Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.62473489
We also demonstrate a rapid and transient increase in Hck tyrosine kinase activity in parental ES cells stimulated by LIF and , finally , show that Hck is physically associated with gp 130 , an affinity converter and signal transducing component of the LIF receptor . 0.62473489^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.73243206
In the present study , we investigated potential interactions between gp 130 dependent and AII signaling pathways , by examining AII regulation of LIF induced anti apoptotic effect and STAT 3 activation in cardiac myocytes . 0.73243206^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.50960087
Since LIF together with LIFRalpha appear to form a more stable complex with gp 130 than OSM with gp 130 and OSMRbeta , co activation of LIFR and OSMR resulted in a predominant LIF like response . 0.50960087^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.56758369
Residues in human leukemia inhibitory factor ( hLIF ) crucial for binding to both the human LIF receptor ( R ) and gp 130 were identified by analysis of alanine scanning mutants of hLIF in assays for both receptor binding and bioactivity . 0.56758369^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.75910522
After activation of gp 130 with leukemia inhibitory factor ( LIF ) , expression of VEGF mRNA rapidly increased with a peak at 3 h in cultured cardiac myocytes . 0.75910522^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.58521356
The truncated forms of LIFR alpha subunit ( gp190EX ) and gp 130 ( gp130EX ) which can compete with the wild type receptor for binding to leukemia inhibitory factor ( LIF ) were expressed on the membrane of U 937 cells . 0.58521356^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The IL 6 signal transducer , gp 130 , is also an affinity converter for the LIF receptor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The LIF receptor is most related to the gp 130 signal transducing component of the IL 6 receptor , a feature that may provide a molecular basis for the intertwined biologies of LIF and IL 6 in the absence of obvious structural similarly between the ligands . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Here we present data indicating that gp 130 functions as a common signal transducer for IL 6 , oncostatin M ( OM ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophic factor ( CNTF ) . ^^^ Since LIF functions as a cholinergic differentiation factor in nerve cells as does CNTF , these results suggest that gp 130 may also play a role in the neural system . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The LIF receptor is structurally related to the gp 130 signal transducing component of the IL 6 receptor and to the G CSF receptor . ^^^ The high affinity receptors for LIF , OSM and IL 6 share the common subunit , gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The IL 6 signal transducer , gp 130 : an oncostatin M receptor and affinity converter for the LIF receptor . ^^^ The converter conferred high affinity binding of both LIF and OSM when expressed with the low affinity LIF receptor and is identical to the signal transducing subunit of the IL 6 receptor , gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL 6 signal transducing receptor component gp 130 . ^^^ We provide a basis for the overlapping actions of these three factors by demonstrating that the shared CNTF and LIF signaling pathways involve the IL 6 signal transducing receptor component gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The LIF receptor is related to the gp 130 ' signal transducing ' component of the IL 6 receptor and to the G CSF receptor , with the transmembrane and cytoplasmic regions of the LIF receptor and gp 130 being most closely related . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Interleukin 11 ( IL 11 ) , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OM ) , all of which use gp 130 as a signal transducer , significantly inhibited mouse placental lactogen 2 ( mPL 2 ) secretion by cultured placental cells from Days 7 , 9 , and 12 of pregnancy . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and interleukin 6 ( IL 6 ) compose a family of distantly related cytokines that initiate signaling by inducing either homodimerization of the `` beta ' ' signal transducing receptor component gp 130 ( in the case of IL 6 ) or heterodimerization between gp 130 and the gp 130 related LIFR beta ( in the case of CNTF , LIF , and OSM ) ; dimerization of beta receptor components in turn activates members of the Jak / Tyk family of receptor associated tyrosine kinases . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The presence of leukaemia inhibitory factor ( LIF ) binding and expression of the gp 130 component of the LIF receptor were studied in the rabbit uterus during pregnancy . ^^^ The coexpression of LIF binding and gp 130 may indicate the presence of high affinity LIF receptor , which matches the pattern of LIF protein expression and , as in mice , suggests its importance for implantation . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The gp 130 family cytokines IL 6 , LIF and OSM but not IL 11 can reverse the anti proliferative effect of dexamethasone on human myeloma cells . ^^^ In order to understand the mechanisms supporting steroid escape in patients with multiple myeloma ( MM ) , three IL 6 autocrine human myeloma cell lines , LP 1 , OPM 2 and L 363 , have been treated with dexamethasone in the presence or absence of cytokines belonging to the gp 130 family : IL 6 , LIF , OSM and IL 11 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
OM was also suggested to bind to the LIF receptor ( LIF / OM receptor ) , which consists of a signal transducing subunit for LIF and IL 6 ( gp 130 ) and a LIF receptor alpha subunit . ^^^ PCR amplification clearly revealed high levels of gp 130 expression in AIDS KS cells , while the transcript of LIF receptor alpha subunit or IL 6 receptor alpha subunit was not observed . ^^^ Therefore , we conclude that ( a ) AIDS KS cells express the OM specific receptor with high and low affinity , but not the LIF / OM receptor ; ( b ) gp 130 on AIDS KS cells plays a key role in OM binding and signaling on the OM specific receptor ; and ( c ) the lack of biological response of AIDS KS cells to IL 6 and LIF can be explained by the absence of the IL 6 and LIF / OM receptors . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
While it has been proposed that the OSM receptor may include the gp 130 subunit of the IL 6 receptor and alpha chain of leukemia inhibitory factor ( LIF ) receptor , neither LIF nor r . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The IL 6 receptor system consists of an 80 kDa IL 6 receptor and a gp 130 which functions as a signal transducer not only for IL 6R but also for LIF , OSM , ciliary neurotrophic factor ( CNTF ) , and IL 11 receptors . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The reverse transcription polymerase chain reaction and immunohistochemical analysis revealed the expression and localization , on the trophoblasts , of glycoprotein 130 ( gp 130 ) , an IL 6 signal transducer receptor component shared by the cytokines such as LIF and IL 6 . ^^^ Recombinant LIF induced CG production was significantly blocked by anti gp 130 antibody but not by anti IL 6 receptor antibody , whereas rIL 6 induced CG was completely blocked by both antibodies . ^^^ Recombinant LIF and rIL 6 induced CG productions were both significantly blocked by genistein , a tyrosine kinase inhibitor , suggesting an involvement of tyrosine kinase in gp 130 mediated CG production . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
CT 1 and LIF cross compete for binding to M 1 cells , Kd [ CT 1 ] approximately 0 . 7 nM , and this binding is inhibited by an anti gp 130 monoclonal antibody . ^^^ These data show that CT 1 has a wide range of hematopoietic , neuronal , and developmental activities and that it can act via the LIF receptor and the gp 130 signaling subunit . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Moreover , in situ hybridization revealed an identical pattern of gene expression in cultivated KS spindle cells and KS spindle cells in vivo with respect to the above mentioned cytokines [ PDGF B , IL 1 beta , IL 1 alpha , IL 6 , OSM ] and their receptors [ PDGF beta receptor , gp 130 , IL 6 receptor , leukemia inhibitory factor ( LIF ) receptor ] . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) , IL 11 , leukemia inhibitory factor ( LIF ) , and oncostatin M , which all use gp 130 as a signal transducer , significantly inhibited mGHRF secretion by cultured placental cells . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The capacity to bind IL 11 with high affinity ( Kd = 300 800 pM ) appeared to require coexpression of both NR 1 and gp 130 , the common subunit of the IL 6 , leukaemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) and ciliary neurotrophic factor ( CNTF ) receptors . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Previously it had been thought that the gp 130 alone is sufficient to bind ligand and transduce signal and that oncostatin M could bind to and activate the LIF receptor , but these data show this is not always the case . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
A 549 epithelial cells are subjected to growth inhibition only in the presence of OSM ( ED 50 = 6 ng / ml ) , even though they expressed LIF R and gp 130 transcripts . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Recently , gp 130 , the signal transducer for interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophice factor ( CNTF ) , was identified as the low affinity receptor for oncostatin M ( OM ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Like other cytokines such as IL 6 , leukemia inhibitory factor ( LIF ) , oncostatin M ( ONC ) and ciliary neurotrophic factor ( CNTF ) , IL 11 has been shown to utilize IL 6 signal transducer , gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Four cytokines , ciliary neurotropic factor ( CNTF ) , IL 11 , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OM ) , use the same transducer chain ( signal transducer gp 130 ) as IL 6 and share numerous biological activities with this IL . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Consistent with this prediction , the CNTF receptor complex is composed of the CNTF alpha receptor , the LIF beta receptor and gp 130 a signalling molecule for LIF and interleukin 6 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
These data directly implicate SCL in components of the macrophage differentiation program ( suggesting that LIF receptor / gp130 heterodimers utilize an SCL inhibitable pathway while gp 130 homodimers do not ) and demonstrate differential regulation of components of the mature macrophage phenotype . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In addition to including a CNTF specific component , known as CNTFR alpha , the CNTF receptor complex utilizes two receptor components , gp 130 and LIFR beta , that are shared with members of a family of broadly acting cytokines , including leukemia inhibitory factor ( LIF ) and interleukin 6 ( IL 6 ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
LIF and OM directly interact with a soluble form of gp 130 , the IL 6 receptor signal transducing subunit . ^^^ Since OM signaling can be prevented by binding gp 130 with anti gp 130 mAbs we also investigated the potential of sgp 130 Rg to prevent the biological activities of both LIF and OM . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
We analyzed the stimulatory effect of oncostatin M ( OSM ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , IL 11 , and the inhibitory effect of anti IL 6 antibody ( Ab ) , anti IL 6 receptor monoclonal antibody ( mAb ) , and anti gp 130 mAb on the growth of human plasmacytoma cells freshly isolated from a patient with multiple myeloma . ^^^ Furthermore , anti gp 130 mAb completely inhibited the proliferation of the cells induced by OSM , LIF , as well as IL 6 . ^^^ These data indicate that OSM , LIF , and IL 6 can act as growth factors of human plasmacytoma cells through a common signal transducer , gp 130 , on their cell surface , and also suggest the potential therapeutic application of anti gp 130 mAb , as well as anti IL 6R mAb against myeloma / plasmacytomas . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Interleukin 11 ( IL 11 ) shares the common signal transducer gp 130 with IL 6 , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) and triggers activation of unknown tyrosine kinases as the early steps of signal transduction pathway . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The biological functions of LIF are mediated through a receptor and a signal transducer , gp 130 , which is also used by factors like interleukin 6 ( IL 6 ) , cilliary neurotropic factor ( CNTF ) , and oncostatin M ( OSM ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The receptor for leukemia inhibitory factor ( LIFR ) , in combination with the signal transducing subunit for interleukin 6 type cytokine receptors , gp 130 , and LIF , activates transcription of acute phase plasma protein genes in human and rat hepatoma cells and the vasoactive intestinal peptide gene in a human neuroblastoma cell line . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The beta receptor components for this cytokine family , gp 130 and LIF receptor beta , constitutively associate with Jak Tyk kinases . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Specific low affinity receptors for leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ; gp 130 ) , and ciliary neurotrophic factor ( CNTF ; receptor alpha , CNTFR alpha ) may be utilized in various combinations to generate high affinity binding sites and signal transduction . ^^^ Coexpression of the LIF receptor and gp 130 in these cells conferred high affinity LIF and OSM binding and responsiveness to LIF and OSM . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
To begin defining whether NG neurons were capable of responding to CNTF and LIF in vivo , Northern blots were used to examine expression of mRNAs coding for CNTF and LIF receptor components ( CNTFR alpha , gp 130 , and LIFR beta ) in the intact ganglion . mRNAs for all three receptor components were present in both E16 . 5 and newborn ganglia , suggesting that LIF and CNTF receptors are expressed in the NG in vivo . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Differentiation induction in murine M 1 leukemia cells by interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) is postulated to occur via a common receptor chain , gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
For example , leukemia inhibitory factor ( LIF ) and IL 6 share many biological activities including platelet production , and the receptors of these cytokines utilize gp 130 as a common signal transducer . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
One of these proteins is the interleukin 6 signal transducing molecule gp 130 , which is required for signal transduction by both CNTF and LIF . ^^^ Cross linking experiments with iodinated factors were carried out on a cell line responsive to CNTF and LIF , as well as on COS cells that were cotransfected with various combinations of gp 130 , LIFR beta , and CNTF receptor ( CNTFR ) alpha , the previously cloned CNTF binding protein . ^^^ These experiments reveal that LIF cross links to LIFR beta alone , as well as to gp 130 when it is coexpressed with LIFR beta . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The ciliary neurotrophic factor ( CNTF ) receptor complex is shown here to include the CNTF binding protein ( CNTFR alpha ) as well as the components of the leukemia inhibitory factor ( LIF ) receptor , LIFR beta ( the LIF binding protein ) and gp 130 [ the signal transducer of interleukin 6 ( IL 6 ) ] . ^^^ Unlike the IL 6 receptor complex in which homodimerization of gp 130 appears to be critical for signal initiation , signaling by the CNTF and LIF receptor complexes depends on the heterodimerization of gp 130 with LIFR beta . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The IL 11 receptor belongs to a family of cytokine receptors which includes the receptors for IL 6 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and ciliary neurotrophic factor ( CNTF ) , which are all capable of interacting with the signal transducing receptor gp 130 after ligand binding . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The IL 6 induced gp 130 homodimer appears to be similar in function to the heterodimer formed between the leukemia inhibitory factor ( LIF ) receptor ( LIFR ) and gp 130 in response to the LIF or ciliary neurotrophic factor ( CNTF ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
BACKGROUND : The receptor of ciliary neurotrophic factor ( CNTF ) contains the signal transduction protein gp 130 , which is also a component of the receptors of cytokines such as interleukin ( IL ) 6 , leukemia inhibitory factor ( LIF ) , IL 11 , and oncostatin M . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Using the reverse transcriptase polymerase chain reaction , we found that the human breast carcinoma MCF 7 cell line expressed the message for both LIF receptor and its signal transducing protein gp 130 , suggesting that these receptors might be biologically active . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The cytokines interleukin ( IL ) 6 , IL 11 , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitor factor ( LIF ) , oncostatin M ( OSM ) and probably the recently cloned cytokine cardiotrophin 1 , signal , in combination with their specific receptors , through the common signal transducer gp 130 . ^^^ Here , we report that the signaling activities of IL 6 , IL 11 , CNTF and OSM / LIF can be specifically blocked by different anti gp 130 monoclonal antibodies ( mAb ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The functional receptor complexes assembled in response to interleukin 6 and 11 ( IL 6 and IL 11 ) , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and ciliary neurotrophic factor ( CNTF ) , all involve the signal transducer gp 130 : IL 6 and IL 11 induce homodimerization of gp 130 , while the rest heterodimerize gp 130 with other gp 130 related beta subunits . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor , LIF receptor , and gp 130 in the mouse uterus during early pregnancy . ^^^ The present study was designed to investigate the changes of LIF protein , LIF receptor , and gp 130 in the mouse uterus during the early pregnancy . ^^^ LIF protein and LIF receptor were at high levels in the mouse uterus near the time of ovulation and on day 4 of pregnancy . gp 130 was highest on days 3 and 4 of pregnancy . ^^^ Both LIF receptor and gp 130 showed strong staining in the stroma of the day 5 uterus , at a time when LIF protein was low . ^^^ The presence of LIF receptor and gp 130 in the luminal epithelium on day 4 and in the stroma on day 5 may indicate the site of the high affinity LIF receptor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Here , we describe the expression of LIF , related members of this group of cytokines , oncostatin M and ciliary neurotrophic factor , and the LIF receptor beta and glycoprotein gp 130 in normal human tissues and in the endometrium of fertile women . ^^^ The associated signal transducing component of the LIF receptor , gp 130 , is also expressed in both the luminal and glandular epithelium throughout the cycle . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The receptor complex for LIF comprises LIF binding subunit and non binding signal transducer , gp 130 . ^^^ The gp 130 was originally identified as a signal transducing subunit of interleukin ( IL ) 6 and later also found to be a functional component of receptor complexes for other LIF related cytokines ( oncostatin M [ OSM ] , ciliary neurotrophic factor [ CNTF ] and IL 11 ) . ^^^ In addition , a combination of IL 6 and soluble IL 6 binding subunit ( sIL 6R ) , which is known to activate intracellular signaling via gp 130 , fully reproduced the LIF action of PGC . ^^^ Both in the presence and absence of LIF , addition of neutralizing antibody against gp 130 in culture remarkably blocked cPGC survival . ^^^ Since EG cells were also obtained by using OSM or the IL 6 / sIL 6R complex in place of LIF , a significant contribution of gp 130 mediated signaling in EG cell formation was further suggested . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Dexamethasone inhibited both basal and LIF induced ACTH secretion ( P < 0 . 05 ) and LIF induction of ACTH was also attenuated by immuneutralization of either the LIF receptor ( 35 % , P < 0 . 05 ) or the gp 130 affinity converter ( 41 % , P < 0 . 05 ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The results showed that the heterocomplex CNTF / alpha CNTF receptor bound to gp 130 with an affinity of 3 5 10 10 ( 10 ) M , whereas LIF interacted mainly with gp 190 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In the case of IL 6 and LIF , which share a signal transducing receptor gp 130 , STAT 3 is specifically tyrosine phosphorylated and activated by stimulation with each cytokine in various cell types . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In addition , Raf 1 is also required for IL 6 , LIF and OSM induced proliferation whose receptors share the gp 130 subunit . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In agreement with OSMs ability to directly bind gp 130 , preincubation of BMCs with OSM inhibits progenitor cell growth stimulated by the combination of LIF or IL 6 plus SLF . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Moreover , other members of the CNTF cytokine family that use gp 130 and / or LIF receptor beta as their signal transducing receptors LIF , oncostatin M , interleukin 6 , and interleukin 11 had similar effects on increasing ChAT activity and reducing 5HT expression in RN46A cells . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In this study , in vivo and in vitro expression of LIF and its signal transducer genes , LIFR and gp 130 in medulloblastoma cells and its role ( s ) in the cell proliferation were investigated by different approaches . ^^^ The results revealed that 12 out of 13 cases examined were found to express LIF and more than 90 % of the samples to express LIFR and gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Growth of XG 4 CNTF cells using the gp 130 IL 6 transducer was also supported by other cytokines : IL 6 , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OM ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) and oncastsin M ( OSM ) high affinity binding require additional receptor subunits besides GP 130 and GP 190 . ^^^ Heterodimerization of gp 190 and gp 130 has been proposed to form a high affinity receptor ( type 1 ) shared by LIF and OSM , while heterodimerization of gp 130 with an as yet unidentified subunit is proposed to form a high affinity OSM receptor ( type 2 ) not shared by LIF . ^^^ They indicate rather that third chains of 140 150 kDa molecular mass , in addition to the gp 130 and gp 190 subunits , enter in the structure of LIF and OSM high affinity receptors . ^^^ CHO cells co transfected with the human gp 190 and gp 130 cDNAs expressed high affinity LIF receptors but no high affinity OSM receptors , indicating that an additional component is required for high affinity OSM binding . ^^^ High affinity LIF cross linking on these cells also showed the association of LIF with a 150 kDa component in addition to the gp 130 and gp 190 subunits . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
IL 6 triggers homodimerization of gp 130 , whereas CNTF and LIF induce heterodimerization of gp 130 and LIF receptor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Interaction of the human IL 11R alpha with murine gp 130 was demonstrated : expression of the human IL 11R alpha in murine M 1 cells which constitutively express murine gp 130 ( and murine LIF receptor ) , resulted in the generation of specific high affinity binding sites for IL 11 ( Kd = 250 pM ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
We hypothesize that the LIF / LIFR gp 130 system may be involved in the expansion and differentiation of the liver stem cell compartment . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
This report documents the mRNA expression profiles of LIF and the two components of the LIF receptor complex , LIF R and gp 130 , during early mouse embryogenesis . ^^^ High levels of LIF R and gp 130 mRNAs were observed in the deciduum , however . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
LIF and CNTF , which share the gp 130 transduction system , stimulate hepatic lipid metabolism in rats . ^^^ The combination of LIF plus CNTF showed no additive effects consistent with the action of both cytokines through the gp 130 transduction system . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Cardiotrophin 1 : a multifunctional cytokine that signals via LIF receptor gp 130 dependent pathways . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
LIF induced the tyrosine phosphorylation of gp 130 within 15 min after it was added to cardiac myocytes . ^^^ These results suggest that LIF activates gp 130 and induces myocardial hypertrophy by acting as an autocrine / paracrine factor in cardiac myocytes . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Characteristic localization of gp 130 ( the signal transducing receptor component used in common for IL 6 / IL 11 / CNTF / LIF / OSM ) in the rat brain . ^^^ The localization of gp 130 , the signal transducing receptor component used in common for interleukin ( IL ) 6 , IL 11 , ciliary neurotrophic factor ( CNTF ) , LIF and OSM , in the rat brain was demonstrated by immunohistochemistry using an antibody specific to gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
To determine whether these two signaling pathways through gp 130 are present in cardiac myocytes , we examined their activation by using leukemia inhibitory factor ( LIF ) , which is a member of the IL 6 cytokine family . ^^^ Tyrosine phosphorylation of gp 130 , JAK 1 , and STAT 3 was observed after LIF stimulation in cardiac myocytes . ^^^ Furthermore , anti gp 130 antibody significantly inhibited the LIF induced activation of JAK 1 , STAT 3 , and MAPKs . ^^^ To examine whether these signaling pathways were also activated in the adult heart in vivo , LIF was injected intravenously into a 6 week old mouse , and the heart was examined subsequently . gp 130 , STAT 3 , and MAPKs were activated in the heart after LIF treatment . ^^^ CONCLUSIONS : These results demonstrate for the first time that a JAK STAT pathway and a MAPK pathway are present down stream of gp 130 in cardiac myocytes and are rapidly activated by LIF both in vitro and in vivo . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
METHODS : We incubated highly differentiated human hepatoma cells ( Hep G 2 ) and human umbilical vein endothelial cells ( HUVECs ) for 24 h with recombinant human leukaemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) cytokines that are implicated in acute phase reactions during inflammation and which bind to the same cell surface receptor unit ( glycoprotein gp 130 ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The leukemia inhibitory factor / interleukin 6 ( LIF / IL6 ) family of cytokines promotes cell type specific pleiotropic effects by engaging multimeric receptor complexes that share the common affinity converter / signal transducing subunit gp 130 . ^^^ Functional involvement of Hck and p 21 ( ras ) activation in gp 130 mediated signaling is supported by the finding that the introduction of constitutively activated Hck or 5 Ha ras partially alleviates the requirement of ES cells for LIF to remain undifferentiated . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leptin stimulation induces tyrosine phosphorylation of neither gp 130 nor LIFR , while LIF stimulation does both . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
RT PCR analyses demonstrated that gp 130 was expressed in 12 / 12 breast cell lines and the specific receptor alpha chains for IL 6 , LIF , IL 11 and CNTF were expressed in the majority of these cell lines . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Three cytokines , interleukin 6 ( IL 6 ) , leukaemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) , that bind to composite receptors including a common signal transducer gp 130 suppressed proliferation of a mouse B cell hybridoma cell line 2E3 O cultured in serum free medium , while they enhanced antibody production of the cells . ^^^ As a whole , this work suggests that gp 130 , which is commonly involved in each receptor for IL 6 , LIF , and OSM , transduces signals for suppressing proliferation and possibly for enhancing antibody production in the hybridoma cells . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
This observation is consistent with previous in vitro findings showing that the mRNA for CT 1 is expressed in several tissues , and that CT 1 can function through binding to the leukaemia inhibitory factor ( LIF ) receptor and signalling through the gp 130 pathway . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Investigations of the signal transduction system showed that gp 130 and leukemia inhibitory factor ( LIF ) receptor beta subunit mRNA were detectable in porcine thyroid cells by reverse transcription ( RT ) polymerase chain reaction ( PCR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Other cytokines oncostatin M ( OM ) , leukemia inhibitory factor ( LIF ) or ciliary neurotrophic factor ( CNTF ) also use the gp 130 transducer and induce its heterodimerization with LIF receptor ( LIFR ) . ^^^ IL 6RA with two mutated gp 130 binding sites did not affect IL 11 , CNTF , LIF or OM activities . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
A family of cytokines [ IL 6 , IL 11 , oncostatin M ( OM ) , leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotrophin 1 ] involved in various inflammatory or tumoral diseases share the same gp 130 signal transducer chain . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Oncostatin M ( OSM ) is a cytokine whose structural and functional features are similar to other members of the interleukin ( IL ) 6 family of cytokines ( IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , granulocyte colonystimulating factor , ciliary neurotrophic factor , and cardiotrophin 1 ) , many of which utilize gp 130 as a common receptor subunit . ^^^ We have cloned and characterized an alternative subunit ( OSMRbeta ) for an OSM receptor complex ( a heterodimer of gp 130 and OSMRbeta ) that is activated by OSM but not by LIF . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The cytokines IL 6 , LIF , CNTF , OSM , IL 11 , and CT 1 have been grouped into the family of IL 6 type cytokines , since they all require gp 130 for signal transduction . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
To define the specificity of the signal transduction by the LIF / OSM receptor ( a heterodimer of gp 130 and LIF receptor ( LIFR ) ) and the OSM specific receptor ( a heterodimer of gp 130 and OSM receptor ( OSMR ) ) , we reconstituted the receptor function by transfection into receptor negative Hep3B hepatoma cells . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Two other cytokines which also utilize the gp 130 receptor , oncostatin M ( OSM ) and leukemia inhibitory factor ( LIF ) , were also able to upregulate endothelial cell protein S . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
