| Interacting proteins: O15534 and Q16665 |
Pubmed |
SVM Score :0.0 |
| Finally , sequence comparison of the currently known bHLH / PAS proteins indicates a division into two phylogenetic groups : the Arnt group , containing Arnt , Arnt 2 , and Per , and the AhR group , consisting of AhR , Sim , and Hif 1alpha . . ^^^ |
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| Interacting proteins: O15534 and Q16665 |
Pubmed |
SVM Score :0.0 |
| ARNT forms heterodimeric complexes with the arylhydrocarbon receptor , HIF 1alpha , Sim and the PAS protein Per . ^^^ |
|
| Interacting proteins: O15534 and Q16665 |
Pubmed |
SVM Score :0.0 |
| Considering these results and that Arnt or Arnt 2 functions as a common partner in the formation of transcriptional regulators with other bHLH / PAS proteins such as AhR , HLF , and HIF 1alpha , the possibility arises that CBP / p300 is extensively involved as a coactivator in the transactivation process by bHLH / PAS ( a conserved sequence motif among Per , Arnt , and Sim ) heterodimer transcription factors through interaction with Arnt or Arnt2 . . ^^^ |
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| Interacting proteins: O15534 and Q16665 |
Pubmed |
SVM Score :0.0 |
| In response to decreased cellular oxygen concentrations the basic helix loop helix ( bHLH ) / PAS ( Per , Arnt , Sim ) hypoxia inducible transcription factor , HIF 1alpha , mediates activation of networks of target genes involved in angiogenesis , erythropoiesis and glycolysis . ^^^ However , nuclear localization per se was not sufficient for transcriptional activation , since fusion of HIF 1alpha to the heterologous GAL 4 DNA binding domain generated a protein which showed constitutive nuclear localization but required hypoxic stimuli for function as a CBP dependent transcription factor . ^^^ |
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| Interacting proteins: O15534 and Q16665 |
Pubmed |
SVM Score :0.0 |
| The key elements of circadian clockwork and oxygen homeostasis are the PAS protein family members PER and CLOCK and hypoxia inducible factor 1alpha ( HIF 1alpha ) . ^^^ Based on coimmunoprecipitation experiments that showed protein protein interaction between PER 1 and the alpha subunit of HIF 1 , we suggest that these hypoxic effects may be modulated by HIF 1alpha . ^^^ |
|
| Interacting proteins: O15534 and Q16665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15534 and Q16665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15534 and Q16665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15534 and Q16665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15534 and Q16665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15534 and Q16665 |
Pubmed |
SVM Score :0.0 |
| NA |
|