| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| DDB 1 ( p 127 ) is a UV damaged DNA binding protein that is involved , as part of a complex with DDB 2 ( p 48 ) , in nucleotide excision repair and the hereditary disease xeroderma pigmentosum . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| Hepatitis B virus 10 protein associated with UV DDB 1 induces cell death in the nucleus and is functionally antagonized by UV DDB 2 . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| The human UV damaged DNA binding protein ( UV DDB ) , a heterodimeric protein composed of 127 kDa ( UV DDB 1 ) and 48 kDa ( UV DDB 2 ) subunits , has been shown to be involved in DNA repair . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| Chromosomal localization and cDNA cloning of the genes ( DDB 1 and DDB 2 ) for the p 127 and p 48 subunits of a human damage specific DNA binding protein . ^^^ Using a fluorescence in situ hybridization technique , the DDB p 127 locus ( DDB 1 ) was assigned to the chromosomal location 11q12 q 13 , and the DDB p 48 locus ( DDB 2 ) to 11p11 p12 . . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| Studies of the murine DDB 1 and DDB 2 genes . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| However , overexpressed p 48 peptides containing the mutations found in three Ddb ( ) XPE strains are inactive , and wild type p 48 restores DDB activity to extracts from a fourth XPE Ddb ( ) strain , GM 01389 , in which compound heterozygous mutations in DDB 2 ( p 48 ) lead to a L350P change from one allele and a Asn 349 deletion from the other . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| In all donors , the most highly responsive gene identified was DDB 2 , which codes for the p 48 subunit of XPE , a protein known to play a crucial role in repair of ultraviolet ( UV ) radiation damage in DNA . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| The damaged DNA binding protein DDB consists of two subunits , DDB 1 ( 127 kDa ) and DDB 2 ( 48 kDa ) . ^^^ We showed that expression of DDB 1 and DDB 2 stimulated the activity of the cell cycle regulatory transcription factor E2F1 . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| DDB 2 induces nuclear accumulation of the hepatitis B virus 10 protein independently of binding to DDB 1 . ^^^ Because the DDB 2 subunit of DDB is required for the nuclear accumulation of DDB 1 , we investigated the role of DDB 2 in the nuclear accumulation of HBx . ^^^ Several C terminal deletion mutants of DDB 2 that fail to bind DDB 1 are able to associate with HBx , suggesting that DDB 2 may associate with HBx independently of binding to DDB 1 . ^^^ We also show that DDB 2 enhances the nuclear accumulation of HBx independently of binding to DDB 1 , since a mutant that does not bind DDB 1 is able to enhance the nuclear accumulation of HBx . ^^^ We show that the nuclear levels of DDB 1 and DDB 2 are tightly regulated in hepatocytes . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| Damaged DNA binding activity comprises two major protein components , DDB 1 and DDB 2 , which are implicated in the repair of ultraviolet ( UV ) radiation induced DNA damage . ^^^ Interestingly , a mutated form of DDB 2 , which is defective in interacting with DDB 1 and binding to UV damaged DNA , also markedly inhibited the activation of apoptosis executioners . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| The association of c Abl with DDB 1 required the kinase domain of c Abl and preserved the interaction between DDB 1 and the small subunit ( DDB 2 ) of the UV DDB complex . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| Damaged DNA recognition activity has been identified from primate cells as a complex of DDB 1 ( 127 kD ) and DDB 2 ( 48 kD ) subunits . ^^^ There is a cell type dependent expression of DDB 1 and DDB 2 . ^^^ These results also suggest that the profusion of DDB 2 , but not DDB 1 , may moderate UV damaged DNA recognition activity . . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| Mutations in DDB 2 are responsible for Xeroderma Pigmentosum group E , but no mutants of mammalian DDB 1 have been described . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| We find that the Xeroderma Pigmentosum Complementation group E ( XPE ) mutated Damaged DNA binding protein p 48 ( DDB 2 ) is upregulated by BRCA 1 in a p 53 dependent manner following UVC , Adriamycin , or Cisplatin exposure . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| Furthermore , STAT 1 is degraded in GM 02415 ( 2RO ) cells , which have a mutation in DDB 2 ( the p 48 subunit of DDB ) which abolishes its ability to interact with DDB 1 , thereby demonstrating that the role of DDB 1 in STAT 1 degradation is independent of its association with DDB 2 . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| There is some controversy regarding the precise mechanism of upregulation of XPE DDB 2 or XPC by BRCA 1 , with some evidence suggesting that p 53 is involved in their regulation . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| UV damaged DNA binding protein ( UV DDB ) is composed of two subunits , DDB 1 ( p 127 ) and DDB 2 ( p 48 ) . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| DDB ( damaged DNA binding protein ) is a heterodimer , comprised of p 48 ( DDB 2 ) and p 127 ( DDB 1 ) subunits , which has a high affinity for a variety of DNA lesions including UV photoproducts . ^^^ Furthermore , the chicken DDB 1 ( tagged with enhanced GFP ) transiently expressed in human cells mainly localized in the cytoplasm , and coexpression of human DDB 2 dramatically changed the localization from the cytoplasm to nucleus . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| One such multiprotein complex containing DDB 1 and DDB 2 is closely related to a complex containing DDB 1 and the Cockayne syndrome group A ( CSA ) protein . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| Damaged DNA binding protein ( DDB ) is a heterodimer ( DDB 1 and DDB 2 ) , which is implicated in the repair of UV irradiated DNA damage . ^^^ Based on these results , D 1 and D 2 are dominant negative inhibitors of DNA repair , which is probably due to disruption of complex formation between DDB 1 and DDB 2 WT and of DDB 1 nuclear import . . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| The complex consists of a heterodimer of p 127 ( DDB 1 ) and p 48 ( DDB 2 ) , the latter also being known as XPE . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| In addition , DDB 2 in conjunction with DDB 1 associates with cullin 4A and the Cop9 / signalosome . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| Basal transcriptional regulation of human damage specific DNA binding protein genes DDB 1 and DDB 2 by Sp 1 , E2F , N myc and NF 1 elements . ^^^ The human DDB 1 and DDB 2 genes encode the 127 and 48 kDa subunits , respectively , of the damage specific DNA binding protein ( DDB ) . ^^^ Transient expression analysis in HeLa cells using a luciferase reporter system indicated the presence of core promoters located within 292 bp ( DDB 1 ) and 220 bp ( DDB 2 ) upstream of the putative transcription initiation sites . ^^^ Both core promoters contain multiple active Sp 1 sites , with those of DDB 1 at 123 to 115 and of DDB 2 at 29 to 22 being critical determinants of promoter activity . ^^^ In addition , an N myc site at 56 to 51 for DDB 1 is an essential transcription element , and mutations in a DDB 1 NF 1 site at 104 to 92 , a DDB 2 NF 1 site at 68 to 56 and a DDB 2 E2F site at +36 to +43 also reduce promoter activity . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Ultraviolet radiation ( UV ) damaged DNA binding ( DDB ) activity comprises two major components : damaged DNA binding protein 1 ( DDB 1 ) and 2 ( DDB 2 ) . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| Here , we show that DDB 2 and CSA are each integrated into nearly identical complexes via interaction with DDB 1 . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| The UV damaged DNA binding activity protein ( UV DDB ) consists of two subunits , DDB 1 and DDB 2 , and functions in DNA repair and cell cycle regulation . ^^^ Thus , SV 5 5 and HBx bind to DDB 1 in a mutually exclusive manner , and SV 5 5 shares with HBx the ability to enhance the steady state levels of DDB 1 and to inhibit its association with DDB 2 . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| DDB 2 together with DDB 1 comprises a heterodimer called DDB complex , which is involved in damaged DNA binding and nucleotide excision repair . ^^^ Immunoprecipitation confirmed that Cul4A interacts with DDB 1 and also associates with DDB 2 . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| DDB 1 DDB 2 ( xeroderma pigmentosum group E ) protein complex recognizes a cyclobutane pyrimidine dimer , mismatches , apurinic / apyrimidinic sites , and compound lesions in DNA . ^^^ The DDB protein complex , comprising the subunits DDB 1 and DDB 2 , binds tightly to UV light irradiated DNA . ^^^ Co purified DDB 1 DDB2 or DDB reconstituted with individual DDB 1 and DDB 2 subunits binds to damaged DNA as a ternary complex . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| We previously showed that the breast and ovarian cancer susceptibility gene product BRCA 1 , through p 53 , upregulates expression of the XPE gene DDB 2 encoding the nucleotide excision repair protein p 48 . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| UV DDB comprises two subunits , products of the DDB 1 and DDB 2 genes , respectively . ^^^ The UV DDB complex is a component of the newly identified cullin 4A based ubiquitin E 3 ligase , DDB 1 CUL4A ( DDB 2 ) . ^^^ We demonstrate that monoubiquitinated histone H2A in native chromatin coimmunoprecipitates with the endogenous DDB 1 CUL4A ( DDB 2 ) complex in response to UV irradiation . ^^^ Further , mutations in DDB 2 alter the formation and binding activity of the DDB 1 CUL4A ( DDB 2 ) ligase , accompanied by impaired monoubiquitination of H2A after UV treatment of XP E cells , compared with repair proficient cells . ^^^ This finding indicates that DDB 2 , as the substrate receptor of the DDB 1 CUL4A based ligase , specifically targets histone H2A for monoubiquitination in a photolesion binding dependent manner . ^^^ |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92466 and Q16531 |
Pubmed |
SVM Score :0.0 |
| NA |
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