We described recently the activation of the Janus kinasesignal transducer and activator of transcription ( JakSTAT ) and mitogen activated protein ( MAP ) kinase pathways by leukemia inhibitory factor ( LIF ) through gp 130 , a signal transducer of IL 6 related cytokines , that transduces hypertrophic signals in cardiac myocytes . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Forced overexpression of SSI 1 complementary DNA interfered with IL 6 and LIF mediated apoptosis and macrophage differentiation of M 1 cells , as well as IL 6 induced tyrosine phosphorylation of a receptor glycoprotein component , gp 130 , and of Stat 3 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Oncostatin M ( OSM ) and leukemia inhibitory factor ( LIF ) are members of the interleukin 6 ( IL 6 ) subfamily of cytokines that use a common signal transducer gp 130 . ^^^ Human OSM ( hOSM ) and LIF share a functional high affinity receptor that is composed of gp 130 and LIF receptor beta subunit ( LIFRbeta ) . ^^^ Murine hematopoietic cell lines M 1 and DA1 . a , an embryonic stem cell line CCE , and Ba / F3 transfectants expressing gp 130 and LIFRbeta responded to murine LIF ( mLIF ) and hOSM equally well , while these cells responded to mOSM only at a 30 fold to 100 fold higher concentration than those of mLIF and hOSM . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Human OSM is known to exhibit biological activities similar to LIF , because they share the same functional receptor composed of the LIF receptor and gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
We have shown recently that leukemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) , two members of the gp 130 dependent cytokine family , stimulate murine proopiomelanocortin ( POMC ) transcription and adrenocorticotropin hormone ( ACTH ) secretion . ^^^ Using RT PCR , mRNA expression of receptors for LIF , IL 6 , and CRH , and the gp 130 subunit , were all detected in fetal pituitaries of 18 and 31 wk gestation . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
To continue these studies , we examined the mRNA expression of signal transducing molecule , gp 130 , and the LIF R as associated members of a receptor family . ^^^ The levels of gp 130 and LIF R mRNA expression had a maximum 2 3 fold increase over a 24 h period . ^^^ Injection of purified recombinant rat IL 6 ( rIL 6 ) had little effect on LIF R mRNA levels , but had a dramatic inducing effect on gp 130 mRNA levels . ^^^ Rats were also injected ( i . p . ) with Dexamethasone ( Dex ) and this had no effect on either gp 130 or LIF R mRNA level expression . ^^^ We found that the maximum IL 6R ( gp 80 ) , gp 130 and LIF R mRNA levels peaked at different times depending on the type of acute inflammation induced in the rat . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) is a hematopoietic cytokine which elicits its effects on diverse cell types via both gp 130 and a more specific LIF receptor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Carcinoma cells constitutively express LIF mRNA , and 23 lines ( 92 . 0 % ) and all ( 100 % ) of 25 lines express LIF receptor mRNAs of LIFRbeta and gp 130 , respectively . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukaemia inhibitory factor ( LIF ) is a polyfunctional cytokine that is known to require at least two distinct receptor components ( LIF receptor alpha chain and gp 130 ) in order to form a high affinity , functional , receptor complex . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In the present study we show that CT 1 binds to the KB epidermoid cancer cell surface through a tripartite receptor complex which includes the gp 130 signal transducing protein , LIF receptor beta ( LIFR beta ) and a third component displaying a molecular weight of 80 kDa . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The stimulation by Flk 2 ligand ( FL ) of blast colony formation by murine bone marrow cells was selectively potentiated by the addition of regulators sharing in common the gp 130 signaling receptor leukemia inhibitory factor ( LIF ) , oncostatin M , interleukin 11 , or interleukin 6 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Each of these cytokines induces the hetero oligomerization of LIF R with gp 130 , a signal transducing subunit shared with interleukin 6 and interleukin 11 . ^^^ The introduction of mutations into human LIF that reduced the affinity for gp 130 while retaining affinity for LIF R has generated antagonists for LIF . ^^^ On cells that express LIF R and gp 130 , all LIF R ligands were antagonized . ^^^ Ligand triggered tyrosine phosphorylation of both LIF R and gp 130 was blocked by the antagonist . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Treatment of HepG 2 cells with CT 1 resulted in the induction of tyrosine phosphorylation of both transducing receptor subunits , gp 130 and LIF receptor , and this phosphorylation was completely inhibited by a neutralizing anti gp 130 mAb . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Taken together these results demonstrate that transcription of LIFR beta and gp 130 takes place throughout human preimplantation development , and suggest that functional LIF receptors might be present at these stages . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
These responses are thought to be mediated through the functional LIF receptor ( LIFR ) , consisting of a heterodimeric complex of LIFR alpha chain ( LIFRalpha ) and gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Proliferation in the absence of differentiation of blastodermal cells is stimulated by the presence of Leukemia Inhibitory Factor ( LIF ) and other ligands that interact with the gp 130 receptor , and differentiation is stimulated by exposure to retinoic acid . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
LIF ( 10 ( 3 ) U / mL ) induced rapid tyrosine phosphorylation of gp 130 , JAK 1 , JAK 2 , STAT 1 , and STAT 3 but not Tyk 2 or STAT 2 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
LIF , CNTF , and CT 1 act through the known receptors LIF receptor beta ( LIFRbeta ) and gp 130 and well defined signaling pathways including receptor phosphorylation and STAT 3 activation . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
This synergy also extended to the inhibition of LIF or oncostatin M ( OSM ) induced proliferation of a Ba / F3 cell line co transfected with human gp 130 and gp 190 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
METHODS : Active transcription of LIF , IL 6 , and OSM , their related receptors ( LIF R , IL 6 R , and gp 130 ) , and the consecutive signal transducing molecules ( STAT 1 , STAT 3 , and STAT 5a ) were analyzed in reverse transcriptase polymerase chain reaction experiments . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
To investigate the respective roles of IL 6 related cytokines and receptors in osteprogenitor differentiation , and their regulatory interplay with Dex , we used reverse transcribed polymerase chain reaction , bioassay , and blocking antibody techniques to assess the time courses of LIF , IL 6 , LIF transmembrane receptor , IL 6 receptor , and gp 130 expression in RC cell cultures grown with and without Dex . ^^^ The levels of the mRNAs for IL 6 , LIF , and gp 130 decreased concomitantly with the formation of bone nodules . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The percentage of neurones surrounded by TH IR baskets within the L 3 and L 4 dorsal root ganglia following sciatic axotomy was significantly reduced in animals treated continuously for 2 weeks with a monoclonal antibody against the LIF receptor motif , gp 130 ( 0 . 833 mg ml 1 ) ( P < 0 . 05 , Mann Whitney U test ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Additionally , LIF enhances association of SHP 2 with the gp 130 subunit of the LIF receptor signaling complex . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) belongs to a gp 130 pleiotropic family of growth factors that has recently been shown to enhance the survival of rat testicular gonocytes and Sertoli cells . ^^^ In this study , we show the expression of gp 130 and LIF messenger RNAs ( mRNAs ) in the somatic ( the Sertoli and Leydig cells ) and specific germ cells ( spermatogonia , pachytene , round , and elongated spermatids ) of rodent testis , suggestive of cell specific LIF mediated functions . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) is a polyfunctional cytokine known to require at least two distinct receptor components ( LIF receptor alpha chain and gp 130 ) in order to form a high affinity , functional receptor complex . ^^^ Both forms of gp 130 bound LIF specifically and were capable of forming heterotrimeric complexes with soluble human LIF receptor alpha chain in the presence of human LIF . ^^^ In addition to the soluble forms of gp 130 , a soluble form of LIF receptor alpha chain was also detected in human urine and plasma . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Differential temporal expression of mRNAs for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptors ( CNTFR alpha , LIFR beta , IL 6R alpha and gp 130 ) in injured peripheral nerves . ^^^ The mRNA expression of the neuropoietic cytokines , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptor components ( CNTFRalpha , LIFRbeta , IL 6Ralpha and gp 130 ) was examined in peripheral nerves after two different types of injury , crush and transection . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Western blot analysis revealed an inhibition of LIF stimulated gp 130 and STAT 3 phosphorylation in SOCS 3 overexpressing AtT 20 cells . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The LIF receptor complex is composed of a heterodimer of LIF receptor alpha ( LIFR alpha ) and gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
IL 6 family of cytokines : signaling mechanisms and thrombopoietic activities . gp 130 is a common signal transducing component of the functional receptor complexes for the interleukin ( IL ) 6 family of cytokines , ie , IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
CONCLUSIONS : These results suggest that the STAT 3 dependent signaling pathway downstream of gp 130 promotes cardiac myocyte hypertrophy under stimulation with LIF . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
LIF receptor gp 130 interaction investigated by homology modeling : implications for LIF binding . ^^^ Leukemia inhibitory factor ( LIF ) , a member of the gp 130 family of helical cytokines , is involved in the hemopoietic and neural systems . ^^^ The LIF signal transducing complex contains two receptor molecules , the LIF receptor ( LIFR ) and gp 130 . ^^^ Although some mutagenesis data on LIF are available , it is not yet known which regions of LIFR or gp 130 bind LIF . ^^^ Analyses of the electrostatic isopotential surfaces of the CBD models suggest that gp 130 and the membrane proximal CBD of LIFR hetero dimerize and bind LIF through contacts similar to those seen in the growth hormone receptor dimer . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In NIH 3T3 cells ( which endogenously express gp 130 , LIF receptor beta [ LIFRbeta ] , and the protein product , c 12 , of the cDNA described here ) , mouse LIF , human LIF , and human OSM signaled through receptors containing the LIFRbeta and gp 130 but not through the mouse OSM receptor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In absence of TpO , neither gp 130 activating cytokines ( IL 6 , IL 11 , LIF , CNTF ) nor the other hematopoietic growth factors or cytokines ( KL , IL 3 , GM CSF , EpO ) were able , when added alone , to stimulate the growth of human CFU Meg colonies . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The biological activities of OSM are mediated through two types of receptor complexes , the LIF / OSM shared receptor ( type 1 ) and OSM specific receptor ( OSM R , type 2 ) , which is composed of gp 130 as a binding subunit and a newly identified affinity conversion subunit , OSM R beta . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The transmembrane protein gp 130 is a shared component of the receptor complexes for the interleukin 6 ( IL 6 ) type cytokines , which include IL 6 , leukemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) . ^^^ In the present study we have examined the role of the N terminal located , extracellular immunoglobulin ( Ig ) like module of gp 130 in signal transduction by IL 6 and LIF . ^^^ We have expressed wild type human gp 130 or three mutants in murine myeloid M 1 UR21 cells that lack functional endogenous gp 130 but express the IL 6 receptor ( IL 6R ) and the LIF receptor ( LIFR ) . ^^^ By measuring cellular responses , such as morphological changes upon differentiation , soft agar colony formation , and induction of tyrosine phosphorylation of the signal transducer and activator of transcription , STAT 3 , we show that signaling by IL 6 , but not LIF , is significantly reduced by mutations in the Ig like module of gp 130 . ^^^ We also present evidence that the Ig like module forms part of the epitope of an anti gp 130 monoclonal antibody that neutralizes the bioactivity of IL 6 , but not of LIF or OSM . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In addition , cytokines or their receptors not known to be expressed in RPE were included to widen our picture of cytokine gene expression in the eye : stem cell factor ( SCF ) , its receptor ( SCF R ) , low affinity nerve growth factor receptor p 75 ( p 75 ( NGF R ) , ciliary neutrothropic factor ( CNTF ) , and its receptor ( CNTF R ) , glycoprotein 130 interleukin 6 transducer ( gp 130 ( IL 6 SD ) , leukemia inhibitory factor ( LIF ) , and its receptor ( LIF R ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The functional receptor for ciliary neurotrophic factor ( CNTF ) is comprised of a CNTF binding entity termed CNTF receptor alpha ( CNTFRalpha ) , and 2 signaling molecules called LIF receptor beta and gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The established glioma cell lines were also examined for expression of members of the neuropoietic cytokine family , CNTF and LIF , and their respective receptor components CNTFRalpha , LIFRbeta and gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The propagation of pluripotential mouse embryonic stem ( ES ) cells is sustained by leukemia inhibitory factor ( LIF ) or related cytokines that act through a common receptor complex comprising the LIF receptor subunit ( LIF R ) and the signal transducer gp 130 . ^^^ However , the findings that embryos lacking LIF R or gp 130 can develop beyond gastrulation argue for the existence of an alternative pathway ( s ) governing the maintenance of pluripotency in vivo . ^^^ This activity , which we name ES cell renewal factor ( ESRF ) , is distinct from members of the IL 6 / LIF family because ( 1 ) it is effective on ES cells lacking LIF R ; ( 2 ) it is not blocked by anti gp 130 neutralizing antibodies ; and ( 3 ) it acts without activation of STAT 3 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The specific binding of leukemia inhibitory factor ( LIF ) or oncostatin M ( OSM ) to transmembrane gp 190 or gp 130 leads to their oligomerization which is necessary for signal transduction . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The cytokines ciliary neurotrophic factor ( CNTF ) and leukemia inhibitory factor ( LIF ) signal through a receptor complex formed between two transmembrane proteins , gp 130 and LIFRbeta . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukaemia inhibitory factor ( LIF ) plays an essential role during cell differentiation and implantation in the mouse exerting its effects via the two dimerizing receptor subunits glycoprotein 130 ( gp 130 ) and LIF receptor beta ( LR beta ) . ^^^ This study investigated the mRNA expression of bovine LIF ( bLIF ) , gp 130 and LR beta in pooled or individual bovine oocytes and embryos generated in vitro or in vivo after superovulation . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Cytokines that transduce their signals either through glycoprotein 130 ( gp 130 ) homodimers or gp 130 / leukemia inhibitory factor ( LIF ) receptor beta heterodimers are potent inducers of osteoclast development in vitro as well as in vivo ; and interleukin ( IL ) 6 has been recognized as an important pathogenic factor in diseases characterized by increased bone remodeling , such as the osteoporosis of sex steroid deficiency . ^^^ This pattern of specificity was accounted for by the finding that EF cells express gp 130 , but not the ligand binding subunit of the IL 6 receptor ( gp 80 ) nor the LIF receptor beta . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The functional receptor for LIF is composed of LIFR alpha chain ( LIFRalpha ) and gp 130 both of which are shared in the functional receptors for oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ By using stable transfection of wild type or cytoplasmic deletion mutants of LIFRalpha together with full length gp 130 into Ba / F3 cells , we found that cells expressing gp 130 and an extensively deleted mutant LIFRalpha containing only the box 1 region were capable of proliferating in response to LIF , although LIF dependent long term growth of these cells was seriously impaired . ^^^ Using a similar strategy to generate WEHI 3BD+ cells expressing gp 130 and wild type or truncation mutants of LIFRalpha , studies revealed that the box 1 region of the LIFRalpha was also sufficient for LIF dependent induction of different aspects of differentiation , including up regulation of macrophage surface marker expression , morphological change , and cell migration in agar culture . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Several other cytokines including oncostatin M , IL 11 , leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotropin 1 ( CT 1 ) use gp 130 as a common signal transducing molecule and therefore have similar biological activities . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
OM signals are transduced through two different OM receptor complexes : a leukemia inhibitory factor ( LIF ) / OM receptor ( a heterodimer of LIFR beta and gp 130 ) and an OM specific receptor ( a heterodimer of OMR beta and gp 130 ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Two types of functional hOSM receptors are known : the type 1 OSM receptor is identical to the LIF receptor that consists of gp 130 and the LIF receptor beta subunit ( LIFRbeta ) , and the type 2 OSM receptor consists of gp 130 and the OSM receptor beta subunit ( OSMRbeta ) . ^^^ To elucidate the molecular structure of the functional mOSM receptor , we cloned a cDNA encoding mOSMRbeta , which is 55 . 5 % identical to the hOSMRbeta at the amino acid level . mOSM responsive cell lines express high affinity mOSM receptors , as well as mOSMRbeta , whereas embryonic stem cells , which are responsive to LIF but not to mOSM , do not express mOSMRbeta . mOSMRbeta alone binds mOSM with low affinity ( kd = 13 . 0 nmol / L ) and forms a high affinity receptor ( kd = 606 pmol / L ) with gp 130 . ^^^ Ba / F3 transfectants expressing both mOSMRbeta and gp 130 proliferated in response to mOSM , but failed to respond to LIF and human OSM . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Plasma levels of interleukin ( IL ) 6 , soluble IL 6 receptor , soluble gp 130 , leukemia inhibitory factor ( LIF ) , and ciliary neutrophic factor ( CNTF ) were analyzed in 32 patients with severe malaria . ^^^ Plasma concentrations of gp 130 and LIF did not differ between the malaria groups or normal controls . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
An antibody to gp 130 blocked the effects of LIF and CNTF , and both cytokines induced phosphorylation and nuclear translocation of stat 3 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) induces growth arrest and macrophage differentiation of mouse myeloid leukemic cells through the functional LIF receptor ( LIFR ) , which comprises a heterodimeric complex of the LIFR subunit and gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukaemia inhibitory factor ( LIF ) signals via a heterodimeric receptor complex comprised of the LIF receptor ( LIFR ) and the interleukin ( IL ) 6 signal transducer gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Cell type specific responses to the leukemia inhibitory factor ( LIF ) / interleukin 6 cytokine family are mediated by dimerization of the LIF receptor alpha chain ( LIFRalpha ) with the signal transducer gp 130 or of two gp 130 molecules followed by activation of the JAK / STAT and Ras / mitogen activated protein kinase cascades . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
IL 6 ) , whereas CNTF and leukemia inhibitory factor ( LIF ) signal via a heterodimer of gp 130 and LIF receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
LIF acts through a receptor complex composed of a low affinity LIF receptor ( LIFRbeta ) and gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
This spontaneous astrocyte differentiation is completely impaired when neuroepithelial cells deficient for gp 130 , a signal transducing receptor component for LIF , are used . ^^^ Taken together with our previous finding that prenatal mouse brain deficient for gp 130 exhibits a severe reduction of astrocytes , it is suggested that LIF acts cooperatively with BMP 2 in vivo to induce astrocyte differentiation in mouse developing brain . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Interleukin 11 ( IL 11 ) belongs to the interleukin 6 ( IL 6 ) type subfamily of long chain helical cytokines including IL 6 , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M , and cardiotrophin 1 , which all share the glycoprotein gp 130 as a signal transducing receptor component . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
OSM and LIF can bind to the same functional receptor complex ( LIF receptor beta and gp 130 heteromultidimers ) and thus mediate overlapping spectra of biological activities . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
To investigate the role of CNTF / LIF signaling in regenerative responses of motoneurons , we studied the expression of the three receptor components , CNTF receptor alpha ( CNTFRalpha ) , LIF receptor beta ( LIFRbeta ) , and gp 130 , and the activation of the STAT 3 signal transduction pathway in the rat facial nucleus following peripheral nerve transection . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The present study also suggests that cardiotrophin 1 , but not LIF , is a possible candidate for natural ligand of a gp 130 signaling pathway in the heart . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) and leukemia inhibitory factor ( LIF ) are members of a subfamily of related cytokines that share gp 130 as common signal transducing receptor component . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Therefore , in vivo and in vitro expression of LIF , IL 6 and their signal transducer genes encoding LIF receptor ( LIFR ) , IL 6 receptor ( IL 6R ) and gp 130 in human medulloblastoma cells were investigated by multiple cellular and molecular biology approaches . ^^^ The results revealed that LIF expression could be found in 26 out of 28 tumors / cell line and over 90 % of the samples expressed LIFR , IL 6R and gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The receptor gp 130 is used by the interleukin 6 ( IL 6 ) type cytokines , which include IL 6 and leukaemia inhibitory factor ( LIF ) . ^^^ Whereas the binding affinities of ( 125 ) 1 labelled IL 6 to ( GR FNIII ) gp 130 , or of ( 125 ) 1 Tyr 1 , 3 G CSF to ( gp 130 FNIII ) GR , were similar to wild type gp 130 and wild type G CSFR , respectively , ( 125 ) 1 LIF failed to bind with high affinity to ( GR FNIII ) gp 130 . ^^^ In assays measuring differentiation the ( gp 130 FNIII ) GR cells were fully responsive to G CSF , whereas the ( GR FNIII ) gp 130 cells responded fully to the agonistic anti gp 130 monoclonal antibody ( mAb ) B S 12 , but not to IL 6 or LIF . ^^^ Neutralizing mAbs that recognize the membrane proximal FNIII modules of gp 130 or the G CSFR differentially interfered with signalling by B S 12 , LIF and G CSF . ^^^ The data suggest that B S 12 and G CSF induce the correct orientation or conformation for signalling by the wild type and chimaeric homodimeric receptors , that the membrane proximal region of gp 130 is important for the correct formation of the signalling IL 6 IL 6 receptor gp 130 complex and that this region is also involved in LIF dependent receptor heterodimerization and signalling . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukaemia inhibitory factor ( LIF ) and interleukin ( IL ) 6 are members of a cytokine group that share a common signal transducer gp 130 and induce pleiotropic biological effects in cells of diverse lineage . ^^^ LIF and IL 6 receptors , and gp 130 were demonstrated in MDMs by immunocytochemistry and RT PCR . ^^^ Anti LIF receptor and anti gp 130 antibodies attenuated the effect of LIF on TF expression as assayed by both bioassay and flow cytometry . ^^^ Thus , LIF may regulate by a gp 130 dependent pathway macrophage mediated procoagulant function in diverse pathological states involving inflammation and thrombosis and seems to serve as an important mediator at the interface between these processes . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Induction of gp 130 and LIF by differentiation inducers in human myeloid leukemia K 562 cells . ^^^ In the present study , we examined the ability of several differentiation inducers to regulate the expression of the signal transducing receptor component for IL 6 , gp 130 , and cytokine leukemia inhibitory factor ( LIF ) in K 562 cells . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
To investigate the roles of cytokines that act through the gp 130 signaling chain in the residual platelet production of mpl ( / ) mice , mpl ( / ) IL 6 ( / ) , mpl ( / ) LIF ( / ) , and mpl ( / ) IL 11Ralpha ( / ) double mutant mice were generated . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) and interleukin 6 ( IL 6 ) , two cytokines sharing the common gp 130 receptor subunit and functioning through activation of the intracellular JAK / STAT pathway , induce POMC synthesis and ACTH release . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Gp 130 is the common signal transducing receptor subunit of interleukin ( IL ) 6 , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor and cardiotrophin 1 . ^^^ Here we show that a gp 130 mutant lacking domain 1 , although unresponsive to IL 6 and IL 11 , can still activate signal transducer and activator of transcription ( STAT ) transcription factors in response to LIF or OSM . ^^^ Moreover , point mutations in the CBM of gp 130 ( F191E and V252D ) that severely impair signal transduction in response to IL 6 and IL 11 differentially interfere with gp 130 activation in response to LIF and OSM . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The neurally active cytokine leukemia inhibitory factor ( LIF ) signals through a bipartite receptor complex composed of LIF receptor alpha ( LIFR ) and gp 130 . gp 130 and LIFR contain consensus binding motifs for the protein tyrosine phosphatase SHP 2 surrounding tyrosines 118 and 115 ( Y 118 and Y 115 ) of their cytoplasmic domains , respectively . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The receptor for leukemia inhibitory factor ( LIF ) consists of two polypeptides , the LIF receptor and gp 130 . ^^^ We found that gp 130 fusion proteins were phosphorylated exclusively on Ser 782 by LIF and growth factor stimulated 3T3 L 1 cell extracts . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
These results indicated that angiotensin 2 induced IL 6 , LIF , and cardiotrophin 1 in cardiac fibroblasts , and that these cytokines , particularly LIF and cardiotrophin 1 , activated gp 130 linked signaling and contributed to angiotensin 2 induced cardiomyocyte hypertrophy . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Soluble glycoprotein 130 ( gp 130 ) attenuates OSM and LIF induced cartilage proteoglycan catabolism . ^^^ The two cytokines bind with high affinity to the same receptor ( LIF / OSM receptor ) , which consists of the LIF receptor alpha chain ( LIFRalpha ) and the signal transduction unit gp 130 . ^^^ In this study , we sought to determine whether recombinant sgp 130 or anti gp 130 Ab could attenuate the resorption of proteoglycans induced by OSM and LIF in articular cartilage explants . ^^^ The failure of anti gp 130 to attenuate LIF stimulated PG resorption may be due to the normal interaction of LIF with LIFRalpha and unfettered heterodimerization of LIFRalpha with gp 130 in the presence of the antibody . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Gp 130 cytokine receptor is involved in the formation of multimeric functional receptors for interleukin 6 ( IL 6 ) , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ To generate type 1 or type 2 OSM receptors , gp 130 mutants were expressed together with either LIF receptor beta or OSM receptor beta . ^^^ Interestingly , binding of LIF to type 1 receptor was not affected , corroborating the notion that in this case gp 130 mostly behaves as a converter protein rather than a binding receptor . ^^^ The present study demonstrates that positions 189 192 of gp 130 cytokine binding domain are essential for OSM binding to both gp130 / LIF receptor beta and gp130 / OSM receptor beta heterocomplexes . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
HCG release induced by recombinant human OSM was completely blocked by antibodies against OSM and the signal transducer , gp 130 , but only partially inhibited by antibodies against the leukaemia inhibiting factor ( LIF ) receptor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The biological actions of interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophic factor ( CNTF ) are mediated via respective functional receptor complexes consisting of a common signal transducing component , gp 130 , and other specific receptor components , IL 6 receptor alpha ( IL 6R ) , LIF receptor beta ( LIFR ) , and CNTF receptor alpha ( CNTFR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Dependent signalling pathway is not enhanced in gp 130 transgenic heart after LIF stimulation . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The CNTF receptor CNTFRalpha mRNA displayed only small changes , whereas the mRNA for membrane glycoprotein 130 ( gp 130 ) , which is a critical receptor component for LIF and CNTF transduction , was profoundly down regulated in motoneurons after ventral root avulsion . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Acute obstructive cholangiopathy in interleukin 6 deficient mice : compensation by leukemia inhibitory factor ( LIF ) suggests importance of gp 130 signaling in the ductular reaction . ^^^ Leukemia inhibitory factor ( LIF ) , another gp 130 ligand , also showed marked peri biliary upregulation after BDL in both groups , and also induced BEC DNA synthesis , in vitro . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The LIF receptor shares a common gp 130 receptor subunit with the IL 6 cytokine superfamily . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) signals via the heterodimeric receptor complex comprising the LIF receptor alpha subunit ( LIFRalpha ) and the common signal transducing subunit for interleukin 6 cytokine receptors , gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Following earlier findings that OM 85 BV induces the synthesis of IL 6 , a study was undertaken to investigate its possible effect on other gp 130 binding cytokines including IL 11 , IL 12 , leukaemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and ciliary neutrophil factor ( CNTF ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Furthermore , almost no phosphorylated STAT 3 ( signal transducer and activator of transcription 3 ) , downstream of the LIF receptor and the gp 130 signaling subunit , was observed in the ventricles of JVS and control mice . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Gp 130 , a signal transducing receptor component of LIF , was mainly localized in the glandular epithelium . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
