| Interacting proteins: Q92905 and Q16665 |
Pubmed |
SVM Score :0.89241795 |
| The interaction of Jab 1 with HIF 1alpha was confirmed by GST pull down assay and also reproduced in vivo in HEK 293 cells , where endogenous Jab 1 was coimmunoprecipitated with the overexpressed HIF 1alpha . 0.89241795^^^ Here , using the yeast two hybrid screening system , we found that HIF 1alpha interacts with Jab 1 ( Jun activation domain binding protein 1 ) , which is a coactivator of AP 1 transcription factor and fifth subunit of COP 9 signalosome complex . 0.85208795^^^ Jab 1 interacts directly with HIF 1alpha and regulates its stability . 0.84742405^^^ |
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| Interacting proteins: Q92905 and Q16665 |
Pubmed |
SVM Score :0.0 |
| It was recently reported that HIF 1alpha binds a co activator of the AP 1 transcription factor , Jab 1 , which inhibits the p 53 dependent degradation of HIF 1 and enhances the transcriptional activity of HIF 1 and the subsequent VEGF expression under hypoxic conditions . ^^^ |
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| Interacting proteins: Q92905 and Q16665 |
Pubmed |
SVM Score :0.0 |
| Jab 1 and p 53 bind competitively to the same domain on HIF 1alpha resulting in either stabilization or degradation of HIF 1alpha , respectively . ^^^ Moreover , p 53 is stabilized by binding to HIF 1alpha , whereas its interaction with Jab 1 targets p 53 for degradation . ^^^ |
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| Interacting proteins: Q92905 and Q16665 |
Pubmed |
SVM Score :0.0 |
| Recent studies have shown that a protein known as CSN 5 or JAB 1 interacts with both the HIF 1alpha oxygen responsive transcription factor and its oxygen dependent regulator , the Von Hippel Lindau ( pVHL ) tumor suppressor . ^^^ The exact function of the CSN 5 interaction with pVHL and HIF 1alpha remains to be fully elucidated , but it is clear that the interaction is both oxygen dependent and that CSN 5 may play different roles under oxic and hypoxic responses . ^^^ Further , evidence has also been published indicating that pVHL can be potentially post translationally modified by CSN 5 ( de neddylation ) and that CSN 5 transcription is regulated by hypoxia as are many of the key pVHL / HIF 1alpha regulatory genes such as the PHDs and OS 9 . ^^^ This review will give a broad overview of known CSN 5 and COP 9 Signalosome functions and how these functions impact the pVHL / HIF 1alpha signaling complex and potentially other oxygen sensitive response networks . . ^^^ |
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