| Interacting proteins: Q2M1K9 and Q9UH73 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q2M1K9 and Q9UH73 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q2M1K9 and Q9UH73 |
Pubmed |
SVM Score :0.0 |
| Evi 3 is highly related to the early B cell factor associated zinc finger gene ( Ebfaz ) , and all 30 zinc fingers found in EVI 3 are conserved in EBFAZ . ^^^ EBFAZ binds to and negatively regulates early B cell factor ( EBF ) ( also known as olfactory 1 , OLF 1 ) , a basic helix loop helix ( bHLH ) transcription factor required for B lineage commitment and the development of the olfactory epithelium . ^^^ Furthermore , our results suggest that EVI 3 , not EBFAZ , is the member of this protein family that interacts with and regulates EBF in B cells . . ^^^ |
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| Interacting proteins: Q2M1K9 and Q9UH73 |
Pubmed |
SVM Score :0.0 |
| The early B cell factor ( EBF ) associated zinc finger protein ( EBFAZ ) binds to and negatively regulates EBF , a basic helix loop helix transcription factor required for B cell lineage commitment and development of the olfactory epithelium . ^^^ |
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| Interacting proteins: Q2M1K9 and Q9UH73 |
Pubmed |
SVM Score :0.0 |
| The Evi 3 gene encodes a zinc finger protein with sequence similarity to the Early B cell Factor Associated Zinc finger gene ( EBFAZ ) . ^^^ Evi 3 , a zinc finger protein related to EBFAZ , regulates EBF activity in B cell leukemia . ^^^ |
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| Interacting proteins: Q2M1K9 and Q9UH73 |
Pubmed |
SVM Score :0.0 |
| Zinc finger protein 423 ( also known as Ebf associated zinc finger protein , Ebfaz ) binds to and negatively regulates Ebf 1 , a basic helix loop helix transcription factor required for B cell lineage commitment and olfactory epithelium development . ^^^ |
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| Interacting proteins: Q2M1K9 and Q9UH73 |
Pubmed |
SVM Score :0.0 |
| Cloning and functional characterization of Roaz , a zinc finger protein that interacts with O / E 1 to regulate gene expression : implications for olfactory neuronal development . ^^^ We have identified a protein , Rat O / E 1 associated zinc finger protein ( Roaz ) , that plays a role in regulating the temporal and spatial pattern of olfactory neuronal specific gene expression . ^^^ We showed that the Roaz protein bound specifically to O / E 1 by using the yeast two hybrid system . ^^^ Introduction of Roaz and O / E 1 into cells containing an olfactory promoter driven luciferase reporter demonstrated that Roaz abolished O / E 1 mediated transcriptional activation . ^^^ We propose that the function of Roaz is to modulate negatively the transactivational activity of O / E 1 and to act as a switch protein in the coordination of olfactory sensory neuron differentiation . . ^^^ |
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