All of these cell lines express the receptor components of OSM and leukemia inhibitory factor ( LIF ) gp 130 , LIFR and the OSM specific OSMRbeta . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The cytoplasmic domain of LIF R can generate the signals for growth arrest and differentiation of mouse myeloid leukemic cells when they are induced to form a homodimer of the cytoplasmic domain independently of gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
LIF , LIF receptor , gp 130 , as well as type 1 and 2 T helper cytokine expressions were investigated by reverse transcription polymerasse chain reaction , in situ hybridization , and histological studies . ^^^ The gp 130 expression was only observed in LIF treated B6D2F1 to BALB / c allografting on day 21 posttransplantation . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Western blot analysis showed that bone marrow derived mast cells failed to express both LIF receptor ( LIFR ) and gp 130 , whereas 3T3 fibroblasts expressed both LIFR and gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
IL 6 , but not LIF , similarly promoted gp 130 dependent macrophage chemotaxis . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Signalling of interleukin 6 type cytokines via gp 130 , leukemia inhibitory factor ( LIF ) receptor and oncostatin M receptor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
BACKGROUND : Leukemia inhibitory factor ( LIF ) is a member of the interleukin 6 family of cytokines that utilize gp 130 as a common signaling component . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
LIF , a member of the gp 130 sharing cytokine family , modulates pituitary development , POMC gene expression , and ACTH secretion . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Involving of the cytoplasmic region of leukemia inhibitory factor receptor alpha subunit , IL 6 related signal transducer gp 130 or fas death domain for MAPK p42 / 44 activation in HL 60 cell with LIF or anti Fas IgG . ^^^ The chimeric receptors were prepared by exchanging the cytoplasmic region between leukemia inhibitory factor ( LIF ) receptor alpha subunit ( gp 190 ) and the other subunit gp 130 ( 190 / 130 , 130 / 190 ) and separately transduced into leukemia line HL 60 ( to have the wild type subunit ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Expression of mRNAs for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptors ( CNTFR alpha , LIFR beta , IL 6R alpha , and gp 130 ) in human peripheral neuropathies . ^^^ The mRNA levels of neuropoietic cytokines , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , and interleukin 6 ( IL 6 ) , and their receptor components ( CNTFR alpha , LIFR beta , IL 6R alpha , and gp 130 ) were examined in seventy six patients with various peripheral neuropathies to determine the extent of expression of these cytokines and receptors , and their relationship to nerve fiber pathology and cell infiltration in the diseased nerves . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The mRNAs for LIF / LIFR , IL 6 / IL 6R , and their common signal transduction molecule , gp 130 , in olfactory nasal mucosa from control mice and from 3 day post OBX mice were detected with reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Two of the most potent cytokines regulating anterior pituitary cell function are leukemia inhibitory factor ( LIF ) and interleukin ( IL ) 6 , which belong to the cytokine family using the common gp 130 signal transducer . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The receptor subunit gp 130 transduces multiple cell type specific activities of the leukemia inhibitory factor ( LIF ) / interleukin ( IL ) 6 family of cytokines through the signal transducer and activator of transcription ( STAT ) and src homology 2 domain bearing protein tyrosine phosphatase ( SHP ) 2 / ras / Erk pathways . ^^^ To define STAT dependent physiological responses , we generated mice with a COOH terminal gp 130 ( DeltaSTAT ) `` knock in ' ' mutation which deleted all STAT binding sites . gp 130 ( DeltaSTAT ) mice phenocopyed mice deficient for IL 6 ( impaired humoral and mucosal immune and hepatic acute phase responses ) and LIF ( failure of blastocyst implantation ) . ^^^ Mitogenic hyperresponsiveness of synovial cells to the LIF / IL 6 family of cyto kines was caused by sustained gp 130 mediated SHP 2 / ras / Erk activation due to impaired STAT mediated induction of suppressor of cytokine signaling ( SOCS ) proteins which normally limits gp 130 signaling . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The cytokines that signal through the common receptor subunit gp 130 , including ciliary neurotrophic factor ( CNTF ) , interleukin 6 , leukemia inhibitory factor ( LIF ) and oncostatin M , have pleiotropic functions in CNS development . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The pericryptal fibroblast cells expressed messenger RNA ( mRNA ) for interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , LIF receptor alpha , and the common coreceptor glycoprotein 130 ( GP 130 ) , but not the IL 6 receptor alpha . ^^^ In comparison , normal colonic epithelial cells express mRNA for LIF but not IL 6 as well as the receptors for GP 130 , IL 6 receptor alpha but not LIF receptor alpha . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The receptor for the cytokine leukemia inhibitory factor ( LIF ) associates the low affinity binding component gp 190 and the high affinity converter gp 130 , both of which are members of the family of hematopoietic receptors characterized by the cytokine receptor homology ( CRH ) domain . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The secondary structure of leptin has similarities to the long chain helical cytokines family , which includes interleukin 6 ( IL 6 ) , IL 11 , CNTF , and LIF , and the leptin receptor is homologous to the gp 130 signal transducing subunit of the IL 6 type cytokine receptors . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Binding of LIF to LIF receptor and gp 130 activates signal transduction pathways . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Immunohistochemistry was used to detect leukaemia inhibitory factor ( LIF ) , IL 6 and glycoprotein 130 ( gp 130 ) in myocardial tissues . ^^^ Immunohistochemical analysis localized IL 6 , LIF and their common receptor subunit gp 130 to myocytes and vascular smooth muscle cells . ^^^ Myocardial IL 6 and gp 130 mRNA levels were not statistically different between patients and donors , but in contrast to LIF mRNA expression in heart explants , gp 130 mRNA levels were significantly higher in left atrium compared with left ventricle in both patients and donors . ^^^ CONCLUSIONS : Both mRNA and proteins of gp 130 and its ligands IL 6 and LIF are expressed in both nonfailing and failing human myocardium . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The activity in NKCM was dose dependent and could not be neutralized by an excess of antibodies to IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , gp 130 , stromal cell derived factor 1a ( SDF 1a ) , and thrombopoietin ( TPO ) . ^^^ These findings indicate that IL 2 stimulated NK cells produce a novel peptide , distinct from TPO , IL 6 , IL 11 , LIF , other gp 130 associated interleukins , and SDF1a , that can induce in vitro endomitosis in immature human megakaryocytes in the presence of IL 3 and SCF . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The present study demonstrates an upregulation of both the LIF receptor ( LIFR ) alpha subunit and the signal transducing subunit gp 130 following endothelial denudation of the carotid artery by balloon catheter . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Among the proinflammatory mediators , leukemia inhibitory factor ( LIF ) , which shares a receptor component ( gp 130 subunit ) with interleukin 6 ( IL 6 ) , has been identified as a mast cell growth enhancing factor produced by cells of the keratinocyte derived cell line ( KCMH 1 ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The primary structure of leptin receptor belongs to the cytokine class 1 family , the single membrane spanning receptor , and is highly related to the gp 130 signal transducing component of the interleukin 6 ( IL 6 ) receptor , the granulocyte colony stimulating factor ( G CSF ) receptor , and the leukemia inhibitory factor ( LIF ) receptor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
We examined the expression of CT 1 , leukemia inhibitory factor ( LIF ) , and gp 130 by competitive RT PCR and Western blotting in Dahl salt sensitive ( DS ) rats with a high salt diet , which showed a distinct transition from left ventricular hypertrophy ( LVH ) to congestive heart failure ( CHF ) . ^^^ The expression levels of CT 1 mRNA and protein were significantly increased at the CHF stage compared with the LVH stage and age matched Dahl salt resistant ( DR ) rats ( n = 6 for each group ) . mRNA expression of LIF was not changed in the left ventricle at any stage by RT PCR . gp 130 mRNA and protein levels of DS rats at 11 and 17 wk were significantly increased compared with age matched DR rats . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
This study was designed to identify the presence and action of CT 1 and its receptor complex , glycoprotein 130 ( gp 130 ) and leukemia inhibitory factor ( LIF ) receptor , on cardiac fibroblast growth in cultured adult canine cardiac fibroblasts . ^^^ Blockade of gp 130 or LIF receptor inhibited basal growth as well as CT 1 or ET 1 stimulated cardiac fibroblast growth . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The receptor for the cytokine leukemia inhibitory factor ( LIF ) associates the low affinity binding component gp 190 and the high affinity converter gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In contrast , LIF does not activate STAT 3 , ERK , or the gp 130 receptor in human N tera 2 / D1 EC cells , although all receptor components are expressed . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Oncostatin M can activate two related receptors , one consisting of a low affinity LIF receptor subunit , LIFR beta , which forms a heterocomplex with the gp 130 signal transducing protein and can recognize both oncostatin M and LIF , and a second heterocomplex consisting of a subunit that specifically recognizes oncostatin M , OSMR beta , and the gp 130 protein . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Here , we report the construction and expression of a CNTF / soluble CNTF receptor ( sCNTF R ) fusion protein ( Hyper CNTF ) with enhanced biological activity on cells expressing gp 130 and leukemia inhibitory factor receptor ( LIF R ) , but not membrane bound CNTF R . ^^^ Hyper CNTF efficiently induced dose dependent STAT 3 phosphorylation and proliferation of BAF 3 cells stably transfected with gp 130 and LIF R cDNAs . ^^^ These data indicate that although LIF and Hyper CNTF use the same heterodimeric receptor complex of gp 130 and LIFR , only Hyper CNTF induces neuronal differentiation . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Exposure of these cells to other gp 130 receptor family cytokines , including leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and IL 11 , do not significantly affect DNA synthesis or induction of tPA / PAI 1 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
IL 6 signaling is mediated exclusively by the common signal transducing component gp 130 , which is also essential for signal transduction of other cytokines of the leukemia inhibitory factor ( LIF ) / IL 6 family . ^^^ Synovial cells from this mouse exhibited mitogenic hyper responsiveness to cytokines of the LIF / IL 6 family , a phenomenon that was caused by sustained gp 130 mediated SHP 2 / Ras / Erk activation due to a defect in the induction of SOCS 1 ( suppressor of cytokine signaling 1 ; also known as SSI or JAB ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
A functional role of the membrane proximal extracellular domains of the signal transducer gp 130 in heterodimerization with the leukemia inhibitory factor receptor . gp 130 is the common signal transducing receptor subunit of interleukin ( IL ) 6 type cytokines . gp 130 either homodimerizes in response to IL 6 and IL 11 or forms heterodimers with the leukemia inhibitory factor ( LIF ) receptor ( LIFR ) in response to LIF , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , cardiotrophin 1 ( CT 1 ) or cardiotrophin like cytokine resulting in the onset of cytoplasmic tyrosine phosphorylation cascades . ^^^ Deletion of each of the membrane proximal domains of gp 130 ( Delta 4 , Delta 5 and Delta 6 ) leads to LIF unresponsiveness . ^^^ Replacement of the gp 130 domains by the corresponding domains of the related GCSF receptor either restores weak LIF responsiveness ( D 4 GCSFR ) , leads to constitutive activation of gp 130 ( D 5 GCSFR ) or results in an inactive receptor ( D 6 GCSFR ) . ^^^ Mutation of a specific cysteine in D 5 of gp 130 ( C458A ) leads to constitutive heterodimerization with the LIFR and increased sensitivity towards LIF stimulation . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Immunolocalization of gp 130 , IL 6R , and the LIF receptor showed that the glandular epithelium and also endothelial cells are targets for IL 6 and LIF . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Interleukin ( IL ) 6 , leukaemia inhibitory factor ( LIF ) and IL 11 belong to the same family of cytokines whose receptors utilize gp 130 as the signalling molecule . ^^^ IL 6 receptor , LIF receptor and gp 130 were all expressed by cultured stromal and epithelial cells , showing that the lack of effect is not due to lack of expression of the receptor components . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The aim of this study was to assess the expression and regulation of LIF receptor ( LIFR ) and gp 130 mRNA in mouse uterus during early pregnancy using in situ hybridization and reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In contrast , injection of leukemia inhibitory factor ( LIF ) , a gp 130 ligand , into the lateral cerebral ventricle of wild type embryos exo utero induced hyperplasia of the cerebral cortex and increased the incorporation of BrdU in progenitor cells . ^^^ Furthermore , chronologically controlled injection of LIF followed or preceded by BrdU revealed that gp 130 mediated signals promote the progenitor cells to reenter the stem cell cycle without affecting the duration of cell cycle and enhance the migration of postmitotic neurons in the developing cerebrum . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Continuous treatment with Dex ( 10 ( 8 ) mol / L ) inhibited the endogenous production of IL 6 , LIF , OSM , IL 11R , and OSMR , but had no detectable effect on the expression of IL 11 , CT 1 , CNTF , CNTFR , LIFR , or gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
OBJECTIVE : The development of megakaryocytes is regulated by thrombopoietin ( TPO ) , which binds to the c mpl receptor , and by several other cytokines such as interleukin ( IL ) 6 , IL 11 , leukemia inhibitory factor ( LIF ) , cilliary neurotropic factor ( CNTF ) , and oncostatin ( OSM ) , which bind to gp 130 protein coupled receptors . ^^^ To our surprise , none of the other gp 130 protein related cytokines tested ( IL 11 , LIF , CNTF , and OSM ) activated these signaling pathways in CD34+ cells , megakaryoblasts , or platelets . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Group 1 received only a control vehicle , group 2 received leukemia inhibitory factor ( LIF ) , cDNA treated , group 3 received combined treatment of LIF and anti gp 130 antibody , and group 4 was the anti gp 130 treated group . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Here we show that Cdk 9 interacts with gp 130 , the receptor of the Interleukin 6 ( IL 6 ) family of cytokines , which includes Leukemia Inhibitory Factor ( LIF ) , Oncostatin M ( OSM ) , Ciliary Neurotrophic Factor ( CNTF ) , Interleukin 11 ( IL 11 ) and Cardiotrophin ( CT 1 ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The neurokine leukemia inhibitory factor ( LIF ) initiates signaling through heterodimerization of the low affinity LIF receptor ( LIFR ) and gp 130 . ^^^ Tyrosine 759 of gp 130 is required for the negative regulation of LIF mediated signaling by both the protein tyrosine phosphatase SHP 2 and the suppressor of cytokine signaling 3 ( SOCS 3 ) . ^^^ This indicates that STAT signaling is necessary for LIF and CNTF stimulated VIP and ChAT expression and Y 759 of gp 130 mediates the activities of SHP 2 and SOCS 3 , which act to negatively regulate STAT activity . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Upon binding LIF or cardiotrophin 1 , the LIF receptor alpha subunit ( LIFRalpha ) dimerizes with gp 130 , leading to activation of constitutively associated Jak 1 proteins and LIFRalpha gp 130 tyrosine phosphorylation . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Also , they show no response to the LIF and gp 130 signals , which are widely used to repress spontaneous differentiation of mouse ES cell colonies . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Oncostatin M ( OSM ) is a member of the IL 6 / LIF ( or gp 130 ) cytokine family , and its potential role in inflammation is supported by a number of activities identified in vitro . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
LIF acts on responding cells by binding to a heterodimeric membrane receptor composed of a low affinity LIF specific receptor and the gp 130 receptor chain also used as the receptor for interleukin 6 , oncostatin M , cardiotrophin 1 , and ciliary neurotrophic factor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , interleukin ( IL ) 6 , and IL 11 regulate hemopoiesis and LIF , OSM , and IL 6 also inhibit the proliferation of myeloid leukemic cell lines through the signal transducing subunit gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukaemia inhibitory factor ( LIF ) , a member of the gp 130 cytokine family , is involved in osteoarticular tissue metabolism and might participate in osteogenesis . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Normal human pituitary tissue expressed LIF , as well as the LIF receptor ( LIFR ) signaling subunits , gp 130 and LIFR . ^^^ Although all of 19 prolactinomas tested expressed gp 130 and LIFR subunit mRNA and immunoreactive protein , only 3 of 19 prolactinomas expressed LIF mRNA . ^^^ These results show that even though human prolactinomas express gp 130 and LIFR , and respond to exogenous LIF , albeit less than normal lactotrophs , they are largely devoid of LIF . ^^^ Moreover , PRL suppression by LIF may be mediated by gp 130 and D2R interaction . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Here we studied the expression of cytokines IL 6 , LIF , IL 1beta and TNFalpha and cytokine receptors IL 6R , LIFR and Gp 130 in the rat brain after kainic acid induced status epilepticus using Northern blot analysis and in situ hybridization histochemistry . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The leukemia inhibitory factor ( LIF ) receptor comprises the low affinity binding chain gp 190 and the high affinity converter gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) , cardiotrophin 1 ( CT 1 ) , and oncostatin M ( OSM ) are four helix bundle cytokines acting through a common heterodimeric receptor composed of gp 130 and LIF receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
OBJECTIVE : LIF and its corresponding receptors gp 130 and LIF receptor alpha ( LIFR alpha ) were studied in lymphoid tissue ( LT ) to reveal potential systemic immunoregulatory effects during the course of HIV 1 infection . ^^^ METHODS : LIF , gp 130 , LIFR alpha and HIV 1 replicating cells were identified at the single cell level by immunohistochemistry and quantified by computerized in situ imaging in tonsil and lymph nodes biopsies ( LT ) from patients with primary HIV 1 infection ( PHI ) , chronic HIV 1 infection ( cHI ) , long term non progressors ( LTNP ) and HIV 1 seronegative controls . ^^^ RESULTS : LIF and its receptors , gp 130 and LIFR alpha were significantly ( P < 0 . 005 ) upregulated in LT from PHI patients as compared with HIV 1 seronegative controls . ^^^ LIF receptors , gp 130 and LIFR alpha were significantly upregulated in cHI ( P < 0 . 005 ) but downregulated in LTNP ( P < 0 . 05 and P < 0 . 005 , respectively ) . ^^^ CONCLUSIONS : LIF , gp 130 and LIFR alpha showed increased expression in LT from patients with PHI . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
We further demonstrate that lesion induces upregulation of CNTF related cytokines ( LIF , NNT 1 ) and , interestingly , a more pronounced upregulation of cytokine receptor components ( LIF receptor beta , gp 130 ) and TGFbeta in CNTF deficient animals . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukaemia inhibitory factor ( LIF ) is a gp 130 neurocytokine that is thought to act as an ' injury factor ' , triggering the early injury phenotype within neurons and potentially boosting their regenerative potential after secondary nerve repair . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
We previously demonstrated that interleukin 6 related cytokine , leukemia inhibitory factor ( LIF ) , induced cardiac hypertrophy through gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
HACMs were treated with the gp 130 ligands CT 1 , IL 6 , LIF or OSM and VEGF 1 was determined by a specific ELISA in the conditioned media of these cells . ^^^ RT PCR and Western blot analysis was used in order to detect gp 130 , IL 6 receptor , LIF receptor or OSM receptor specific protein and mRNA in human adult cardiac myocytes and for detection of VEGF 1 specific mRNA in cardiac myocytes after incubation with OSM . ^^^ We detected high levels of mRNA for gp 130 and the OSM receptor in freshly isolated human cardiac myocytes but only low amounts of mRNA for the IL 6 receptor whereas mRNA for the LIF receptor was hardly detectable by RT PCR . ^^^ CONCLUSION : The gp 130 gp130 ligand system is also involved in VEGF regulation in human cardiac myocytes and OSM is the gp 130 ligand responsible for this effect in the human system whereas LIF and CT 1 which had been shown to regulate VEGF expression in mouse and rat cardiac myocytes had no effect . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Results indicated that association of GPL to the intracellular portions of gp 130 , or LIF receptor , allowed the signaling cascade . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) induced cell signaling occurs following sequential binding to the LIF receptor alpha chain ( LIFR ) , then to the gp 130 co receptor used by all members of the interleukin 6 family of cytokines . ^^^ Despite increases in LIFR binding affinity , these mutants did not show any increase in activity as agonists of LIF induced proliferation of Ba / F3 cells expressing human LIFR and gp 130 compared with wild type LIF . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
This PEG peptide conjugate was found to be both an antagonist of LIF LIFR binding and of LIF signaling in engineered Ba / F3 cells expressing LIFR and the gp 130 coreceptor . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Therefore , using the lithium pilocarpine status epilepticus model , we performed a detailed in situ hybridization time course study of five gp 130 cytokines ( interleukin [ IL ] 6 , leukemia inhibitory factor [ LIF ] , IL 11 , oncostatin m [ OSM ] , and ciliary neurotrophic factor ) , gp 130 , and the receptors of the cytokines we found to be induced ( IL 6 receptor [ IL 6R ] , LIF receptor [ LIF R ] , and IL 11 receptor [ IL 11R ] ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Tu11 cells , a subline of the IL 6 dependent human plasma cell line INA 6 expressing gp 130 and the receptor for leukaemia inhibitory factor ( LIF ) , stimulation with BSF 3 induced tyrosine phosphorylation of signal transducer and activator of transcription 3 ( STAT 3 ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Because other members of the IL 6 family such as leukaemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) share gp 130 , the signal transduction subunit of their receptors , interpretation of the data without considering the expression of these cytokines and their specific receptor subunits could be misleading . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
RESULTS : Proliferation by CFU GM and BFU E was enhanced synergistically when common beta chain receptor cytokines ( IL 3 or GM CSF ) were combined with G CSF or EPO , but not with gp 130 receptor cytokines ( LIF or IL 6 ) or tyrosine kinase receptor cytokines ( SCF , HGF , Flt 3 ligand , or PDGF ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Patients with heart failure have increased cardiac gene expression of leukaemia inhibitory factor ( LIF ) , a cytokine that signals through the gp 130 receptor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
We have determined the crystal structure of human leukemia inhibitory factor ( LIF ) bound to the cytokine binding region ( CHR ) of gp 130 at 2 . 5 A resolution . ^^^ Strikingly , we find that the shared binding site on gp 130 has an entirely rigid core , while the LIF binding interface diverges sharply in structure and chemistry from that of other gp 130 ligands . ^^^ Dissection of the LIF gp 130 interface , along with comparative studies of other gp 130 cytokines , reveal that gp 130 has evolved a `` thermodynamic plasticity ' ' that is relatively insensitive to ligand structure , to enable crossreactivity . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Thermal control of adhesion is maintained in IL 6 deficient mice through a gp 130 dependent compensatory mechanism mediated by IL 6 related cytokines ( i . e . , oncostatin M [ OSM ] , leukemia inhibitory factor [ LIF ] , and IL 11 ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The fixed samples were prepared for a study of immunocytochemical staining of LIF and its two receptor units ( LIF R and gp 130 ) . mRNA was extracted from the frozen ovarian samples , and the expression of LIF , LIF R and gp 130 was investigated by RT PCR . ^^^ There was strong to moderate immunocytochemical staining for LIF and LIF R in oocytes from the primordial follicular stages onwards , and very weak to moderate staining for gp 130 . ^^^ Transcripts of LIF , LIF R and gp 130 RNA were identified by RT PCR in all samples . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) signals via a tripartite receptor complex consisting of the glycosyl phosphatidylinositol ( GPI ) anchored CNTF receptor ( CNTF R ) , the leukaemia inhibitory factor receptor ( LIF R ) and the interleukin 6 ( IL 6 ) signal transducer gp 130 . ^^^ Whereas the CNTF R cofractionated quantitatively with lipid rafts independently of the method used , gp 130 and the LIF R were found to associate with lipid rafts only partially when detergents were used for isolation . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
OB R is a single membrane spanning receptor most related to the gp 130 signal transducing component of the IL 6 receptor , the G CSF receptor , and the LIF receptor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
While the expression of many of the markers was similar in mouse and human cells , significant differences were found in the expression of vimentin , beta 3 tubulin , alpha fetoprotein , eomesodermin , HEB , ARNT , and FoxD 3 as well as in the expression of the LIF receptor complex LIFR / IL6ST ( gp 130 ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
We show here that neural precursor cells isolated from embryonic rat cortices abundantly secrete leukemia inhibitory factor ( LIF ) and express its receptor components , gp 130 and LIF receptor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Human ES cells express LIF , IL 6 , and gp 130 receptors , as well as the downstream signaling molecules . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
IL 6 has many overlapping biological effects with the related gp 130 cytokines LIF and OSM that can be explained by the shared usage of the signalling receptor , gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Here , we demonstrate that the stimulation of gp 130 with leukemia inhibitory factor ( LIF ) promoted cell adhesion in a cadherin dependent manner in cultured cardiomyocytes . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In this study , we show that the LIFRbeta and the signaling subunit gp 130 are expressed in hESCs and that human LIF can induce STAT 3 phosphorylation and nuclear translocation in hESCs . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The leukemia inhibitory factor ( LIF ) / glycoprotein 130 ( gp 130 ) / signal transducer and activator of transcription 3 ( STAT 3 ) pathway plays an essential role in the maintenance of self renewal and pluripotency in mouse embryonic stem ( ES ) cells . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
To date , more than 10 different four helix bundle ligands have been identified that incorporate gp 130 , or one of its close relatives such as LIF receptor , into functional oligomeric signaling complexes . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The relationship between circulating C reactive protein concentrations and potential cytokine and receptor mediators ( interleukin 6 , leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) , soluble IL 6 receptor , soluble gp 130 , soluble TNF receptor , interleukin 1 receptor antagonist and interleukin 8 ( IL 8 ) ) of this acute phase protein were examined in healthy subjects ( n=11 ) and patients with non small cell lung cancer ( n=50 ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Signalling of leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) , cardiotrophin 1 ( CT 1 ) , CT 1 like factor ( CLC ) or oncostatin M ( OSM ) through gp130 / LIF R is believed to be similar due to the presence of the common signal transducer gp 130 within the receptor complexes utilized , but the difference in the composition of gp130 / gp130 homodimers and gp130 / LIF R heterodimers is likely to be reflected in different signalling . ^^^ The inhibitory tyrosine motifs within the cytoplasmic parts of gp 130 and the LIF R act independently . ^^^ Whereas SHP 2 and SOCS 3 bind directly to the inhibitory motif of gp 130 , only SHP 2 was found to bind to the corresponding inhibitory sequence of the LIF R . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor receptor and gp 130 were expressed in neurons , and the ischemic damage of these proteins was rescued in the high LIF group . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
