| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| The absence of dystrophin leads to a dramatic reduction of the dystrophin associated proteins ( 156DAG , 59DAP , 50DAG , 43DAG and 35DAG ) in the sarcolemma of patients with Duchenne muscular dystrophy and mdx mice . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| We recently reported that the dystrophin associated glycoprotein ( DAG ) complex is biochemically divided into two subcomplexes : one is the dystroglycan complex comprised of 156DAG and 43DAG and the other is the sarcoglycan complex comprised of 50DAG , A3b , and 35DAG . ^^^ In the present study , we examined the striated muscles of the dystrophic hamster with anti A3b antibody in addition to anti 50DAG , anti 43DAG , anti 35DAG , anti dystrophin , and anti laminin antibodies by both immunohistochemistry and immunoblot analysis and found that 50DAG , A3b , and 35DAG are selectively lost . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| In particular , we found that the glycoprotein complex stated above was dissociated into two distinct groups : one composed of 156DAG and 43DAG ( A3a ) and the other composed of 50DAG , 35DAG and A3b . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| Dystrophin associated glycoprotein complex is classified into two subcomplexes : the dystroglycan complex ( 156DAG and 43DAG ) and the sarcoglycan complex ( 50DAG , A3b , and 35DAG ) . ^^^ We examined muscles from five SCARMD patients and found that dystrophin and 43DAG were present in almost normal levels while 35DAG and the newly identified protein A3b in addition to 50DAG were absent or greatly reduced . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| Antibodies against dystrophin , utrophin and DAGs including 50DAG ( A 2 ) , 43DAG ( A3a ) and 35DAG ( A 4 ) were employed for the examination . ^^^ On the other hand , in the dystrophic hamster 50DAG ( A 2 ) and 35DAG ( A 4 ) were selectively defective , and 43DAG ( A3a ) was also decreased , although to a lesser degree . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| Dystrophin associated proteins are comprised of an extracellular glycoprotein of 156 kDa ( 156DAG ) , transmembrane glycoproteins of 50 kDa ( 50DAG ) , 43 kDa ( 43DAG ) and 35 kDa ( 35DAG ) , and a cytoskeletal protein of 59 kDa ( 59DAP ) . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| The dystrophin associated proteins are classified into three groups : ( 1 ) alpha and beta dystroglycan , ( 2 ) adhalin , 35DAG and A3b , and ( 3 ) members of the syntrophin family . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| Pathogenetic mutations involving one gene for sarcoglycan complex components were identified in 13 patients : alpha sarcoglycan in seven , beta sarcoglycan in two , gamma sarcoglycan in four , and none in the delta sarcoglycan gene . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| We investigated the expression of alpha sarcoglycan , beta sarcoglycan , gamma sarcoglycan , and delta sarcoglycan immunohistochemically in three patients with mutations of the alpha sarcoglycan gene and a patient with a mutation of the gamma sarcoglycan gene . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| Interestingly , restoration of alpha , as well as beta sarcoglycan was homogeneous and properly localized throughout transduced muscle , and appeared unaffected by dramatic overexpression of delta sarcoglycan in the cytoplasm of some myofibers . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| The absence of sarcoglycan leads to alterations of membrane permeability and apoptosis , two shared features of a number of dystrophies . beta sarcoglycan and delta sarcoglycan may form the core of the sarcoglycan subcomplex with alpha and gamma sarcoglycan less tightly associated to this core . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| The classification of families was as follows : calpainopathy 7 , dysferlinopathy 3 , alpha sarcoglycan deficiency 2 , beta sarcoglycan deficiency 7 , gamma sarcoglycan deficiency 5 , delta sarcoglycan deficiency 1 , and merosinopathy 2 . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analysis of the dystrophin associated proteins revealed a reduction of beta sarcoglycan and delta sarcoglycan in the sarcolemma of cardiac muscle but not skeletal muscle tissue . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| At 1 and 3 weeks after transfection , immunostaining showed extensive restoration of delta sarcoglycan as well as alpha and beta sarcoglycan proteins to the myocyte membranes , despite loss of beta galactosidase expression at 3 weeks . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| They are : calpain 3 ( LGMD2A ) , dysferlin ( LGMD2B ) , alpha sarcoglycan ( LGMD2D ) , beta sarcoglycan ( LGMD2E ) , gamma sarcoglycan ( LGMD2C ) , delta sarcoglycan ( LGMD2F ) , telethonin ( LGMD2G ) , TRIM 32 ( LGMD2H ) , fukutin related protein ( LGMD2I ) and titin ( LGMD2J ) . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| We have designed Multiplex Amplifiable Probe Hybridization ( MAPH ) probes for 28 exons of the sarcoglycan genes SGCA , SGCB , SGCG , and SGCD . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| To get a closer view on the differentiating molecular events responsible for the muscular dystrophies , we have carried out a comparative gene expression profiling of hindlimb muscles of the following mouse models : dystrophin deficient ( mdx , mdx ( 3cv ) ) , sarcoglycan deficient ( Sgca null , Sgcb null , Sgcg null , Sgcd null ) , dysferlin deficient ( Dysf null , SJL ( Dysf ) ) , sarcospan deficient ( Sspn null ) , and wild type ( C57Bl / 6 , C57Bl / 10 ) mice . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| Mutations in SGCA , SGCB , SGCG and SGCD genes are associated with LGMD 2D , 2E , 2C and 2F , respectively . ^^^ |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16585 and Q92629 |
Pubmed |
SVM Score :0.0 |
| NA |
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