| Interacting proteins: Q16665 and P17980 |
Pubmed |
SVM Score :0.0 |
| TBP 1 associates with the beta domain of pVHL and complexes with pVHL and Hif 1 alpha in vivo . ^^^ Overexpression of TBP 1 promotes degradation of Hif 1 alpha in a pVHL dependent manner that requires the ATPase domain of TBP 1 . ^^^ Blockade of TBP 1 expression by small interfering RNA ( siRNA ) causes prolonged degradation kinetics of Hif 1 alpha . ^^^ A pVHL mutant containing a P154L substitution coimmunoprecipitates with Hif 1 alpha , but not TBP 1 , and does not promote degradation of Hif 1 alpha . ^^^ Thus , the ability of pVHL to degrade Hif 1 alpha depends in part on its interaction with TBP 1 and suggests a new mechanism for Hif 1 alpha stabilization in some pVHL deficient tumors . . ^^^ |
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| Interacting proteins: Q16665 and P17980 |
Pubmed |
SVM Score :0.0 |
| In particular , we demonstrate that p14ARF interacts with the SUMO E 2 conjugating enzyme , Ubc 9 and enhances the sumoylation of its binding partners , hdm 2 , E2F 1 , HIF 1alpha , TBP 1 and p120E4F . ^^^ |
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