| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| The expression of apoptosis related genes BCL 2 , BAX , BCL2L1 , BCL2A1 , MCL 1 , DAPK 1 and MYC was studied by quantitative real time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia ( ALL , n = 16 ) , acute myeloid leukaemia ( AML , n = 27 ) , chronic myeloid leukaemia ( CML , n = 12 ) , mantle cell lymphoma ( MCL , n = 19 ) and chronic lymphoid leukaemia ( CLL , n = 32 ) . ^^^ BCL 2 , BAX , BCL2A1 , MCL 1 , DAPK 1 and MYC were overexpressed in all patient groups . ^^^ BCL 2 , BCL2L1 , BCL2A1 and MCL 1 were overexpressed and DAPK 1 was underexpressed in CLL samples with a 11q23 deletion . ^^^ |
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| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| Genes overexpressed only in hyperplasia were : MDM 2 , MCL 1 , BCL2A1 , BLK , RIPK 2 , CD40LG , TRAF 5 , HUS 1 , BNIP 3 . ^^^ |
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| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| In the yeast two hybrid system , Bok interacted strongly with some ( Mcl 1 , BHRF 1 , and Bfl 1 ) but not other ( Bcl 2 , Bcl xL , and Bcl w ) anti apoptotic members . ^^^ |
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| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| In the yeast cell assay , BOD interacts with diverse antiapoptotic Bcl 2 proteins [ Mcl 1 , Bcl 2 , Bcl xL , Bcl w , Bfl 1 , and Epstein Barr virus ( EBV ) BHRF 1 ] but not with different proapoptotic Bcl 2 proteins ( BAD , Bak , Bok , and Bax ) . ^^^ |
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| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| In the yeast two hybrid system , Mcl 1 binds to the hypophosphorylated mutant of BAD and interacts preferentially with different proapoptotic ( Bax , Bak , Bok , Bik , and BOD ) compared with antiapoptotic Bcl 2 family members ( Bcl 2 , Bcl xL , Bcl w , Bfl 1 , CED 9 , and BHRF 1 ) . ^^^ |
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| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| Even though wild type BAD only interacted with selected numbers of antiapoptotic proteins , underphosphorylated mutant BAD interacted with all antiapoptotic Bcl 2 proteins tested ( Bcl 2 , Bcl w , Bcl xL , Bfl 1 / A1 , Mcl 1 , Ced 9 , and BHRF 1 ) . ^^^ |
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| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| The response includes inhibition of caspase activity , activation of NF kappaB , and expression of mcl 1 , bcl 2 , and bfl 1 in the tumor cells . ^^^ |
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| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| Spontaneous apoptosis of B CLL cells by in vitro culture resulted in decreased bcl 2 , bcl w , bfl 1 , mcl 1 , bak , bax , and bcl 2 / bax expression . ^^^ |
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| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| Our main findings were : 1 ) IL 10 enhances lipid accumulation in oxLDL stimulated THP 1 macrophages , at least partly by counteracting oxLDL induced apoptosis ; 2 ) This antiapoptotic effect of IL 10 involves increased expression of the antiapoptotic genes Bfl 1 and Mcl 1 , accompanied by protective effects on mitochondria function ; 3 ) By silencing Bfl 1 and Mcl 1 genes using siRNAs , we were able to abolish this IL 10 mediated effect on lipid accumulation ; 4 ) IL 10 also induced lipid accumulation in oxLDL stimulated macrophages from patients with ACS , but not in macrophages from healthy controls ; 5 ) In ACS patients , this enhancing effect of IL 10 on lipid accumulation was accompanied by enhanced Mcl 1 expression . ^^^ |
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| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| A . phagocytophilum infection also altered the apoptotic program of NB 4 cells and resulted in increased transcription of antiapoptotic genes ( MCL 1 and BFL 1 ) . ^^^ |
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| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| We show that the antiapoptotic proteins BCL 2 , BCL XL , MCL 1 , BFL 1 , and BCL w each bear a unique pattern of interaction with a panel of peptides derived from BH 3 domains of BH 3 only proteins . ^^^ |
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| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16548 and Q07820 |
Pubmed |
SVM Score :0.0 |
| NA |
|