| Interacting proteins: Q16611 and Q16548 |
Pubmed |
SVM Score :0.0 |
| In the yeast cell assay , BOD interacts with diverse antiapoptotic Bcl 2 proteins [ Mcl 1 , Bcl 2 , Bcl xL , Bcl w , Bfl 1 , and Epstein Barr virus ( EBV ) BHRF 1 ] but not with different proapoptotic Bcl 2 proteins ( BAD , Bak , Bok , and Bax ) . ^^^ |
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| Interacting proteins: Q16611 and Q16548 |
Pubmed |
SVM Score :0.0 |
| Mammary gland tissue , similar to many other tissues , expresses a number of different Bcl 2 relatives including bcl 10 , bax , bak , bad , bcl w , bfl 1 , bcl 2 as well as the bcl 2 binding protein Bag 1 . ^^^ Bak , bad , bcl w , and bfl 1 are also up regulated during involution . ^^^ |
|
| Interacting proteins: Q16611 and Q16548 |
Pubmed |
SVM Score :0.0 |
| In the yeast two hybrid system , Mcl 1 binds to the hypophosphorylated mutant of BAD and interacts preferentially with different proapoptotic ( Bax , Bak , Bok , Bik , and BOD ) compared with antiapoptotic Bcl 2 family members ( Bcl 2 , Bcl xL , Bcl w , Bfl 1 , CED 9 , and BHRF 1 ) . ^^^ |
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| Interacting proteins: Q16611 and Q16548 |
Pubmed |
SVM Score :0.0 |
| Using reverse transcriptase polymerase chain reaction , cloning , and sequencing techniques , we have found that HL 60 cells express bak , bik , bax , bad , bcl 2 , bcl xL , bcl w , bfl 1 , fas , and caspases 1 4 and 7 10 . ^^^ After DMSO treatment , bak , bcl w , bfl 1 , fas , and caspases 1 and 9 were up regulated , whereas bik , bcl 2 , and caspases 2 , 3 , and 10 were down regulated at different degrees , achieving mRNA expression levels that correlated with those detected in peripheral blood neutrophils . ^^^ Bak and bfl 1 mRNA levels were largely increased during DMSO induced differentiation of HL 60 cells , and these genes were the bcl 2 family members that were expressed most abundantly in mature neutrophils . ^^^ Peripheral blood neutrophils expressed bak , bad , bcl w , bfl 1 , fas , and caspases 1 , 3 , 4 , and 7 10 , but hardly expressed bcl 2 , bcl xL , bik , bax , and caspase 2 . ^^^ |
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| Interacting proteins: Q16611 and Q16548 |
Pubmed |
SVM Score :0.0 |
| Adult mice exposed to greater than 95 % oxygen concentrations for 48 to 88 hours had increased whole lung mRNA levels of Bax and Bcl 10 ( L ) , no change in Bak , Bad , or Bcl 2 , and decreased levels of Bcl w and Bfl 1 . ^^^ |
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| Interacting proteins: Q16611 and Q16548 |
Pubmed |
SVM Score :0.0 |
| Bcl 2 family member Bfl 1 / A1 sequesters truncated bid to inhibit is collaboration with pro apoptotic Bak or Bax . ^^^ However , Bfl 1 remains tightly and selectively bound to tBid and blocks collaboration between tBid and Bax or Bak in the plane of the mitochondrial membrane , thereby preventing mitochondrial apoptotic activation . ^^^ Lack of demonstrable interaction between Bfl 1 and Bak or Bax in the mitochondrial membrane suggests that Bfl 1 generally prevents the formation of a pro apoptotic complex by sequestering BH 3 domain only proteins . . ^^^ |
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| Interacting proteins: Q16611 and Q16548 |
Pubmed |
SVM Score :0.0 |
| Spontaneous apoptosis of B CLL cells by in vitro culture resulted in decreased bcl 2 , bcl w , bfl 1 , mcl 1 , bak , bax , and bcl 2 / bax expression . ^^^ |
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| Interacting proteins: Q16611 and Q16548 |
Pubmed |
SVM Score :0.0 |
| In the absence of C / EBPdelta , involution is delayed , the pro apoptotic genes encoding p 53 , BAK , IGFBP 5 and SGP2 / clusterin are not activated , while the anti apoptotic genes coding for BFL 1 and Cyclin D 1 are not repressed . ^^^ |
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| Interacting proteins: Q16611 and Q16548 |
Pubmed |
SVM Score :0.0 |
| Hepatic mRNA levels were measured for several pro apoptotic adaptors / regulators , including FasL , Fas receptor , FADD , TRADD , Bad , Bak , Bax , and Bcl 10 ( S ) , and anti apoptotic regulators , including Bcl w , Bcl 10 ( L ) , Bcl 2 , and Bfl 1 . ^^^ |
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| Interacting proteins: Q16611 and Q16548 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16611 and Q16548 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16611 and Q16548 |
Pubmed |
SVM Score :0.0 |
| NA |
|