LIF acts on cells by binding to the LIF receptor ( LIFR ) and gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Using a dominant negative LIF mutant ( hLIF 05 ) , we showed that in RC cell cultures mouse OSM ( mOSM ) activates exclusively glycoprotein 130 ( gp 130 ) / OSMR . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The mRNA levels of IL 6 , leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotrophin 1 ( CT 1 ) as well as their receptor subunits , glycoprotein 130 ( gp 130 ) , IL 6 receptor ( IL 6R ) , LIFR , and CNTFR , were measured by semi quantitative RT PCR . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Gene activities of cytokines and their receptors interleukin ( IL ) 6 , leukemia inhibitory factor ( LIF ) , IL 11 and IL 6 receptor ( IL 6 R ) , LIF receptor and gp 130 relevant to implantation revealed a 17 beta estradiol ( E 2 ) mediated up regulation of IL 6 and an E 2 and P 4 mediated up regulation of IL 6 R in hTERT EECs . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In addition also the other gp 130 ligands tested , cardiotrophin 1 ( CT 1 ) , interleukin 6 ( IL 6 ) and leukemia inhibitory factor ( LIF ) had no effect on the expression of TIMPs and MMPs studied . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) is a member of the gp 130 cytokine family and signals through the receptor complex of gp 130 and the LIF receptor ( LIFR ) to activate the JAK / STAT signaling cascade . ^^^ These findings indicate that LIF has similar and distinct effects in comparison with the effects of other gp 130 cytokines on cultured fat cells . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
PURPOSE : Activating ligands of gp 130 , including leukemia inhibitory factor ( LIF ) , can block differentiation and function of retinal neurons . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) is a pleiotropic cytokine belonging to the gp 130 family . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Inhibition of MEKI and MEKII using the drug U 0126 and stimulation of gp 130 signaling by elevating the level of LIF present gave rise to ES like lines in 22 . 6 % of explants . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Of known importance are members of the gp 130 family such as interleukin 11 ( IL 11 ) and leukaemia inhibitory factor ( LIF ) , the transforming growth factor beta ( TGFbeta ) superfamily including the activins , the colony stimulating factors ( CSF ) , the IL 1 system and IL 15 system . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The receptor for leukemia inhibitory factor ( LIF ) consists of two polypeptides , the low affinity LIF receptor ( LIFR ) and gp 130 . ^^^ We previously demonstrated that LIF stimulation caused phosphorylation of gp 130 at Ser 782 , adjacent to a dileucine internalization motif , and that transient expression of a mutant receptor lacking Ser 782 resulted in increased cell surface expression and increased LIF stimulated gene expression compared to wild type receptor . ^^^ Phosphorylation of Ser 782 on gp 130 fusion protein by LIF stimulated 3T3 L 1 cell extracts was inhibited 61 % by autocamtide 2 related inhibitory peptide ( AIP ) , a highly specific and highly effective inhibitor of calmodulin dependent protein kinase type 2 ( CaMKII ) . ^^^ Furthermore , antibodies targeting CaMKII and CaMKIV were able to immunoprecipitate gp 130 phosphorylating activity from LIF stimulated 3T3 L 1 lysates . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Our results indicate that a subset of gp 130 cytokines , in particular CT 1 , LIF , and OSM , has the ability to impair subsequent signaling activity initiated by gp 130 cytokines . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
LIF binds to a receptor complex of LIFR beta and gp 130 and signals via the Janus kinase signal transducer and activator of transcription ( JAK STAT ) pathway , with signalling attenuated by suppressor of cytokine signalling ( SOCS ) proteins . ^^^ The absence of SOCS 3 enhanced JAK STAT and extracellular signal related kinase 1 / 2 ( ERK 1 / 2 ) mitogen activated protein kinase ( MAPK ) signal transduction via gp 130 , with higher levels of phosphorylated STAT 1 , STAT 3 , SH 2 domain containing cytoplasmic protein tyrosine phosphatase 2 ( SHP 2 ) , and ERK 1 / 2 in steady state and in response to LIF stimulation . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) belongs to the interleukin 6 cytokine family , all members of which signal through the common gp 130 receptor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) signals through gp 130 homodimers whereas leukaemia inhibitory factor ( LIF ) exerts its action through a heterodimer of gp 130 and the LIF receptor ( LIFR ) . ^^^ However , FRET between YFP tagged gp 130 and CFP tagged LIFR considerably increased upon LIF stimulation . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
LIF and other cytokines acting via the gp 130 signal transducing receptor have been reported to decrease obesity . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Evidence for heterodimeric association of leukemia inhibitory factor ( LIF ) receptor and gp 130 in the mouse uterus for LIF signaling during blastocyst implantation . ^^^ Here we have provided evidence that major cell types expressing theLIF receptor ( LIFR ) and its signal transducing partner gp 130 are mostly disparate in the mouse uterus during the glandular LIF expression in the morning of day 4 . ^^^ In contrast , LIFR and gp 130 expressions overlap in the luminal epithelium at the time of blastocyst attachment on the evening of day 4 when the second phase of LIF expression occurs in stromal cells surrounding the blastocyst , suggesting that LIF participates in implantation in a paracrine manner . ^^^ Coimmunoprecipitation experiments showed that LIFR and gp 130 form heterodimers and are available for LIF signaling at the time of blastocyst attachment . ^^^ Collectively , our results have provided evidence that LIFR and gp 130 form a functional heterodimer in the uterus during the attachment reaction to direct LIF signaling . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
LIF activates the JAK STAT 3 pathway through the class 1 cytokine receptor gp 130 , which forms a trimeric complex with LIF and the class 1 cytokine receptor LIF receptor beta . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
To investigate gp 130 dimerization , we performed co precipitation experiments with the endogenous cytokine receptors gp 130 and leukemia inhibitory factor receptor ( LIF R ) and with gp 130 variants carrying two different C terminal peptide tags . ^^^ Confocal laser scanning microscopy was used for FRET detection in live cells . gp 130 and LIF R could be coprecipitated in the absence of ligand . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Immunohistochemistry was used to assay LIF , LIF receptor , and gp 130 protein expression . ^^^ RESULT ( S ) : The expression of LIF , LIF receptor , and gp 130 messenger RNA and protein was increased in spontaneously differentiated HS 237 cells compared with undifferentiated cells , with high expression of an inhibitor of LIF mediated signaling , suppressor of cytokine signaling 1 , in undifferentiated hESCs . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Other cytokines such as leukemia inhibitory factor , oncostatin M and ciliary neurotrophic factor have also been shown to utilize gp 130 as a signal transducer . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : We studied the expression of LIF and its receptor components , LIF receptor beta and gp 130 , by immunohistochemistry , western blotting and RT PCR in normal rat pancreas , pancreas with duct ligation induced islet neogenesis , and in pancreatic cell cultures . ^^^ Both LIF receptor beta and gp 130 were detected by RT PCR in the pancreas . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Tyrosine phosphorylation was also observed in response to other cytokines , such as leukemia inhibitory factor , oncostatin M , and ciliary neurotrophic factor , whose receptors share the IL 6 receptor signal transducer gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The tyrosine kinase activity of the 72 kD molecule was enhanced by the stimulation through an IL 6 signal transducer , gp 130 , that was shared among the receptors for the IL 6 related cytokine subfamily , such as leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotrophic factor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The receptor for granulocyte colony stimulating factor ( G CSFR ) and chimeric receptors consisting of the extracellular domain of G CSFR and the transmembrane and cytoplasmic domain of the leukemia inhibitory factor receptor , gp 130 , or c mpl function as homodimeric complexes . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Activation of Fes tyrosine kinase by gp 130 , an interleukin 6 family cytokine signal transducer , and their association . gp 130 is a signal transducing subunit of receptors for the interleukin 6 ( IL 6 ) related cytokine subfamily including IL 6 , leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotrophic factor , indicating that gp 130 mediated signals are involved in the immune response , hematopoiesis , inflammation , and endocrine and nervous system activity . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Using c raf antisense oligonucleotides to block Raf 1 expression , we have established that Raf 1 is required for hematopoietic growth factor induced proliferation of murine cell lines stimulated by growth factors whose receptors are members of several different structural classes : ( a ) the hematopoietin receptor family , including interleukin ( IL ) 2 , IL 3 , IL 4 , granulocyte colony stimulating factor , granulocyte / macrophage colony stimulating factor ( GM CSF ) , and erythropoietin ; ( b ) the tyrosine kinase receptor class , including Steel factor and CSF 1 ; and ( c ) IL 6 , leukemia inhibitory factor , and oncostatin M , whose receptors include the gp 130 receptor subunit . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor , oncostatin M , leukemia inhibitory factor , and interleukin 6 are related cytokines that initiate signaling by homodimerizing the signal transducing receptor component gp 130 or by heterodimerizing gp 130 with a gp 130 related receptor component . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Here we present data indicating that gp 130 functions as a common signal transducer for IL 6 , oncostatin M , leukemia inhibitory factor , and ciliary neurotrophic factor . ^^^ Since leukemia inhibitory factor functions as a cholinergic differentiation factor in nerve cells , as does ciliary neurotrophic factor , these results suggest that gp 130 may also play a role in the nervous system . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
These cytokines initiate signaling by inducing either homodimerization of gp 130 or heterodimerization of gp 130 with leukemia inhibitory factor receptor beta components . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The low affinity receptor for leukemia inhibitory factor ( LIFR ) interacts with gp 130 to induce an intracellular signal cascade . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
It is a member of the hemopoietin receptor superfamily and is most closely related over its entire length to gp 130 and the receptors for granulocyte CSF ( G CSF ) and leukemia inhibitory factor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
These factors all activate gp 130 associated signaling processes , as does the previously characterized ES cell maintenance factor Differentiation Inhibiting Activity ( Leukemia Inhibitory Factor ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In conclusion , IL 11 , along with IL 6 , leukemia inhibitory factor , oncostatin M and ciliary neurotrophic factor , belongs to the same family of cytokines , using gp 130 as a transducing protein . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
B 9 11 cells responded only to human IL 11 and IL 6 and not to other human cytokines using the same gp 130 transducer chain ( ciliary neurotrophic factor , leukemia inhibitory factor and oncostatin M ) or to other human interleukins ( interleukin 1 to interleukin 13 ) , human hematopoietic cytokines ( granulocyte colony stimulating factor , granulocyte macrophage colony stimulating factor , colony stimulating factor 1 ) and various other human cytokines ( interferon alpha , tumor necrosis factor alpha , tumor necrosis factor beta , fibroblast growth factor and nerve growth factor ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The interleukin 6 receptor associated signal transducer , gp 130 , is shared by receptor complexes for leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and interleukin 11 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Interleukin 6 , leukemia inhibitory factor , and oncostatin M exert a broad range of similar biological activities through association of their receptors with the signal transducing component gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) , leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotropic factor are a family of cytokines and neuronal differentiation factors which bind to composite plasma membrane receptors sharing the signal transducing subunit gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Factors such as IL 11 , oncostatin M , and leukemia inhibitory factor , which are known to exert their functions through gp 130 ( the signal transducing chain of IL 6R ) , also induced MNC formation in our coculture system . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) , leukemia inhibitory factor , oncostatin M , interleukin 11 , and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Recently , gp 130 has been shown to be involved in the signaling processes of oncostatin M , leukemia inhibitory factor , and ciliary neurotropic factor , in addition to those of IL 6 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Interestingly , in leukemia inhibitory factor , another cytokine that signals through gp 130 , site 3 , is topologically conserved but has evolved to bind leukemia inhibitory factor receptor . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Other growth factor ligand and receptor transcripts were expressed in a stage specific manner : these included receptors for interleukin ( IL ) 6 ( IL 6R ) , leukemia inhibitory factor ( LIFR ) , tumor necrosis factor alpha ( TNF alpha ) ( TNFRp 80 and TNFRp 60 ) , and gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Targeted disruption of gp 130 , a common signal transducer for the interleukin 6 family of cytokines , leads to myocardial and hematological disorders . gp 130 is a ubiquitously expressed signal transducing receptor component shared by interleukin 6 , interleukin 11 , leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In contrast , when IL 6 or leukemia inhibitory factor ( two other cytokines that share gp 130 receptor components with OM ) were used in a similar fashion in combination with IL 1 alpha , neither cytokine consistently altered the IL 1 induced levels of IL 8 , GM CSF , or IL 6 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Anti gp 130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor , interleukin 6 , interleukin 11 , leukemia inhibitory factor or oncostatin M . ^^^ Five cytokines activate the gp 130 IL 6 transducer : ciliary neurotrophic factor , interleukin 6 , interleukin 11 , leukemia inhibitory factor and oncostatin M . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
This was borne out in cellular assays since the extract inhibited activation of HepG 2 cells stimulated with oncostatin M or leukemia inhibitory factor , cytokines which also use gp 130 for signal transduction . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Gp 130 transducing protein was shown to be involved in the formation of the high affinity receptors for interleukin 6 ( IL 6 ) , interleukin 11 ( IL 11 ) , leukemia inhibitory factor , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , and cardiotrophin 1 . ^^^ The B R 3 pan blocking antibody weakly interfered with the binding of the radiolabeled ligands ( with the exception of OSM , whose binding was abrogated in the presence of B R 3 monoclonal antibody ) but inhibited the gp 130 homodimerization or its association with gp190 / leukemia inhibitory factor receptor , as well as the subsequent tyrosine phosphorylation events . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The high affinity receptor for interleukin 11 ( IL 11 ) is composed of two subunits , IL 11 receptor alpha chain ( IL 11R alpha ) and gp 130 , the common subunit of the interleukin 6 ( IL 6 ) , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor , and oncostatin M receptors . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) drives the sequential assembly of a receptor complex containing the ligand specific alpha receptor subunit ( CNTFR alpha ) and the signal transducers gp 130 and leukemia inhibitory factor receptor beta ( LIFR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Some cytokines that stimulate megakaryopoiesis ( IL 6 , IL 11 , leukemia inhibitory factor , and oncostatin M ) bind to receptors that use gp 130 as a signal transduction subunit . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) associates with an alpha subunit ( CNTFRalpha ) of the receptor complex to initiate signal transduction by facilitating heterodimerization of the gp 130 transducing protein and the leukemia inhibitory factor receptor ( LIFR ) beta . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
It is composed of a four helix bundle structure and shares the transmembrane signal transducing proteins , glycoprotein 130 ( gp 130 ) and leukemia inhibitory factor receptor ( LIF R ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The interleukin 6 ( IL 6 ) family of cytokines activates signaling through the formation of either gp 130 homodimers , as for IL 6 , or gp 130 leukemia inhibitory factor receptor ( LIFR ) heterodimers as for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor , oncostatinM , and cardiotrophin 1 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
This newly identified huIL 12R subunit is a member of the cytokine receptor superfamily , with closest resemblance to the beta type cytokine receptor gp 130 and the receptors for leukemia inhibitory factor and granulocyte colony stimulating factor . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Cardiotrophin 1 ( CT 1 ) is a member of the gp 130 family of cytokines that includes interleukin 6 , interleukin 11 , ciliary neurotrophic factor , leukemia inhibitory factor , and oncostatin M . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
IL 6 belongs to a family of related cytokines that includes leukemia inhibitory factor , oncostatin M , IL 11 , ciliary neurotropic factor , and cardiotropin 1 , all of which initiate signaling through a receptor associated gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Box 3 independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha and gp 130 mediated stimulation of mitogen activated protein kinase . ^^^ Chimeric receptors containing the entire or various cytoplasmic domains of either gp 130 or leukemia inhibitory factor receptor alpha ( LIFR ) were used to identify signaling molecules and regions of these polypeptides required for the stimulation of mitogen activated protein kinase ( MAPK ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) drives the sequential assembly of a receptor complex containing the ligand specific alpha receptor subunit ( CNTFR ) and the signal transducing beta subunits gp 130 and leukemia inhibitory factor receptor beta ( LIFR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The gp 130 cytokines leukemia inhibitory factor and interleukin 6 are neuroactive cytokines associated with peripheral nerve injury . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor , which is one of the cytokines and has the common receptor subunit gp 130 , activated MAP kinase and the response was completely blocked by pretreatment of the Atg / cardiac myocytes with RX 435 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Other cytokines that activate gp 130 as a common signal transducer , IL 6 and leukemia inhibitory factor , did not have such effects . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The pleiotrophic but overlapping functions of the cytokine family that includes interleukin ( IL ) 6 , IL 11 , leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 are mediated by the cytokine receptor subunit gp 130 as the common signal transducer . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The receptor gp 130 is utilized by cytokines including interleukin 6 , leukemia inhibitory factor , oncostatin M , cilary neurotrophic factor and cardiotrophin . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Glycoprotein 130 ( gp 130 ) belongs to the family of class 1 cytokine receptors and is the common signal transducing receptor subunit shared by the so called IL 6 type cytokines ( IL 6 , IL 11 , ciliary neurotrophic factor , leukemia inhibitory factor , oncostatin M , and cardiotrophin 1 ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor action is mediated by a heterodimeric receptor consisting of two subunits , gp 130 and the low affinity leukemia inhibitory factor receptor ( LIFR ) . 2 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor is a member of a family of structurally related cytokines sharing the receptor component gp 130 . ^^^ Activation of gp 130 by leukemia inhibitory factor is sufficient to induce myocardial cell hypertrophy accompanied by specific changes in the pattern of gene expression . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Leukemia inhibitory factor , Interleukin 6 , and other cytokines using the GP 130 transducing receptor : roles in inflammation and injury . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Cardiotrophin 1 ( CT 1 ) is a recently discovered member of the gp 130 cytokine family , which includes IL 6 , IL 11 , leukemia inhibitory factor , ciliary neurotrophic factor , and oncostatin M . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
To assess the existence of IL 6 receptor complex ( including IL 6R and gp 130 ) with the treatment of PG cells by use of recombinant human IL 6 ( rhIL 6 ) , recombinant human oncostatin M ( rhOSM ) , and recombinant human leukemia inhibitory factor ( rhLIF ) , respectively . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Developmental requirement of gp 130 signaling in neuronal survival and astrocyte differentiation . gp 130 is a signal transducing receptor component used in common by the interleukin 6 ( IL 6 ) family of hematopoietic and neurotrophic cytokines , including IL 6 , IL 11 , leukemia inhibitory factor , ciliary neurotrophic factor , oncostatin M , and cardiotrophin 1 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In contrast , N terminal modification of the sgp 130 with the FLAG epitope did not interfere with the binding of leukemia inhibitory factor or oncostatin M ( other cytokines that signal through gp 130 ) to sgp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
We measured plasma levels of interleukin ( IL ) 1beta , IL 6 , tumor necrosis factor alpha ( TNF alpha ) , soluble forms of the cytokine receptor proteins gp 130 and leukemia inhibitory factor receptor ( LIF R ) , the anti inflammatory Clara cell 16 kD protein ( CC 16 ) , prolactin ( PRL ) , cortisol and 17beta estradiol in 21 anorexic women , 21 bulimic women and 21 healthy females . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NNT 1 / BSF 3 induces tyrosine phosphorylation of glycoprotein 130 ( gp 130 ) , leukemia inhibitory factor receptor beta , and signal transducer and activator of transcription 3 in the SK N MC human neuroblastoma cells . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Serum concentrations of interleukin 6 ( IL 6 ) , IL 6 receptor ( IL 6R ) , gp 130 ( the IL 6 signaling protein ) , IL 1R antagonist ( IL 1RA ) and leukemia inhibitory factor receptor ( LIFR ) were assayed in 22 nonpregnant women and in 91 pregnant women before delivery and 1 and 3 days after delivery . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Two of the most potent cytokines regulating anterior pituitary cell function are leukemia inhibitory factor and interleukin 6 ( IL 6 ) , which belong to the cytokine receptor family using the common gp 130 signal transducer . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Using neutralizing antibodies to gp 130 , the OSM receptor ( OSMR ) , and the leukemia inhibitory factor receptor ( LIFR ) , we document that OSM exclusively uses the OSMR / gp 130 heterodimer in signaling events , rather than the LIFR / gp 130 heterodimer . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The Y 759 motif in gp 130 also attenuates gene induction mediated by the oncostatin M and leukemia inhibitory factor receptor complexes , which both contain gp 130 as the shared subunit . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Its receptor complex consists of a non signaling alpha chain , CNTFR , and two signaling beta chains , gp 130 and the leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Its receptor complex consists of a ligand binding component , CNTF receptor ( CNTFR ) , associated with two signaling receptor components , gp 130 and leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
For signal transduction , CNTF requires a receptor complex , composed of the IL 6 signal transducing molecule gp 130 , leukemia inhibitory factor receptor ( LIFR ) beta , and CNTFR alpha . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Flow cytometric analyses detected both the OSM specific receptor and the gp 130 receptor at the chondrocyte cell surface , but failed to detect the leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Oncostatin M regulates the synthesis and turnover of gp 130 , leukemia inhibitory factor receptor alpha , and oncostatin M receptor beta by distinct mechanisms . ^^^ The cytokine receptor subunits gp 130 , leukemia inhibitory factor receptor alpha ( LIFRalpha ) , and oncostatin M receptor beta ( OSMRbeta ) transduce OSM signals that regulate gene expression and cell proliferation . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Using RT PCR we detected transcripts of the receptor components involved in OSM signaling , gp 130 , OSM receptor ( OSMR ) beta , and leukemia inhibitory factor receptor ( LIFR ) , in HCEC . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
We demonstrated expression of three components of the OSM receptor ; gp 130 , the leukemia inhibitory factor receptor ( LIFRbeta ) and the OSM specific receptor ( OSMRbeta ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The functional receptor complex of CNTF is composed of the CNTF receptor alpha ( CNTFR ) , gp 130 and the leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
We show that these clones display IL 6 and leukemia inhibitory factor receptors with reduced binding affinities and express gp 130 at reduced levels . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
METHODS AND RESULTS : This study was designed to determine left ventricular expression of CT 1 and its glycoprotein 130 ( gp 130 ) / leukemia inhibitory factor receptor complex in human end stage heart failure due to ischemic and dilated cardiomyopathy . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
In addition to CNTF , the mRNAs of leukemia inhibitory factor , interleukin 6 , ciliary neurotrophic factor receptor component alpha and gp 130 were detected in the Schwann cells . . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Novel neurotrophin 1 / B cell stimulating factor 3 ( NNT 1 / BSF 3 ) is a recently cloned gp 130 cytokine , acting through the tripartite ciliary neurotrophic factor receptor ( CNTFR ) alpha / leukemia inhibitory factor receptor ( LIFR ) / gp130 receptor complex . ^^^ Using RT PCR , expression of ciliary neurotrophic factor receptor alpha , leukemia inhibitory factor receptor , and gp 130 could be demonstrated in mRNA derived from murine corticotroph AtT 20 cells and murine pituitary tissue . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Human CNTF elicits cellular responses by induction of a receptor complex consisting of the CNTF alpha receptor ( CNTFR ) , which is not involved in signal transduction , and the beta receptors gp 130 and leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
The functional receptor complex of ciliary neurotrophic factor ( CNTF ) , a member of the gp 130 family of cytokines , is composed of CNTF , the CNTF receptor alpha ( CNTFR ) , gp 130 , and the leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
OnM induced desensitization also prevents responses to other gp 130 signaling cytokines ( e . g . leukemia inhibitory factor and interleukin 11 ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
A chimeric receptor ( 130 / 190 ) containing the cytoplasmic region of leukemia inhibitory factor receptor alpha subunit ( LIFRalpha , or gp 190 ) and the extracellular transmembrane region of gp 130 was generated . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
It acts through a membrane receptor complex comprising CNTF receptor alpha component ( CNTFRalpha ) , gp 130 , and leukemia inhibitory factor receptor to activate signal transducer and activator of transcription 3 signaling pathway . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
CNTF mediates its function by activating a tripartite receptor comprising the CNTF receptor alpha chain ( CNTFRalpha ) , the leukemia inhibitory factor receptor beta chain ( LIFRbeta ) and gp 130 . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
RESULTS : 22Rv1 cells express both subunits of the IL 6 receptor ( gp 80 and gp 130 ) and leukemia inhibitory factor receptor beta ( LIFR beta ) but not OSMR beta . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) forms a functional receptor complex containing the CNTF receptor , gp 130 , and the leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and Q17RA0	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.62473489
We also demonstrate a rapid and transient increase in Hck tyrosine kinase activity in parental ES cells stimulated by LIF and , finally , show that Hck is physically associated with gp 130 , an affinity converter and signal transducing component of the LIF receptor . 0.62473489^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.56758369
Residues in human leukemia inhibitory factor ( hLIF ) crucial for binding to both the human LIF receptor ( R ) and gp 130 were identified by analysis of alanine scanning mutants of hLIF in assays for both receptor binding and bioactivity . 0.56758369^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.73243206
In the present study , we investigated potential interactions between gp 130 dependent and AII signaling pathways , by examining AII regulation of LIF induced anti apoptotic effect and STAT 3 activation in cardiac myocytes . 0.73243206^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.75910522
After activation of gp 130 with leukemia inhibitory factor ( LIF ) , expression of VEGF mRNA rapidly increased with a peak at 3 h in cultured cardiac myocytes . 0.75910522^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.50960087
Since LIF together with LIFRalpha appear to form a more stable complex with gp 130 than OSM with gp 130 and OSMRbeta , co activation of LIFR and OSMR resulted in a predominant LIF like response . 0.50960087^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.58521356
The truncated forms of LIFR alpha subunit ( gp190EX ) and gp 130 ( gp130EX ) which can compete with the wild type receptor for binding to leukemia inhibitory factor ( LIF ) were expressed on the membrane of U 937 cells . 0.58521356^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The aim of this study was to assess the expression and regulation of LIF receptor ( LIFR ) and gp 130 mRNA in mouse uterus during early pregnancy using in situ hybridization and reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ Expression of leukemia inhibitory factor receptor and gp 130 in mouse uterus during early pregnancy . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
