| Here we map the E2F 4 transactivation domain and show that E2F 1 and E2F 4 transactivation domains bind the acetyltransferase GCN 5 and cofactor TRRAP in vivo . ^^^ E2F 4 proteins with subtle mutations in the transactivation domain exhibited a positive correlation among transcriptional activation and GCN 5 and TRRAP binding capacity and associated acetyltransferase activity . ^^^ |