| Interacting proteins: Q16665 and Q00987 |
Pubmed |
SVM Score :0.5511339 |
| The interaction between HIF 1alpha , Mdm 2 , and p 53 proteins during hypoxia has received recent attention . 0.5511339^^^ |
|
| Interacting proteins: Q16665 and Q00987 |
Pubmed |
SVM Score :1.3295868 |
| Here , we found that HIF 1 alpha directly binds Mdm 2 both in vitro and in vivo ; in contrast , p 53 fails to directly interact with HIF 1 alpha in vitro . 1.3295868^^^ Direct interactions between HIF 1 alpha and Mdm 2 modulate p 53 function . 0.79522474^^^ |
|
| Interacting proteins: Q16665 and Q00987 |
Pubmed |
SVM Score :0.0 |
| Suppression of hypoxia inducible factor 1alpha ( HIF 1alpha ) by YC 1 is dependent on murine double minute 2 ( Mdm 2 ) . ^^^ |
|
| Interacting proteins: Q16665 and Q00987 |
Pubmed |
SVM Score :0.0 |
| Depletion of dephosphorylated HIF 1alpha also prevented hypoxia induced nuclear accumulation of HDM 2 , a negative regulator of p 53 . ^^^ |
|
| Interacting proteins: Q16665 and Q00987 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor transcriptional activation is mediated by hypoxia inducible factor 1alpha , HDM 2 , and p70S6K1 in response to phosphatidylinositol 3 kinase / AKT signaling . ^^^ |
|
| Interacting proteins: Q16665 and Q00987 |
Pubmed |
SVM Score :0.0 |
| The additional molecular targets considered here include the type 1 insulin like growth factor receptor , the epidermal growth factor receptor , mammalian target of rapamycin , NF kappaB , hypoxia inducible factor 1alpha , hsp 90 , cyclooxygenase 2 , protein kinase A type 1 , vascular endothelial growth factor , 5 lipoxygenase , 12 lipoxygenase , angiotensin 2 receptor type 1 , bradykinin receptor type 1 , c Src , interleukin 6 , ras , MDM 2 , bcl 2 / bclxL , vitamin D receptor , estrogen receptor beta , and PPAR . ^^^ |
|
| Interacting proteins: Q16665 and Q00987 |
Pubmed |
SVM Score :0.0 |
| The association of HIF 1alpha with von Hippel Lindau protein was not affected , whereas that with mouse double minute 2 ( MDM 2 ) was greatly reduced in the presence of Nur 77 . ^^^ Finally , PD 98059 decreased Nur 77 induced HIF 1alpha stability and recovered MDM 2 expression , indicating that the extracellular signal regulated kinase pathway is critical in the Nur 77 induced activation of HIF 1alpha . ^^^ |
|
| Interacting proteins: Q16665 and Q00987 |
Pubmed |
SVM Score :0.0 |
| These irradiated MDR cells also exhibited the reduction of other chemoresistance related proteins , including BCL 2 , NF kappaB , EGFR , MDM 2 and Ku70 / 80 , and the suppression of HIF 1alpha expression induced by hypoxia . ^^^ |
|
| Interacting proteins: Q16665 and Q00987 |
Pubmed |
SVM Score :0.0 |
| In particular , we demonstrate that p14ARF interacts with the SUMO E 2 conjugating enzyme , Ubc 9 and enhances the sumoylation of its binding partners , hdm 2 , E2F 1 , HIF 1alpha , TBP 1 and p120E4F . ^^^ |
|
| Interacting proteins: Q16665 and Q00987 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and Q00987 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and Q00987 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and Q00987 |
Pubmed |
SVM Score :0.0 |
| NA |
|