METHODS AND RESULTS : This study was designed to determine left ventricular expression of CT 1 and its glycoprotein 130 ( gp 130 ) / leukemia inhibitory factor receptor complex in human end stage heart failure due to ischemic and dilated cardiomyopathy . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Here we show that Cdk 9 interacts with gp 130 , the receptor of the Interleukin 6 ( IL 6 ) family of cytokines , which includes Leukemia Inhibitory Factor ( LIF ) , Oncostatin M ( OSM ) , Ciliary Neurotrophic Factor ( CNTF ) , Interleukin 11 ( IL 11 ) and Cardiotrophin ( CT 1 ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The neurokine leukemia inhibitory factor ( LIF ) initiates signaling through heterodimerization of the low affinity LIF receptor ( LIFR ) and gp 130 . ^^^ Tyrosine 759 of gp 130 is required for the negative regulation of LIF mediated signaling by both the protein tyrosine phosphatase SHP 2 and the suppressor of cytokine signaling 3 ( SOCS 3 ) . ^^^ This indicates that STAT signaling is necessary for LIF and CNTF stimulated VIP and ChAT expression and Y 759 of gp 130 mediates the activities of SHP 2 and SOCS 3 , which act to negatively regulate STAT activity . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Upon binding LIF or cardiotrophin 1 , the LIF receptor alpha subunit ( LIFRalpha ) dimerizes with gp 130 , leading to activation of constitutively associated Jak 1 proteins and LIFRalpha gp 130 tyrosine phosphorylation . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Also , they show no response to the LIF and gp 130 signals , which are widely used to repress spontaneous differentiation of mouse ES cell colonies . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Oncostatin M ( OSM ) is a member of the IL 6 / LIF ( or gp 130 ) cytokine family , and its potential role in inflammation is supported by a number of activities identified in vitro . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
LIF acts on responding cells by binding to a heterodimeric membrane receptor composed of a low affinity LIF specific receptor and the gp 130 receptor chain also used as the receptor for interleukin 6 , oncostatin M , cardiotrophin 1 , and ciliary neurotrophic factor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , interleukin ( IL ) 6 , and IL 11 regulate hemopoiesis and LIF , OSM , and IL 6 also inhibit the proliferation of myeloid leukemic cell lines through the signal transducing subunit gp 130 . ^^^ Leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , interleukin ( IL ) 6 , and IL 11 regulate hemopoiesis and LIF , OSM , and IL 6 also inhibit the proliferation of myeloid leukemic cell lines through the signal transducing subunit gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukaemia inhibitory factor ( LIF ) , a member of the gp 130 cytokine family , is involved in osteoarticular tissue metabolism and might participate in osteogenesis . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Normal human pituitary tissue expressed LIF , as well as the LIF receptor ( LIFR ) signaling subunits , gp 130 and LIFR . ^^^ Although all of 19 prolactinomas tested expressed gp 130 and LIFR subunit mRNA and immunoreactive protein , only 3 of 19 prolactinomas expressed LIF mRNA . ^^^ These results show that even though human prolactinomas express gp 130 and LIFR , and respond to exogenous LIF , albeit less than normal lactotrophs , they are largely devoid of LIF . ^^^ Moreover , PRL suppression by LIF may be mediated by gp 130 and D2R interaction . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Here we studied the expression of cytokines IL 6 , LIF , IL 1beta and TNFalpha and cytokine receptors IL 6R , LIFR and Gp 130 in the rat brain after kainic acid induced status epilepticus using Northern blot analysis and in situ hybridization histochemistry . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The leukemia inhibitory factor ( LIF ) receptor comprises the low affinity binding chain gp 190 and the high affinity converter gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In addition to CNTF , the mRNAs of leukemia inhibitory factor , interleukin 6 , ciliary neurotrophic factor receptor component alpha and gp 130 were detected in the Schwann cells . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Novel neurotrophin 1 / B cell stimulating factor 3 ( NNT 1 / BSF 3 ) is a recently cloned gp 130 cytokine , acting through the tripartite ciliary neurotrophic factor receptor ( CNTFR ) alpha / leukemia inhibitory factor receptor ( LIFR ) / gp130 receptor complex . ^^^ Using RT PCR , expression of ciliary neurotrophic factor receptor alpha , leukemia inhibitory factor receptor , and gp 130 could be demonstrated in mRNA derived from murine corticotroph AtT 20 cells and murine pituitary tissue . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Human CNTF elicits cellular responses by induction of a receptor complex consisting of the CNTF alpha receptor ( CNTFR ) , which is not involved in signal transduction , and the beta receptors gp 130 and leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The functional receptor complex of ciliary neurotrophic factor ( CNTF ) , a member of the gp 130 family of cytokines , is composed of CNTF , the CNTF receptor alpha ( CNTFR ) , gp 130 , and the leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) , cardiotrophin 1 ( CT 1 ) , and oncostatin M ( OSM ) are four helix bundle cytokines acting through a common heterodimeric receptor composed of gp 130 and LIF receptor ( LIFR ) . ^^^ Leukemia inhibitory factor ( LIF ) , cardiotrophin 1 ( CT 1 ) , and oncostatin M ( OSM ) are four helix bundle cytokines acting through a common heterodimeric receptor composed of gp 130 and LIF receptor ( LIFR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
OnM induced desensitization also prevents responses to other gp 130 signaling cytokines ( e . g . leukemia inhibitory factor and interleukin 11 ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
OBJECTIVE : LIF and its corresponding receptors gp 130 and LIF receptor alpha ( LIFR alpha ) were studied in lymphoid tissue ( LT ) to reveal potential systemic immunoregulatory effects during the course of HIV 1 infection . ^^^ METHODS : LIF , gp 130 , LIFR alpha and HIV 1 replicating cells were identified at the single cell level by immunohistochemistry and quantified by computerized in situ imaging in tonsil and lymph nodes biopsies ( LT ) from patients with primary HIV 1 infection ( PHI ) , chronic HIV 1 infection ( cHI ) , long term non progressors ( LTNP ) and HIV 1 seronegative controls . ^^^ RESULTS : LIF and its receptors , gp 130 and LIFR alpha were significantly ( P < 0 . 005 ) upregulated in LT from PHI patients as compared with HIV 1 seronegative controls . ^^^ LIF receptors , gp 130 and LIFR alpha were significantly upregulated in cHI ( P < 0 . 005 ) but downregulated in LTNP ( P < 0 . 05 and P < 0 . 005 , respectively ) . ^^^ CONCLUSIONS : LIF , gp 130 and LIFR alpha showed increased expression in LT from patients with PHI . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
We further demonstrate that lesion induces upregulation of CNTF related cytokines ( LIF , NNT 1 ) and , interestingly , a more pronounced upregulation of cytokine receptor components ( LIF receptor beta , gp 130 ) and TGFbeta in CNTF deficient animals . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukaemia inhibitory factor ( LIF ) is a gp 130 neurocytokine that is thought to act as an ' injury factor ' , triggering the early injury phenotype within neurons and potentially boosting their regenerative potential after secondary nerve repair . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
We previously demonstrated that interleukin 6 related cytokine , leukemia inhibitory factor ( LIF ) , induced cardiac hypertrophy through gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
HACMs were treated with the gp 130 ligands CT 1 , IL 6 , LIF or OSM and VEGF 1 was determined by a specific ELISA in the conditioned media of these cells . ^^^ RT PCR and Western blot analysis was used in order to detect gp 130 , IL 6 receptor , LIF receptor or OSM receptor specific protein and mRNA in human adult cardiac myocytes and for detection of VEGF 1 specific mRNA in cardiac myocytes after incubation with OSM . ^^^ We detected high levels of mRNA for gp 130 and the OSM receptor in freshly isolated human cardiac myocytes but only low amounts of mRNA for the IL 6 receptor whereas mRNA for the LIF receptor was hardly detectable by RT PCR . ^^^ CONCLUSION : The gp 130 gp130 ligand system is also involved in VEGF regulation in human cardiac myocytes and OSM is the gp 130 ligand responsible for this effect in the human system whereas LIF and CT 1 which had been shown to regulate VEGF expression in mouse and rat cardiac myocytes had no effect . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Results indicated that association of GPL to the intracellular portions of gp 130 , or LIF receptor , allowed the signaling cascade . . ^^^ GPL , a novel cytokine receptor related to GP 130 and leukemia inhibitory factor receptor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
We have determined the crystal structure of human leukemia inhibitory factor ( LIF ) bound to the cytokine binding region ( CHR ) of gp 130 at 2 . 5 A resolution . ^^^ Strikingly , we find that the shared binding site on gp 130 has an entirely rigid core , while the LIF binding interface diverges sharply in structure and chemistry from that of other gp 130 ligands . ^^^ Dissection of the LIF gp 130 interface , along with comparative studies of other gp 130 cytokines , reveal that gp 130 has evolved a `` thermodynamic plasticity ' ' that is relatively insensitive to ligand structure , to enable crossreactivity . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) induced cell signaling occurs following sequential binding to the LIF receptor alpha chain ( LIFR ) , then to the gp 130 co receptor used by all members of the interleukin 6 family of cytokines . ^^^ Despite increases in LIFR binding affinity , these mutants did not show any increase in activity as agonists of LIF induced proliferation of Ba / F3 cells expressing human LIFR and gp 130 compared with wild type LIF . ^^^ Leukemia inhibitory factor ( LIF ) induced cell signaling occurs following sequential binding to the LIF receptor alpha chain ( LIFR ) , then to the gp 130 co receptor used by all members of the interleukin 6 family of cytokines . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
This PEG peptide conjugate was found to be both an antagonist of LIF LIFR binding and of LIF signaling in engineered Ba / F3 cells expressing LIFR and the gp 130 coreceptor . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Therefore , using the lithium pilocarpine status epilepticus model , we performed a detailed in situ hybridization time course study of five gp 130 cytokines ( interleukin [ IL ] 6 , leukemia inhibitory factor [ LIF ] , IL 11 , oncostatin m [ OSM ] , and ciliary neurotrophic factor ) , gp 130 , and the receptors of the cytokines we found to be induced ( IL 6 receptor [ IL 6R ] , LIF receptor [ LIF R ] , and IL 11 receptor [ IL 11R ] ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Tu11 cells , a subline of the IL 6 dependent human plasma cell line INA 6 expressing gp 130 and the receptor for leukaemia inhibitory factor ( LIF ) , stimulation with BSF 3 induced tyrosine phosphorylation of signal transducer and activator of transcription 3 ( STAT 3 ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Because other members of the IL 6 family such as leukaemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) share gp 130 , the signal transduction subunit of their receptors , interpretation of the data without considering the expression of these cytokines and their specific receptor subunits could be misleading . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
RESULTS : Proliferation by CFU GM and BFU E was enhanced synergistically when common beta chain receptor cytokines ( IL 3 or GM CSF ) were combined with G CSF or EPO , but not with gp 130 receptor cytokines ( LIF or IL 6 ) or tyrosine kinase receptor cytokines ( SCF , HGF , Flt 3 ligand , or PDGF ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Patients with heart failure have increased cardiac gene expression of leukaemia inhibitory factor ( LIF ) , a cytokine that signals through the gp 130 receptor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Thermal control of adhesion is maintained in IL 6 deficient mice through a gp 130 dependent compensatory mechanism mediated by IL 6 related cytokines ( i . e . , oncostatin M [ OSM ] , leukemia inhibitory factor [ LIF ] , and IL 11 ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
A chimeric receptor ( 130 / 190 ) containing the cytoplasmic region of leukemia inhibitory factor receptor alpha subunit ( LIFRalpha , or gp 190 ) and the extracellular transmembrane region of gp 130 was generated . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The fixed samples were prepared for a study of immunocytochemical staining of LIF and its two receptor units ( LIF R and gp 130 ) . mRNA was extracted from the frozen ovarian samples , and the expression of LIF , LIF R and gp 130 was investigated by RT PCR . ^^^ There was strong to moderate immunocytochemical staining for LIF and LIF R in oocytes from the primordial follicular stages onwards , and very weak to moderate staining for gp 130 . ^^^ Transcripts of LIF , LIF R and gp 130 RNA were identified by RT PCR in all samples . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
It acts through a membrane receptor complex comprising CNTF receptor alpha component ( CNTFRalpha ) , gp 130 , and leukemia inhibitory factor receptor to activate signal transducer and activator of transcription 3 signaling pathway . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) signals via a tripartite receptor complex consisting of the glycosyl phosphatidylinositol ( GPI ) anchored CNTF receptor ( CNTF R ) , the leukaemia inhibitory factor receptor ( LIF R ) and the interleukin 6 ( IL 6 ) signal transducer gp 130 . ^^^ Whereas the CNTF R cofractionated quantitatively with lipid rafts independently of the method used , gp 130 and the LIF R were found to associate with lipid rafts only partially when detergents were used for isolation . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
OB R is a single membrane spanning receptor most related to the gp 130 signal transducing component of the IL 6 receptor , the G CSF receptor , and the LIF receptor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
While the expression of many of the markers was similar in mouse and human cells , significant differences were found in the expression of vimentin , beta 3 tubulin , alpha fetoprotein , eomesodermin , HEB , ARNT , and FoxD 3 as well as in the expression of the LIF receptor complex LIFR / IL6ST ( gp 130 ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
We show here that neural precursor cells isolated from embryonic rat cortices abundantly secrete leukemia inhibitory factor ( LIF ) and express its receptor components , gp 130 and LIF receptor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Human ES cells express LIF , IL 6 , and gp 130 receptors , as well as the downstream signaling molecules . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
IL 6 has many overlapping biological effects with the related gp 130 cytokines LIF and OSM that can be explained by the shared usage of the signalling receptor , gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Here , we demonstrate that the stimulation of gp 130 with leukemia inhibitory factor ( LIF ) promoted cell adhesion in a cadherin dependent manner in cultured cardiomyocytes . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In this study , we show that the LIFRbeta and the signaling subunit gp 130 are expressed in hESCs and that human LIF can induce STAT 3 phosphorylation and nuclear translocation in hESCs . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The leukemia inhibitory factor ( LIF ) / glycoprotein 130 ( gp 130 ) / signal transducer and activator of transcription 3 ( STAT 3 ) pathway plays an essential role in the maintenance of self renewal and pluripotency in mouse embryonic stem ( ES ) cells . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
To date , more than 10 different four helix bundle ligands have been identified that incorporate gp 130 , or one of its close relatives such as LIF receptor , into functional oligomeric signaling complexes . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
CNTF mediates its function by activating a tripartite receptor comprising the CNTF receptor alpha chain ( CNTFRalpha ) , the leukemia inhibitory factor receptor beta chain ( LIFRbeta ) and gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The relationship between circulating C reactive protein concentrations and potential cytokine and receptor mediators ( interleukin 6 , leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) , soluble IL 6 receptor , soluble gp 130 , soluble TNF receptor , interleukin 1 receptor antagonist and interleukin 8 ( IL 8 ) ) of this acute phase protein were examined in healthy subjects ( n=11 ) and patients with non small cell lung cancer ( n=50 ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Signalling of leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) , cardiotrophin 1 ( CT 1 ) , CT 1 like factor ( CLC ) or oncostatin M ( OSM ) through gp130 / LIF R is believed to be similar due to the presence of the common signal transducer gp 130 within the receptor complexes utilized , but the difference in the composition of gp130 / gp130 homodimers and gp130 / LIF R heterodimers is likely to be reflected in different signalling . ^^^ The inhibitory tyrosine motifs within the cytoplasmic parts of gp 130 and the LIF R act independently . ^^^ Whereas SHP 2 and SOCS 3 bind directly to the inhibitory motif of gp 130 , only SHP 2 was found to bind to the corresponding inhibitory sequence of the LIF R . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
RESULTS : 22Rv1 cells express both subunits of the IL 6 receptor ( gp 80 and gp 130 ) and leukemia inhibitory factor receptor beta ( LIFR beta ) but not OSMR beta . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor receptor and gp 130 were expressed in neurons , and the ischemic damage of these proteins was rescued in the high LIF group . ^^^ Leukemia inhibitory factor receptor and gp 130 were expressed in neurons , and the ischemic damage of these proteins was rescued in the high LIF group . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
LIF acts on cells by binding to the LIF receptor ( LIFR ) and gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Using a dominant negative LIF mutant ( hLIF 05 ) , we showed that in RC cell cultures mouse OSM ( mOSM ) activates exclusively glycoprotein 130 ( gp 130 ) / OSMR . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The mRNA levels of IL 6 , leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotrophin 1 ( CT 1 ) as well as their receptor subunits , glycoprotein 130 ( gp 130 ) , IL 6 receptor ( IL 6R ) , LIFR , and CNTFR , were measured by semi quantitative RT PCR . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Gene activities of cytokines and their receptors interleukin ( IL ) 6 , leukemia inhibitory factor ( LIF ) , IL 11 and IL 6 receptor ( IL 6 R ) , LIF receptor and gp 130 relevant to implantation revealed a 17 beta estradiol ( E 2 ) mediated up regulation of IL 6 and an E 2 and P 4 mediated up regulation of IL 6 R in hTERT EECs . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In addition also the other gp 130 ligands tested , cardiotrophin 1 ( CT 1 ) , interleukin 6 ( IL 6 ) and leukemia inhibitory factor ( LIF ) had no effect on the expression of TIMPs and MMPs studied . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) is a member of the gp 130 cytokine family and signals through the receptor complex of gp 130 and the LIF receptor ( LIFR ) to activate the JAK / STAT signaling cascade . ^^^ These findings indicate that LIF has similar and distinct effects in comparison with the effects of other gp 130 cytokines on cultured fat cells . ^^^ Leukemia inhibitory factor ( LIF ) is a member of the gp 130 cytokine family and signals through the receptor complex of gp 130 and the LIF receptor ( LIFR ) to activate the JAK / STAT signaling cascade . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
PURPOSE : Activating ligands of gp 130 , including leukemia inhibitory factor ( LIF ) , can block differentiation and function of retinal neurons . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) is a pleiotropic cytokine belonging to the gp 130 family . ^^^ Leukemia inhibitory factor ( LIF ) is a pleiotropic cytokine belonging to the gp 130 family . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Inhibition of MEKI and MEKII using the drug U 0126 and stimulation of gp 130 signaling by elevating the level of LIF present gave rise to ES like lines in 22 . 6 % of explants . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Of known importance are members of the gp 130 family such as interleukin 11 ( IL 11 ) and leukaemia inhibitory factor ( LIF ) , the transforming growth factor beta ( TGFbeta ) superfamily including the activins , the colony stimulating factors ( CSF ) , the IL 1 system and IL 15 system . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The receptor for leukemia inhibitory factor ( LIF ) consists of two polypeptides , the low affinity LIF receptor ( LIFR ) and gp 130 . ^^^ We previously demonstrated that LIF stimulation caused phosphorylation of gp 130 at Ser 782 , adjacent to a dileucine internalization motif , and that transient expression of a mutant receptor lacking Ser 782 resulted in increased cell surface expression and increased LIF stimulated gene expression compared to wild type receptor . ^^^ Phosphorylation of Ser 782 on gp 130 fusion protein by LIF stimulated 3T3 L 1 cell extracts was inhibited 61 % by autocamtide 2 related inhibitory peptide ( AIP ) , a highly specific and highly effective inhibitor of calmodulin dependent protein kinase type 2 ( CaMKII ) . ^^^ Furthermore , antibodies targeting CaMKII and CaMKIV were able to immunoprecipitate gp 130 phosphorylating activity from LIF stimulated 3T3 L 1 lysates . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) forms a functional receptor complex containing the CNTF receptor , gp 130 , and the leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Our results indicate that a subset of gp 130 cytokines , in particular CT 1 , LIF , and OSM , has the ability to impair subsequent signaling activity initiated by gp 130 cytokines . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
LIF binds to a receptor complex of LIFR beta and gp 130 and signals via the Janus kinase signal transducer and activator of transcription ( JAK STAT ) pathway , with signalling attenuated by suppressor of cytokine signalling ( SOCS ) proteins . ^^^ The absence of SOCS 3 enhanced JAK STAT and extracellular signal related kinase 1 / 2 ( ERK 1 / 2 ) mitogen activated protein kinase ( MAPK ) signal transduction via gp 130 , with higher levels of phosphorylated STAT 1 , STAT 3 , SH 2 domain containing cytoplasmic protein tyrosine phosphatase 2 ( SHP 2 ) , and ERK 1 / 2 in steady state and in response to LIF stimulation . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) belongs to the interleukin 6 cytokine family , all members of which signal through the common gp 130 receptor . ^^^ Leukemia inhibitory factor ( LIF ) belongs to the interleukin 6 cytokine family , all members of which signal through the common gp 130 receptor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) signals through gp 130 homodimers whereas leukaemia inhibitory factor ( LIF ) exerts its action through a heterodimer of gp 130 and the LIF receptor ( LIFR ) . ^^^ However , FRET between YFP tagged gp 130 and CFP tagged LIFR considerably increased upon LIF stimulation . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : We studied the expression of LIF and its receptor components , LIF receptor beta and gp 130 , by immunohistochemistry , western blotting and RT PCR in normal rat pancreas , pancreas with duct ligation induced islet neogenesis , and in pancreatic cell cultures . ^^^ Both LIF receptor beta and gp 130 were detected by RT PCR in the pancreas . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
LIF and other cytokines acting via the gp 130 signal transducing receptor have been reported to decrease obesity . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Evidence for heterodimeric association of leukemia inhibitory factor ( LIF ) receptor and gp 130 in the mouse uterus for LIF signaling during blastocyst implantation . ^^^ Here we have provided evidence that major cell types expressing theLIF receptor ( LIFR ) and its signal transducing partner gp 130 are mostly disparate in the mouse uterus during the glandular LIF expression in the morning of day 4 . ^^^ In contrast , LIFR and gp 130 expressions overlap in the luminal epithelium at the time of blastocyst attachment on the evening of day 4 when the second phase of LIF expression occurs in stromal cells surrounding the blastocyst , suggesting that LIF participates in implantation in a paracrine manner . ^^^ Coimmunoprecipitation experiments showed that LIFR and gp 130 form heterodimers and are available for LIF signaling at the time of blastocyst attachment . ^^^ Collectively , our results have provided evidence that LIFR and gp 130 form a functional heterodimer in the uterus during the attachment reaction to direct LIF signaling . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
LIF activates the JAK STAT 3 pathway through the class 1 cytokine receptor gp 130 , which forms a trimeric complex with LIF and the class 1 cytokine receptor LIF receptor beta . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
To investigate gp 130 dimerization , we performed co precipitation experiments with the endogenous cytokine receptors gp 130 and leukemia inhibitory factor receptor ( LIF R ) and with gp 130 variants carrying two different C terminal peptide tags . ^^^ Confocal laser scanning microscopy was used for FRET detection in live cells . gp 130 and LIF R could be coprecipitated in the absence of ligand . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Immunohistochemistry was used to assay LIF , LIF receptor , and gp 130 protein expression . ^^^ RESULT ( S ) : The expression of LIF , LIF receptor , and gp 130 messenger RNA and protein was increased in spontaneously differentiated HS 237 cells compared with undifferentiated cells , with high expression of an inhibitor of LIF mediated signaling , suppressor of cytokine signaling 1 , in undifferentiated hESCs . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Ciliary neurotropic factor , interleukin 11 , leukemia inhibitory factor , and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Other cytokines such as leukemia inhibitory factor , oncostatin M and ciliary neurotrophic factor have also been shown to utilize gp 130 as a signal transducer . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The IL 6 signal transducer , gp 130 , is also an affinity converter for the LIF receptor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The LIF receptor is most related to the gp 130 signal transducing component of the IL 6 receptor , a feature that may provide a molecular basis for the intertwined biologies of LIF and IL 6 in the absence of obvious structural similarly between the ligands . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Here we present data indicating that gp 130 functions as a common signal transducer for IL 6 , oncostatin M ( OM ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophic factor ( CNTF ) . ^^^ Since LIF functions as a cholinergic differentiation factor in nerve cells as does CNTF , these results suggest that gp 130 may also play a role in the neural system . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The LIF receptor is structurally related to the gp 130 signal transducing component of the IL 6 receptor and to the G CSF receptor . ^^^ The high affinity receptors for LIF , OSM and IL 6 share the common subunit , gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Here we present data indicating that gp 130 functions as a common signal transducer for IL 6 , oncostatin M , leukemia inhibitory factor , and ciliary neurotrophic factor . ^^^ Since leukemia inhibitory factor functions as a cholinergic differentiation factor in nerve cells , as does ciliary neurotrophic factor , these results suggest that gp 130 may also play a role in the nervous system . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The IL 6 signal transducer , gp 130 : an oncostatin M receptor and affinity converter for the LIF receptor . ^^^ The converter conferred high affinity binding of both LIF and OSM when expressed with the low affinity LIF receptor and is identical to the signal transducing subunit of the IL 6 receptor , gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL 6 signal transducing receptor component gp 130 . ^^^ We provide a basis for the overlapping actions of these three factors by demonstrating that the shared CNTF and LIF signaling pathways involve the IL 6 signal transducing receptor component gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The LIF receptor is related to the gp 130 ' signal transducing ' component of the IL 6 receptor and to the G CSF receptor , with the transmembrane and cytoplasmic regions of the LIF receptor and gp 130 being most closely related . ^^^ Leukemia inhibitory factor receptor is structurally related to the IL 6 signal transducer , gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Interleukin 11 ( IL 11 ) , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OM ) , all of which use gp 130 as a signal transducer , significantly inhibited mouse placental lactogen 2 ( mPL 2 ) secretion by cultured placental cells from Days 7 , 9 , and 12 of pregnancy . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
