| Interacting proteins: Q16665 and P63165 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P63165 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P63165 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P63165 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P63165 |
Pubmed |
SVM Score :0.0 |
| In this present study , we found that the ectopic expression of SUMO 1 increased HIF 1alpha stability by the co transfection study with HIF 1alpha and SUMO 1 . ^^^ Furthermore , the ectopic expression of SUMO 1 enhanced the transcriptional activity of HIF 1alpha . ^^^ In the subsequent immunoprecipitation assay , SUMO 1 was co immunoprecipitated with HIF 1alpha , implying that HIF 1alpha is covalently modified by SUMO 1 . ^^^ Altogether , we demonstrate that HIF 1alpha is upregulated through SUMO 1 modification at Lys ( 391 ) / Lys ( 477 ) residues , which may stabilize HIF 1alpha and enhance its transcriptional activity . . ^^^ |
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