| Interacting proteins: Q5TD97 and P16220 |
Pubmed |
SVM Score :0.0 |
| We have recently described the first tissue specific coactivator of CREB family transcription factors , ACT ( activator of CREM in testis ) . ^^^ |
|
| Interacting proteins: Q5TD97 and P16220 |
Pubmed |
SVM Score :0.0 |
| CBP independent activation of CREM and CREB by the LIM only protein ACT . ^^^ As ACT bypasses the classical requirements for activation , namely phosphorylation of Ser 117 and interaction with CBP , it represents a new route for transcriptional activation by CREM and CREB . ^^^ |
|
| Interacting proteins: Q5TD97 and P16220 |
Pubmed |
SVM Score :0.0 |
| Mechanisms of activation by CREB and CREM : phosphorylation , CBP , and a novel coactivator , ACT . ^^^ |
|
| Interacting proteins: Q5TD97 and P16220 |
Pubmed |
SVM Score :0.0 |
| After Act treatment of RAW cells , we detected an increased translocation of NF kappaB and cAMP responsive element binding protein ( CREB ) to the nucleus using gel shift assays . ^^^ |
|
| Interacting proteins: Q5TD97 and P16220 |
Pubmed |
SVM Score :0.0 |
| In addition , KinetWorks proteomics screening of whole cell lysates revealed Act induced phosphorylation of cyclic AMP response element binding protein ( CREB ) , c Jun , adducin , protein kinase C , and signal transducer and activator of transcription 3 ( STAT 3 ) and decreased phosphorylation of protein kinase Balpha , 5 raf 1 murine leukemia viral oncogene homolog 1 ( i . e . , Raf 1 ) , and STAT 1 . ^^^ |
|
| Interacting proteins: Q5TD97 and P16220 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q5TD97 and P16220 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q5TD97 and P16220 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q5TD97 and P16220 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q5TD97 and P16220 |
Pubmed |
SVM Score :0.0 |
| NA |
|