| Interacting proteins: Q9HBZ2 and Q16665 |
Pubmed |
SVM Score :0.0 |
| Finally , sequence comparison of the currently known bHLH / PAS proteins indicates a division into two phylogenetic groups : the Arnt group , containing Arnt , Arnt 2 , and Per , and the AhR group , consisting of AhR , Sim , and Hif 1alpha . . ^^^ |
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| Interacting proteins: Q9HBZ2 and Q16665 |
Pubmed |
SVM Score :0.0 |
| Considering these results and that Arnt or Arnt 2 functions as a common partner in the formation of transcriptional regulators with other bHLH / PAS proteins such as AhR , HLF , and HIF 1alpha , the possibility arises that CBP / p300 is extensively involved as a coactivator in the transactivation process by bHLH / PAS ( a conserved sequence motif among Per , Arnt , and Sim ) heterodimer transcription factors through interaction with Arnt or Arnt2 . . ^^^ |
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| Interacting proteins: Q9HBZ2 and Q16665 |
Pubmed |
SVM Score :0.0 |
| Expression of ARNT , ARNT 2 , HIF 1 alpha , HIF 2 alpha and Ah receptor mRNAs in the developing mouse . ^^^ |
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| Interacting proteins: Q9HBZ2 and Q16665 |
Pubmed |
SVM Score :0.0 |
| ARNT 2 is a conserved ARNT homolog that is highly expressed in neurons , suggesting that ARNT2 / HIF 1alpha heterodimers mediate transcriptional responses to oxygen deprivation in the nervous system . ^^^ |
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| Interacting proteins: Q9HBZ2 and Q16665 |
Pubmed |
SVM Score :0.0 |
| Two splice variants of the hypoxia inducible factor HIF 1alpha as potential dimerization partners of ARNT 2 in neurons . ^^^ Here , using in situ hybridization and immunocytochemistry , we show that HIF 1alpha is expressed in normoxic cerebral neurons together with not only ARNT 1 but also ARNT 2 , a cerebral translocator homologous to ARNT 1 but displaying , unlike ARNT 1 , a selective neuronal expression . ^^^ We also identify two splice variants of HIF 1alpha in brain , one of which dimerizes with ARNT 2 even more avidly than with ARNT 1 . ^^^ We therefore propose that HIF 1alpha and ARNT 2 function as preferential dimerization partners in neurons to control specific responses , some of which may not be triggered by hypoxia . ^^^ In support of this proposal , in nonhypoxic PC 12 cells constitutively coexpressing HIF 1alpha , ARNT 1 and ARNT 2 , downregulation of either HIF 1alpha or ARNT 2 , obtained with selective antisense nucleotides , resulted in inhibition of [ 3H ] thymidine incorporation . . ^^^ |
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| Interacting proteins: Q9HBZ2 and Q16665 |
Pubmed |
SVM Score :0.0 |
| In neuronal cells , ARNT 1 and ARNT 2 can form a heterodimer with HIF 1alpha , generating a functional HIF 1 complex . ^^^ |
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| Interacting proteins: Q9HBZ2 and Q16665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HBZ2 and Q16665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HBZ2 and Q16665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HBZ2 and Q16665 |
Pubmed |
SVM Score :0.0 |
| NA |
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