^^ Immunoreactivity for RAR alpha , RXR alpha , RXR beta and RXR gamma was widely distributed compared to that of RAR beta and RAR gamma in DCIS , ADH and PDWA . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Investigation of retinoid receptor expression , known to mediate intracellular RA signaling , revealed presence of RAR alpha , RAR gamma , RXR beta , and RXR gamma transcripts in all cell lines studied , and HMC 1 cells were the only line lacking RXR alpha . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
The expression of CRBP mRNA , as determined by Northern analysis , was greater in snouts of fetuses exposed to ethanol , but there was no change in RAR alpha , beta , gamma or retinoid 10 receptor beta mRNA . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
RAR alpha , beta and RXR beta were expressed in most of them . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
RAR alpha and RXR beta are expressed in skin ( `` velvet ' ' ) and the underlying perichondrium . ^^^ In cartilage , which is vascularised , RXR beta is specifically expressed in chondrocytes , which express type 2 collagen , and RAR alpha in perivascular cells , which also express type 1 collagen , a marker of the osteoblast phenotype . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
For RR patients on IFN beta1a therapy , expression of the some RAR subtypes was noted as well as expression of RXR beta and RXR gamma . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Our data , based on qualitative RT PCR analysis has shown that human PBMC are capable to express RAR alpha , RAR gamma , RXR alpha , and RXR beta . . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Naive DO11 . 10 T lymphocytes expressed mRNA and protein for RAR alpha , RXR alpha , and RXR beta . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
PURPOSE : The aim of this study is to investigate whether there are any abnormalities in the in vivo expression of retinoid acid receptors ( RAR alpha , RAR beta and RAR gamma ) and retinoid 10 receptors ( RXR alpha , RXR beta and RXR gamma ) in sebaceous cell carcinoma . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
In gel mobility shift assays , heterodimers of retinoic acid receptor alpha ( RARalpha ) and retinoid 10 receptor beta ( RXRbeta ) bound specifically to this element . ^^^
Interacting proteins: Q6I9R7 and P28702 Pubmed SVM Score :0.0
Total RNA extracted from in vitro cultured cumulus granulosa cells was subjected to reverse transcription polymerase chain reaction ( RT PCR ) and mRNA expression for retinol binding protein ( RBP ) , retinoic acid receptor alpha ( RARalpha ) , retinoic acid receptor beta ( RARbeta ) , retinoic acid receptor gamma ( RARgamma ) , retinoid 10 receptor alpha ( RXRalpha ) , retinoid 10 receptor beta ( RXRbeta ) , retinaldehyde dehydrogenase 2 ( RALDH 2 ) , and peroxisome proliferator activated receptor gamma ( PPARgamma ) . ^^^