| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :1.0626533 |
| It could be shown by use of in vitro luciferase assays , electrophoretic mobility shift assays , and immunoprecipitation that hypoxia inducible factor 1alpha interacts with c Jun / AP 1 and may thereby contribute to Cyr 61 transcriptional regulation under hypoxia . 1.0626533^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| Hypoxia in vivo and SHYPO in vitro increased the expression of hypoxia inducible factor 1alpha ( HIF 1alpha ) and c jun , as well as CYP3A6 . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| Moreover , TGF beta treated HT 1080 cells contained higher levels of HIF 1alpha and c jun proteins in nuclear extracts . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| Here we describe evidence obtained by using wild type and HIF 1 alpha nullizygous mouse embryonic fibroblasts ( mEFs ) that the induction of c jun mRNA expression and c Jun phosphorylation by prolonged hypoxia are completely dependent on the presence of the oxygen regulated transcription factor hypoxia inducible factor 1 alpha ( HIF 1 alpha ) . ^^^ In contrast , transient hypoxia induced c jun expression in both types of mEFs , showing that the early or rapid induction of this gene is independent of HIF 1 alpha . ^^^ Exposure of these mEFs to prolonged hypoxia demonstrated an absolute requirement for N terminal sites for HIF 1 alpha dependent phosphorylation of c Jun . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| Hypoxia activates the VEGF promoter via response elements that bind the transcription factors hypoxia inducible factor 1 alpha ( HIF 1 alpha ) and activator protein 1 ( AP 1 ) . ^^^ The IGF 1 induced up regulation of VEGF production was associated with activation of AP 1 and HIF 1 alpha and was abrogated by phosphatidylinositol 3 kinase inhibitors ( wortmannin and LY 294002 ) ; Jun kinase inhibitor ( SP 600125 ) ; HIF 1 alpha antisense oligonucleotide ; or geldanamycin , an inhibitor of the heat shock protein 90 molecular chaperone , which regulates the three dimensional conformation and function of IGF 1 receptor and Akt . ^^^ These data indicate that IGF 1 stimulates VEGF synthesis in thyroid carcinomas in an Akt dependent pathway via AP 1 and HIF 1 alpha and provide the framework for clinical use of small molecule inhibitors , including geldanamycin analogs , to abrogate proangiogenic cascades in thyroid cancer . . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : HMG CoA reductase inhibitors downregulate the activation of transcription factors NF kappaB , AP 1 , and hypoxia inducible factor 1alpha . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| Recent mechanistic studies indicate that the pleiotropic activities of 2ME2 are not mediated through alpha and beta estrogen receptors . 2ME2 ' s actions are mediated through inhibition of the proangiogenic transcription factor hypoxia inducible factor 1 alpha , c Jun NH 2 terminal kinase signaling , and the generation of reactive oxygen species . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| Electrophoretic mobility gel shift assay demonstrated significant enhancement in DNA binding activity of hypoxia inducible factor 1alpha ( HIF 1alpha ) and activator protein 1 ( AP 1 ) in nuclear extracts from CoCl 2 treated hearts . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| In vitro , HIF 1alpha is phosphorylated by p 42 and p 44 mitogen activated protein kinases ( MAPKs ) and not by p 38 MAPK or c Jun N terminal kinase . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| Interestingly , Ape1 / ref 1 is a multifunctional protein that not only is a DNA repair enzyme , but also functions as a redox factor maintaining transcription factors , such as Fos , Jun , nuclear factor kappaB , PAX ( paired box containing family of genes ) , hypoxia inducible factor lalpha ( HIF 1alpha ) , HIF 1 like factor , and p 53 , in an active reduced state . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| Here , using the yeast two hybrid screening system , we found that HIF 1alpha interacts with Jab 1 ( Jun activation domain binding protein 1 ) , which is a coactivator of AP 1 transcription factor and fifth subunit of COP 9 signalosome complex . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| This cooperative effect is not due to an increase in the nuclear amount of the HIF 1alpha subunit , nor does it require direct binding of c Jun to DNA . c Jun and HIF 1alpha are able to associate in vivo but not in vitro , suggesting that this interaction involves the participation of additional proteins and / or a posttranslational modification of these factors . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| Experiments in mouse fibroblast cell lines , lacking expression of c Jun N terminal kinases 1 and 2 , suggested that these kinases are not required for induction of HIF 1alpha protein and VEGF mRNA . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| It was recently reported that HIF 1alpha binds a co activator of the AP 1 transcription factor , Jab 1 , which inhibits the p 53 dependent degradation of HIF 1 and enhances the transcriptional activity of HIF 1 and the subsequent VEGF expression under hypoxic conditions . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| Besides its function in DNA repair , APE serves to maintain several transcription factors in an active reduced state such as c Fos , c Jun , NF kappaB , p 53 and HIF 1alpha , all of which have been shown to play a role in tumorigenesis . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| We found that systemic inhibition of IGF 1 signaling with a receptor neutralizing antibody , or with inhibitors of PI 3 kinase ( PI 3K ) , c Jun kinase ( JNK ) , or Akt , suppressed retinal Akt , JNK , HIF 1alpha , nuclear factor ( NF ) kappaB , and AP 1 activity , vascular endothelial growth factor ( VEGF ) expression , as well as intercellular adhesion molecule 1 levels , leukostasis , and blood retinal barrier breakdown , in a relevant animal model . ^^^ Intravitreous administration of IGF 1 increased retinal Akt , JNK , HIF 1alpha , NF kappaB , and AP 1 activity , and VEGF levels . ^^^ IGF 1 stimulated VEGF promoter activity in vitro , mainly via HIF 1alpha , and secondarily via NF kappaB and AP 1 . ^^^ In conclusion , IGF 1 participates in the pathophysiology of diabetic retinopathy by inducing retinal VEGF expression via PI 3K / Akt , HIF 1alpha , NF kappaB , and secondarily , JNK / AP 1 activation . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| Although A 23187 activated extracellular signal regulated kinase ( ERK ) , Jun N terminal kinase ( JNK ) , and p 38 mitogen activated protein kinase ( MAPK ) , as well as protein kinase B , it appeared that the enhancement of HIF 1alpha by A 23187 was only mediated via the ERK pathway . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| Electrophoretic mobility shift assay experiments showed that NSC 13502 inhibited binding of HIF 1alpha and HIF 1beta proteins to a HRE sequence but not binding of the corresponding proteins to activator protein 1 ( AP 1 ) or nuclear factor kappaB ( NF kappaB ) consensus sequences . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| Effects of polycyclic aromatic hydrocarbons ( PAHs ) on vascular endothelial growth factor induction through phosphatidylinositol 3 kinase / AP 1 dependent , HIF 1alpha independent pathway . ^^^ Exposure of cells to B [ a ] PDE and 5 MCDE did not induce HIF 1alpha activation , whereas AP 1 was significantly activated . ^^^ Considering our previous findings that PI 3K is an upstream mediator for c Jun / AP 1 activation , we conclude that the VEGF induction by B [ a ] PDE and 5 MCDE is through PI 3K / AP 1 dependent and HIF 1alpha independent pathways . ^^^ |
|
| Interacting proteins: Q16665 and P05412 |
Pubmed |
SVM Score :0.0 |
| In summary , this study shows that inhibition of PARP on itself is able to control tumor growth , and PARP inhibition or genetic deletion of PARP 1 prevents from tumor promotion through their ability to cooperate with the activation AP 1 , NF kappaB , and HIF 1alpha . . ^^^ |
|