| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| Furthermore , heterodimers containing E2F 4 , a family member lacking the cyclin A binding domain found in E2F 1 , are not efficiently phosphorylated or functionally down regulated by cyclin A dependent kinases . ^^^ However , addition of the E2F 1 cyclin A binding domain to E2F 4 conferred cyclin A dependent kinase mediated down regulation of the E2F 4 DP 1 heterodimer . ^^^ |
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| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis of BIP with cyclins / CDKs and E2F antisera indicated association with cdc 2 , cdk 2 , cdk 4 , cyclin B , cyclin D , cyclin A and E2F 4 but not with cdk 3 , cdk 5 , cdk 6 , E2F 1 , E2F 2 , E2F 3 , E2F 5 and cyclin E . ^^^ |
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| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| In agreement with this conclusion , we find that the cyclin A promoter only poorly interacts with E2F 4 , which is the major E2F family member in G 0 cells , while a clear binding is seen with E2F 1 and 3 , which are up regulated in late G1 . . ^^^ |
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| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| TSA enhanced the protein expression of p 21 ( WAF 1 ) , CREB binding protein , cyclinE , cyclin A , Bak and Bax , while it reduced the expression of E2F 1 , E2F 4 , HDAC 1 , p 53 and hyperphosphorylated form of Rb . ^^^ |
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| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| No differences were observed between RA sensitive and RA resistant ovarian carcinoma cells in the levels of expression of many cell cycle genes including cyclin A , B and E , cdk 2 , 4 and 6 , E2F 1 , E2F 2 , E2F 3 , E2F 4 , E2F 5 , DP 1 and DP 2 . ^^^ |
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| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| Tat 10 E2F 4 complexes were shown to bind to E2F cis regions with increased efficiency compared with E2F 4 alone and to mediate the activity of E2F dependent promoters including HIV 1 long terminal repeat and cyclin A . ^^^ |
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| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| Chromatin immunoprecipitation analysis demonstrated that the cyclin A promoter is predominantly bound in proliferating keratinocytes by complexes containing E2F 3 and E2F 4 . ^^^ Thus , the mechanisms of decreased expression of cyclin A in the presence of dnDP 1 seem to involve inactivation of DP 1 complexes containing E2F 3 and E2F 4 . ^^^ |
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| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| RT PCR analyses revealed that the GCN 5 deficiency exhibited opposite influences on transcriptions of G1 / S phase transition related genes , i . e . repressions for E2F 1 , E2F 3 , E2F 4 , E2F 6 , DP 2 , cyclin A , cyclin D 3 , PCNA , cdc25B and p 107 ; and activations for p 27 , c myc , cyclin D 2 and cyclin G 1 . ^^^ |
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| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| When DP 1 was connected to cyclin A Cdk 2 through E2F4 and p 107 , its phosphorylation was very inefficient , although its association with cyclin A Cdk 2 was stable . ^^^ In contrast , DP 1 was efficiently phosphorylated when weakly connected to cyclin A Cdk 2 via E2F1 or E2F4 with a fused cyclin A binding domain of E2F1 . ^^^ |
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| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| Dissociation of cyclin A cyclin dependent kinase 2 from E2F4 p 130 complexes . ^^^ E2F4 p 130 becomes the predominant E2F pocket complex formed on E2F sites , but , unlike the complex that typifies resting cells , cyclin A and CDK 2 are also present . ^^^ Administration of dexamethasone at this , but not earlier stages , results in reduction of cyclin A and CDK 2 levels with a parallel decrease in the associated kinase activity , dissociation of cyclin A CDK 2 from the E2F4 p 130 complexes , and inhibition of G ( 1 ) / S transition . ^^^ |
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| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| Quantitative real time PCR revealed that E2F1 , E2F2 , E2F3 , and E2F4 alleviate G 0 arrest by induction of cyclinA and E cyclins . ^^^ |
|
| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| In both the E2F3a and E2F4 transgenic lenses , cyclin A 2 and cyclin B 1 expression were upregulated . ^^^ |
|
| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| Cell cycle regulators p 105 , p 107 , Rb2 / p130 , E2F4 , p21CIP1 / WAF1 , cyclin A in predicting cervical intraepithelial neoplasia , high risk human papillomavirus infections and their outcome in women screened in three new independent states of the former Soviet Union . ^^^ METHODS : Totally , 232 biopsy samples tested high risk HPV positive and / or Papanicolaou smear positive women were immunohistochemically stained for the following cell cycle markers : p 105 , p 107 , p 130 , E2F4 , p 21 ( CIP1 / WAF1 / SDI1 ) , cyclin A , and Ki 67 . ^^^ |
|
| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16254 and P20248 |
Pubmed |
SVM Score :0.0 |
| NA |
|