| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| Transcription of the HIF1A gene was initiated over a 15 nt region downstream of two SP 1 sites . ^^^ |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| Finally , we demonstrate that HIF1A gene transcription is dependent on Sp 1 binding sites and that the 5 ' UTR sequence also contains other important cis acting elements . . ^^^ |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| Regulatory elements binding known transcription factors , such as Sp 1 , Pit 1 , glucocorticoid receptor , and hypoxia inducible factor 1 alpha ( HIF 1alpha ) were also identified . ^^^ |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| Among the differentially expressed genes , we chose for further validation histone deacetylase 1 ( HDAC 1 ) , von Hippel Lindau and decorin as upregulated genes , and Sp 1 , hypoxia inducible factor 1 alpha and DNA primase as downregulated genes . ^^^ |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| RESULTS : From a total of 345 screened TFs , 7 activity differential TFs were found , of which 5 showed increased activity , including p 53 , hypoxia inducible factor 1 alpha ( HIF 1alpha ) , signal transducer and activator of transcription 3 ( Stat 3 ) and Sp 1 , and 2 showed decreased activity including Rb and Smad 3 . ^^^ |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| However , this full induction is achieved only if the TGF beta pathway is mediating a cross talk between promoter ( Sp 1 ) and enhancer ( HIF 1alpha ) regions through Smad 3 . ^^^ |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| HIF 1alpha displaces the transcriptional activator Myc from Sp 1 binding to repress MutSalpha expression in a p 53 dependent manner ; Sp 1 serves as a molecular switch by recruiting HIF 1alpha to the gene promoter under hypoxia . ^^^ |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| In particular , the constitutively bound transcription factor Sp 1 serves as a molecular switch by recruiting HIF 1alpha in hypoxia to displace the transcription activator Myc from the promoter . ^^^ |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| Together , these results suggest that gefitinib decreases VEGF expression both by decreasing Sp 1 binding to the proximal core VEGF promoter and by down regulating HIF 1alpha expression . ^^^ |
|
| Interacting proteins: Q16665 and P08047 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that in control cells insulin stimulation leads to H2O2 generation , a biphasic activation of p42 / 44 MAPK and the induction of both Sp 1 and HIF 1alpha . ^^^ |
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