These cytokines initiate signaling by inducing either homodimerization of gp 130 or heterodimerization of gp 130 with leukemia inhibitory factor receptor beta components . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Tyrosine phosphorylation was also observed in response to other cytokines , such as leukemia inhibitory factor , oncostatin M , and ciliary neurotrophic factor , whose receptors share the IL 6 receptor signal transducer gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and interleukin 6 ( IL 6 ) compose a family of distantly related cytokines that initiate signaling by inducing either homodimerization of the `` beta ' ' signal transducing receptor component gp 130 ( in the case of IL 6 ) or heterodimerization between gp 130 and the gp 130 related LIFR beta ( in the case of CNTF , LIF , and OSM ) ; dimerization of beta receptor components in turn activates members of the Jak / Tyk family of receptor associated tyrosine kinases . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The tyrosine kinase activity of the 72 kD molecule was enhanced by the stimulation through an IL 6 signal transducer , gp 130 , that was shared among the receptors for the IL 6 related cytokine subfamily , such as leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotrophic factor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The receptor for granulocyte colony stimulating factor ( G CSFR ) and chimeric receptors consisting of the extracellular domain of G CSFR and the transmembrane and cytoplasmic domain of the leukemia inhibitory factor receptor , gp 130 , or c mpl function as homodimeric complexes . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Activation of Fes tyrosine kinase by gp 130 , an interleukin 6 family cytokine signal transducer , and their association . gp 130 is a signal transducing subunit of receptors for the interleukin 6 ( IL 6 ) related cytokine subfamily including IL 6 , leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotrophic factor , indicating that gp 130 mediated signals are involved in the immune response , hematopoiesis , inflammation , and endocrine and nervous system activity . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Using c raf antisense oligonucleotides to block Raf 1 expression , we have established that Raf 1 is required for hematopoietic growth factor induced proliferation of murine cell lines stimulated by growth factors whose receptors are members of several different structural classes : ( a ) the hematopoietin receptor family , including interleukin ( IL ) 2 , IL 3 , IL 4 , granulocyte colony stimulating factor , granulocyte / macrophage colony stimulating factor ( GM CSF ) , and erythropoietin ; ( b ) the tyrosine kinase receptor class , including Steel factor and CSF 1 ; and ( c ) IL 6 , leukemia inhibitory factor , and oncostatin M , whose receptors include the gp 130 receptor subunit . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The presence of leukaemia inhibitory factor ( LIF ) binding and expression of the gp 130 component of the LIF receptor were studied in the rabbit uterus during pregnancy . ^^^ The coexpression of LIF binding and gp 130 may indicate the presence of high affinity LIF receptor , which matches the pattern of LIF protein expression and , as in mice , suggests its importance for implantation . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor , oncostatin M , leukemia inhibitory factor , and interleukin 6 are related cytokines that initiate signaling by homodimerizing the signal transducing receptor component gp 130 or by heterodimerizing gp 130 with a gp 130 related receptor component . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The gp 130 family cytokines IL 6 , LIF and OSM but not IL 11 can reverse the anti proliferative effect of dexamethasone on human myeloma cells . ^^^ In order to understand the mechanisms supporting steroid escape in patients with multiple myeloma ( MM ) , three IL 6 autocrine human myeloma cell lines , LP 1 , OPM 2 and L 363 , have been treated with dexamethasone in the presence or absence of cytokines belonging to the gp 130 family : IL 6 , LIF , OSM and IL 11 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
OM was also suggested to bind to the LIF receptor ( LIF / OM receptor ) , which consists of a signal transducing subunit for LIF and IL 6 ( gp 130 ) and a LIF receptor alpha subunit . ^^^ PCR amplification clearly revealed high levels of gp 130 expression in AIDS KS cells , while the transcript of LIF receptor alpha subunit or IL 6 receptor alpha subunit was not observed . ^^^ Therefore , we conclude that ( a ) AIDS KS cells express the OM specific receptor with high and low affinity , but not the LIF / OM receptor ; ( b ) gp 130 on AIDS KS cells plays a key role in OM binding and signaling on the OM specific receptor ; and ( c ) the lack of biological response of AIDS KS cells to IL 6 and LIF can be explained by the absence of the IL 6 and LIF / OM receptors . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The IL 6 receptor system consists of an 80 kDa IL 6 receptor and a gp 130 which functions as a signal transducer not only for IL 6R but also for LIF , OSM , ciliary neurotrophic factor ( CNTF ) , and IL 11 receptors . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The reverse transcription polymerase chain reaction and immunohistochemical analysis revealed the expression and localization , on the trophoblasts , of glycoprotein 130 ( gp 130 ) , an IL 6 signal transducer receptor component shared by the cytokines such as LIF and IL 6 . ^^^ Recombinant LIF induced CG production was significantly blocked by anti gp 130 antibody but not by anti IL 6 receptor antibody , whereas rIL 6 induced CG was completely blocked by both antibodies . ^^^ Recombinant LIF and rIL 6 induced CG productions were both significantly blocked by genistein , a tyrosine kinase inhibitor , suggesting an involvement of tyrosine kinase in gp 130 mediated CG production . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
CT 1 and LIF cross compete for binding to M 1 cells , Kd [ CT 1 ] approximately 0 . 7 nM , and this binding is inhibited by an anti gp 130 monoclonal antibody . ^^^ These data show that CT 1 has a wide range of hematopoietic , neuronal , and developmental activities and that it can act via the LIF receptor and the gp 130 signaling subunit . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Moreover , in situ hybridization revealed an identical pattern of gene expression in cultivated KS spindle cells and KS spindle cells in vivo with respect to the above mentioned cytokines [ PDGF B , IL 1 beta , IL 1 alpha , IL 6 , OSM ] and their receptors [ PDGF beta receptor , gp 130 , IL 6 receptor , leukemia inhibitory factor ( LIF ) receptor ] . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The low affinity receptor for leukemia inhibitory factor ( LIFR ) interacts with gp 130 to induce an intracellular signal cascade . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Consistent with this prediction , the CNTF receptor complex is composed of the CNTF alpha receptor , the LIF beta receptor and gp 130 a signalling molecule for LIF and interleukin 6 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
While it has been proposed that the OSM receptor may include the gp 130 subunit of the IL 6 receptor and alpha chain of leukemia inhibitory factor ( LIF ) receptor , neither LIF nor r . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
These data directly implicate SCL in components of the macrophage differentiation program ( suggesting that LIF receptor / gp130 heterodimers utilize an SCL inhibitable pathway while gp 130 homodimers do not ) and demonstrate differential regulation of components of the mature macrophage phenotype . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In addition to including a CNTF specific component , known as CNTFR alpha , the CNTF receptor complex utilizes two receptor components , gp 130 and LIFR beta , that are shared with members of a family of broadly acting cytokines , including leukemia inhibitory factor ( LIF ) and interleukin 6 ( IL 6 ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
LIF and OM directly interact with a soluble form of gp 130 , the IL 6 receptor signal transducing subunit . ^^^ Since OM signaling can be prevented by binding gp 130 with anti gp 130 mAbs we also investigated the potential of sgp 130 Rg to prevent the biological activities of both LIF and OM . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) , IL 11 , leukemia inhibitory factor ( LIF ) , and oncostatin M , which all use gp 130 as a signal transducer , significantly inhibited mGHRF secretion by cultured placental cells . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
It is a member of the hemopoietin receptor superfamily and is most closely related over its entire length to gp 130 and the receptors for granulocyte CSF ( G CSF ) and leukemia inhibitory factor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The capacity to bind IL 11 with high affinity ( Kd = 300 800 pM ) appeared to require coexpression of both NR 1 and gp 130 , the common subunit of the IL 6 , leukaemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) and ciliary neurotrophic factor ( CNTF ) receptors . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
These factors all activate gp 130 associated signaling processes , as does the previously characterized ES cell maintenance factor Differentiation Inhibiting Activity ( Leukemia Inhibitory Factor ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In conclusion , IL 11 , along with IL 6 , leukemia inhibitory factor , oncostatin M and ciliary neurotrophic factor , belongs to the same family of cytokines , using gp 130 as a transducing protein . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Previously it had been thought that the gp 130 alone is sufficient to bind ligand and transduce signal and that oncostatin M could bind to and activate the LIF receptor , but these data show this is not always the case . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
B 9 11 cells responded only to human IL 11 and IL 6 and not to other human cytokines using the same gp 130 transducer chain ( ciliary neurotrophic factor , leukemia inhibitory factor and oncostatin M ) or to other human interleukins ( interleukin 1 to interleukin 13 ) , human hematopoietic cytokines ( granulocyte colony stimulating factor , granulocyte macrophage colony stimulating factor , colony stimulating factor 1 ) and various other human cytokines ( interferon alpha , tumor necrosis factor alpha , tumor necrosis factor beta , fibroblast growth factor and nerve growth factor ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
A 549 epithelial cells are subjected to growth inhibition only in the presence of OSM ( ED 50 = 6 ng / ml ) , even though they expressed LIF R and gp 130 transcripts . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Recently , gp 130 , the signal transducer for interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophice factor ( CNTF ) , was identified as the low affinity receptor for oncostatin M ( OM ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Like other cytokines such as IL 6 , leukemia inhibitory factor ( LIF ) , oncostatin M ( ONC ) and ciliary neurotrophic factor ( CNTF ) , IL 11 has been shown to utilize IL 6 signal transducer , gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The interleukin 6 receptor associated signal transducer , gp 130 , is shared by receptor complexes for leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and interleukin 11 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Interleukin 6 , leukemia inhibitory factor , and oncostatin M exert a broad range of similar biological activities through association of their receptors with the signal transducing component gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
We analyzed the stimulatory effect of oncostatin M ( OSM ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , IL 11 , and the inhibitory effect of anti IL 6 antibody ( Ab ) , anti IL 6 receptor monoclonal antibody ( mAb ) , and anti gp 130 mAb on the growth of human plasmacytoma cells freshly isolated from a patient with multiple myeloma . ^^^ Furthermore , anti gp 130 mAb completely inhibited the proliferation of the cells induced by OSM , LIF , as well as IL 6 . ^^^ These data indicate that OSM , LIF , and IL 6 can act as growth factors of human plasmacytoma cells through a common signal transducer , gp 130 , on their cell surface , and also suggest the potential therapeutic application of anti gp 130 mAb , as well as anti IL 6R mAb against myeloma / plasmacytomas . . ^^^ Oncostatin M , leukemia inhibitory factor , and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer , gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) , leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotropic factor are a family of cytokines and neuronal differentiation factors which bind to composite plasma membrane receptors sharing the signal transducing subunit gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Interleukin 11 ( IL 11 ) shares the common signal transducer gp 130 with IL 6 , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) and triggers activation of unknown tyrosine kinases as the early steps of signal transduction pathway . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The biological functions of LIF are mediated through a receptor and a signal transducer , gp 130 , which is also used by factors like interleukin 6 ( IL 6 ) , cilliary neurotropic factor ( CNTF ) , and oncostatin M ( OSM ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The receptor for leukemia inhibitory factor ( LIFR ) , in combination with the signal transducing subunit for interleukin 6 type cytokine receptors , gp 130 , and LIF , activates transcription of acute phase plasma protein genes in human and rat hepatoma cells and the vasoactive intestinal peptide gene in a human neuroblastoma cell line . ^^^ Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp 130 cooperate in signal transduction in hepatic and neuronal cells . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Factors such as IL 11 , oncostatin M , and leukemia inhibitory factor , which are known to exert their functions through gp 130 ( the signal transducing chain of IL 6R ) , also induced MNC formation in our coculture system . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) , leukemia inhibitory factor , oncostatin M , interleukin 11 , and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
To begin defining whether NG neurons were capable of responding to CNTF and LIF in vivo , Northern blots were used to examine expression of mRNAs coding for CNTF and LIF receptor components ( CNTFR alpha , gp 130 , and LIFR beta ) in the intact ganglion . mRNAs for all three receptor components were present in both E16 . 5 and newborn ganglia , suggesting that LIF and CNTF receptors are expressed in the NG in vivo . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Recently , gp 130 has been shown to be involved in the signaling processes of oncostatin M , leukemia inhibitory factor , and ciliary neurotropic factor , in addition to those of IL 6 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Differentiation induction in murine M 1 leukemia cells by interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) is postulated to occur via a common receptor chain , gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
For example , leukemia inhibitory factor ( LIF ) and IL 6 share many biological activities including platelet production , and the receptors of these cytokines utilize gp 130 as a common signal transducer . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
One of these proteins is the interleukin 6 signal transducing molecule gp 130 , which is required for signal transduction by both CNTF and LIF . ^^^ Cross linking experiments with iodinated factors were carried out on a cell line responsive to CNTF and LIF , as well as on COS cells that were cotransfected with various combinations of gp 130 , LIFR beta , and CNTF receptor ( CNTFR ) alpha , the previously cloned CNTF binding protein . ^^^ These experiments reveal that LIF cross links to LIFR beta alone , as well as to gp 130 when it is coexpressed with LIFR beta . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The ciliary neurotrophic factor ( CNTF ) receptor complex is shown here to include the CNTF binding protein ( CNTFR alpha ) as well as the components of the leukemia inhibitory factor ( LIF ) receptor , LIFR beta ( the LIF binding protein ) and gp 130 [ the signal transducer of interleukin 6 ( IL 6 ) ] . ^^^ Unlike the IL 6 receptor complex in which homodimerization of gp 130 appears to be critical for signal initiation , signaling by the CNTF and LIF receptor complexes depends on the heterodimerization of gp 130 with LIFR beta . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The IL 11 receptor belongs to a family of cytokine receptors which includes the receptors for IL 6 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and ciliary neurotrophic factor ( CNTF ) , which are all capable of interacting with the signal transducing receptor gp 130 after ligand binding . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The beta receptor components for this cytokine family , gp 130 and LIF receptor beta , constitutively associate with Jak Tyk kinases . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Specific low affinity receptors for leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ; gp 130 ) , and ciliary neurotrophic factor ( CNTF ; receptor alpha , CNTFR alpha ) may be utilized in various combinations to generate high affinity binding sites and signal transduction . ^^^ Coexpression of the LIF receptor and gp 130 in these cells conferred high affinity LIF and OSM binding and responsiveness to LIF and OSM . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The IL 6 induced gp 130 homodimer appears to be similar in function to the heterodimer formed between the leukemia inhibitory factor ( LIF ) receptor ( LIFR ) and gp 130 in response to the LIF or ciliary neurotrophic factor ( CNTF ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
BACKGROUND : The receptor of ciliary neurotrophic factor ( CNTF ) contains the signal transduction protein gp 130 , which is also a component of the receptors of cytokines such as interleukin ( IL ) 6 , leukemia inhibitory factor ( LIF ) , IL 11 , and oncostatin M . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Interestingly , in leukemia inhibitory factor , another cytokine that signals through gp 130 , site 3 , is topologically conserved but has evolved to bind leukemia inhibitory factor receptor . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Other growth factor ligand and receptor transcripts were expressed in a stage specific manner : these included receptors for interleukin ( IL ) 6 ( IL 6R ) , leukemia inhibitory factor ( LIFR ) , tumor necrosis factor alpha ( TNF alpha ) ( TNFRp 80 and TNFRp 60 ) , and gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Targeted disruption of gp 130 , a common signal transducer for the interleukin 6 family of cytokines , leads to myocardial and hematological disorders . gp 130 is a ubiquitously expressed signal transducing receptor component shared by interleukin 6 , interleukin 11 , leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Using the reverse transcriptase polymerase chain reaction , we found that the human breast carcinoma MCF 7 cell line expressed the message for both LIF receptor and its signal transducing protein gp 130 , suggesting that these receptors might be biologically active . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The cytokines interleukin ( IL ) 6 , IL 11 , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitor factor ( LIF ) , oncostatin M ( OSM ) and probably the recently cloned cytokine cardiotrophin 1 , signal , in combination with their specific receptors , through the common signal transducer gp 130 . ^^^ Here , we report that the signaling activities of IL 6 , IL 11 , CNTF and OSM / LIF can be specifically blocked by different anti gp 130 monoclonal antibodies ( mAb ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The functional receptor complexes assembled in response to interleukin 6 and 11 ( IL 6 and IL 11 ) , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and ciliary neurotrophic factor ( CNTF ) , all involve the signal transducer gp 130 : IL 6 and IL 11 induce homodimerization of gp 130 , while the rest heterodimerize gp 130 with other gp 130 related beta subunits . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In addition , Raf 1 is also required for IL 6 , LIF and OSM induced proliferation whose receptors share the gp 130 subunit . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In contrast , when IL 6 or leukemia inhibitory factor ( two other cytokines that share gp 130 receptor components with OM ) were used in a similar fashion in combination with IL 1 alpha , neither cytokine consistently altered the IL 1 induced levels of IL 8 , GM CSF , or IL 6 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Anti gp 130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor , interleukin 6 , interleukin 11 , leukemia inhibitory factor or oncostatin M . ^^^ Five cytokines activate the gp 130 IL 6 transducer : ciliary neurotrophic factor , interleukin 6 , interleukin 11 , leukemia inhibitory factor and oncostatin M . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor , LIF receptor , and gp 130 in the mouse uterus during early pregnancy . ^^^ The present study was designed to investigate the changes of LIF protein , LIF receptor , and gp 130 in the mouse uterus during the early pregnancy . ^^^ LIF protein and LIF receptor were at high levels in the mouse uterus near the time of ovulation and on day 4 of pregnancy . gp 130 was highest on days 3 and 4 of pregnancy . ^^^ Both LIF receptor and gp 130 showed strong staining in the stroma of the day 5 uterus , at a time when LIF protein was low . ^^^ The presence of LIF receptor and gp 130 in the luminal epithelium on day 4 and in the stroma on day 5 may indicate the site of the high affinity LIF receptor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Here , we describe the expression of LIF , related members of this group of cytokines , oncostatin M and ciliary neurotrophic factor , and the LIF receptor beta and glycoprotein gp 130 in normal human tissues and in the endometrium of fertile women . ^^^ The associated signal transducing component of the LIF receptor , gp 130 , is also expressed in both the luminal and glandular epithelium throughout the cycle . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The receptor complex for LIF comprises LIF binding subunit and non binding signal transducer , gp 130 . ^^^ The gp 130 was originally identified as a signal transducing subunit of interleukin ( IL ) 6 and later also found to be a functional component of receptor complexes for other LIF related cytokines ( oncostatin M [ OSM ] , ciliary neurotrophic factor [ CNTF ] and IL 11 ) . ^^^ In addition , a combination of IL 6 and soluble IL 6 binding subunit ( sIL 6R ) , which is known to activate intracellular signaling via gp 130 , fully reproduced the LIF action of PGC . ^^^ Both in the presence and absence of LIF , addition of neutralizing antibody against gp 130 in culture remarkably blocked cPGC survival . ^^^ Since EG cells were also obtained by using OSM or the IL 6 / sIL 6R complex in place of LIF , a significant contribution of gp 130 mediated signaling in EG cell formation was further suggested . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Dexamethasone inhibited both basal and LIF induced ACTH secretion ( P < 0 . 05 ) and LIF induction of ACTH was also attenuated by immuneutralization of either the LIF receptor ( 35 % , P < 0 . 05 ) or the gp 130 affinity converter ( 41 % , P < 0 . 05 ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The results showed that the heterocomplex CNTF / alpha CNTF receptor bound to gp 130 with an affinity of 3 5 10 10 ( 10 ) M , whereas LIF interacted mainly with gp 190 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Gp 130 transducing protein was shown to be involved in the formation of the high affinity receptors for interleukin 6 ( IL 6 ) , interleukin 11 ( IL 11 ) , leukemia inhibitory factor , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , and cardiotrophin 1 . ^^^ The B R 3 pan blocking antibody weakly interfered with the binding of the radiolabeled ligands ( with the exception of OSM , whose binding was abrogated in the presence of B R 3 monoclonal antibody ) but inhibited the gp 130 homodimerization or its association with gp190 / leukemia inhibitory factor receptor , as well as the subsequent tyrosine phosphorylation events . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
We hypothesize that the LIF / LIFR gp 130 system may be involved in the expansion and differentiation of the liver stem cell compartment . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In agreement with OSMs ability to directly bind gp 130 , preincubation of BMCs with OSM inhibits progenitor cell growth stimulated by the combination of LIF or IL 6 plus SLF . ^^^ Direct synergistic effects of leukemia inhibitory factor on hematopoietic progenitor cell growth : comparison with other hematopoietins that use the gp 130 receptor subunit . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Moreover , other members of the CNTF cytokine family that use gp 130 and / or LIF receptor beta as their signal transducing receptors LIF , oncostatin M , interleukin 6 , and interleukin 11 had similar effects on increasing ChAT activity and reducing 5HT expression in RN46A cells . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In this study , in vivo and in vitro expression of LIF and its signal transducer genes , LIFR and gp 130 in medulloblastoma cells and its role ( s ) in the cell proliferation were investigated by different approaches . ^^^ The results revealed that 12 out of 13 cases examined were found to express LIF and more than 90 % of the samples to express LIFR and gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Growth of XG 4 CNTF cells using the gp 130 IL 6 transducer was also supported by other cytokines : IL 6 , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OM ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
This was borne out in cellular assays since the extract inhibited activation of HepG 2 cells stimulated with oncostatin M or leukemia inhibitory factor , cytokines which also use gp 130 for signal transduction . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In the case of IL 6 and LIF , which share a signal transducing receptor gp 130 , STAT 3 is specifically tyrosine phosphorylated and activated by stimulation with each cytokine in various cell types . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Interaction of the human IL 11R alpha with murine gp 130 was demonstrated : expression of the human IL 11R alpha in murine M 1 cells which constitutively express murine gp 130 ( and murine LIF receptor ) , resulted in the generation of specific high affinity binding sites for IL 11 ( Kd = 250 pM ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The high affinity receptor for interleukin 11 ( IL 11 ) is composed of two subunits , IL 11 receptor alpha chain ( IL 11R alpha ) and gp 130 , the common subunit of the interleukin 6 ( IL 6 ) , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor , and oncostatin M receptors . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) drives the sequential assembly of a receptor complex containing the ligand specific alpha receptor subunit ( CNTFR alpha ) and the signal transducers gp 130 and leukemia inhibitory factor receptor beta ( LIFR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Some cytokines that stimulate megakaryopoiesis ( IL 6 , IL 11 , leukemia inhibitory factor , and oncostatin M ) bind to receptors that use gp 130 as a signal transduction subunit . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) associates with an alpha subunit ( CNTFRalpha ) of the receptor complex to initiate signal transduction by facilitating heterodimerization of the gp 130 transducing protein and the leukemia inhibitory factor receptor ( LIFR ) beta . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) and oncastsin M ( OSM ) high affinity binding require additional receptor subunits besides GP 130 and GP 190 . ^^^ Heterodimerization of gp 190 and gp 130 has been proposed to form a high affinity receptor ( type 1 ) shared by LIF and OSM , while heterodimerization of gp 130 with an as yet unidentified subunit is proposed to form a high affinity OSM receptor ( type 2 ) not shared by LIF . ^^^ They indicate rather that third chains of 140 150 kDa molecular mass , in addition to the gp 130 and gp 190 subunits , enter in the structure of LIF and OSM high affinity receptors . ^^^ CHO cells co transfected with the human gp 190 and gp 130 cDNAs expressed high affinity LIF receptors but no high affinity OSM receptors , indicating that an additional component is required for high affinity OSM binding . ^^^ High affinity LIF cross linking on these cells also showed the association of LIF with a 150 kDa component in addition to the gp 130 and gp 190 subunits . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
IL 6 triggers homodimerization of gp 130 , whereas CNTF and LIF induce heterodimerization of gp 130 and LIF receptor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
This report documents the mRNA expression profiles of LIF and the two components of the LIF receptor complex , LIF R and gp 130 , during early mouse embryogenesis . ^^^ High levels of LIF R and gp 130 mRNAs were observed in the deciduum , however . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
LIF and CNTF , which share the gp 130 transduction system , stimulate hepatic lipid metabolism in rats . ^^^ The combination of LIF plus CNTF showed no additive effects consistent with the action of both cytokines through the gp 130 transduction system . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Cardiotrophin 1 : a multifunctional cytokine that signals via LIF receptor gp 130 dependent pathways . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
It is composed of a four helix bundle structure and shares the transmembrane signal transducing proteins , glycoprotein 130 ( gp 130 ) and leukemia inhibitory factor receptor ( LIF R ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Characteristic localization of gp 130 ( the signal transducing receptor component used in common for IL 6 / IL 11 / CNTF / LIF / OSM ) in the rat brain . ^^^ The localization of gp 130 , the signal transducing receptor component used in common for interleukin ( IL ) 6 , IL 11 , ciliary neurotrophic factor ( CNTF ) , LIF and OSM , in the rat brain was demonstrated by immunohistochemistry using an antibody specific to gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
To determine whether these two signaling pathways through gp 130 are present in cardiac myocytes , we examined their activation by using leukemia inhibitory factor ( LIF ) , which is a member of the IL 6 cytokine family . ^^^ Tyrosine phosphorylation of gp 130 , JAK 1 , and STAT 3 was observed after LIF stimulation in cardiac myocytes . ^^^ Furthermore , anti gp 130 antibody significantly inhibited the LIF induced activation of JAK 1 , STAT 3 , and MAPKs . ^^^ To examine whether these signaling pathways were also activated in the adult heart in vivo , LIF was injected intravenously into a 6 week old mouse , and the heart was examined subsequently . gp 130 , STAT 3 , and MAPKs were activated in the heart after LIF treatment . ^^^ CONCLUSIONS : These results demonstrate for the first time that a JAK STAT pathway and a MAPK pathway are present down stream of gp 130 in cardiac myocytes and are rapidly activated by LIF both in vitro and in vivo . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
METHODS : We incubated highly differentiated human hepatoma cells ( Hep G 2 ) and human umbilical vein endothelial cells ( HUVECs ) for 24 h with recombinant human leukaemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) cytokines that are implicated in acute phase reactions during inflammation and which bind to the same cell surface receptor unit ( glycoprotein gp 130 ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The leukemia inhibitory factor / interleukin 6 ( LIF / IL6 ) family of cytokines promotes cell type specific pleiotropic effects by engaging multimeric receptor complexes that share the common affinity converter / signal transducing subunit gp 130 . ^^^ Functional involvement of Hck and p 21 ( ras ) activation in gp 130 mediated signaling is supported by the finding that the introduction of constitutively activated Hck or 5 Ha ras partially alleviates the requirement of ES cells for LIF to remain undifferentiated . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The interleukin 6 ( IL 6 ) family of cytokines activates signaling through the formation of either gp 130 homodimers , as for IL 6 , or gp 130 leukemia inhibitory factor receptor ( LIFR ) heterodimers as for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor , oncostatinM , and cardiotrophin 1 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
