| Interacting proteins: P56645 and Q16526 |
Pubmed |
SVM Score :0.0 |
| The basic helix loop helix PAS proteins CLOCK and BMAL 1 are positive regulators and drive the expression of the negative regulators CRY 1 and CRY 2 , as well as PER 1 , PER 2 , and PER 3 . ^^^ |
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| Interacting proteins: P56645 and Q16526 |
Pubmed |
SVM Score :0.0 |
| We have found that in rat heart all mammalian homologues of known Drosophila clock genes ( bmal 1 , clock , cry 1 , cry 2 , per 1 , per 2 , per 3 , dbp , hlf , and tef ) show circadian patterns of expression and that the induction of clock output genes ( the PAR [ rich in proline and acidic amino acid residues ] transcription factors dbp , hlf , and tef ) is attenuated in the pressure overloaded hypertrophied heart . ^^^ |
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| Interacting proteins: P56645 and Q16526 |
Pubmed |
SVM Score :0.0 |
| The circadian patterns of gene expression of seven components of the mammalian clock ( bmal 1 , clock , cry 1 , cry 2 , per 1 , per 2 and per 3 ) , as well as three clock output genes ( dbp , hlf and tef ) , were compared in hearts isolated from control and STZ induced diabetic rats . ^^^ |
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| Interacting proteins: P56645 and Q16526 |
Pubmed |
SVM Score :0.0 |
| The expression of per 3 , cry 1 , 2 , clock , npas 2 , bmal 1 , and casein kinase 1epsilon did not change with sleep deprivation . ^^^ |
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| Interacting proteins: P56645 and Q16526 |
Pubmed |
SVM Score :0.0 |
| Among the components of the negative limb of the feedback loop , Per 1 , Per 2 , Per 3 , Cry 2 but not Cry 1 genes show a shortened duration of their peak expression under SP compared with LP . ^^^ Moreover , mRNA expression of Per 1 , Per 3 and Cry 1 are phase advanced in SP compared with LP . ^^^ |
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| Interacting proteins: P56645 and Q16526 |
Pubmed |
SVM Score :0.0 |
| The endogenous oscillation machinery involves interactive positive and negative transcriptional and posttranslational feedback loops involving the clock genes Per 1 , Per 2 , Per 3 , Clock , Bmal 1 , Cry 1 and Cry 2 . ^^^ |
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| Interacting proteins: P56645 and Q16526 |
Pubmed |
SVM Score :0.0 |
| Advances in chronobiology have identified the suprachiasmatic nucleus ( SCN ) as the center of biological rhythms and the area in which clock genes such as PER 1 , PER 2 , PER 3 , CLOCK , BMAL 1 , TIM , CRY 1 , CRY 2 , tau act to generate and coordinate biological rhythms . ^^^ |
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| Interacting proteins: P56645 and Q16526 |
Pubmed |
SVM Score :0.0 |
| Per1 , Per 3 , Cry 2 and Cry 1 clock genes are expressed in the pineal gland and their transcription is increased during the night . ^^^ In contrast , Per 3 and Cry 1 day and night mRNA levels are not responsive to adrenergic ligands ( as previously reported for Per 2 ) and daily expression of Per 3 and Cry 1 appears strongly damped or abolished in constant darkness . ^^^ The expression of Per 3 and Cry 1 displays a daily rhythm not regulated by norepinephrine , suggesting the involvement of another day / night regulated transmitter ( s ) . . ^^^ |
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| Interacting proteins: P56645 and Q16526 |
Pubmed |
SVM Score :0.0 |
| This group includes putative clock elements cry 1 and per 3 in addition to several previously unidentified and uninvestigated genes exhibiting profiles of mRNA abundance that varied markedly under daily and constant conditions . ^^^ |
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| Interacting proteins: P56645 and Q16526 |
Pubmed |
SVM Score :0.0 |
| For this purpose , the 24 h expression of nine clock genes ( bmal 1 , clock , per 1 , per 2 , per 3 , cry 1 , cry 2 , dec 1 and dec 2 ) and the aa nat gene was monitored under light dark 8 : 16 and light dark 16 : 8 in the rat pineal by using real time RT PCR . ^^^ |
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| Interacting proteins: P56645 and Q16526 |
Pubmed |
SVM Score :0.0 |
| Additionally , expressions of Per 1 , Per 2 , Per 3 , Bmal 1 , Bmal 2 , Clock , Cry 1 , and Cry 2 clock genes were simultaneously detected in single chicken pineal glands . . ^^^ |
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| Interacting proteins: P56645 and Q16526 |
Pubmed |
SVM Score :0.0 |
| For this purpose , the 24 h profiles of nine clock genes ( bmal 1 , clock , per 1 , per 2 , per 3 , dec 1 , dec 2 , cry 1 and cry 2 ) and the arylalkylamine N acetyltransferase gene as an indicator of the circadian pacemaker output were compared between light dark periods of 8 : 16 and 16 : 8 h . ^^^ |
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| Interacting proteins: P56645 and Q16526 |
Pubmed |
SVM Score :0.0 |
| To investigate avian clock gene expression , partial cDNA sequences of six mammalian clock gene homologs ( Bmal 1 , Clock , Per 2 , Per 3 , Cry 1 , and Cry 2 ) and a novel avian cryptochrome gene ( Cry 4 ) were cloned from the house sparrow , a model system in circadian research . ^^^ |
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| Interacting proteins: P56645 and Q16526 |
Pubmed |
SVM Score :0.0 |
| NA |
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