| Interacting proteins: Q14188 and Q16254 |
Pubmed |
SVM Score :0.0 |
| Northern blot analysis of the expression of E2F and DP family members showed that the E2F 1 , E2F 4 , and E2F 5 mRNA was growth and senescence dependent , whereas E2F 3 , DP 1 , and DP 2 expression was constitutive and senescence independent . ^^^ |
|
| Interacting proteins: Q14188 and Q16254 |
Pubmed |
SVM Score :0.0 |
| Unlike E2F 1 , 2 , and 3 , E2F 4 did not accumulate in the nucleus unless it was coexpressed with DP 2 , p 107 and p 130 , but not pRb , stimulated nuclear localization of E2F 4 , either alone or in combination with DP 2 . ^^^ |
|
| Interacting proteins: Q14188 and Q16254 |
Pubmed |
SVM Score :0.0 |
| Cotransfection of expression vectors encoding p 107 , p 130 , or DP 2 , but not DP 1 , resulted in the nuclear localization of E2F 4 and 5 . ^^^ |
|
| Interacting proteins: Q14188 and Q16254 |
Pubmed |
SVM Score :0.0 |
| However , it has no effect on the transcription of the E2F 3 , E2F 4 , E2F 5 , DP 1 , DP 2 , or p16 / Ink4 genes . ^^^ |
|
| Interacting proteins: Q14188 and Q16254 |
Pubmed |
SVM Score :0.0 |
| The crystal structure of an E2F4 DP 2 DNA complex shows that the DNA binding domains of the E2F and DP proteins both have a fold related to the winged helix DNA binding motif . ^^^ E2F4 and DP 2 interact through an extensive protein protein interface , and structural features of this interface suggest it contributes to the preference for heterodimers over homodimers in DNA binding . . ^^^ |
|
| Interacting proteins: Q14188 and Q16254 |
Pubmed |
SVM Score :0.0 |
| Alteration in transactivation of the E2F consensus promoter sequence was also examined by transient cotransfection of a E2F 4 with a DP 2 construct into cultured human cells . ^^^ |
|
| Interacting proteins: Q14188 and Q16254 |
Pubmed |
SVM Score :0.0 |
| No differences were observed between RA sensitive and RA resistant ovarian carcinoma cells in the levels of expression of many cell cycle genes including cyclin A , B and E , cdk 2 , 4 and 6 , E2F 1 , E2F 2 , E2F 3 , E2F 4 , E2F 5 , DP 1 and DP 2 . ^^^ |
|
| Interacting proteins: Q14188 and Q16254 |
Pubmed |
SVM Score :0.0 |
| It has been proposed that E2F 4 and E2F 5 , which lack defined nuclear localization signal ( NLS ) consensus sequences , enter the nucleus in association with NLS containing DP 2 or pRB family proteins . ^^^ |
|
| Interacting proteins: Q14188 and Q16254 |
Pubmed |
SVM Score :0.0 |
| Low density DNA array analysis revealed that telomerase activity increases the expression of G 1 regulating genes including cyclin D 3 , cyclin E 1 , E2F 4 , and DP 2 , associated with hyperphosphorylation of retinoblastoma ( pRb ) , leading to the extended proliferative capacity of BMSSC Ts . ^^^ |
|
| Interacting proteins: Q14188 and Q16254 |
Pubmed |
SVM Score :0.0 |
| Here we investigated the role of E2F1 and E2F4 expression , with or without co expression of DP 1 or DP 2 , on cell proliferation in transiently transfected primary rat MCs . ^^^ |
|
| Interacting proteins: Q14188 and Q16254 |
Pubmed |
SVM Score :0.0 |
| RT PCR analyses revealed that the GCN 5 deficiency exhibited opposite influences on transcriptions of G1 / S phase transition related genes , i . e . repressions for E2F 1 , E2F 3 , E2F 4 , E2F 6 , DP 2 , cyclin A , cyclin D 3 , PCNA , cdc25B and p 107 ; and activations for p 27 , c myc , cyclin D 2 and cyclin G 1 . ^^^ |
|
| Interacting proteins: Q14188 and Q16254 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14188 and Q16254 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14188 and Q16254 |
Pubmed |
SVM Score :0.0 |
| NA |
|