LIF induced the tyrosine phosphorylation of gp 130 within 15 min after it was added to cardiac myocytes . ^^^ These results suggest that LIF activates gp 130 and induces myocardial hypertrophy by acting as an autocrine / paracrine factor in cardiac myocytes . . ^^^ Leukemia inhibitory factor induces a hypertrophic response mediated by gp 130 in murine cardiac myocytes . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leptin stimulation induces tyrosine phosphorylation of neither gp 130 nor LIFR , while LIF stimulation does both . ^^^ The structure of the receptor for this factor , OB R , is considerably similar to those of gp 130 , the common signal transducing receptor component for the interleukin 6 ( IL 6 ) family of cytokines , and leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
RT PCR analyses demonstrated that gp 130 was expressed in 12 / 12 breast cell lines and the specific receptor alpha chains for IL 6 , LIF , IL 11 and CNTF were expressed in the majority of these cell lines . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Three cytokines , interleukin 6 ( IL 6 ) , leukaemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) , that bind to composite receptors including a common signal transducer gp 130 suppressed proliferation of a mouse B cell hybridoma cell line 2E3 O cultured in serum free medium , while they enhanced antibody production of the cells . ^^^ As a whole , this work suggests that gp 130 , which is commonly involved in each receptor for IL 6 , LIF , and OSM , transduces signals for suppressing proliferation and possibly for enhancing antibody production in the hybridoma cells . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
This observation is consistent with previous in vitro findings showing that the mRNA for CT 1 is expressed in several tissues , and that CT 1 can function through binding to the leukaemia inhibitory factor ( LIF ) receptor and signalling through the gp 130 pathway . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Investigations of the signal transduction system showed that gp 130 and leukemia inhibitory factor ( LIF ) receptor beta subunit mRNA were detectable in porcine thyroid cells by reverse transcription ( RT ) polymerase chain reaction ( PCR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
This newly identified huIL 12R subunit is a member of the cytokine receptor superfamily , with closest resemblance to the beta type cytokine receptor gp 130 and the receptors for leukemia inhibitory factor and granulocyte colony stimulating factor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Cardiotrophin 1 ( CT 1 ) is a member of the gp 130 family of cytokines that includes interleukin 6 , interleukin 11 , ciliary neurotrophic factor , leukemia inhibitory factor , and oncostatin M . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Oncostatin M ( OSM ) is a cytokine whose structural and functional features are similar to other members of the interleukin ( IL ) 6 family of cytokines ( IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , granulocyte colonystimulating factor , ciliary neurotrophic factor , and cardiotrophin 1 ) , many of which utilize gp 130 as a common receptor subunit . ^^^ We have cloned and characterized an alternative subunit ( OSMRbeta ) for an OSM receptor complex ( a heterodimer of gp 130 and OSMRbeta ) that is activated by OSM but not by LIF . ^^^ A biologically active OSM receptor has been previously described that consists of a heterodimer of leukemia inhibitory factor receptor ( LIFR ) and gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The cytokines IL 6 , LIF , CNTF , OSM , IL 11 , and CT 1 have been grouped into the family of IL 6 type cytokines , since they all require gp 130 for signal transduction . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Two other cytokines which also utilize the gp 130 receptor , oncostatin M ( OSM ) and leukemia inhibitory factor ( LIF ) , were also able to upregulate endothelial cell protein S . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
We described recently the activation of the Janus kinasesignal transducer and activator of transcription ( JakSTAT ) and mitogen activated protein ( MAP ) kinase pathways by leukemia inhibitory factor ( LIF ) through gp 130 , a signal transducer of IL 6 related cytokines , that transduces hypertrophic signals in cardiac myocytes . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Box 3 independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha and gp 130 mediated stimulation of mitogen activated protein kinase . ^^^ Chimeric receptors containing the entire or various cytoplasmic domains of either gp 130 or leukemia inhibitory factor receptor alpha ( LIFR ) were used to identify signaling molecules and regions of these polypeptides required for the stimulation of mitogen activated protein kinase ( MAPK ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Other cytokines oncostatin M ( OM ) , leukemia inhibitory factor ( LIF ) or ciliary neurotrophic factor ( CNTF ) also use the gp 130 transducer and induce its heterodimerization with LIF receptor ( LIFR ) . ^^^ IL 6RA with two mutated gp 130 binding sites did not affect IL 11 , CNTF , LIF or OM activities . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
A family of cytokines [ IL 6 , IL 11 , oncostatin M ( OM ) , leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotrophin 1 ] involved in various inflammatory or tumoral diseases share the same gp 130 signal transducer chain . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
IL 6 belongs to a family of related cytokines that includes leukemia inhibitory factor , oncostatin M , IL 11 , ciliary neurotropic factor , and cardiotropin 1 , all of which initiate signaling through a receptor associated gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
To continue these studies , we examined the mRNA expression of signal transducing molecule , gp 130 , and the LIF R as associated members of a receptor family . ^^^ The levels of gp 130 and LIF R mRNA expression had a maximum 2 3 fold increase over a 24 h period . ^^^ Injection of purified recombinant rat IL 6 ( rIL 6 ) had little effect on LIF R mRNA levels , but had a dramatic inducing effect on gp 130 mRNA levels . ^^^ Rats were also injected ( i . p . ) with Dexamethasone ( Dex ) and this had no effect on either gp 130 or LIF R mRNA level expression . ^^^ We found that the maximum IL 6R ( gp 80 ) , gp 130 and LIF R mRNA levels peaked at different times depending on the type of acute inflammation induced in the rat . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
To define the specificity of the signal transduction by the LIF / OSM receptor ( a heterodimer of gp 130 and LIF receptor ( LIFR ) ) and the OSM specific receptor ( a heterodimer of gp 130 and OSM receptor ( OSMR ) ) , we reconstituted the receptor function by transfection into receptor negative Hep3B hepatoma cells . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Carcinoma cells constitutively express LIF mRNA , and 23 lines ( 92 . 0 % ) and all ( 100 % ) of 25 lines express LIF receptor mRNAs of LIFRbeta and gp 130 , respectively . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Forced overexpression of SSI 1 complementary DNA interfered with IL 6 and LIF mediated apoptosis and macrophage differentiation of M 1 cells , as well as IL 6 induced tyrosine phosphorylation of a receptor glycoprotein component , gp 130 , and of Stat 3 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Oncostatin M ( OSM ) and leukemia inhibitory factor ( LIF ) are members of the interleukin 6 ( IL 6 ) subfamily of cytokines that use a common signal transducer gp 130 . ^^^ Human OSM ( hOSM ) and LIF share a functional high affinity receptor that is composed of gp 130 and LIF receptor beta subunit ( LIFRbeta ) . ^^^ Murine hematopoietic cell lines M 1 and DA1 . a , an embryonic stem cell line CCE , and Ba / F3 transfectants expressing gp 130 and LIFRbeta responded to murine LIF ( mLIF ) and hOSM equally well , while these cells responded to mOSM only at a 30 fold to 100 fold higher concentration than those of mLIF and hOSM . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Human OSM is known to exhibit biological activities similar to LIF , because they share the same functional receptor composed of the LIF receptor and gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
We have shown recently that leukemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) , two members of the gp 130 dependent cytokine family , stimulate murine proopiomelanocortin ( POMC ) transcription and adrenocorticotropin hormone ( ACTH ) secretion . ^^^ Using RT PCR , mRNA expression of receptors for LIF , IL 6 , and CRH , and the gp 130 subunit , were all detected in fetal pituitaries of 18 and 31 wk gestation . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Taken together these results demonstrate that transcription of LIFR beta and gp 130 takes place throughout human preimplantation development , and suggest that functional LIF receptors might be present at these stages . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
These responses are thought to be mediated through the functional LIF receptor ( LIFR ) , consisting of a heterodimeric complex of LIFR alpha chain ( LIFRalpha ) and gp 130 . ^^^ Distinct roles for leukemia inhibitory factor receptor alpha chain and gp 130 in cell type specific signal transduction . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Proliferation in the absence of differentiation of blastodermal cells is stimulated by the presence of Leukemia Inhibitory Factor ( LIF ) and other ligands that interact with the gp 130 receptor , and differentiation is stimulated by exposure to retinoic acid . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) is a hematopoietic cytokine which elicits its effects on diverse cell types via both gp 130 and a more specific LIF receptor . ^^^ Leukemia inhibitory factor ( LIF ) is a hematopoietic cytokine which elicits its effects on diverse cell types via both gp 130 and a more specific LIF receptor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
LIF , CNTF , and CT 1 act through the known receptors LIF receptor beta ( LIFRbeta ) and gp 130 and well defined signaling pathways including receptor phosphorylation and STAT 3 activation . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukaemia inhibitory factor ( LIF ) is a polyfunctional cytokine that is known to require at least two distinct receptor components ( LIF receptor alpha chain and gp 130 ) in order to form a high affinity , functional , receptor complex . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) drives the sequential assembly of a receptor complex containing the ligand specific alpha receptor subunit ( CNTFR ) and the signal transducing beta subunits gp 130 and leukemia inhibitory factor receptor beta ( LIFR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In the present study we show that CT 1 binds to the KB epidermoid cancer cell surface through a tripartite receptor complex which includes the gp 130 signal transducing protein , LIF receptor beta ( LIFR beta ) and a third component displaying a molecular weight of 80 kDa . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The stimulation by Flk 2 ligand ( FL ) of blast colony formation by murine bone marrow cells was selectively potentiated by the addition of regulators sharing in common the gp 130 signaling receptor leukemia inhibitory factor ( LIF ) , oncostatin M , interleukin 11 , or interleukin 6 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Each of these cytokines induces the hetero oligomerization of LIF R with gp 130 , a signal transducing subunit shared with interleukin 6 and interleukin 11 . ^^^ The introduction of mutations into human LIF that reduced the affinity for gp 130 while retaining affinity for LIF R has generated antagonists for LIF . ^^^ On cells that express LIF R and gp 130 , all LIF R ligands were antagonized . ^^^ Ligand triggered tyrosine phosphorylation of both LIF R and gp 130 was blocked by the antagonist . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Treatment of HepG 2 cells with CT 1 resulted in the induction of tyrosine phosphorylation of both transducing receptor subunits , gp 130 and LIF receptor , and this phosphorylation was completely inhibited by a neutralizing anti gp 130 mAb . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
LIF ( 10 ( 3 ) U / mL ) induced rapid tyrosine phosphorylation of gp 130 , JAK 1 , JAK 2 , STAT 1 , and STAT 3 but not Tyk 2 or STAT 2 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
This synergy also extended to the inhibition of LIF or oncostatin M ( OSM ) induced proliferation of a Ba / F3 cell line co transfected with human gp 130 and gp 190 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
METHODS : Active transcription of LIF , IL 6 , and OSM , their related receptors ( LIF R , IL 6 R , and gp 130 ) , and the consecutive signal transducing molecules ( STAT 1 , STAT 3 , and STAT 5a ) were analyzed in reverse transcriptase polymerase chain reaction experiments . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Additionally , LIF enhances association of SHP 2 with the gp 130 subunit of the LIF receptor signaling complex . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) belongs to a gp 130 pleiotropic family of growth factors that has recently been shown to enhance the survival of rat testicular gonocytes and Sertoli cells . ^^^ In this study , we show the expression of gp 130 and LIF messenger RNAs ( mRNAs ) in the somatic ( the Sertoli and Leydig cells ) and specific germ cells ( spermatogonia , pachytene , round , and elongated spermatids ) of rodent testis , suggestive of cell specific LIF mediated functions . ^^^ Leukemia inhibitory factor ( LIF ) belongs to a gp 130 pleiotropic family of growth factors that has recently been shown to enhance the survival of rat testicular gonocytes and Sertoli cells . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) is a polyfunctional cytokine known to require at least two distinct receptor components ( LIF receptor alpha chain and gp 130 ) in order to form a high affinity , functional receptor complex . ^^^ Both forms of gp 130 bound LIF specifically and were capable of forming heterotrimeric complexes with soluble human LIF receptor alpha chain in the presence of human LIF . ^^^ In addition to the soluble forms of gp 130 , a soluble form of LIF receptor alpha chain was also detected in human urine and plasma . . ^^^ Identification and characterization of two distinct truncated forms of gp 130 and a soluble form of leukemia inhibitory factor receptor alpha chain in normal human urine and plasma . ^^^ Leukemia inhibitory factor ( LIF ) is a polyfunctional cytokine known to require at least two distinct receptor components ( LIF receptor alpha chain and gp 130 ) in order to form a high affinity , functional receptor complex . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
To investigate the respective roles of IL 6 related cytokines and receptors in osteprogenitor differentiation , and their regulatory interplay with Dex , we used reverse transcribed polymerase chain reaction , bioassay , and blocking antibody techniques to assess the time courses of LIF , IL 6 , LIF transmembrane receptor , IL 6 receptor , and gp 130 expression in RC cell cultures grown with and without Dex . ^^^ The levels of the mRNAs for IL 6 , LIF , and gp 130 decreased concomitantly with the formation of bone nodules . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The percentage of neurones surrounded by TH IR baskets within the L 3 and L 4 dorsal root ganglia following sciatic axotomy was significantly reduced in animals treated continuously for 2 weeks with a monoclonal antibody against the LIF receptor motif , gp 130 ( 0 . 833 mg ml 1 ) ( P < 0 . 05 , Mann Whitney U test ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The LIF receptor complex is composed of a heterodimer of LIF receptor alpha ( LIFR alpha ) and gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
LIF receptor gp 130 interaction investigated by homology modeling : implications for LIF binding . ^^^ Leukemia inhibitory factor ( LIF ) , a member of the gp 130 family of helical cytokines , is involved in the hemopoietic and neural systems . ^^^ The LIF signal transducing complex contains two receptor molecules , the LIF receptor ( LIFR ) and gp 130 . ^^^ Although some mutagenesis data on LIF are available , it is not yet known which regions of LIFR or gp 130 bind LIF . ^^^ Analyses of the electrostatic isopotential surfaces of the CBD models suggest that gp 130 and the membrane proximal CBD of LIFR hetero dimerize and bind LIF through contacts similar to those seen in the growth hormone receptor dimer . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The gp 130 cytokines leukemia inhibitory factor and interleukin 6 are neuroactive cytokines associated with peripheral nerve injury . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In NIH 3T3 cells ( which endogenously express gp 130 , LIF receptor beta [ LIFRbeta ] , and the protein product , c 12 , of the cDNA described here ) , mouse LIF , human LIF , and human OSM signaled through receptors containing the LIFRbeta and gp 130 but not through the mouse OSM receptor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor , which is one of the cytokines and has the common receptor subunit gp 130 , activated MAP kinase and the response was completely blocked by pretreatment of the Atg / cardiac myocytes with RX 435 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In absence of TpO , neither gp 130 activating cytokines ( IL 6 , IL 11 , LIF , CNTF ) nor the other hematopoietic growth factors or cytokines ( KL , IL 3 , GM CSF , EpO ) were able , when added alone , to stimulate the growth of human CFU Meg colonies . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The biological activities of OSM are mediated through two types of receptor complexes , the LIF / OSM shared receptor ( type 1 ) and OSM specific receptor ( OSM R , type 2 ) , which is composed of gp 130 as a binding subunit and a newly identified affinity conversion subunit , OSM R beta . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Differential temporal expression of mRNAs for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptors ( CNTFR alpha , LIFR beta , IL 6R alpha and gp 130 ) in injured peripheral nerves . ^^^ The mRNA expression of the neuropoietic cytokines , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptor components ( CNTFRalpha , LIFRbeta , IL 6Ralpha and gp 130 ) was examined in peripheral nerves after two different types of injury , crush and transection . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Western blot analysis revealed an inhibition of LIF stimulated gp 130 and STAT 3 phosphorylation in SOCS 3 overexpressing AtT 20 cells . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
IL 6 family of cytokines : signaling mechanisms and thrombopoietic activities . gp 130 is a common signal transducing component of the functional receptor complexes for the interleukin ( IL ) 6 family of cytokines , ie , IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
CONCLUSIONS : These results suggest that the STAT 3 dependent signaling pathway downstream of gp 130 promotes cardiac myocyte hypertrophy under stimulation with LIF . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The transmembrane protein gp 130 is a shared component of the receptor complexes for the interleukin 6 ( IL 6 ) type cytokines , which include IL 6 , leukemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) . ^^^ In the present study we have examined the role of the N terminal located , extracellular immunoglobulin ( Ig ) like module of gp 130 in signal transduction by IL 6 and LIF . ^^^ We have expressed wild type human gp 130 or three mutants in murine myeloid M 1 UR21 cells that lack functional endogenous gp 130 but express the IL 6 receptor ( IL 6R ) and the LIF receptor ( LIFR ) . ^^^ By measuring cellular responses , such as morphological changes upon differentiation , soft agar colony formation , and induction of tyrosine phosphorylation of the signal transducer and activator of transcription , STAT 3 , we show that signaling by IL 6 , but not LIF , is significantly reduced by mutations in the Ig like module of gp 130 . ^^^ We also present evidence that the Ig like module forms part of the epitope of an anti gp 130 monoclonal antibody that neutralizes the bioactivity of IL 6 , but not of LIF or OSM . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In addition , cytokines or their receptors not known to be expressed in RPE were included to widen our picture of cytokine gene expression in the eye : stem cell factor ( SCF ) , its receptor ( SCF R ) , low affinity nerve growth factor receptor p 75 ( p 75 ( NGF R ) , ciliary neutrothropic factor ( CNTF ) , and its receptor ( CNTF R ) , glycoprotein 130 interleukin 6 transducer ( gp 130 ( IL 6 SD ) , leukemia inhibitory factor ( LIF ) , and its receptor ( LIF R ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The functional receptor for ciliary neurotrophic factor ( CNTF ) is comprised of a CNTF binding entity termed CNTF receptor alpha ( CNTFRalpha ) , and 2 signaling molecules called LIF receptor beta and gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Other cytokines that activate gp 130 as a common signal transducer , IL 6 and leukemia inhibitory factor , did not have such effects . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The established glioma cell lines were also examined for expression of members of the neuropoietic cytokine family , CNTF and LIF , and their respective receptor components CNTFRalpha , LIFRbeta and gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The propagation of pluripotential mouse embryonic stem ( ES ) cells is sustained by leukemia inhibitory factor ( LIF ) or related cytokines that act through a common receptor complex comprising the LIF receptor subunit ( LIF R ) and the signal transducer gp 130 . ^^^ However , the findings that embryos lacking LIF R or gp 130 can develop beyond gastrulation argue for the existence of an alternative pathway ( s ) governing the maintenance of pluripotency in vivo . ^^^ This activity , which we name ES cell renewal factor ( ESRF ) , is distinct from members of the IL 6 / LIF family because ( 1 ) it is effective on ES cells lacking LIF R ; ( 2 ) it is not blocked by anti gp 130 neutralizing antibodies ; and ( 3 ) it acts without activation of STAT 3 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukaemia inhibitory factor ( LIF ) plays an essential role during cell differentiation and implantation in the mouse exerting its effects via the two dimerizing receptor subunits glycoprotein 130 ( gp 130 ) and LIF receptor beta ( LR beta ) . ^^^ This study investigated the mRNA expression of bovine LIF ( bLIF ) , gp 130 and LR beta in pooled or individual bovine oocytes and embryos generated in vitro or in vivo after superovulation . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The pleiotrophic but overlapping functions of the cytokine family that includes interleukin ( IL ) 6 , IL 11 , leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 are mediated by the cytokine receptor subunit gp 130 as the common signal transducer . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Cytokines that transduce their signals either through glycoprotein 130 ( gp 130 ) homodimers or gp 130 / leukemia inhibitory factor ( LIF ) receptor beta heterodimers are potent inducers of osteoclast development in vitro as well as in vivo ; and interleukin ( IL ) 6 has been recognized as an important pathogenic factor in diseases characterized by increased bone remodeling , such as the osteoporosis of sex steroid deficiency . ^^^ This pattern of specificity was accounted for by the finding that EF cells express gp 130 , but not the ligand binding subunit of the IL 6 receptor ( gp 80 ) nor the LIF receptor beta . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The functional receptor for LIF is composed of LIFR alpha chain ( LIFRalpha ) and gp 130 both of which are shared in the functional receptors for oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ By using stable transfection of wild type or cytoplasmic deletion mutants of LIFRalpha together with full length gp 130 into Ba / F3 cells , we found that cells expressing gp 130 and an extensively deleted mutant LIFRalpha containing only the box 1 region were capable of proliferating in response to LIF , although LIF dependent long term growth of these cells was seriously impaired . ^^^ Using a similar strategy to generate WEHI 3BD+ cells expressing gp 130 and wild type or truncation mutants of LIFRalpha , studies revealed that the box 1 region of the LIFRalpha was also sufficient for LIF dependent induction of different aspects of differentiation , including up regulation of macrophage surface marker expression , morphological change , and cell migration in agar culture . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The receptor gp 130 is utilized by cytokines including interleukin 6 , leukemia inhibitory factor , oncostatin M , cilary neurotrophic factor and cardiotrophin . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The specific binding of leukemia inhibitory factor ( LIF ) or oncostatin M ( OSM ) to transmembrane gp 190 or gp 130 leads to their oligomerization which is necessary for signal transduction . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The cytokines ciliary neurotrophic factor ( CNTF ) and leukemia inhibitory factor ( LIF ) signal through a receptor complex formed between two transmembrane proteins , gp 130 and LIFRbeta . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Two types of functional hOSM receptors are known : the type 1 OSM receptor is identical to the LIF receptor that consists of gp 130 and the LIF receptor beta subunit ( LIFRbeta ) , and the type 2 OSM receptor consists of gp 130 and the OSM receptor beta subunit ( OSMRbeta ) . ^^^ To elucidate the molecular structure of the functional mOSM receptor , we cloned a cDNA encoding mOSMRbeta , which is 55 . 5 % identical to the hOSMRbeta at the amino acid level . mOSM responsive cell lines express high affinity mOSM receptors , as well as mOSMRbeta , whereas embryonic stem cells , which are responsive to LIF but not to mOSM , do not express mOSMRbeta . mOSMRbeta alone binds mOSM with low affinity ( kd = 13 . 0 nmol / L ) and forms a high affinity receptor ( kd = 606 pmol / L ) with gp 130 . ^^^ Ba / F3 transfectants expressing both mOSMRbeta and gp 130 proliferated in response to mOSM , but failed to respond to LIF and human OSM . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Plasma levels of interleukin ( IL ) 6 , soluble IL 6 receptor , soluble gp 130 , leukemia inhibitory factor ( LIF ) , and ciliary neutrophic factor ( CNTF ) were analyzed in 32 patients with severe malaria . ^^^ Plasma concentrations of gp 130 and LIF did not differ between the malaria groups or normal controls . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Glycoprotein 130 ( gp 130 ) belongs to the family of class 1 cytokine receptors and is the common signal transducing receptor subunit shared by the so called IL 6 type cytokines ( IL 6 , IL 11 , ciliary neurotrophic factor , leukemia inhibitory factor , oncostatin M , and cardiotrophin 1 ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
An antibody to gp 130 blocked the effects of LIF and CNTF , and both cytokines induced phosphorylation and nuclear translocation of stat 3 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) induces growth arrest and macrophage differentiation of mouse myeloid leukemic cells through the functional LIF receptor ( LIFR ) , which comprises a heterodimeric complex of the LIFR subunit and gp 130 . ^^^ Leukemia inhibitory factor ( LIF ) induces growth arrest and macrophage differentiation of mouse myeloid leukemic cells through the functional LIF receptor ( LIFR ) , which comprises a heterodimeric complex of the LIFR subunit and gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor action is mediated by a heterodimeric receptor consisting of two subunits , gp 130 and the low affinity leukemia inhibitory factor receptor ( LIFR ) . 2 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Cell type specific responses to the leukemia inhibitory factor ( LIF ) / interleukin 6 cytokine family are mediated by dimerization of the LIF receptor alpha chain ( LIFRalpha ) with the signal transducer gp 130 or of two gp 130 molecules followed by activation of the JAK / STAT and Ras / mitogen activated protein kinase cascades . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
IL 6 ) , whereas CNTF and leukemia inhibitory factor ( LIF ) signal via a heterodimer of gp 130 and LIF receptor ( LIFR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor is a member of a family of structurally related cytokines sharing the receptor component gp 130 . ^^^ Activation of gp 130 by leukemia inhibitory factor is sufficient to induce myocardial cell hypertrophy accompanied by specific changes in the pattern of gene expression . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Several other cytokines including oncostatin M , IL 11 , leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotropin 1 ( CT 1 ) use gp 130 as a common signal transducing molecule and therefore have similar biological activities . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor , Interleukin 6 , and other cytokines using the GP 130 transducing receptor : roles in inflammation and injury . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Cardiotrophin 1 ( CT 1 ) is a recently discovered member of the gp 130 cytokine family , which includes IL 6 , IL 11 , leukemia inhibitory factor , ciliary neurotrophic factor , and oncostatin M . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
OM signals are transduced through two different OM receptor complexes : a leukemia inhibitory factor ( LIF ) / OM receptor ( a heterodimer of LIFR beta and gp 130 ) and an OM specific receptor ( a heterodimer of OMR beta and gp 130 ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
To assess the existence of IL 6 receptor complex ( including IL 6R and gp 130 ) with the treatment of PG cells by use of recombinant human IL 6 ( rhIL 6 ) , recombinant human oncostatin M ( rhOSM ) , and recombinant human leukemia inhibitory factor ( rhLIF ) , respectively . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Developmental requirement of gp 130 signaling in neuronal survival and astrocyte differentiation . gp 130 is a signal transducing receptor component used in common by the interleukin 6 ( IL 6 ) family of hematopoietic and neurotrophic cytokines , including IL 6 , IL 11 , leukemia inhibitory factor , ciliary neurotrophic factor , oncostatin M , and cardiotrophin 1 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukaemia inhibitory factor ( LIF ) signals via a heterodimeric receptor complex comprised of the LIF receptor ( LIFR ) and the interleukin ( IL ) 6 signal transducer gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In contrast , N terminal modification of the sgp 130 with the FLAG epitope did not interfere with the binding of leukemia inhibitory factor or oncostatin M ( other cytokines that signal through gp 130 ) to sgp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
