| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| It is not inhibited or activated significantly by a panel of inhibitors or activators of protein kinase A , protein kinase G , rhodopsin kinase , CaM kinase 2 , casein kinase 2 , or cyclin dependent kinase 5 , at concentrations 50 or more times higher than their reported IC ( 50 ) or K ( 1 ) values . ^^^ |
|
| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| In squid eye membranes , arrestin was phosphorylated in a Ca2+ dependent manner and this phosphorylation was inhibited by antibodies raised against squid rhodopsin kinase , but not by inhibitors of protein kinase C or calmodulin kinase . ^^^ |
|
| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that calmodulin , another mediator of calcium signaling , is a potent inhibitor of GRK activity with a selectivity for GRK 5 ( IC 50 approximately 50 nM ) > GRK 6 > > GRK 2 ( IC 50 approximately 2 microM ) > > GRK 1 . ^^^ |
|
| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| This mechanism , however , is highly selective with respect to the GRK subtypes : GRK 1 , but not GRK 2 and GRK 5 , is regulated by recoverin and other NCS , but GRK 4 , 5 , and 6 , which belong to the GRK 4 subfamily are potently inhibited by CaM , which has little or no effect on members of other GRK subfamilies . ^^^ |
|
| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| This mechanism is , however , highly selective with respect to the GRK subtypes : while GRK 1 , but not GRK 2 and GRK 5 , is regulated by recoverin and other NCS , GRK 4 , 5 and 6 , that belong to the GRK 4 subfamily , are potently inhibited by CaM , which had little or no effect on members of other GRK subfamilies . . ^^^ |
|
| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| Some involve calcium binding proteins like recoverin , guanylyl cyclase activating protein and calmodulin , and their target proteins rhodopsin kinase , guanylyl cyclase , the cGMP gated channel , and NO synthase . ^^^ |
|
| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| While GRK 1 ( rhodopsin kinase ) is inhibited by the photoreceptor specific Ca2+ binding protein recoverin , other GRKs can be inhibited by Ca2+ calmodulin . ^^^ |
|
| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15835 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|