LIF acts through a receptor complex composed of a low affinity LIF receptor ( LIFRbeta ) and gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The present study also suggests that cardiotrophin 1 , but not LIF , is a possible candidate for natural ligand of a gp 130 signaling pathway in the heart . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) and leukemia inhibitory factor ( LIF ) are members of a subfamily of related cytokines that share gp 130 as common signal transducing receptor component . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Therefore , in vivo and in vitro expression of LIF , IL 6 and their signal transducer genes encoding LIF receptor ( LIFR ) , IL 6 receptor ( IL 6R ) and gp 130 in human medulloblastoma cells were investigated by multiple cellular and molecular biology approaches . ^^^ The results revealed that LIF expression could be found in 26 out of 28 tumors / cell line and over 90 % of the samples expressed LIFR , IL 6R and gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
This spontaneous astrocyte differentiation is completely impaired when neuroepithelial cells deficient for gp 130 , a signal transducing receptor component for LIF , are used . ^^^ Taken together with our previous finding that prenatal mouse brain deficient for gp 130 exhibits a severe reduction of astrocytes , it is suggested that LIF acts cooperatively with BMP 2 in vivo to induce astrocyte differentiation in mouse developing brain . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
We measured plasma levels of interleukin ( IL ) 1beta , IL 6 , tumor necrosis factor alpha ( TNF alpha ) , soluble forms of the cytokine receptor proteins gp 130 and leukemia inhibitory factor receptor ( LIF R ) , the anti inflammatory Clara cell 16 kD protein ( CC 16 ) , prolactin ( PRL ) , cortisol and 17beta estradiol in 21 anorexic women , 21 bulimic women and 21 healthy females . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NNT 1 / BSF 3 induces tyrosine phosphorylation of glycoprotein 130 ( gp 130 ) , leukemia inhibitory factor receptor beta , and signal transducer and activator of transcription 3 in the SK N MC human neuroblastoma cells . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Interleukin 11 ( IL 11 ) belongs to the interleukin 6 ( IL 6 ) type subfamily of long chain helical cytokines including IL 6 , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M , and cardiotrophin 1 , which all share the glycoprotein gp 130 as a signal transducing receptor component . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
OSM and LIF can bind to the same functional receptor complex ( LIF receptor beta and gp 130 heteromultidimers ) and thus mediate overlapping spectra of biological activities . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
To investigate the role of CNTF / LIF signaling in regenerative responses of motoneurons , we studied the expression of the three receptor components , CNTF receptor alpha ( CNTFRalpha ) , LIF receptor beta ( LIFRbeta ) , and gp 130 , and the activation of the STAT 3 signal transduction pathway in the rat facial nucleus following peripheral nerve transection . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukaemia inhibitory factor ( LIF ) and interleukin ( IL ) 6 are members of a cytokine group that share a common signal transducer gp 130 and induce pleiotropic biological effects in cells of diverse lineage . ^^^ LIF and IL 6 receptors , and gp 130 were demonstrated in MDMs by immunocytochemistry and RT PCR . ^^^ Anti LIF receptor and anti gp 130 antibodies attenuated the effect of LIF on TF expression as assayed by both bioassay and flow cytometry . ^^^ Thus , LIF may regulate by a gp 130 dependent pathway macrophage mediated procoagulant function in diverse pathological states involving inflammation and thrombosis and seems to serve as an important mediator at the interface between these processes . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Induction of gp 130 and LIF by differentiation inducers in human myeloid leukemia K 562 cells . ^^^ In the present study , we examined the ability of several differentiation inducers to regulate the expression of the signal transducing receptor component for IL 6 , gp 130 , and cytokine leukemia inhibitory factor ( LIF ) in K 562 cells . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
To investigate the roles of cytokines that act through the gp 130 signaling chain in the residual platelet production of mpl ( / ) mice , mpl ( / ) IL 6 ( / ) , mpl ( / ) LIF ( / ) , and mpl ( / ) IL 11Ralpha ( / ) double mutant mice were generated . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) and interleukin 6 ( IL 6 ) , two cytokines sharing the common gp 130 receptor subunit and functioning through activation of the intracellular JAK / STAT pathway , induce POMC synthesis and ACTH release . ^^^ Leukemia inhibitory factor ( LIF ) and interleukin 6 ( IL 6 ) , two cytokines sharing the common gp 130 receptor subunit and functioning through activation of the intracellular JAK / STAT pathway , induce POMC synthesis and ACTH release . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The receptor gp 130 is used by the interleukin 6 ( IL 6 ) type cytokines , which include IL 6 and leukaemia inhibitory factor ( LIF ) . ^^^ Whereas the binding affinities of ( 125 ) 1 labelled IL 6 to ( GR FNIII ) gp 130 , or of ( 125 ) 1 Tyr 1 , 3 G CSF to ( gp 130 FNIII ) GR , were similar to wild type gp 130 and wild type G CSFR , respectively , ( 125 ) 1 LIF failed to bind with high affinity to ( GR FNIII ) gp 130 . ^^^ In assays measuring differentiation the ( gp 130 FNIII ) GR cells were fully responsive to G CSF , whereas the ( GR FNIII ) gp 130 cells responded fully to the agonistic anti gp 130 monoclonal antibody ( mAb ) B S 12 , but not to IL 6 or LIF . ^^^ Neutralizing mAbs that recognize the membrane proximal FNIII modules of gp 130 or the G CSFR differentially interfered with signalling by B S 12 , LIF and G CSF . ^^^ The data suggest that B S 12 and G CSF induce the correct orientation or conformation for signalling by the wild type and chimaeric homodimeric receptors , that the membrane proximal region of gp 130 is important for the correct formation of the signalling IL 6 IL 6 receptor gp 130 complex and that this region is also involved in LIF dependent receptor heterodimerization and signalling . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Soluble glycoprotein 130 ( gp 130 ) attenuates OSM and LIF induced cartilage proteoglycan catabolism . ^^^ The two cytokines bind with high affinity to the same receptor ( LIF / OSM receptor ) , which consists of the LIF receptor alpha chain ( LIFRalpha ) and the signal transduction unit gp 130 . ^^^ In this study , we sought to determine whether recombinant sgp 130 or anti gp 130 Ab could attenuate the resorption of proteoglycans induced by OSM and LIF in articular cartilage explants . ^^^ The failure of anti gp 130 to attenuate LIF stimulated PG resorption may be due to the normal interaction of LIF with LIFRalpha and unfettered heterodimerization of LIFRalpha with gp 130 in the presence of the antibody . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Serum concentrations of interleukin 6 ( IL 6 ) , IL 6 receptor ( IL 6R ) , gp 130 ( the IL 6 signaling protein ) , IL 1R antagonist ( IL 1RA ) and leukemia inhibitory factor receptor ( LIFR ) were assayed in 22 nonpregnant women and in 91 pregnant women before delivery and 1 and 3 days after delivery . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Gp 130 cytokine receptor is involved in the formation of multimeric functional receptors for interleukin 6 ( IL 6 ) , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ To generate type 1 or type 2 OSM receptors , gp 130 mutants were expressed together with either LIF receptor beta or OSM receptor beta . ^^^ Interestingly , binding of LIF to type 1 receptor was not affected , corroborating the notion that in this case gp 130 mostly behaves as a converter protein rather than a binding receptor . ^^^ The present study demonstrates that positions 189 192 of gp 130 cytokine binding domain are essential for OSM binding to both gp130 / LIF receptor beta and gp130 / OSM receptor beta heterocomplexes . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Gp 130 is the common signal transducing receptor subunit of interleukin ( IL ) 6 , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor and cardiotrophin 1 . ^^^ Here we show that a gp 130 mutant lacking domain 1 , although unresponsive to IL 6 and IL 11 , can still activate signal transducer and activator of transcription ( STAT ) transcription factors in response to LIF or OSM . ^^^ Moreover , point mutations in the CBM of gp 130 ( F191E and V252D ) that severely impair signal transduction in response to IL 6 and IL 11 differentially interfere with gp 130 activation in response to LIF and OSM . ^^^ Different epitopes are required for gp 130 activation by interleukin 6 , oncostatin M and leukemia inhibitory factor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The neurally active cytokine leukemia inhibitory factor ( LIF ) signals through a bipartite receptor complex composed of LIF receptor alpha ( LIFR ) and gp 130 . gp 130 and LIFR contain consensus binding motifs for the protein tyrosine phosphatase SHP 2 surrounding tyrosines 118 and 115 ( Y 118 and Y 115 ) of their cytoplasmic domains , respectively . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The LIF receptor shares a common gp 130 receptor subunit with the IL 6 cytokine superfamily . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) signals via the heterodimeric receptor complex comprising the LIF receptor alpha subunit ( LIFRalpha ) and the common signal transducing subunit for interleukin 6 cytokine receptors , gp 130 . ^^^ Leukemia inhibitory factor ( LIF ) signals via the heterodimeric receptor complex comprising the LIF receptor alpha subunit ( LIFRalpha ) and the common signal transducing subunit for interleukin 6 cytokine receptors , gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Following earlier findings that OM 85 BV induces the synthesis of IL 6 , a study was undertaken to investigate its possible effect on other gp 130 binding cytokines including IL 11 , IL 12 , leukaemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and ciliary neutrophil factor ( CNTF ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Using neutralizing antibodies to gp 130 , the OSM receptor ( OSMR ) , and the leukemia inhibitory factor receptor ( LIFR ) , we document that OSM exclusively uses the OSMR / gp 130 heterodimer in signaling events , rather than the LIFR / gp 130 heterodimer . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Furthermore , almost no phosphorylated STAT 3 ( signal transducer and activator of transcription 3 ) , downstream of the LIF receptor and the gp 130 signaling subunit , was observed in the ventricles of JVS and control mice . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Gp 130 , a signal transducing receptor component of LIF , was mainly localized in the glandular epithelium . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Two of the most potent cytokines regulating anterior pituitary cell function are leukemia inhibitory factor and interleukin 6 ( IL 6 ) , which belong to the cytokine receptor family using the common gp 130 signal transducer . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The receptor for leukemia inhibitory factor ( LIF ) consists of two polypeptides , the LIF receptor and gp 130 . ^^^ We found that gp 130 fusion proteins were phosphorylated exclusively on Ser 782 by LIF and growth factor stimulated 3T3 L 1 cell extracts . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
These results indicated that angiotensin 2 induced IL 6 , LIF , and cardiotrophin 1 in cardiac fibroblasts , and that these cytokines , particularly LIF and cardiotrophin 1 , activated gp 130 linked signaling and contributed to angiotensin 2 induced cardiomyocyte hypertrophy . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Acute obstructive cholangiopathy in interleukin 6 deficient mice : compensation by leukemia inhibitory factor ( LIF ) suggests importance of gp 130 signaling in the ductular reaction . ^^^ Leukemia inhibitory factor ( LIF ) , another gp 130 ligand , also showed marked peri biliary upregulation after BDL in both groups , and also induced BEC DNA synthesis , in vitro . ^^^ Leukemia inhibitory factor ( LIF ) , another gp 130 ligand , also showed marked peri biliary upregulation after BDL in both groups , and also induced BEC DNA synthesis , in vitro . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
All of these cell lines express the receptor components of OSM and leukemia inhibitory factor ( LIF ) gp 130 , LIFR and the OSM specific OSMRbeta . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The cytoplasmic domain of LIF R can generate the signals for growth arrest and differentiation of mouse myeloid leukemic cells when they are induced to form a homodimer of the cytoplasmic domain independently of gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
LIF , LIF receptor , gp 130 , as well as type 1 and 2 T helper cytokine expressions were investigated by reverse transcription polymerasse chain reaction , in situ hybridization , and histological studies . ^^^ The gp 130 expression was only observed in LIF treated B6D2F1 to BALB / c allografting on day 21 posttransplantation . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Western blot analysis showed that bone marrow derived mast cells failed to express both LIF receptor ( LIFR ) and gp 130 , whereas 3T3 fibroblasts expressed both LIFR and gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
IL 6 , but not LIF , similarly promoted gp 130 dependent macrophage chemotaxis . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Signalling of interleukin 6 type cytokines via gp 130 , leukemia inhibitory factor ( LIF ) receptor and oncostatin M receptor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
HCG release induced by recombinant human OSM was completely blocked by antibodies against OSM and the signal transducer , gp 130 , but only partially inhibited by antibodies against the leukaemia inhibiting factor ( LIF ) receptor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The Y 759 motif in gp 130 also attenuates gene induction mediated by the oncostatin M and leukemia inhibitory factor receptor complexes , which both contain gp 130 as the shared subunit . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The biological actions of interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophic factor ( CNTF ) are mediated via respective functional receptor complexes consisting of a common signal transducing component , gp 130 , and other specific receptor components , IL 6 receptor alpha ( IL 6R ) , LIF receptor beta ( LIFR ) , and CNTF receptor alpha ( CNTFR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Its receptor complex consists of a non signaling alpha chain , CNTFR , and two signaling beta chains , gp 130 and the leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Dependent signalling pathway is not enhanced in gp 130 transgenic heart after LIF stimulation . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The CNTF receptor CNTFRalpha mRNA displayed only small changes , whereas the mRNA for membrane glycoprotein 130 ( gp 130 ) , which is a critical receptor component for LIF and CNTF transduction , was profoundly down regulated in motoneurons after ventral root avulsion . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
BACKGROUND : Leukemia inhibitory factor ( LIF ) is a member of the interleukin 6 family of cytokines that utilize gp 130 as a common signaling component . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
LIF , a member of the gp 130 sharing cytokine family , modulates pituitary development , POMC gene expression , and ACTH secretion . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Involving of the cytoplasmic region of leukemia inhibitory factor receptor alpha subunit , IL 6 related signal transducer gp 130 or fas death domain for MAPK p42 / 44 activation in HL 60 cell with LIF or anti Fas IgG . ^^^ The chimeric receptors were prepared by exchanging the cytoplasmic region between leukemia inhibitory factor ( LIF ) receptor alpha subunit ( gp 190 ) and the other subunit gp 130 ( 190 / 130 , 130 / 190 ) and separately transduced into leukemia line HL 60 ( to have the wild type subunit ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Its receptor complex consists of a ligand binding component , CNTF receptor ( CNTFR ) , associated with two signaling receptor components , gp 130 and leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Expression of mRNAs for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptors ( CNTFR alpha , LIFR beta , IL 6R alpha , and gp 130 ) in human peripheral neuropathies . ^^^ The mRNA levels of neuropoietic cytokines , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , and interleukin 6 ( IL 6 ) , and their receptor components ( CNTFR alpha , LIFR beta , IL 6R alpha , and gp 130 ) were examined in seventy six patients with various peripheral neuropathies to determine the extent of expression of these cytokines and receptors , and their relationship to nerve fiber pathology and cell infiltration in the diseased nerves . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The mRNAs for LIF / LIFR , IL 6 / IL 6R , and their common signal transduction molecule , gp 130 , in olfactory nasal mucosa from control mice and from 3 day post OBX mice were detected with reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Two of the most potent cytokines regulating anterior pituitary cell function are leukemia inhibitory factor ( LIF ) and interleukin ( IL ) 6 , which belong to the cytokine family using the common gp 130 signal transducer . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Immunohistochemistry was used to detect leukaemia inhibitory factor ( LIF ) , IL 6 and glycoprotein 130 ( gp 130 ) in myocardial tissues . ^^^ Immunohistochemical analysis localized IL 6 , LIF and their common receptor subunit gp 130 to myocytes and vascular smooth muscle cells . ^^^ Myocardial IL 6 and gp 130 mRNA levels were not statistically different between patients and donors , but in contrast to LIF mRNA expression in heart explants , gp 130 mRNA levels were significantly higher in left atrium compared with left ventricle in both patients and donors . ^^^ CONCLUSIONS : Both mRNA and proteins of gp 130 and its ligands IL 6 and LIF are expressed in both nonfailing and failing human myocardium . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Flow cytometric analyses detected both the OSM specific receptor and the gp 130 receptor at the chondrocyte cell surface , but failed to detect the leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The cytokines that signal through the common receptor subunit gp 130 , including ciliary neurotrophic factor ( CNTF ) , interleukin 6 , leukemia inhibitory factor ( LIF ) and oncostatin M , have pleiotropic functions in CNS development . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The pericryptal fibroblast cells expressed messenger RNA ( mRNA ) for interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , LIF receptor alpha , and the common coreceptor glycoprotein 130 ( GP 130 ) , but not the IL 6 receptor alpha . ^^^ In comparison , normal colonic epithelial cells express mRNA for LIF but not IL 6 as well as the receptors for GP 130 , IL 6 receptor alpha but not LIF receptor alpha . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Oncostatin M regulates the synthesis and turnover of gp 130 , leukemia inhibitory factor receptor alpha , and oncostatin M receptor beta by distinct mechanisms . ^^^ The cytokine receptor subunits gp 130 , leukemia inhibitory factor receptor alpha ( LIFRalpha ) , and oncostatin M receptor beta ( OSMRbeta ) transduce OSM signals that regulate gene expression and cell proliferation . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The receptor for the cytokine leukemia inhibitory factor ( LIF ) associates the low affinity binding component gp 190 and the high affinity converter gp 130 , both of which are members of the family of hematopoietic receptors characterized by the cytokine receptor homology ( CRH ) domain . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Using RT PCR we detected transcripts of the receptor components involved in OSM signaling , gp 130 , OSM receptor ( OSMR ) beta , and leukemia inhibitory factor receptor ( LIFR ) , in HCEC . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The receptor subunit gp 130 transduces multiple cell type specific activities of the leukemia inhibitory factor ( LIF ) / interleukin ( IL ) 6 family of cytokines through the signal transducer and activator of transcription ( STAT ) and src homology 2 domain bearing protein tyrosine phosphatase ( SHP ) 2 / ras / Erk pathways . ^^^ To define STAT dependent physiological responses , we generated mice with a COOH terminal gp 130 ( DeltaSTAT ) `` knock in ' ' mutation which deleted all STAT binding sites . gp 130 ( DeltaSTAT ) mice phenocopyed mice deficient for IL 6 ( impaired humoral and mucosal immune and hepatic acute phase responses ) and LIF ( failure of blastocyst implantation ) . ^^^ Mitogenic hyperresponsiveness of synovial cells to the LIF / IL 6 family of cyto kines was caused by sustained gp 130 mediated SHP 2 / ras / Erk activation due to impaired STAT mediated induction of suppressor of cytokine signaling ( SOCS ) proteins which normally limits gp 130 signaling . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
For signal transduction , CNTF requires a receptor complex , composed of the IL 6 signal transducing molecule gp 130 , leukemia inhibitory factor receptor ( LIFR ) beta , and CNTFR alpha . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
We demonstrated expression of three components of the OSM receptor ; gp 130 , the leukemia inhibitory factor receptor ( LIFRbeta ) and the OSM specific receptor ( OSMRbeta ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Among the proinflammatory mediators , leukemia inhibitory factor ( LIF ) , which shares a receptor component ( gp 130 subunit ) with interleukin 6 ( IL 6 ) , has been identified as a mast cell growth enhancing factor produced by cells of the keratinocyte derived cell line ( KCMH 1 ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The primary structure of leptin receptor belongs to the cytokine class 1 family , the single membrane spanning receptor , and is highly related to the gp 130 signal transducing component of the interleukin 6 ( IL 6 ) receptor , the granulocyte colony stimulating factor ( G CSF ) receptor , and the leukemia inhibitory factor ( LIF ) receptor . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
We examined the expression of CT 1 , leukemia inhibitory factor ( LIF ) , and gp 130 by competitive RT PCR and Western blotting in Dahl salt sensitive ( DS ) rats with a high salt diet , which showed a distinct transition from left ventricular hypertrophy ( LVH ) to congestive heart failure ( CHF ) . ^^^ The expression levels of CT 1 mRNA and protein were significantly increased at the CHF stage compared with the LVH stage and age matched Dahl salt resistant ( DR ) rats ( n = 6 for each group ) . mRNA expression of LIF was not changed in the left ventricle at any stage by RT PCR . gp 130 mRNA and protein levels of DS rats at 11 and 17 wk were significantly increased compared with age matched DR rats . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
This study was designed to identify the presence and action of CT 1 and its receptor complex , glycoprotein 130 ( gp 130 ) and leukemia inhibitory factor ( LIF ) receptor , on cardiac fibroblast growth in cultured adult canine cardiac fibroblasts . ^^^ Blockade of gp 130 or LIF receptor inhibited basal growth as well as CT 1 or ET 1 stimulated cardiac fibroblast growth . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The secondary structure of leptin has similarities to the long chain helical cytokines family , which includes interleukin 6 ( IL 6 ) , IL 11 , CNTF , and LIF , and the leptin receptor is homologous to the gp 130 signal transducing subunit of the IL 6 type cytokine receptors . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Binding of LIF to LIF receptor and gp 130 activates signal transduction pathways . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The activity in NKCM was dose dependent and could not be neutralized by an excess of antibodies to IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , gp 130 , stromal cell derived factor 1a ( SDF 1a ) , and thrombopoietin ( TPO ) . ^^^ These findings indicate that IL 2 stimulated NK cells produce a novel peptide , distinct from TPO , IL 6 , IL 11 , LIF , other gp 130 associated interleukins , and SDF1a , that can induce in vitro endomitosis in immature human megakaryocytes in the presence of IL 3 and SCF . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The present study demonstrates an upregulation of both the LIF receptor ( LIFR ) alpha subunit and the signal transducing subunit gp 130 following endothelial denudation of the carotid artery by balloon catheter . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Oncostatin M can activate two related receptors , one consisting of a low affinity LIF receptor subunit , LIFR beta , which forms a heterocomplex with the gp 130 signal transducing protein and can recognize both oncostatin M and LIF , and a second heterocomplex consisting of a subunit that specifically recognizes oncostatin M , OSMR beta , and the gp 130 protein . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The receptor for the cytokine leukemia inhibitory factor ( LIF ) associates the low affinity binding component gp 190 and the high affinity converter gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In contrast , LIF does not activate STAT 3 , ERK , or the gp 130 receptor in human N tera 2 / D1 EC cells , although all receptor components are expressed . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
The functional receptor complex of CNTF is composed of the CNTF receptor alpha ( CNTFR ) , gp 130 and the leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
We show that these clones display IL 6 and leukemia inhibitory factor receptors with reduced binding affinities and express gp 130 at reduced levels . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
IL 6 signaling is mediated exclusively by the common signal transducing component gp 130 , which is also essential for signal transduction of other cytokines of the leukemia inhibitory factor ( LIF ) / IL 6 family . ^^^ Synovial cells from this mouse exhibited mitogenic hyper responsiveness to cytokines of the LIF / IL 6 family , a phenomenon that was caused by sustained gp 130 mediated SHP 2 / Ras / Erk activation due to a defect in the induction of SOCS 1 ( suppressor of cytokine signaling 1 ; also known as SSI or JAB ) . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
A functional role of the membrane proximal extracellular domains of the signal transducer gp 130 in heterodimerization with the leukemia inhibitory factor receptor . gp 130 is the common signal transducing receptor subunit of interleukin ( IL ) 6 type cytokines . gp 130 either homodimerizes in response to IL 6 and IL 11 or forms heterodimers with the leukemia inhibitory factor ( LIF ) receptor ( LIFR ) in response to LIF , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , cardiotrophin 1 ( CT 1 ) or cardiotrophin like cytokine resulting in the onset of cytoplasmic tyrosine phosphorylation cascades . ^^^ Deletion of each of the membrane proximal domains of gp 130 ( Delta 4 , Delta 5 and Delta 6 ) leads to LIF unresponsiveness . ^^^ Replacement of the gp 130 domains by the corresponding domains of the related GCSF receptor either restores weak LIF responsiveness ( D 4 GCSFR ) , leads to constitutive activation of gp 130 ( D 5 GCSFR ) or results in an inactive receptor ( D 6 GCSFR ) . ^^^ Mutation of a specific cysteine in D 5 of gp 130 ( C458A ) leads to constitutive heterodimerization with the LIFR and increased sensitivity towards LIF stimulation . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Here , we report the construction and expression of a CNTF / soluble CNTF receptor ( sCNTF R ) fusion protein ( Hyper CNTF ) with enhanced biological activity on cells expressing gp 130 and leukemia inhibitory factor receptor ( LIF R ) , but not membrane bound CNTF R . ^^^ Hyper CNTF efficiently induced dose dependent STAT 3 phosphorylation and proliferation of BAF 3 cells stably transfected with gp 130 and LIF R cDNAs . ^^^ These data indicate that although LIF and Hyper CNTF use the same heterodimeric receptor complex of gp 130 and LIFR , only Hyper CNTF induces neuronal differentiation . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Exposure of these cells to other gp 130 receptor family cytokines , including leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and IL 11 , do not significantly affect DNA synthesis or induction of tPA / PAI 1 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
In contrast , injection of leukemia inhibitory factor ( LIF ) , a gp 130 ligand , into the lateral cerebral ventricle of wild type embryos exo utero induced hyperplasia of the cerebral cortex and increased the incorporation of BrdU in progenitor cells . ^^^ Furthermore , chronologically controlled injection of LIF followed or preceded by BrdU revealed that gp 130 mediated signals promote the progenitor cells to reenter the stem cell cycle without affecting the duration of cell cycle and enhance the migration of postmitotic neurons in the developing cerebrum . . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Continuous treatment with Dex ( 10 ( 8 ) mol / L ) inhibited the endogenous production of IL 6 , LIF , OSM , IL 11R , and OSMR , but had no detectable effect on the expression of IL 11 , CT 1 , CNTF , CNTFR , LIFR , or gp 130 . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
OBJECTIVE : The development of megakaryocytes is regulated by thrombopoietin ( TPO ) , which binds to the c mpl receptor , and by several other cytokines such as interleukin ( IL ) 6 , IL 11 , leukemia inhibitory factor ( LIF ) , cilliary neurotropic factor ( CNTF ) , and oncostatin ( OSM ) , which bind to gp 130 protein coupled receptors . ^^^ To our surprise , none of the other gp 130 protein related cytokines tested ( IL 11 , LIF , CNTF , and OSM ) activated these signaling pathways in CD34+ cells , megakaryoblasts , or platelets . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Group 1 received only a control vehicle , group 2 received leukemia inhibitory factor ( LIF ) , cDNA treated , group 3 received combined treatment of LIF and anti gp 130 antibody , and group 4 was the anti gp 130 treated group . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Immunolocalization of gp 130 , IL 6R , and the LIF receptor showed that the glandular epithelium and also endothelial cells are targets for IL 6 and LIF . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
Interleukin ( IL ) 6 , leukaemia inhibitory factor ( LIF ) and IL 11 belong to the same family of cytokines whose receptors utilize gp 130 as the signalling molecule . ^^^ IL 6 receptor , LIF receptor and gp 130 were all expressed by cultured stromal and epithelial cells , showing that the lack of effect is not due to lack of expression of the receptor components . ^^^
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q17RA0 and P15018	Pubmed	SVM Score :0.0
NA